Abstract：
:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance of ion concentrations across the cell membrane and results in more abnormal secretion and mucus plugging in the gastrointestinal tract and in the lungs of CF patients. The direct introduction of fully functional CFTR by gene therapy has long been pursued as a therapeutical option to restore CFTR function independent of the specific CFTR mutation, but the different clinical trials failed to propose persuasive evidence of this strategy. The last ten years has led to the development of new pharmacotherapies which can activate CFTR function in a mutation-specific manner. Although approximately 2,000 different disease-associated mutations have been identified, a single codon deletion, F508del, is by far the most common and is present on at least one allele in approximately 70% of the patients in CF populations. This strategy is limited by chemistry, the knowledge on CFTR and the heterogenicity of the patients. New research efforts in CF aim to develop other therapeutical approaches to combine different strategies. Targeting RNA appears as a new and an important opportunity to modulate dysregulated biological processes. Abnormal miRNA activity has been linked to numerous diseases, and over the last decade, the critical role of miRNA in regulating biological processes has fostered interest in how miRNA binds to and interacts explicitly with the target protein. Herein, this review describes the different strategies to identify dysregulated miRNA opens up a new concept and new opportunities to correct CFTR deficiency. This review describes therapeutic applications of antisense techniques currently under investigation in CF.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Bardin P,Sonneville F,Corvol H,Tabary Odoi
10.3389/fphar.2018.01113subject
Has Abstractpub_date
2018-10-08 00:00:00pages
1113issn
1663-9812journal_volume
9pub_type
杂志文章,评审abstract：:Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal medicine, has been traditionally prescribed in China and other countries to treat affective disorders. The medicinal parts of ginseng, the roots and flower buds, have become increasingly popular as dietary supplements due to the current holisti...
journal_title：Frontiers in pharmacology
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abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We studied the effects of Aβ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
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abstract：Background:Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction, an early marker for atherosclerosis. In addition, intercellular...
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abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
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journal_title：Frontiers in pharmacology
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00097
更新日期：2020-02-28 00:00:00
abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01401
更新日期：2019-11-29 00:00:00
abstract：:Abelmoschus manihot (L.) Medik. (Malvaceae) is a herb used in traditional Chinese medicine to treat some kidney diseases. To date, the detailed mechanisms by which A. manihot improves some kinds of renal disease are not fully understood. In this study, we established Adriamycin-induced NRK-52E cells, the normal rat ki...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00567
更新日期：2019-05-28 00:00:00
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.01328
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abstract：:Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5'-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most cases by giving la...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01086
更新日期：2019-09-20 00:00:00
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00652
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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doi：10.3389/fphar.2019.00157
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.01242
更新日期：2018-10-31 00:00:00
abstract：:This research evaluated the effects of triterpenes on the regulation of STZ-induced hyperglycaemic diabetes through an anti-inflammatory response. Diabetic mice were orally administered various concentrations of triterpenes on a daily basis. Weight gain, volume of drinking water, and liver and spleen weight were recor...
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doi：10.3389/fphar.2017.00908
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pub_type： 杂志文章
doi：10.3389/fphar.2020.527495
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pub_type： 杂志文章,评审
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