The Glp-1 Analog Liraglutide Protects Against Angiotensin II and Pressure Overload-Induced Cardiac Hypertrophy via PI3K/Akt1 and AMPKa Signaling.

abstract：:Background: Formal definitions allow selecting terms (e.g., identifying all terms related to "Infectious disease" using the query "has causative agent organism") and terminological reasoning (e.g., "hepatitis B" is a "hepatitis" and is an "infectious disease"). However, the standard international terminology Medical D...

journal_title：Frontiers in pharmacology

authors： Bousquet C,Souvignet J,Sadou É,Jaulent MC,Declerck G

更新日期：2019-09-10 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive...

journal_title：Frontiers in pharmacology

authors： Krisai P,Rudin D,Grünig D,Scherer K,Pichler W,Terracciano L,Krähenbühl S

更新日期：2019-09-11 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD in vivo would also...

journal_title：Frontiers in pharmacology

authors： Wheal AJ,Jadoon K,Randall MD,O'Sullivan SE

更新日期：2017-05-18 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:A dominant area of antibody research is the extension of the use of this mighty experimental and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and activity blocking. Despite the ability to raise antibodies against different proteins, numerous applications of antibodies in bas...

journal_title：Frontiers in pharmacology

authors： Slastnikova TA,Ulasov AV,Rosenkranz AA,Sobolev AS

更新日期：2018-10-24 00:00:00

abstract：:Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE) countries. Methods: A questionnaire-based survey was conducted between Novem...

journal_title：Frontiers in pharmacology

authors： Kawalec P,Stawowczyk E,Tesar T,Skoupa J,Turcu-Stiolica A,Dimitrova M,Petrova GI,Rugaja Z,Männik A,Harsanyi A,Draganic P

更新日期：2017-06-08 00:00:00

abstract：PURPOSE:Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. METHODS:A rat model of renal I/R injury was indu...

journal_title：Frontiers in pharmacology

authors： Li J,Hong Z,Liu H,Zhou J,Cui L,Yuan S,Chu X,Yu P

更新日期：2016-04-22 00:00:00

abstract：:Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., a type of sensiti...

journal_title：Frontiers in pharmacology

authors： Wuo-Silva R,Fukushiro-Lopes DF,Fialho BP,Hollais AW,Santos-Baldaia R,Marinho EAV,Mári-Kawamoto E,Yokoyama TS,Lopes-Silva LB,Berro LF,Frussa-Filho R,Longo BM

更新日期：2019-03-11 00:00:00

abstract：:Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

journal_title：Frontiers in pharmacology

authors： Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

更新日期：2020-02-28 00:00:00

abstract：:Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the pres...

journal_title：Frontiers in pharmacology

authors： Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

更新日期：2019-09-13 00:00:00

abstract：:Breast cancer (BC) is one of the most prevalent types of cancer worldwide with high morbidity and mortality rates. Treatment modalities include systemic therapy, in which chemotherapy is a major component in many cases. Several chemotherapeutic agents are used in combinations or as single agents with many adverse even...

journal_title：Frontiers in pharmacology

authors： Al-Mahayri ZN,Patrinos GP,Ali BR

更新日期：2020-04-15 00:00:00

abstract：:Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability ...

journal_title：Frontiers in pharmacology

authors： Filatova E,Kasian A,Kolomin T,Rybalkina E,Alieva A,Andreeva L,Limborska S,Myasoedov N,Pavlova G,Slominsky P,Shadrina M

更新日期：2017-02-28 00:00:00

abstract：:Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and scientific interest about therapeutic properties of these compounds for the treatment of several neurologic diseases, not just epilepsy. The discovered role of the endocannabinoid system in epile...

journal_title：Frontiers in pharmacology

authors： Raucci U,Pietrafusa N,Paolino MC,Di Nardo G,Villa MP,Pavone P,Terrin G,Specchio N,Striano P,Parisi P

更新日期：2020-09-29 00:00:00

abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...

journal_title：Frontiers in pharmacology

authors： Mahmoud AB,Danton O,Kaiser M,Khalid S,Hamburger M,Mäser P

更新日期：2020-08-14 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

journal_title：Frontiers in pharmacology

authors： Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

更新日期：2013-01-28 00:00:00

abstract：:Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates oxidative stress response, but also represses inflammation by regulating cytokines production and cross-talking with NF-κB signaling pathways. Nrf2 plays an essential role in liver injury induced by oxidative stress and inflamma...

journal_title：Frontiers in pharmacology

authors： Yang YQ,Yan XT,Wang K,Tian RM,Lu ZY,Wu LL,Xu HT,Wu YS,Liu XS,Mao W,Xu P,Liu B

更新日期：2018-08-29 00:00:00

abstract：:Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular ...

journal_title：Frontiers in pharmacology

authors： Dawood M,Hamdoun S,Efferth T

更新日期：2018-02-27 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

journal_title：Frontiers in pharmacology

authors： Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

更新日期：2020-10-02 00:00:00

abstract：:Parkinson's disease (PD), characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neurodegenerative disorder. Along with the largely aging population in the world, the incidence is increasing year by year, which imposes the negative impacts on patients, their fam...

journal_title：Frontiers in pharmacology

authors： Li X,Zhang Y,Wang Y,Xu J,Xin P,Meng Y,Wang Q,Kuang H

更新日期：2017-09-19 00:00:00

abstract：:Direct-to-consumer (DTC) DNA testing has grown from contentious beginnings into a global industry, by providing a wide range of personal genomic information directly to its clients. These companies, typified by the well-established 23andMe, generally carry out a gene-chip analysis of single-nucleotide polymorphisms (S...

journal_title：Frontiers in pharmacology

authors： Chua EW,Kennedy MA

更新日期：2012-08-20 00:00:00

abstract：:We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined the safety and tol...

journal_title：Frontiers in pharmacology

authors： Alfaro VY,Goldblatt DL,Valverde GR,Munsell MF,Quinton LJ,Walker AK,Dantzer R,Varadhachary A,Scott BL,Evans SE,Tuvim MJ,Dickey BF

更新日期：2014-02-06 00:00:00

abstract：:Upon interaction, neutrophils can potentially release neutrophil extracellular traps (NETs) on the surface of an implanted electrospun template, which may be a significant preconditioning event for implantable biomaterials of yet unknown consequences. In this study, we investigated the potential of polydioxanone templ...

journal_title：Frontiers in pharmacology

authors： Fetz AE,Neeli I,Buddington KK,Read RW,Smeltzer MP,Radic MZ,Bowlin GL

更新日期：2018-03-28 00:00:00

abstract：:Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critical for hypertensive...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang F,Yang P,Wang X,Xu R,Chen J,Yuan Y,Lu Z,Duan J

更新日期：2018-03-09 00:00:00

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：Objective:To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods:Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the...

journal_title：Frontiers in pharmacology

authors： Zhang B,Wang C,Cui L,Gao J,Wang C,Tan X,Fang S

更新日期：2020-03-31 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver...

journal_title：Frontiers in pharmacology

authors： Li F,Gao C,Yan P,Zhang M,Wang Y,Hu Y,Wu X,Wang X,Sheng J

更新日期：2018-11-22 00:00:00

abstract：:Objectives: Indigenous Latin American populations have used extracts from Calophyllum brasiliense, a native hardwood, to treat gastrointestinal symptoms for generations. The hexane extract of Calophyllum brasiliense stem bark (HECb) protects against ethanol-mediated gastric ulceration in Swiss-Webster mice. We investi...

journal_title：Frontiers in pharmacology

authors： Lemos LM,Miyajima F,Castilho GR,Martins DT,Pritchard DM,Burkitt MD

更新日期：2017-02-27 00:00:00