Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering.

abstract：:Pre-eclampsia is a hypertensive disorder of pregnancy initiated by placental insufficiency and chronic ischemia. In response, several pathways activated in the placenta are responsible for the maternal syndrome, including increased production of the anti-angiogenic protein, sFlt-1, and inflammatory cytokines, especial...

journal_title：Frontiers in pharmacology

authors： George EM,Stout JM,Stec DE,Granger JP

更新日期：2015-08-17 00:00:00

abstract：:Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

journal_title：Frontiers in pharmacology

authors： Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

更新日期：2020-02-28 00:00:00

abstract：:Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emergin...

journal_title：Frontiers in pharmacology

authors： Akone SH,Ntie-Kang F,Stuhldreier F,Ewonkem MB,Noah AM,Mouelle SEM,Müller R

更新日期：2020-08-13 00:00:00

abstract：:Alzheimer's disease (AD) is the most widespread form of dementia, affecting about 45 million people worldwide. Although the β-amyloid peptide (Aβ) remains the most acknowledged culprit of AD, the multiple failures of Aβ-centric therapies call for alternative therapeutic approaches. Conceivably, the complexity of the A...

journal_title：Frontiers in pharmacology

authors： Balducci C,Forloni G

更新日期：2019-07-03 00:00:00

abstract：:Direct-to-consumer (DTC) DNA testing has grown from contentious beginnings into a global industry, by providing a wide range of personal genomic information directly to its clients. These companies, typified by the well-established 23andMe, generally carry out a gene-chip analysis of single-nucleotide polymorphisms (S...

journal_title：Frontiers in pharmacology

authors： Chua EW,Kennedy MA

更新日期：2012-08-20 00:00:00

abstract：:The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of...

journal_title：Frontiers in pharmacology

authors： Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

更新日期：2020-12-10 00:00:00

abstract：:The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (Kv) channels KCNQ1 and hERG as well as the voltage-gated sodium (Nav) channel encoded by SCN5A. ...

journal_title：Frontiers in pharmacology

authors： Brewer KR,Kuenze G,Vanoye CG,George AL Jr,Meiler J,Sanders CR

更新日期：2020-05-04 00:00:00

abstract：:Tumor cells acquire invasive and metastatic behavior by sensing changes in the localization and activation of signaling pathways, which in turn determine changes in actin cytoskeleton. The core-scaffold machinery associated to β-arrestin (β-arr) is a key mechanism of G-protein coupled receptors (GPCR) to achieve spati...

journal_title：Frontiers in pharmacology

authors： Bagnato A,Rosanò L

更新日期：2019-02-19 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detected constantly, and some are associated with a series of adverse effects, including seizures. CUMYL-4CN-BINACA (1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide) is structural...

journal_title：Frontiers in pharmacology

authors： Kevin RC,Anderson L,McGregor IS,Boyd R,Manning JJ,Glass M,Connor M,Banister SD

更新日期：2019-05-29 00:00:00

abstract：:The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

journal_title：Frontiers in pharmacology

authors： Schurman LD,Lichtman AH

更新日期：2017-02-17 00:00:00

abstract：:A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

journal_title：Frontiers in pharmacology

authors： Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

更新日期：2019-03-19 00:00:00

abstract：PURPOSE:Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. METHODS:A rat model of renal I/R injury was indu...

journal_title：Frontiers in pharmacology

authors： Li J,Hong Z,Liu H,Zhou J,Cui L,Yuan S,Chu X,Yu P

更新日期：2016-04-22 00:00:00

abstract：:This research evaluated the effects of triterpenes on the regulation of STZ-induced hyperglycaemic diabetes through an anti-inflammatory response. Diabetic mice were orally administered various concentrations of triterpenes on a daily basis. Weight gain, volume of drinking water, and liver and spleen weight were recor...

journal_title：Frontiers in pharmacology

authors： Wu YS,Chen SN

更新日期：2016-06-13 00:00:00

abstract：:Background: Cefoperazone/sulbactam is a broad-spectrum antibacterial agent. Drug-induced immune hemolytic anemia is a rare but serious condition, and reactive thrombocytosis is caused by processes extrinsic to the megakaryocyte. Limited data are available for cefoperazone/sulbactam-associated hemolytic anemia and reac...

journal_title：Frontiers in pharmacology

authors： Zhou L,Bao J,Ma J

更新日期：2019-11-08 00:00:00

abstract：:Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

journal_title：Frontiers in pharmacology

authors： Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

更新日期：2018-01-08 00:00:00

abstract：:Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significan...

journal_title：Frontiers in pharmacology

authors： Agrawal S,Adholeya A,Deshmukh SK

更新日期：2016-10-25 00:00:00

abstract：:Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...

journal_title：Frontiers in pharmacology

authors： Belo RF,Martins MLF,Shvachiy L,Costa-Coelho T,de Almeida-Borlido C,Fonseca-Gomes J,Neves V,Vicente Miranda H,Outeiro TF,Coelho JE,Xapelli S,Valente CA,Heras M,Bardaji E,Castanho MARB,Diógenes MJ,Sebastião AM

更新日期：2020-07-09 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an ex vivo model of global myocardial I/R was investigated. After treatment with different concentrati...

journal_title：Frontiers in pharmacology

authors： Li D,Lu N,Han J,Chen X,Hao W,Xu W,Liu X,Ye L,Zheng Q

更新日期：2018-01-30 00:00:00

abstract：:Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system - Ayurveda - it is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therape...

journal_title：Frontiers in pharmacology

authors： Balkrishna A,Thakur P,Varshney A

更新日期：2020-03-03 00:00:00

abstract：:Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

journal_title：Frontiers in pharmacology

authors： Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

更新日期：2019-09-24 00:00:00

abstract：:Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological methods. Here, we first explored the mechanism of action of DSD with the as...

journal_title：Frontiers in pharmacology

authors： Pan B,Wang Y,Wu C,Jia J,Huang C,Fang S,Liu L

更新日期：2021-01-11 00:00:00

abstract：:Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

journal_title：Frontiers in pharmacology

authors： Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

更新日期：2019-09-20 00:00:00

abstract：:Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to ...

journal_title：Frontiers in pharmacology

authors： Cenini G,Voos W

更新日期：2019-08-23 00:00:00

abstract：Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...

journal_title：Frontiers in pharmacology

authors： Zhang W,Liu C,Li J,Liu R,Zhuang J,Feng F,Yao Y,Sun C

更新日期：2020-08-07 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：Background:Among factors influencing the higher risk of developing unknown or rare adverse drug reactions (ADRs) among children and adolescents, there is the frequent off-label use of drugs that seems to be very common in pediatric oncological patients. Our study aim to collect and evaluate data on the safety profile o...

journal_title：Frontiers in pharmacology

authors： Mascolo A,Scavone C,Bertini M,Brusco S,Punzo F,Pota E,Di Martino M,Di Pinto D,Rossi F

更新日期：2020-05-07 00:00:00

abstract：:Phytoestrogen has been proposed as an alternative to hormone replacement therapy, which has been demonstrated to promote a high risk of breast cancer. However, the effect of phytoestrogen on breast cancer development has not been fully understood. Bakuchiol is an active ingredient of a traditional Chinese herbal medic...

journal_title：Frontiers in pharmacology

authors： Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

更新日期：2016-05-24 00:00:00

abstract：:Endothelial cells play a critical role in the process of angiogenesis during skin wound healing. The migration and proliferation of endothelial cells are processes that are initiated by the hypoxic microenvironment in a wound, but the underlying mechanisms remain largely unknown. Here, we identified a novel role for m...

journal_title：Frontiers in pharmacology

authors： Zhang J,Li L,Zhang Q,Yang X,Zhang C,Zhang X,Zhang D,Lv Y,Song H,Chen B,Liu Y,Hu J,Huang Y

更新日期：2019-04-16 00:00:00

abstract：:Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-O-methyl RNA (2'-OMe-RNA) and phosphoryl guanidine ol...

journal_title：Frontiers in pharmacology

authors： Novopashina D,Vorobyeva M,Nazarov A,Davydova A,Danilin N,Koroleva L,Matveev A,Bardasheva A,Tikunova N,Kupryushkin M,Pyshnyi D,Altman S,Venyaminova A

更新日期：2019-07-19 00:00:00