Mechanisms of cellular fibrosis associated with cancer regimen-related toxicities.

abstract：:Oxidative stress induced by high ammonia, which leads to astrocyte edema, is the key to acute hepatic encephalopathy (AHE). Nuclear factor erythroid 2-related factor 2 (NRF2) has been implicated in oxidative stress, but the mechanism of NRF2 against ammonia-induced astrocytes edema has not been fully studied. We confi...

journal_title：Frontiers in pharmacology

authors： Jia W,Liu J,Hu R,Hu A,Tang W,Li L,Li J

更新日期：2020-04-16 00:00:00

abstract：:Limited data are available on the adherence to opioid therapy and the influence of different patient groups on adherence. This study examined the patterns of adherence in opioid naïve and opioid existing patients with varying age and gender. This retrospective cohort study was conducted using the prescription database...

journal_title：Frontiers in pharmacology

authors： Zin CS,Taufek NH,Ahmad MM

更新日期：2019-10-29 00:00:00

abstract：:Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system - Ayurveda - it is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therape...

journal_title：Frontiers in pharmacology

authors： Balkrishna A,Thakur P,Varshney A

更新日期：2020-03-03 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-α induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). W...

journal_title：Frontiers in pharmacology

authors： Lin CC,Lin WN,Cho RL,Wang CY,Hsiao LD,Yang CM

更新日期：2016-11-25 00:00:00

abstract：:Inflammation-related intestinal diseases are a set of various conditions presenting an overactive enteric immune system. A continuous overproduction of pro-inflammatory cytokines and a decreased production of anti-inflammatory modulators are generally observed, while morpho-functional alterations of the enteric nervou...

journal_title：Frontiers in pharmacology

authors： Dal Ben D,Antonioli L,Lambertucci C,Fornai M,Blandizzi C,Volpini R

更新日期：2018-03-14 00:00:00

abstract：:The inflammatory response to COVID-19 is specifically associated with an impaired type I interferon (IFN) response and complete blockade of IFN-β secretion. Clinically, nebulization of IFN-α-2b has been historically used in China to treat viral pneumonia associated with SARS-CoV. Very recent data show that the use of ...

journal_title：Frontiers in pharmacology

authors： Mary A,Hénaut L,Macq PY,Badoux L,Cappe A,Porée T,Eckes M,Dupont H,Brazier M

更新日期：2020-11-30 00:00:00

abstract：:Exhaustive exercise has emerged as an important health issue nowadays. This study was designed to assess the metabolite abnormalities of rats after exhaustive exercise and the holistic efficacy of Chinese medicine Sanqi oral solution (SQ). Through exhaustive swimming, the exhaustive exercise model in rats was establis...

journal_title：Frontiers in pharmacology

authors： Xu P,Li S,Tian R,Han L,Mao W,Li L,Li C,Wang Y,Luo G,Yang N

更新日期：2019-07-04 00:00:00

abstract：:Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a KO at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP systems, thereby providing hi...

journal_title：Frontiers in pharmacology

authors： Hanstein R,Negoro H,Patel NK,Charollais A,Meda P,Spray DC,Suadicani SO,Scemes E

更新日期：2013-05-09 00:00:00

abstract：:The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumacaftor (VX-809), stab...

journal_title：Frontiers in pharmacology

authors： Laselva O,Marzaro G,Vaccarin C,Lampronti I,Tamanini A,Lippi G,Gambari R,Cabrini G,Bear CE,Chilin A,Dechecchi MC

更新日期：2018-07-04 00:00:00

abstract：:The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in several case reports and open studies, which is thought to act by inhibiting glutamate release through voltage-sensitive sodium channels blockade and neuronal membrane stabilization. However, recent findings have also illust...

journal_title：Frontiers in pharmacology

authors： Prabhavalkar KS,Poovanpallil NB,Bhatt LK

更新日期：2015-10-23 00:00:00

abstract：Introduction:Infliximab (IFX) was the first anti-tumor necrosis factor (TNFα) antibody to be used in the treatment of severe chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. A number of serious adverse drug reactions are known to be associated with IFX use; they include infections, malig...

journal_title：Frontiers in pharmacology

authors： Thillard EM,Gautier S,Babykina E,Carton L,Amad A,Bouzillé G,Beuscart JB,Ficheur G,Chazard E

更新日期：2020-04-22 00:00:00

abstract：:This paper reported a feasibility study strategy of identifying pharmacokinetic (PK) markers for a cardiovascular herbal medicine, Guanxin Danshen drop pill (GDDP). First, quantification analysis revealed the constituent composition in the preparation by high-performance liquid chromatography (HPLC). Subsequently, phy...

journal_title：Frontiers in pharmacology

authors： Yao H,Huang X,Xie Y,Huang X,Ruan Y,Lin X,Huang L,Shi P

更新日期：2018-12-21 00:00:00

abstract：:Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer's disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside (CIG) is a main com...

journal_title：Frontiers in pharmacology

authors： Yang C,Li X,Gao W,Wang Q,Zhang L,Li Y,Li L,Zhang L

更新日期：2018-06-26 00:00:00

abstract：:It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

journal_title：Frontiers in pharmacology

authors： Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

更新日期：2020-06-26 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：:Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

journal_title：Frontiers in pharmacology

authors： Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

更新日期：2017-04-04 00:00:00

abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...

journal_title：Frontiers in pharmacology

authors： Issa ME,Wijeratne EMK,Gunatilaka AAL,Cuendet M

更新日期：2017-09-08 00:00:00

abstract：:This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities. A retrospective study of 42 cases on paraffin-embedded tissue specimens diagnosed with DLBCL was performed using immunohistochemistry (IHC) and fluoresce...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Wang H,Ren C,Yu H,Fang W,Zhang N,Gao S,Hou Q

更新日期：2019-01-07 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

journal_title：Frontiers in pharmacology

authors： Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

更新日期：2019-04-05 00:00:00

abstract：:Upon interaction, neutrophils can potentially release neutrophil extracellular traps (NETs) on the surface of an implanted electrospun template, which may be a significant preconditioning event for implantable biomaterials of yet unknown consequences. In this study, we investigated the potential of polydioxanone templ...

journal_title：Frontiers in pharmacology

authors： Fetz AE,Neeli I,Buddington KK,Read RW,Smeltzer MP,Radic MZ,Bowlin GL

更新日期：2018-03-28 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:Phosphorylation waves drive the propagation of signals generated in response to hormones and growth factors in target cells. cAMP is an ancient second messenger implicated in key biological functions. In mammals, most of the effects elicited by cAMP are mediated by protein kinase A (PKA). Activation of the kinase by c...

journal_title：Frontiers in pharmacology

authors： Rinaldi L,Sepe M,Donne RD,Feliciello A

更新日期：2015-09-04 00:00:00

abstract：:Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in ...

journal_title：Frontiers in pharmacology

authors： Zhao YF,Huang ZD,Gu HY,Guo GL,Yuan RX,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic t...

journal_title：Frontiers in pharmacology

authors： Bordon KCF,Cologna CT,Fornari-Baldo EC,Pinheiro-Júnior EL,Cerni FA,Amorim FG,Anjolette FAP,Cordeiro FA,Wiezel GA,Cardoso IA,Ferreira IG,de Oliveira IS,Boldrini-França J,Pucca MB,Baldo MA,Arantes EC

更新日期：2020-07-24 00:00:00

abstract：:Background: Cefoperazone/sulbactam is a broad-spectrum antibacterial agent. Drug-induced immune hemolytic anemia is a rare but serious condition, and reactive thrombocytosis is caused by processes extrinsic to the megakaryocyte. Limited data are available for cefoperazone/sulbactam-associated hemolytic anemia and reac...

journal_title：Frontiers in pharmacology

authors： Zhou L,Bao J,Ma J

更新日期：2019-11-08 00:00:00

abstract：:More than a century has passed since the first surgical mesh for hernia repair was developed, and, to date, this is still the most widely used method despite the great number of complications it poses. The purpose of this study was to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in ...

journal_title：Frontiers in pharmacology

authors： Marinaro F,Casado JG,Blázquez R,Brun MV,Marcos R,Santos M,Duque FJ,López E,Álvarez V,Usón A,Sánchez-Margallo FM

更新日期：2020-09-25 00:00:00

abstract：:Recent studies have documented that reduced M-current promotes epileptogenesis and attenuates synaptic remodeling. Neurite growth is closely related to the level of 5-HT6 receptor (5-HT6R) in the central nervous system. However, little research is available regarding the relation between 5-HT6R and M-current and the r...

journal_title：Frontiers in pharmacology

authors： Zhu C,Lin R,Liu C,Huang M,Lin F,Zhang G,Zhang Y,Miao J,Lin W,Huang H

更新日期：2020-04-28 00:00:00

abstract：Background:Brazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines from clinical studies, expanded access and compassionate use progr...

journal_title：Frontiers in pharmacology

authors： da Silva RE,Lima EDC,Novaes MRCG,Osorio-de-Castro CGS

更新日期：2020-05-19 00:00:00

abstract：:Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhib...

journal_title：Frontiers in pharmacology

authors： Huang Z,Su W,Lu T,Wang Y,Dong Y,Qin Y,Liu D,Sun L,Jiao W

更新日期：2020-10-07 00:00:00