Perspectives Regarding the Role of Biochanin A in Humans.


:Biochanin A (BCA) is an isoflavone mainly found in red clover with poor solubility and oral absorption that is known to have various effects, including anti-inflammatory, estrogen-like, and glucose and lipid metabolism modulatory activity, as well as cancer preventive, neuroprotective, and drug interaction effects. BCA is already commercially available and is among the main ingredients in many types of supplements used to alleviate postmenopausal symptoms in women. The activity of BCA has not been adequately evaluated in humans. However, the results of many in vitro and in vivo studies investigating the potential health benefits of BCA are available, and the complex mechanisms by which BCA modulates transcription, apoptosis, metabolism, and immune responses have been revealed. Many efforts have been exerted to improve the poor bioavailability of BCA, and very promising results have been reported. This review focuses on the major effects of BCA and its possible molecular targets, potential uses, and limitations in health maintenance and treatment.


Front Pharmacol


Yu C,Zhang P,Lou L,Wang Y




Has Abstract


2019-07-12 00:00:00








  • Cardiovascular Alterations and Management of Patients With White Coat Hypertension: A Meta-Analysis.

    abstract::A large and growing body of literature has focused on the association between "white coat hypertension" (WCH) and the underlying target organ damage. The evidence suggests that WCH is may not an entirely benign phenomenon. However, whether patients with WCH should receive antihypertensive drugs is unresolved. Therefor...

    journal_title:Frontiers in pharmacology



    authors: Xiang H,Xue Y,Wang J,Weng Y,Rong F,Peng Y,Ji K

    更新日期:2020-09-17 00:00:00

  • Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative.

    abstract::Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-D...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Dai Y,Yeo SCM,Barnes PJ,Donnelly LE,Loo LC,Lin HS

    更新日期:2018-07-11 00:00:00

  • Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI.

    abstract::Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells. If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatment of malignant tu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu ST,Liu B,Ai ZZ,Hong ZC,You PT,Wu HZ,Yang YF

    更新日期:2020-03-27 00:00:00

  • Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

    abstract::Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. S...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

    更新日期:2018-10-23 00:00:00

  • Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae.

    abstract::The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

    更新日期:2017-03-30 00:00:00

  • The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.

    abstract::Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

    更新日期:2020-08-12 00:00:00

  • Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro.

    abstract::Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extracted from the Chinese...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sun Z,Zeng J,Wang W,Jia X,Wu Q,Yu D,Mao Y

    更新日期:2020-04-02 00:00:00

  • Practical Barriers to Medication Adherence: What Do Current Self- or Observer-Reported Instruments Assess?

    abstract:Introduction:Practical adherence barriers (e.g., medication frequency) are generally more amenable to intervention than perceptual barriers (e.g., beliefs). Measures which assess adherence barriers exist, however these tend to measure a mix of factors. There is a need to identify what practical barriers are captured by...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Chan AHY,Cooper V,Lycett H,Horne R

    更新日期:2020-05-13 00:00:00

  • In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber.

    abstract::Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

    更新日期:2019-11-08 00:00:00

  • β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling.

    abstract::Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

    更新日期:2018-01-08 00:00:00

  • Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration.

    abstract::Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

    更新日期:2020-11-26 00:00:00

  • Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands.

    abstract::We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined the safety and tol...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Alfaro VY,Goldblatt DL,Valverde GR,Munsell MF,Quinton LJ,Walker AK,Dantzer R,Varadhachary A,Scott BL,Evans SE,Tuvim MJ,Dickey BF

    更新日期:2014-02-06 00:00:00

  • Nuclear Factor Erythroid 2 Related Factor 2 Activator JC-5411 Inhibits Atherosclerosis Through Suppression of Inflammation and Regulation of Lipid Metabolism.

    abstract::Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jiang X,Li Y,Wang W,Han X,Han J,Chen M,Zhang J,Wang C,Li S,Luo J,Wang X,Xu Y,Xu Y,Cheng J,Si S

    更新日期:2020-11-16 00:00:00

  • H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression.

    abstract::Background and Purpose: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tan S,Long Z,Hou X,Lin Y,Xu J,You X,Wang T,Zhang Y

    更新日期:2019-08-05 00:00:00

  • A dynamic interface between ubiquitylation and cAMP signaling.

    abstract::Phosphorylation waves drive the propagation of signals generated in response to hormones and growth factors in target cells. cAMP is an ancient second messenger implicated in key biological functions. In mammals, most of the effects elicited by cAMP are mediated by protein kinase A (PKA). Activation of the kinase by c...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Rinaldi L,Sepe M,Donne RD,Feliciello A

    更新日期:2015-09-04 00:00:00

  • Atorvastatin Inhibits Inflammatory Response, Attenuates Lipid Deposition, and Improves the Stability of Vulnerable Atherosclerotic Plaques by Modulating Autophagy.

    abstract::Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibitio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

    更新日期:2018-05-03 00:00:00

  • Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis.

    abstract::Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central nervous system, and conventional treatments have limited efficacy or side effects. Ghrelin, a 28-amino acid octanoylated peptide, has been reported to have neuroprotective effects, including anti-oxidation, anti-inflammation, and a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu F,Li Z,He X,Yu H,Feng J

    更新日期:2019-11-06 00:00:00

  • Corrigendum: Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism.

    abstract::[This corrects the article on p. 648 in vol. 8, PMID: 28959205.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,已发布勘误


    authors: Zhong ZF,Yu HB,Wang CM,Qiang WA,Wang SP,Zhang JM,Yu H,Cui L,Wu T,Li DQ,Wang YT

    更新日期:2017-12-18 00:00:00

  • Warfarin and the Risk of Death, Stroke, and Major Bleeding in Patients With Atrial Fibrillation Receiving Hemodialysis: A Systematic Review and Meta-Analysis.

    abstract::Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lei H,Yu LT,Wang WN,Zhang SG

    更新日期:2018-11-06 00:00:00

  • Fasudil, a Rho-Kinase Inhibitor, Exerts Cardioprotective Function in Animal Models of Myocardial Ischemia/Reperfusion Injury: A Meta-Analysis and Review of Preclinical Evidence and Possible Mechanisms.

    abstract::Fasudil, a Rho-kinase inhibitor, has shown outstanding therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH) in humans. Studies show various biological effects of fasudil in the cardiovascular system. We conducted a preclinical systematic review to determine the efficacy and possible mecha...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Huang YY,Wu JM,Su T,Zhang SY,Lin XJ

    更新日期:2018-10-01 00:00:00

  • Use of Oral Corticosteroids and Risk of Hip Fracture in the Elderly in a Case-Control Study.

    abstract::Aim: Little is known regarding the relationship between use of oral corticosteroids and hip fracture in the elderly in Taiwan. The aim of the study was to examine this issue. Methods: A retrospective population-based case-control study using the database of the Taiwan National Health Insurance Program (2000-2013) was ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lai SW,Lin CL,Liao KF

    更新日期:2017-09-11 00:00:00

  • Quantification of serotonin O-sulphate by LC-MS method in plasma of healthy volunteers.

    abstract::The objective of this study was to test the hypothesis that serotonin O-sulphate (5-HT-SO4) could be quantified in human plasma using modern liquid chromatography-mass spectrometry (LC-MS) method as well as develop and validate that method. First, a suitable LC-MS method for detection of 5-HT-SO4 in human plasma sampl...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lozda R,Purviņš I

    更新日期:2014-04-08 00:00:00

  • Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway.

    abstract::Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

    更新日期:2018-11-06 00:00:00

  • Validation of a Case-Finding Algorithm for Identifying Patients with Non-small Cell Lung Cancer (NSCLC) in Administrative Claims Databases.

    abstract::Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Turner RM,Chen YW,Fernandes AW

    更新日期:2017-11-30 00:00:00

  • A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica.

    abstract::The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For bi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yerlikaya S,Zengin G,Mollica A,Baloglu MC,Celik Altunoglu Y,Aktumsek A

    更新日期:2017-09-01 00:00:00

  • Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis.

    abstract::Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Recchiuti A,Mattoscio D,Isopi E

    更新日期:2019-04-02 00:00:00

  • Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain.

    abstract::It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

    更新日期:2020-06-26 00:00:00

  • Impact of Antiarrhythmic Drugs on the Outcome of Short QT Syndrome.

    abstract::Short QT syndrome (SQTS) is associated with sudden cardiac arrest. There are limited data on the impact of antiarrhythmic drugs on the outcome of SQTS. Materials and Methods: We studied data that describe the clinical outcome of 62 SQTS patients treated with antiarrhythmic drugs, who were recruited from a pool of pati...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: El-Battrawy I,Besler J,Li X,Lan H,Zhao Z,Liebe V,Schimpf R,Lang S,Wolpert C,Zhou X,Akin I,Borggrefe M

    更新日期:2019-08-02 00:00:00

  • Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses.

    abstract::The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Kim M,Lee SH,Kim Y,Kwon Y,Park Y,Lee HK,Jung HS,Jeoung D

    更新日期:2018-11-06 00:00:00

  • Anti-Methicillin-Resistant Staphylococcus aureus Nanoantibiotics.

    abstract::Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Labruère R,Sona AJ,Turos E

    更新日期:2019-10-04 00:00:00