Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria.

abstract：:Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129 (pSer129-α-syn), wh...

journal_title：Frontiers in pharmacology

authors： Li T,Feng Y,Yang R,Wu L,Li R,Huang L,Yang Q,Chen J

更新日期：2018-04-19 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:Gamithromycin is approved for the treatment and prevention of bovine respiratory disease (BRD), which is caused mainly by Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma species. In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in ...

journal_title：Frontiers in pharmacology

authors： Yang Q,Liu X,Zhang C,Yong K,Clifton AC,Ding H,Liu Y

更新日期：2019-09-24 00:00:00

abstract：:Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isola...

journal_title：Frontiers in pharmacology

authors： Amin A,Tuenter E,Foubert K,Iqbal J,Cos P,Maes L,Exarchou V,Apers S,Pieters L

更新日期：2017-05-01 00:00:00

abstract：:Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed and successfully ap...

journal_title：Frontiers in pharmacology

authors： Sun Z,Yang J,Liu L,Xu Y,Zhou L,Jia Q,Shi Y,Du X,Kang J,Zuo L

更新日期：2019-11-04 00:00:00

abstract：:Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression. Over the years, we and others have uncovered key pathways that regulate macrophage number/function and identified how metabolic d...

journal_title：Frontiers in pharmacology

authors： Flynn MC,Pernes G,Lee MKS,Nagareddy PR,Murphy AJ

更新日期：2019-06-13 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：:The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using the recently publis...

journal_title：Frontiers in pharmacology

authors： Pascual R,Almansa C,Plata-Salamán C,Vela JM

更新日期：2019-05-31 00:00:00

abstract：:Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcu...

journal_title：Frontiers in pharmacology

authors： Li J,Niu C,Jiang Z,Zhang Z,Pan Y,Xing Q,Guo Q,An S,Hu Y,Wang L

更新日期：2020-12-04 00:00:00

abstract：:Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...

journal_title：Frontiers in pharmacology

authors： Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

更新日期：2019-08-06 00:00:00

abstract：:A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

journal_title：Frontiers in pharmacology

authors： Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

更新日期：2019-03-19 00:00:00

abstract：:Background and Aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases. Angiotensin-(1-7) is a member of the renin-angiotensin system (RAS) that binds Mas receptors and has gained growing attention in the last years as a reg...

journal_title：Frontiers in pharmacology

authors： Villalobos LA,San Hipólito-Luengo Á,Ramos-González M,Cercas E,Vallejo S,Romero A,Romacho T,Carraro R,Sánchez-Ferrer CF,Peiró C

更新日期：2016-12-15 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：:At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to ...

journal_title：Frontiers in pharmacology

authors： Galieva LR,Mukhamedshina YO,Arkhipova SS,Rizvanov AA

更新日期：2017-09-08 00:00:00

abstract：:Aims and Hypothesis: NEDD9 is highly expressed in gastric cancer and has a significant involvement in its pathogenesis. However, the mechanism behind hypoxia-promoted cancer cell migration and its regulation because of NEDD9 is still unknown. The aim of this study is to investigate the involvement of NEDD9 in gastric ...

journal_title：Frontiers in pharmacology

authors： Zhao S,Min P,Liu L,Zhang L,Zhang Y,Wang Y,Zhao X,Ma Y,Xie H,Zhu C,Jiang H,Du J,Gu L

更新日期：2019-04-04 00:00:00

abstract：:The need for novel drugs for the treatment of autoimmune diseases is high, since available pharmaceuticals often have substantial side effects and limited efficacy. Natural products are a good starting point in the development of immunosuppressive leads. Since enhanced T cell proliferation is a common feature of autoi...

journal_title：Frontiers in pharmacology

authors： Zimmermann-Klemd AM,Reinhardt JK,Morath A,Schamel WW,Steinberger P,Leitner J,Huber R,Hamburger M,Gründemann C

更新日期：2020-04-08 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:It is currently thought that the dementia of Alzheimer's disease is due to the neurotoxicity of the deposits or aggregates of amyloid-β (Aβ) in the extracellular space of the cerebral cortex. This model has been widely criticized because there is a poor correlation between deposits and dementia. Others have questioned...

journal_title：Frontiers in pharmacology

authors： Holtzman JL

更新日期：2013-05-13 00:00:00

abstract：:Background: The gastrointestinal system hosts roughly 1,800 distinct phyla and about 40,000 bacterial classes, which are known as microbiota, and which are able to influence the brain. For instance, microbiota can also influence the immune response through the activation of the immune system or through the release of ...

journal_title：Frontiers in pharmacology

authors： Cuomo A,Maina G,Rosso G,Beccarini Crescenzi B,Bolognesi S,Di Muro A,Giordano N,Goracci A,Neal SM,Nitti M,Pieraccini F,Fagiolini A

更新日期：2018-10-15 00:00:00

abstract：Background:Huangci Granule is a traditional Chinese medicine for treating metastatic colorectal cancer (mCRC). Objective:To evaluate the efficacy and safety of Huangci Granule combination with chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC. Methods:We performed a randomized, controlled, and do...

journal_title：Frontiers in pharmacology

authors： Liu N,Wu C,Jia R,Cai G,Wang Y,Zhou L,Ji Q,Sui H,Zeng P,Xiao H,Liu H,Huo J,Feng Y,Deng W,Li Q

更新日期：2020-04-21 00:00:00

abstract：:Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotectio...

journal_title：Frontiers in pharmacology

authors： Inserra A

更新日期：2018-04-05 00:00:00

abstract：:The increasing prescription of opioids is fueling an epidemic of addiction and overdose deaths. Morphine is a highly addictive drug characterized by a high relapse rate - even after a long period of abstinence. Serotonin (5-HT) neurotransmission participates in the development of morphine dependence, as well as the ex...

journal_title：Frontiers in pharmacology

authors： Pang G,Wu X,Tao X,Mao R,Liu X,Zhang YM,Li G,Stackman RW Jr,Dong L,Zhang G

更新日期：2016-12-26 00:00:00

abstract：:Repeat expansion mutations in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG translation of this expansion produces dipeptide repeat proteins (DRPs). The arginine containing DRPs, polyGR and polyPR, are consistently...

journal_title：Frontiers in pharmacology

authors： Premasiri AS,Gill AL,Vieira FG

更新日期：2020-09-08 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coro...

journal_title：Frontiers in pharmacology

authors： Gu ZC,Shi FH,Zhu J,Wan F,Shen L,Li H

更新日期：2019-01-15 00:00:00

abstract：:β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), however, they induce severe side effects. Therefore, developing new bronchodilators is essential. Herbal plants were extracted and the extracts' effect on ai...

journal_title：Frontiers in pharmacology

authors： She YS,Ma LQ,Liu BB,Zhang WJ,Qiu JY,Chen YY,Li MY,Xue L,Luo X,Wang Q,Xu H,Zang DA,Zhao XX,Cao L,Shen J,Peng YB,Zhao P,Yu MF,Chen W,Nie X,Shen C,Chen S,Chen S,Qin G,Dai J,Chen J,Liu QH

更新日期：2018-12-04 00:00:00

abstract：:Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to ge...

journal_title：Frontiers in pharmacology

authors： Ali MS,Ichihara MY,Lopes LC,Barbosa GCG,Pita R,Carreiro RP,Dos Santos DB,Ramos D,Bispo N,Raynal F,Canuto V,de Araujo Almeida B,Fiaccone RL,Barreto ME,Smeeth L,Barreto ML

更新日期：2019-09-23 00:00:00

abstract：:Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in ASD; however, these studies are still ongoing, and data on the effects of its use is very limited. In this study ...

journal_title：Frontiers in pharmacology

authors： Barchel D,Stolar O,De-Haan T,Ziv-Baran T,Saban N,Fuchs DO,Koren G,Berkovitch M

更新日期：2019-01-09 00:00:00

abstract：:Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotr...

journal_title：Frontiers in pharmacology

authors： Wang SM

更新日期：2016-03-29 00:00:00

abstract：:The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3-300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw e...

journal_title：Frontiers in pharmacology

authors： Bednarczyk-Cwynar B,Wachowiak N,Szulc M,Kamińska E,Bogacz A,Bartkowiak-Wieczorek J,Zaprutko L,Mikolajczak PL

更新日期：2016-07-12 00:00:00