Abstract：
:In metastatic renal cell carcinoma, complete response to first-line antiangiogenic agents is rare and resistance to therapy often develops. Protocols for sequential treatment with angiogenesis and mTOR inhibitors are under evaluation to improve outcomes. In this observational, real-world study, patients received a first-line therapy with pazopanib until discontinuation for disease progression or toxicity, then a second-line with everolimus. Primary endpoints were overall survival (OS) for sequence, progression free survival (PFS) for each agent, and safety. Thirty-one patients were included in the analysis: 73.3% of patients underwent nephrectomy before treatment, 25.8% had at least three comorbidities. At the beginning of therapy, the median age was 68 years, with more than 60% of patients older than 65 years. The median OS for sequence was 26.5 months (95% CI 17.4-nc); median PFS was 10.6 months (95% CI 6.3-12.1) with pazopanib and 5.3 months (95% CI 3.8-6.7) with everolimus. The median persistence in pazopanib therapy was 8.1 months (Interquartile Range IQR 5.3-12.7), with 31% of patients who required dose reduction, while persistence in everolimus was 4.4 months (IQR 3.4-6.5). Sequence was well tolerated with a different profile of adverse events for each agent. These data confirmed that pazopanib was effective, even in reduced dosing, and well tolerated and suggested that everolimus may represent an opportunity to continue a therapy when patients cannot further tolerate angiogenesis inhibitors or develop a resistance.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Rossetti S,D'Aniello C,Iovane G,Scagliarini S,Laterza MM,De Vita F,Savastano C,Cartenì G,Porricelli MA,Berretta M,Pisconti S,Facchini G,Cavaliere Cdoi
10.3389/fphar.2017.00484subject
Has Abstractpub_date
2017-07-20 00:00:00pages
484issn
1663-9812journal_volume
8pub_type
杂志文章abstract：:Introduction: Over the past decades, early awareness and alert (EAA) activities and systems have gained importance and become a key early health technology assessment (HTA) tool. While a pioneer in HTA, Sweden had no national level EAA activities until 2010. We describe the evolution and current status of the Swedish ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2017.00674
更新日期：2017-10-05 00:00:00
abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.01246
更新日期：2020-08-14 00:00:00
abstract：:Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern heal...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.01115
更新日期：2020-07-24 00:00:00
abstract：:Styryllactones, a class of compounds obtained from the genus Goniothalamus (Annonaceae), have demonstrated in vitro antitumor activity. However, the aqueous solubility of these compounds is poor. In this study, we identified the absolute configurations of the previously isolated compounds, which were first isolated in...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00484
更新日期：2020-04-22 00:00:00
abstract：:Fertility issues are common amongst women with rheumatoid arthritis (RA). Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα), known key players in RA pathogenesis, have been associated with reproductive disorders. This study investigates the role of these cytokines in decreased fertility in women with active ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.604866
更新日期：2020-12-10 00:00:00
abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00947
更新日期：2020-08-13 00:00:00
abstract：:Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01427
更新日期：2019-12-19 00:00:00
abstract：:[This corrects the article on p. 727 in vol. 8, PMID: 29114222.]. ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,已发布勘误
doi：10.3389/fphar.2017.00964
更新日期：2018-01-09 00:00:00
abstract：:This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.01362
更新日期：2018-12-11 00:00:00
abstract：:Background and purpose: As an herbal medicine, adzuki bean has been practiced since the Tang Dynasty of China to maintain health and control weight; this practice is still very popular in China nowadays. However, it is still lack of sufficient scientific basis to explain scientific principle of this popular civil prac...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00687
更新日期：2017-09-27 00:00:00
abstract：:Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.602447
更新日期：2020-12-17 00:00:00
abstract：:There are three members of the endogenous gas transmitter family. The first two are nitric oxide and carbon monoxide, and the third newly added member is hydrogen sulfide (H2S). They all have similar functions: relaxing blood vessels, smoothing muscles, and getting involved in the regulation of neuronal excitation, le...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.00702
更新日期：2020-05-14 00:00:00
abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2015.00017
更新日期：2015-02-09 00:00:00
abstract：:15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), a non-invasive technique for sampling of airway secretions, in patients with cystic fibrosis (CF). Azithromycin has antioxidant properties in experimental models of CF, but its effects on oxidative...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.00595
更新日期：2018-06-18 00:00:00
abstract：Introduction:Infliximab (IFX) was the first anti-tumor necrosis factor (TNFα) antibody to be used in the treatment of severe chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. A number of serious adverse drug reactions are known to be associated with IFX use; they include infections, malig...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00513
更新日期：2020-04-22 00:00:00
abstract：:Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed to investigate the hepatoprotective effects of costunolide again...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.01469
更新日期：2018-12-20 00:00:00
abstract：:Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.532568
更新日期：2020-11-16 00:00:00
abstract：:The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over acti...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2017.00022
更新日期：2017-01-30 00:00:00
abstract：:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhi...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2019.00202
更新日期：2019-03-14 00:00:00
abstract：:Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have significant adverse effects. One approach is targeting either neurotrophic...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00365
更新日期：2017-06-21 00:00:00
abstract：:A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's disease, Huntington disease, amyotrophic lateral sclerosis, Friedrich's ataxia and Parkinson'...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2014.00038
更新日期：2014-03-10 00:00:00
abstract：:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pan...
journal_title：Frontiers in pharmacology
pub_type：
doi：10.3389/fphar.2020.00023
更新日期：2020-02-10 00:00:00
abstract：:In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2018.01436
更新日期：2018-12-04 00:00:00
abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...
journal_title：Frontiers in pharmacology
pub_type：
doi：10.3389/fphar.2017.00652
更新日期：2017-09-25 00:00:00
abstract：:Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00307
更新日期：2019-03-28 00:00:00
abstract：:Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00939
更新日期：2017-12-21 00:00:00
abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00940
更新日期：2019-08-29 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We studied the effects of Aβ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00709
更新日期：2020-05-21 00:00:00
abstract：:Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00850
更新日期：2017-11-21 00:00:00
abstract：:Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2019.00382
更新日期：2019-04-12 00:00:00
