Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.


:In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have long been pursuing. Thirty years ago, when molecular pharmacogenomics evolved, we anticipated that these genetic biomarkers would soon obviate the routine use of drug therapies in a way that patients should adapt to the therapy rather than the opposite. This expected revolution in routine clinical practice never took place as quickly nor with the intensity as initially expected. The concerted action of operating multicenter networks holds great promise for future studies to identify biomarkers related to drug toxicity and to provide better insight into the underlying pathogenesis. Today some pharmacogenomic advances are already widely accepted, but pharmacogenomics still needs further development to elaborate more precise algorithms and many barriers to implementing individualized medicine exist. We briefly discuss our view about these barriers and we provide suggestions and areas of focus to advance in the field.


Front Pharmacol


Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI




Has Abstract


2012-01-19 00:00:00








  • Correlation of Proton Pump Inhibitors with Pulmonary Tuberculosis: A Case-Control Study in Taiwan.

    abstract::Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Cheng KC,Liao KF,Lin CL,Lai SW

    更新日期:2017-07-19 00:00:00

  • Conditioned Serum Enhances the Chondrogenic and Immunomodulatory Behavior of Mesenchymal Stem Cells.

    abstract::Osteoarthritis is one of the most common chronic health conditions associated with pain and disability. Advanced therapies based on mesenchymal stem cells have become valuable options for the treatment of these pathologies. Conditioned serum (CS, "Orthokine") has been used intra-articularly for osteoarthritic patients...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Blázquez R,Sánchez-Margallo FM,Reinecke J,Álvarez V,López E,Marinaro F,Casado JG

    更新日期:2019-06-28 00:00:00

  • Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling.

    abstract::Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues in...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Aminuddin A,Ng PY

    更新日期:2016-08-12 00:00:00

  • Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal Model.

    abstract::More than a century has passed since the first surgical mesh for hernia repair was developed, and, to date, this is still the most widely used method despite the great number of complications it poses. The purpose of this study was to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Marinaro F,Casado JG,Blázquez R,Brun MV,Marcos R,Santos M,Duque FJ,López E,Álvarez V,Usón A,Sánchez-Margallo FM

    更新日期:2020-09-25 00:00:00

  • Fructus mume Extracts Alleviate Diarrhea in Breast Cancer Patients Receiving the Combination Therapy of Lapatinib and Capecitabine.

    abstract::Lapatinib and capecitabine have been widely used in the therapy of breast cancer. However, long-term use of lapatinib and capecitabine often causes the most common side effect diarrhea, which limit the medicine use. Fructus mume (F. mume) has been proved to be effective to treat chronic diarrhea with few side effects....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xing H,Zhang L,Ma J,Liu Z,Song C,Liu Y

    更新日期:2018-05-23 00:00:00

  • Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity.

    abstract::Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till date, reports show...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Kouam AF,Yuan F,Njayou FN,He H,Tsayem RF,Oladejo BO,Song F,Moundipa PF,Gao GF

    更新日期:2017-09-19 00:00:00

  • CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental Regulation.

    abstract::Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid receptors. CB1 receptors are highly expressed in projection neurons and s...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Van Waes V,Beverley JA,Siman H,Tseng KY,Steiner H

    更新日期:2012-03-12 00:00:00

  • Endothelin-1/Nitric Oxide Ratio as a Predictive Factor of Response to Therapy With Terlipressin and Albumin in Patients With Type-1 Hepatorenal Syndrome.

    abstract:Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

    更新日期:2020-01-31 00:00:00

  • Triple-Gene Therapy for Stroke: A Proof-of-Concept in Vivo Study in Rats.

    abstract::Natural brain repair after stroke is extremely limited, and current therapeutic options are even more scarce with no clinical break-through in sight. Despite restricted regeneration in the central nervous system, we have previously proved that human umbilical cord blood mono-nuclear cells (UCB-MC) transduced with aden...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sokolov ME,Bashirov FV,Markosyan VA,Povysheva TV,Fadeev FO,Izmailov AA,Kuztetsov MS,Safiullov ZZ,Shmarov MM,Naroditskyi BS,Palotás A,Islamov RR

    更新日期:2018-02-15 00:00:00

  • Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases.

    abstract::Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

    更新日期:2019-04-12 00:00:00

  • A Preliminary, Multicenter, Prospective and Real World Study on the Hemostasis, Coagulation, and Safety of Hemocoagulase Bothrops Atrox in Patients Undergoing Transurethral Bipolar Plasmakinetic Prostatectomy.

    abstract::Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP). Methods: This study adopted a multicenter, prospective, and real world design. BPH patients undergoing TUPKP ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li BH,Yu ZJ,Wang CY,Zi H,Li XD,Wang XH,Ren XY,Liu TZ,Zheng H

    更新日期:2019-11-27 00:00:00

  • Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study.

    abstract:Objective:Current prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Rajapaksa AE,Do LAH,Suryawijaya Ong D,Sourial M,Veysey D,Beare R,Hughes W,Yang W,Bischof RJ,McDonnell A,Eu P,Yeo LY,Licciardi PV,Mulholland EK

    更新日期:2020-08-19 00:00:00

  • The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates.

    abstract::Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significan...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Agrawal S,Adholeya A,Deshmukh SK

    更新日期:2016-10-25 00:00:00

  • Sirtuins as regulators of the yeast metabolic network.

    abstract::There is growing evidence that the metabolic network is an integral regulator of cellular physiology. Dynamic changes in metabolite concentrations, metabolic flux, or network topology act as reporters of biological or environmental signals, and are required for the cell to trigger an appropriate biological reaction. C...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Ralser M,Michel S,Breitenbach M

    更新日期:2012-03-08 00:00:00

  • Shexiang Baoxin Pill, a Formulated Chinese Herbal Mixture, Induces Neuronal Differentiation of PC12 Cells: A Signaling Triggered by Activation of Protein Kinase A.

    abstract::Background: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), which is commonly used today in treating cardiovascular diseases. SBP consists of seven materials thereof, including Moschus, extract of Ginseng Radix et Rhizoma, Bovis Calculus Artifactus, Cinnamomi Cortex,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xu ML,Zheng ZY,Xia YJ,Liu EY,Chan SK,Hu WH,Duan R,Dong TT,Zhan CS,Shang XH,Tsim KW

    更新日期:2019-10-09 00:00:00

  • TNF-α-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells.

    abstract::Tumor necrosis factor-α (TNF-α) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-α induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). W...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lin CC,Lin WN,Cho RL,Wang CY,Hsiao LD,Yang CM

    更新日期:2016-11-25 00:00:00

  • Magnoflorine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Suppressing NF-κB and MAPK Activation.

    abstract::Acute lung injury (ALI) which is featured by a strong pulmonary inflammation, is a major cause of morbidity and mortality in critically ill patients. Magnoflorine, a quaternary alkaloid isolated from Chinese herb Magnolia or Aristolochia, has been reported to have potent anti-inflammatory properties. However, the effe...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Guo S,Jiang K,Wu H,Yang C,Yang Y,Yang J,Zhao G,Deng G

    更新日期:2018-08-30 00:00:00

  • Advanced Therapy Medicinal Products and Exemptions to the Regulation 1394/2007: How Confident Can We be? An Exploratory Analysis.

    abstract::The market authorization procedure for medicinal products for human use is relying on their demonstrated efficacy, safety, and pharmaceutical quality. This applies to all medicinal products whether of chemical or biological origin. Since October 2009, the first advanced therapy medicinal product (ATMP) has been author...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Van Wilder P

    更新日期:2012-02-14 00:00:00

  • Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems.

    abstract::Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Li C,Huang J,Cheng YC,Zhang YW

    更新日期:2020-05-07 00:00:00

  • Acinetobacter baumannii Ventilator-Associated Pneumonia: Clinical Efficacy of Combined Antimicrobial Therapy and in vitro Drug Sensitivity Test Results.

    abstract::Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against Acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth di...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Huang Y,Zhou Q,Wang W,Huang Q,Liao J,Li J,Long L,Ju T,Zhang Q,Wang H,Xu H,Tu M

    更新日期:2019-02-13 00:00:00

  • Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell Disease.

    abstract::Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5'-UTR and coding regi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jhun EH,Sadhu N,Hu X,Yao Y,He Y,Wilkie DJ,Molokie RE,Wang ZJ

    更新日期:2019-02-07 00:00:00

  • microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis via the MAPK Signaling Pathway Through Targeting SOCS1.

    abstract::The aim of this study was to investigate the regulatory function of the non-coding microRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS1) in alcoholic hepatitis (AH) and its potential mechanism associated with the mitogen-activated protein kinase (MAPK) signaling pathway. Levels of alanine aminotransfer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu D,Han P,Gao C,Gao W,Yao X,Liu S

    更新日期:2020-04-07 00:00:00

  • From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology.

    abstract::All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders. Consequently, to understand the functions of excitable cells and to remedy their path...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Py C,Martina M,Diaz-Quijada GA,Luk CC,Martinez D,Denhoff MW,Charrier A,Comas T,Monette R,Krantis A,Syed NI,Mealing GA

    更新日期:2011-10-03 00:00:00

  • Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor.

    abstract::The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, we have investigated...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Saleh N,Kleinau G,Heyder N,Clark T,Hildebrand PW,Scheerer P

    更新日期:2018-06-01 00:00:00

  • Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis.

    abstract::Introduction: Chronic hepatitis B (HBV) and C (HCV) virus infection is associated with the activation of hepatic stellate cells (HSCs) toward a myofibroblastic phenotype, resulting in excessive deposition of extracellular matrix, the development of liver fibrosis, and its progression toward cirrhosis. The gold standar...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lambrecht J,Jan Poortmans P,Verhulst S,Reynaert H,Mannaerts I,van Grunsven LA

    更新日期:2017-02-09 00:00:00

  • α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve.

    abstract::Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves has specific characteristics and responds differently to alleviating drugs at cephalic versus extracephalic level. This is especially true for tricyclic antidepressants currently used for alleviating neuropathic pain in humans...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: M'Dahoma S,Poitevin M,Dabala E,Payan H,Gabriel C,Mocaër E,Bourgoin S,Hamon M

    更新日期:2018-06-07 00:00:00

  • The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

    abstract::Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Gu ZC,Shi FH,Zhu J,Wan F,Shen L,Li H

    更新日期:2019-01-15 00:00:00

  • Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily.

    abstract::There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

    更新日期:2019-10-09 00:00:00

  • Hepatoprotective Effect of San-Cao Granule on Con A-Induced Liver Injury in Mice and Mechanisms of Action Exploration.

    abstract::Objective: San-Cao granule (SCG), a traditional Chinese herb formula, has been used for treating autoimmune hepatitis (AIH) in our clinics for a long time. However, its active ingredients and mechanisms of action were still unknown due to its complicated chemical compositions. In the present study, the pharmacological...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang Y,Zhang P,Wang Y,Wei S,Zhang L,Wang J,Lu X,Zhou H,Li R,Wen J,Zhou X,Li H,Li K,Zhao Y

    更新日期:2018-06-12 00:00:00

  • Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro.

    abstract::A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Ther...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lewenhofer V,Schweighofer L,Ledermüller T,Eichsteininger J,Kählig H,Zehl M,Nguyen CH,Krupitza G,Özmen A,Krenn L

    更新日期:2018-04-03 00:00:00