Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

abstract：:Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protective effects in apoptosis of cardiomyocytes. The present research was pe...

journal_title：Frontiers in pharmacology

authors： Tian Y,Du YY,Shang H,Wang M,Sun ZH,Wang BQ,Deng D,Wang S,Xu XD,Sun GB,Sun XB

更新日期：2017-11-23 00:00:00

abstract：:The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine r...

journal_title：Frontiers in pharmacology

authors： Kim M,Lee SH,Kim Y,Kwon Y,Park Y,Lee HK,Jung HS,Jeoung D

更新日期：2018-11-06 00:00:00

abstract：:The synthesis, antimicrobial activity evaluations, biomolecule-binding properties (DNA), and absorption and emission properties of a new series of (Z)-1,1,1-trichloro-4-alkyl(aryl)amino-4-arylbut-3-en-2-ones (4, 5) and 2,2-difluoro-3-alkyl(aryl)amino-4-aryl-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides (6, 7...

journal_title：Frontiers in pharmacology

authors： Rosa WC,Rocha IO,Rodrigues MB,Coelho HS,Denardi LB,Ledur PC,Zanatta N,Acunha TV,Iglesias BA,Bonacorso HG

更新日期：2020-09-02 00:00:00

abstract：:In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI). By catalyzing the formation of free radicals, NTBI accumulation results in oxidative stress and cellular damage, being a m...

journal_title：Frontiers in pharmacology

authors： Pinto JP,Arezes J,Dias V,Oliveira S,Vieira I,Costa M,Vos M,Carlsson A,Rikers Y,Rangel M,Porto G

更新日期：2014-02-26 00:00:00

abstract：:Three new dimeric naphthoquinones, 5,4'-dihydroxy-1'-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,5',8'-tetraone (1), 5',8'-dihydroxy-5-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2) and 8,5',8'-trihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (3), were isolated from the roots of Diospyros lotus....

journal_title：Frontiers in pharmacology

authors： Rauf A,Uddin G,Siddiqui BS,Molnár J,Csonka Á,Ahmad B,Szabó D,Farooq U,Khan A

更新日期：2015-12-16 00:00:00

abstract：:Phytoestrogen has been proposed as an alternative to hormone replacement therapy, which has been demonstrated to promote a high risk of breast cancer. However, the effect of phytoestrogen on breast cancer development has not been fully understood. Bakuchiol is an active ingredient of a traditional Chinese herbal medic...

journal_title：Frontiers in pharmacology

authors： Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

更新日期：2016-05-24 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by ...

journal_title：Frontiers in pharmacology

authors： Herradón E,González C,Uranga JA,Abalo R,Martín MI,López-Miranda V

更新日期：2017-05-08 00:00:00

abstract：:The use of therapeutic peptides in various inflammatory diseases and autoimmune disorders has received considerable attention; however, the identification of anti-inflammatory peptides (AIPs) through wet-lab experimentation is expensive and often time consuming. Therefore, the development of novel computational method...

journal_title：Frontiers in pharmacology

authors： Manavalan B,Shin TH,Kim MO,Lee G

更新日期：2018-03-27 00:00:00

abstract：:Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability ...

journal_title：Frontiers in pharmacology

authors： Filatova E,Kasian A,Kolomin T,Rybalkina E,Alieva A,Andreeva L,Limborska S,Myasoedov N,Pavlova G,Slominsky P,Shadrina M

更新日期：2017-02-28 00:00:00

abstract：:Background and Aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases. Angiotensin-(1-7) is a member of the renin-angiotensin system (RAS) that binds Mas receptors and has gained growing attention in the last years as a reg...

journal_title：Frontiers in pharmacology

authors： Villalobos LA,San Hipólito-Luengo Á,Ramos-González M,Cercas E,Vallejo S,Romero A,Romacho T,Carraro R,Sánchez-Ferrer CF,Peiró C

更新日期：2016-12-15 00:00:00

abstract：:Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects ...

journal_title：Frontiers in pharmacology

authors： Arora A,Bhuria V,Hazari PP,Pathak U,Mathur S,Roy BG,Sandhir R,Soni R,Dwarakanath BS,Bhatt AN

更新日期：2018-04-24 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. ...

journal_title：Frontiers in pharmacology

authors： Michalak A,Mosińska P,Fichna J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Previous studies compared the molecular similarity of marketed drugs and endogenous human metabolites (endogenites), using a series of fingerprint-type encodings, variously ranked and clustered using the Tanimoto (Jaccard) similarity coefficient (TS). Because this gives equal weight to all parts of the encod...

journal_title：Frontiers in pharmacology

authors： O'Hagan S,Kell DB

更新日期：2016-08-22 00:00:00

abstract：:Agrocybe aegerita has long been utilized for promoting diuresis in traditional Chinese medicine (TCM) with a close correlation to hypouricemia. Ethanol (AAE) and water (AAW) extracts of the compound led to a remarkable decrease in serum uric acid levels (SUA) in hyperuricemia mice, approaching that of the normal contr...

journal_title：Frontiers in pharmacology

authors： Yong T,Chen S,Xie Y,Shuai O,Li X,Chen D,Su J,Jiao C,Liang Y

更新日期：2018-05-15 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

journal_title：Frontiers in pharmacology

authors： Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

更新日期：2020-02-21 00:00:00

abstract：:Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains unclear. In this s...

journal_title：Frontiers in pharmacology

authors： Yuan XL,Li XQ,Xu K,Hou XD,Zhang ZF,Xue L,Liu XM,Zhang P

更新日期：2020-10-15 00:00:00

abstract：:Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

journal_title：Frontiers in pharmacology

authors： de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

更新日期：2017-12-12 00:00:00

abstract：:UV irradiation-induced oxidative stress and inflammation contribute to the development of skin diseases. Therefore, targeting oxidative stress and inflammation might contribute to reduce skin diseases. Resolvin D1 (RvD1) is a bioactive metabolite generated during inflammation to actively orchestrate the resolution of ...

journal_title：Frontiers in pharmacology

authors： Saito P,Melo CPB,Martinez RM,Fattori V,Cezar TLC,Pinto IC,Bussmann AJC,Vignoli JA,Georgetti SR,Baracat MM,Verri WA Jr,Casagrande R

更新日期：2018-10-31 00:00:00

abstract：:Ethanol-induced gastric mucosal injury is a common gastrointestinal disorder. Polysaccharides separated from herbs have been shown to be effective for ethanol-induced gastric mucosal injury, but whether the polysaccharides from Dendrobium officinale Kimura & Migo leaves (LDOP-1) protected mucosa from ethanol-induced i...

journal_title：Frontiers in pharmacology

authors： Ke Y,Zhan L,Lu T,Zhou C,Chen X,Dong Y,Lv G,Chen S

更新日期：2020-11-11 00:00:00

abstract：:"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unint...

journal_title：Frontiers in pharmacology

authors： Xu C,Rezeng C,Li J,Zhang L,Yan Y,Gao J,Wang Y,Li Z,Chen J

更新日期：2017-09-04 00:00:00

abstract：:[This corrects the article on p. 727 in vol. 8, PMID: 29114222.]. ...

journal_title：Frontiers in pharmacology

authors： Qiao L,Zhang X,Liu M,Liu X,Dong M,Cheng J,Zhang X,Zhai C,Song Y,Lu H,Chen W

更新日期：2018-01-09 00:00:00

abstract：:Pharmaceutical medicine has evolved to be a distinct medical scientific discipline over time. Pharmaceutical medicine has distinctive features related to complex innovative medicines development activities in an often commercially focused competitive environment. This sometimes uneasy mix of professionalism and commer...

journal_title：Frontiers in pharmacology

authors： Morris T,Brostoff JM,Stonier PD,Boyd A

更新日期：2020-01-15 00:00:00

abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...

journal_title：Frontiers in pharmacology

authors： Issa ME,Wijeratne EMK,Gunatilaka AAL,Cuendet M

更新日期：2017-09-08 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:Drug scheduling within the international system of drug control and national legislation has been recently criticized as having insufficient footing in scientific evidence. The legal harms related to non-medical uses of certain drugs (e.g., cannabis) have arguably exceeded their physiological and social harmfulness co...

journal_title：Frontiers in pharmacology

authors： Dubljević V

更新日期：2018-08-20 00:00:00

abstract：:Background: Patients undergoing percutaneous coronary intervention (PCI) who require anticoagulant therapy are at increased risk of bleeding. The optimal regimen for these patients is uncertain. This study aimed to compare safety and efficacy of antithrombotic regimens used in patients undergoing PCI with concomitant ...

journal_title：Frontiers in pharmacology

authors： Bunmark W,Jinatongthai P,Vathesatogkit P,Thakkinstian A,Reid CM,Wongcharoen W,Chaiyakunapruk N,Nathisuwan S

更新日期：2018-11-19 00:00:00

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

journal_title：Frontiers in pharmacology

authors： Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

更新日期：2020-02-25 00:00:00