A Guide to PIN1 Function and Mutations Across Cancers.


:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues.


Front Pharmacol


El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F




Has Abstract


2019-01-22 00:00:00








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    authors: Campos JF,Espindola PPT,Torquato HFV,Vital WD,Justo GZ,Silva DB,Carollo CA,de Picoli Souza K,Paredes-Gamero EJ,Dos Santos EL

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    pub_type: 杂志文章


    authors: Xing X,Chen S,Li L,Cao Y,Chen L,Wang X,Zhu Z

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

    更新日期:2018-05-03 00:00:00