The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates.

abstract：:A leading cause of death worldwide is sepsis that develops as a dysregulated immune response to infection. Serious infection caused by methicillin-resistant Staphylococcus aureus (MRSA) increases the difficulty of treatment in septic patients. Host-directed therapy (HDT) is an emerging approach to bacterial infections...

journal_title：Frontiers in pharmacology

authors： Li T,Qian Y,Miao Z,Zheng P,Shi T,Jiang X,Pan L,Qian F,Yang G,An H,Zheng Y

更新日期：2020-02-21 00:00:00

abstract：:The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of...

journal_title：Frontiers in pharmacology

authors： Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

更新日期：2020-12-10 00:00:00

abstract：Aim:To investigate the variations and the frequencies of the SLCO1B1 gene in the Thai population. Methods:Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the SLCO1B1, using TaqMan® real-time PCR. Results:The minor allele frequenci...

journal_title：Frontiers in pharmacology

authors： Na Nakorn C,Waisayarat J,Dejthevaporn C,Srisawasdi P,Wongwaisayawan S,Sukasem C

更新日期：2020-06-05 00:00:00

abstract：:Background: Sorafenib (Nexavar®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and strongly recommend its combination with other agents aiming at ameliorating its drawbacks. OSU-2S...

journal_title：Frontiers in pharmacology

authors： Omar HA,Tolba MF,Hung JH,Al-Tel TH

更新日期：2016-11-30 00:00:00

abstract：:The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metab...

journal_title：Frontiers in pharmacology

authors： Xiao HH,Sham TT,Chan CO,Li MH,Chen X,Wu QC,Mok DK,Yao XS,Wong MS

更新日期：2018-08-21 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

journal_title：Frontiers in pharmacology

authors： Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

更新日期：2019-02-04 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

journal_title：Frontiers in pharmacology

authors： Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

更新日期：2019-09-20 00:00:00

abstract：:Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

journal_title：Frontiers in pharmacology

authors： Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

更新日期：2017-04-04 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Here, we examined the regulation of tyrosine hydroxylase (TH) by tyramine and beta-phenylethylamine (β-PEA) compared to 3-iodot...

journal_title：Frontiers in pharmacology

authors： Zhang X,Mantas I,Alvarsson A,Yoshitake T,Shariatgorji M,Pereira M,Nilsson A,Kehr J,Andrén PE,Millan MJ,Chergui K,Svenningsson P

更新日期：2018-03-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study w...

journal_title：Frontiers in pharmacology

authors： Gimeno-Hernández R,Cantó A,Fernández-Carbonell A,Olivar T,Hernández-Rabaza V,Almansa I,Miranda M

更新日期：2020-12-23 00:00:00

abstract：Objective:Current prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizu...

journal_title：Frontiers in pharmacology

authors： Rajapaksa AE,Do LAH,Suryawijaya Ong D,Sourial M,Veysey D,Beare R,Hughes W,Yang W,Bischof RJ,McDonnell A,Eu P,Yeo LY,Licciardi PV,Mulholland EK

更新日期：2020-08-19 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：Background:Patients with locally advanced rectal cancer (LARC) are at higher risk of local and distant recurrence and are thus more vulnerable to metastatic diseases. Neoadjuvant chemoradiotherapy (nCRT) and subsequent curative resection with total mesorectal excision (TME) followed by adjuvant chemotherapy have been r...

journal_title：Frontiers in pharmacology

authors： Zhong X,Zhou Y,Cui W,Su X,Guo Z,Hidasa I,Li Q,Wang Z,Song Y

更新日期：2020-05-15 00:00:00

abstract：:The interaction between programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) induces exhaustions of cytotoxic lymphocytes in the tumor microenvironment, which facilitates tumor immune evasion. PD-1/PD-L1 blockade therapy, which prevents the receptors and ligands from binding to each ...

journal_title：Frontiers in pharmacology

authors： Yang J,He X,Lv Q,Jing J,Shi H

更新日期：2019-07-02 00:00:00

abstract：:Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibitio...

journal_title：Frontiers in pharmacology

authors： Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

更新日期：2018-05-03 00:00:00

abstract：:Mint [Mentha longifolia (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic. Recently, its antiproliferative role h...

journal_title：Frontiers in pharmacology

authors： Patti F,Palmioli A,Vitalini S,Bertazza L,Redaelli M,Zorzan M,Rubin B,Mian C,Bertolini C,Iacobone M,Armanini D,Barollo S,Airoldi C,Iriti M,Pezzani R

更新日期：2020-02-10 00:00:00

abstract：:Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator of BKCa channel in the vascular smooth muscle cells (VSMCs). Vascular tension is closely associated with Ca2+ dynamics and...

journal_title：Frontiers in pharmacology

authors： Zhang XD,He CX,Cheng J,Wen J,Li PY,Wang N,Li G,Zeng XR,Cao JM,Yang Y

更新日期：2018-02-02 00:00:00

abstract：:Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protei...

journal_title：Frontiers in pharmacology

authors： Camerino GM,Musumeci O,Conte E,Musaraj K,Fonzino A,Barca E,Marino M,Rodolico C,Tricarico D,Camerino C,Carratù MR,Desaphy JF,De Luca A,Toscano A,Pierno S

更新日期：2017-07-27 00:00:00

abstract：:[This corrects the article on p. 648 in vol. 8, PMID: 28959205.]. ...

journal_title：Frontiers in pharmacology

authors： Zhong ZF,Yu HB,Wang CM,Qiang WA,Wang SP,Zhang JM,Yu H,Cui L,Wu T,Li DQ,Wang YT

更新日期：2017-12-18 00:00:00

abstract：Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...

journal_title：Frontiers in pharmacology

authors： Zhang W,Liu C,Li J,Liu R,Zhuang J,Feng F,Yao Y,Sun C

更新日期：2020-08-07 00:00:00

abstract：:Icariin is a main component of the Chinese medicinal plant Epimedium brevicornu Maxim, exhibits potent activity against inflammatory diseases. Our previous data demonstrated the valid bioactivity of icariin on mitigating rodent asthma. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NF-κB) pathway were involv...

journal_title：Frontiers in pharmacology

authors： Liu J,Liu L,Sun J,Luo Q,Yan C,Zhang H,Liu F,Wei Y,Dong J

更新日期：2020-01-31 00:00:00

abstract：:Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

journal_title：Frontiers in pharmacology

authors： Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

更新日期：2019-02-26 00:00:00

abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

journal_title：Frontiers in pharmacology

authors： Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

更新日期：2020-12-03 00:00:00

abstract：INTRODUCTION:European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. OBJECTIVE:To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future gui...

journal_title：Frontiers in pharmacology

authors： Godman B,Shrank W,Andersen M,Berg C,Bishop I,Burkhardt T,Garuoliene K,Herholz H,Joppi R,Kalaba M,Laius O,Lonsdale J,Malmström RE,Martikainen JE,Samaluk V,Sermet C,Schwabe U,Teixeira I,Tilson L,Tulunay FC,Vlahović-

更新日期：2011-01-07 00:00:00

abstract：:The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammat...

journal_title：Frontiers in pharmacology

authors： Luo JF,Shen XY,Lio CK,Dai Y,Cheng CS,Liu JX,Yao YD,Yu Y,Xie Y,Luo P,Yao XS,Liu ZQ,Zhou H

更新日期：2018-09-04 00:00:00

abstract：:Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury. The p38 mitogen-activated protein kinase (MAPK) is involved in breakdown of the endothelial barrier during LIRI, but the mechanism is still unclear. Therefore, we investi...

journal_title：Frontiers in pharmacology

authors： Wang T,Liu C,Pan LH,Liu Z,Li CL,Lin JY,He Y,Xiao JY,Wu S,Qin Y,Li Z,Lin F

更新日期：2020-12-11 00:00:00

abstract：:The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

journal_title：Frontiers in pharmacology

authors： Schurman LD,Lichtman AH

更新日期：2017-02-17 00:00:00

abstract：:Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

journal_title：Frontiers in pharmacology

authors： Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

更新日期：2018-07-10 00:00:00