Erratum on: Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury.

abstract：:Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. "Resistance to chemotherapy," however, is a ...

journal_title：Frontiers in pharmacology

authors： El-Awady R,Saleh E,Hashim A,Soliman N,Dallah A,Elrasheed A,Elakraa G

更新日期：2017-01-10 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Objectives: The study is performed to analyze the relationship between immune-related long non-coding RNAs (lncRNAs) and the prognosis of cervical cancer patients. We constructed a prognostic model and explored the immune characteristics of different risk groups. Methods: We downloaded the gene expression profiles and...

journal_title：Frontiers in pharmacology

authors： Chen P,Gao Y,Ouyang S,Wei L,Zhou M,You H,Wang Y

更新日期：2020-11-30 00:00:00

abstract：:Scoring functions play an important role in structure-based virtual screening. It has been widely accepted that target-specific scoring functions (TSSFs) may achieve better performance compared with universal scoring functions in actual drug research and development processes. A method that can effectively construct T...

journal_title：Frontiers in pharmacology

authors： Wang D,Cui C,Ding X,Xiong Z,Zheng M,Luo X,Jiang H,Chen K

更新日期：2019-08-22 00:00:00

abstract：:The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated...

journal_title：Frontiers in pharmacology

authors： Thomas M,Winter S,Klumpp B,Turpeinen M,Klein K,Schwab M,Zanger UM

更新日期：2015-11-04 00:00:00

abstract：:Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

journal_title：Frontiers in pharmacology

authors： Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

更新日期：2019-02-26 00:00:00

abstract：Background:Salvianolate, a compound mainly composed of salvia magnesium acetate, is extracted from the Chinese herb Salvia miltiorrhiza. Because of its biological activity, easy quality control and certain efficacy, salvianolate is widely used in treating ischemic cardiocerebral vascular disease, liver damage, renal in...

journal_title：Frontiers in pharmacology

authors： Shen Y,Wang S,Liu Y,Ge L,Xia L,Zhang X,Miao Y,Shen J,Zhou Q

更新日期：2020-06-12 00:00:00

abstract：:Pancreatic cancer (PC) is an aggressive and fatal disease with high incidences of metastasis and recurrence. However, there are no effective treatment options for the majority of PC patients, especially for those with locally advanced tumors and metastatic diseases. Therefore, it is urgently needed to develop safe and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Wang W,Zhou Y,Yang J,Xu J,Xu Z,Xu B,Yan L,Cheng XD,Li M,Qin JJ

更新日期：2020-04-08 00:00:00

abstract：:Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer's disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside (CIG) is a main com...

journal_title：Frontiers in pharmacology

authors： Yang C,Li X,Gao W,Wang Q,Zhang L,Li Y,Li L,Zhang L

更新日期：2018-06-26 00:00:00

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Endothelium dysfunction induced by reactive oxygen species (ROS) is an important initial event at the onset of myocardial ischemia/reperfusion in which the Egr-1 transcription factor often serves as a master switch for various damage pathways following reperfusion injury. We hypothesized that an intracellular ROS/MAPK...

journal_title：Frontiers in pharmacology

authors： Lu S,Zhang Y,Zhong S,Gao F,Chen Y,Li W,Zheng F,Shi G

更新日期：2017-01-05 00:00:00

abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...

journal_title：Frontiers in pharmacology

authors： Tomko A,O'Leary L,Trask H,Achenbach JC,Hall SR,Goralski KB,Ellis LD,Dupré DJ

更新日期：2019-09-27 00:00:00

abstract：:Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

journal_title：Frontiers in pharmacology

authors： Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

更新日期：2020-07-17 00:00:00

abstract：:Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a practical alternative and can be used to administer drugs for both local an...

journal_title：Frontiers in pharmacology

authors： Hua S

更新日期：2019-10-16 00:00:00

abstract：:Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or add...

journal_title：Frontiers in pharmacology

authors： He X,Fang J,Chen X,Zhao Z,Li Y,Meng Y,Huang L

更新日期：2019-10-30 00:00:00

abstract：:Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a referen...

journal_title：Frontiers in pharmacology

authors： Wu G,Chen J,Hu X,Zhou H,Liu J,Lv D,Wu L,Shentu J

更新日期：2017-04-20 00:00:00

abstract：:Several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for retinaldehyde is...

journal_title：Frontiers in pharmacology

authors： Ruiz FX,Porté S,Parés X,Farrés J

更新日期：2012-04-17 00:00:00

abstract：:Agrocybe aegerita has long been utilized for promoting diuresis in traditional Chinese medicine (TCM) with a close correlation to hypouricemia. Ethanol (AAE) and water (AAW) extracts of the compound led to a remarkable decrease in serum uric acid levels (SUA) in hyperuricemia mice, approaching that of the normal contr...

journal_title：Frontiers in pharmacology

authors： Yong T,Chen S,Xie Y,Shuai O,Li X,Chen D,Su J,Jiao C,Liang Y

更新日期：2018-05-15 00:00:00

abstract：:The increasing prescription of opioids is fueling an epidemic of addiction and overdose deaths. Morphine is a highly addictive drug characterized by a high relapse rate - even after a long period of abstinence. Serotonin (5-HT) neurotransmission participates in the development of morphine dependence, as well as the ex...

journal_title：Frontiers in pharmacology

authors： Pang G,Wu X,Tao X,Mao R,Liu X,Zhang YM,Li G,Stackman RW Jr,Dong L,Zhang G

更新日期：2016-12-26 00:00:00

abstract：:Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonists, the S1R-selecti...

journal_title：Frontiers in pharmacology

authors： Cirino TJ,Eans SO,Medina JM,Wilson LL,Mottinelli M,Intagliata S,McCurdy CR,McLaughlin JP

更新日期：2019-06-14 00:00:00

abstract：:The diagnosis and management of pain is an everyday occurrence in dentistry, and its effective control is essential to ensure the wellbeing of patients. Most tooth-associated pain originates from the dental pulp, a highly vascularized and innervated tissue, which is encased within mineralized dentin. It plays a crucia...

journal_title：Frontiers in pharmacology

authors： Schuh CMAP,Benso B,Aguayo S

更新日期：2019-09-18 00:00:00

abstract：:The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. Therefore, the effects of histamine H3 receptor (H3R) antagonist E159 (2.5-10 mg/kg, i.p.) in adult ma...

journal_title：Frontiers in pharmacology

authors： Alachkar A,Łażewska D,Kieć-Kononowicz K,Sadek B

更新日期：2017-10-12 00:00:00

abstract：:The objective of the current project was to explore the pharmacotherapeutic role of Lavandula stoechas (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of L. sto...

journal_title：Frontiers in pharmacology

authors： Mushtaq A,Anwar R,Ahmad M

更新日期：2018-11-23 00:00:00

abstract：:"Lipotoxicity" induced by free fatty acids (FAs) plays a central role in the pathogenesis of many metabolic diseases, with few treatment options available today. Hydrogen sulfide (H2S), a novel gaseous signaling molecule, has been reported to have a variety of pharmacological properties, but its effect on FAs metaboli...

journal_title：Frontiers in pharmacology

authors： Zhao C,Yu N,Li W,Cai H,Liu M,Hu Y,Liu Y,Tang M

更新日期：2020-09-23 00:00:00

abstract：:Cissus quadrangularis (C. quadrangularis) is a plant of the Vitaceae family known for its anticonvulsant effects in traditional medicine. The objective of this study was to elucidate the anxiolytic and antiepileptic effects of aqueous extract of C. quadrangularis. The mice were divided into different groups and treate...

journal_title：Frontiers in pharmacology

authors： Moto FCO,Arsa'a A,Ngoupaye GT,Taiwe GS,Njapdounke JSK,Kandeda AK,Nkantchoua GCN,Omam Omam JP,Pale S,Kouemou NE,Ayissi Mbomo ER,Pahaye DB,Ojong L,Mairara V,Ngo Bum E

更新日期：2018-07-17 00:00:00

abstract：:Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-ind...

journal_title：Frontiers in pharmacology

authors： Franks LN,Ford BM,Prather PL

更新日期：2016-12-22 00:00:00

abstract：:Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), has been extensively used as a synthetic antibacterial agent. To evaluate the reproductive toxicity of MEQ, different concentrations of MEQ were administered to Wistar rats by feeding diets containing 0, 25, 55, 110, and 275 mg/kg, respectively. Each group...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Awais I,Shabbir MAB,Ahmed S,Fatima Z,Wang X,Pan Y,Xie S,Yuan Z

更新日期：2018-08-17 00:00:00

abstract：:The ecto-5'-nucleotidase (ecto-5'NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharm...

journal_title：Frontiers in pharmacology

authors： Caiazzo E,Morello S,Carnuccio R,Ialenti A,Cicala C

更新日期：2019-07-11 00:00:00

abstract：Background:Model-informed precision dosing (MIPD) can serve as a powerful tool during therapeutic drug monitoring (TDM) to help individualize dosing in populations with large pharmacokinetic variation. Yet, adoption of MIPD in the clinical setting has been limited. Overcoming technologic hurdles that allow access to MI...

journal_title：Frontiers in pharmacology

authors： Frymoyer A,Schwenk HT,Zorn Y,Bio L,Moss JD,Chasmawala B,Faulkenberry J,Goswami S,Keizer RJ,Ghaskari S

更新日期：2020-04-29 00:00:00

abstract：:Background: Sorafenib (Nexavar®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and strongly recommend its combination with other agents aiming at ameliorating its drawbacks. OSU-2S...

journal_title：Frontiers in pharmacology

authors： Omar HA,Tolba MF,Hung JH,Al-Tel TH

更新日期：2016-11-30 00:00:00