In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats.

abstract：:Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patte...

journal_title：Frontiers in pharmacology

authors： Wu L,Tai Y,Hu S,Zhang M,Wang R,Zhou W,Tao J,Han Y,Wang Q,Wei W

更新日期：2018-11-27 00:00:00

abstract：:Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bib...

journal_title：Frontiers in pharmacology

authors： Wang CY,Li BH,Ma LL,Zhao MJ,Deng T,Jin YH,Ren XQ

更新日期：2019-02-12 00:00:00

abstract：:This study aimed to determine the population pharmacokinetic (Pop PK) parameters of cefazolin administered prophylactically at 25 mg/kg intravenously (IV) 30 min before surgery in a canine population of 78 dogs and assess whether covariates, such as sex, age, body weight (BW), breed, health status, creatinine level, a...

journal_title：Frontiers in pharmacology

authors： Cagnardi P,Di Cesare F,Toutain PL,Bousquet-Mélou A,Ravasio G,Villa R

更新日期：2018-10-09 00:00:00

abstract：:Pasteurella multocida (PM) can invade the upper respiratory tract of the body and cause death and high morbidity. Tildipirosin, a new 16-membered-ring macrolide antimicrobial, has been recommended for the treatment of respiratory diseases. The objective of this research was to improve the dose regimes of tildipirosin ...

journal_title：Frontiers in pharmacology

authors： Lei Z,Liu Q,Qi Y,Yang B,Khaliq H,Xiong J,Moku GK,Ahmed S,Li K,Zhang H,Zhang W,Cao J,He Q

更新日期：2018-07-26 00:00:00

abstract：:Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environment...

journal_title：Frontiers in pharmacology

authors： Sundar IK,Rahman I

更新日期：2011-08-30 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study w...

journal_title：Frontiers in pharmacology

authors： Gimeno-Hernández R,Cantó A,Fernández-Carbonell A,Olivar T,Hernández-Rabaza V,Almansa I,Miranda M

更新日期：2020-12-23 00:00:00

abstract：:In Mexico, the Adenophyllum aurantium (L.) Strother plant is consumed as an infusion to treat intestinal diseases such as amoebiasis, which is an endemic health problem in Mexico and other countries. However, the effect of A. aurantium on Entamoeba histolytica, the causative agent of amoebiasis, is unknown. An aerial ...

journal_title：Frontiers in pharmacology

authors： Herrera-Martínez M,Hernández-Ramírez VI,Hernández-Carlos B,Chávez-Munguía B,Calderón-Oropeza MA,Talamás-Rohana P

更新日期：2016-06-27 00:00:00

abstract：:The response to pazopanib in patients with metastatic renal cell carcinoma (mRCC) has been found to differ in Western and Eastern populations. Here, we analyzed the efficacy and side effects of pazopanib as first-line therapy in 31 consecutive patients with mRCC who were treated at a single Chinese center. Thirty-one ...

journal_title：Frontiers in pharmacology

authors： Wang B,Song JW,Chen HQ

更新日期：2020-10-29 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00

abstract：:Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with electrophysiological re...

journal_title：Frontiers in pharmacology

authors： Latapiat V,Rodríguez FE,Godoy F,Montenegro FA,Barrera NP,Huidobro-Toro JP

更新日期：2017-12-15 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician know...

journal_title：Frontiers in pharmacology

authors： Weller CD,Team V,Sussman G

更新日期：2020-02-28 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was ...

journal_title：Frontiers in pharmacology

authors： Bukhsh A,Khan TM,Lee SWH,Lee LH,Chan KG,Goh BH

更新日期：2018-04-10 00:00:00

abstract：:Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

journal_title：Frontiers in pharmacology

authors： Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

更新日期：2019-11-08 00:00:00

abstract：:Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricul...

journal_title：Frontiers in pharmacology

authors： Salameh A,Blanke K,Daehnert I

更新日期：2013-06-03 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture due to the reduced bone mass and microstructural degradation. Primary pharmacological strategies for the treatment of osteoporosis, hormone replacement treatment (HRT), and alendronate therapies may produce adverse side-effects a...

journal_title：Frontiers in pharmacology

authors： He J,Li X,Wang Z,Bennett S,Chen K,Xiao Z,Zhan J,Chen S,Hou Y,Chen J,Wang S,Xu J,Lin D

更新日期：2019-11-25 00:00:00

abstract：:Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

journal_title：Frontiers in pharmacology

authors： Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

更新日期：2020-07-14 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

journal_title：Frontiers in pharmacology

authors： Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

更新日期：2020-04-24 00:00:00

abstract：:Background: Satisfaction of patients for pharmaceutical services reflects their preferences and expectations, and the realities of care. It is critical to understand the extent of dissatisfaction for pharmaceutical services and its associated factors in order to optimize the required quality of the services provided. ...

journal_title：Frontiers in pharmacology

authors： Nigussie S,Edessa D

更新日期：2018-10-12 00:00:00

abstract：:Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

journal_title：Frontiers in pharmacology

authors： Ménard C,Quirion R

更新日期：2012-10-12 00:00:00

abstract：Background:Among factors influencing the higher risk of developing unknown or rare adverse drug reactions (ADRs) among children and adolescents, there is the frequent off-label use of drugs that seems to be very common in pediatric oncological patients. Our study aim to collect and evaluate data on the safety profile o...

journal_title：Frontiers in pharmacology

authors： Mascolo A,Scavone C,Bertini M,Brusco S,Punzo F,Pota E,Di Martino M,Di Pinto D,Rossi F

更新日期：2020-05-07 00:00:00

abstract：:Understanding the mechanistic basis for temozolomide (TMZ)-induced glioma resistance is an important obstacle in developing an effective form of chemotherapy for this type of tumor. Glycogenolysis is known to play an essential role in cellular proliferation and potassium homeostasis and involves the glycogen phosphory...

journal_title：Frontiers in pharmacology

authors： Xu J,Zhang Y,Guo X,Sun T

更新日期：2018-08-07 00:00:00

abstract：:Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

journal_title：Frontiers in pharmacology

authors： Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

更新日期：2016-10-13 00:00:00

abstract：:The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistan...

journal_title：Frontiers in pharmacology

authors： Lima R,Del Fiol FS,Balcão VM

更新日期：2019-06-21 00:00:00

abstract：:Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotr...

journal_title：Frontiers in pharmacology

authors： Wang SM

更新日期：2016-03-29 00:00:00

abstract：:Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extracted from the Chinese...

journal_title：Frontiers in pharmacology

authors： Sun Z,Zeng J,Wang W,Jia X,Wu Q,Yu D,Mao Y

更新日期：2020-04-02 00:00:00