A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.

abstract：:We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined the safety and tol...

journal_title：Frontiers in pharmacology

authors： Alfaro VY,Goldblatt DL,Valverde GR,Munsell MF,Quinton LJ,Walker AK,Dantzer R,Varadhachary A,Scott BL,Evans SE,Tuvim MJ,Dickey BF

更新日期：2014-02-06 00:00:00

abstract：:Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates oxidative stress response, but also represses inflammation by regulating cytokines production and cross-talking with NF-κB signaling pathways. Nrf2 plays an essential role in liver injury induced by oxidative stress and inflamma...

journal_title：Frontiers in pharmacology

authors： Yang YQ,Yan XT,Wang K,Tian RM,Lu ZY,Wu LL,Xu HT,Wu YS,Liu XS,Mao W,Xu P,Liu B

更新日期：2018-08-29 00:00:00

abstract：:Agrocybe aegerita has long been utilized for promoting diuresis in traditional Chinese medicine (TCM) with a close correlation to hypouricemia. Ethanol (AAE) and water (AAW) extracts of the compound led to a remarkable decrease in serum uric acid levels (SUA) in hyperuricemia mice, approaching that of the normal contr...

journal_title：Frontiers in pharmacology

authors： Yong T,Chen S,Xie Y,Shuai O,Li X,Chen D,Su J,Jiao C,Liang Y

更新日期：2018-05-15 00:00:00

abstract：:Aims and Hypothesis: NEDD9 is highly expressed in gastric cancer and has a significant involvement in its pathogenesis. However, the mechanism behind hypoxia-promoted cancer cell migration and its regulation because of NEDD9 is still unknown. The aim of this study is to investigate the involvement of NEDD9 in gastric ...

journal_title：Frontiers in pharmacology

authors： Zhao S,Min P,Liu L,Zhang L,Zhang Y,Wang Y,Zhao X,Ma Y,Xie H,Zhu C,Jiang H,Du J,Gu L

更新日期：2019-04-04 00:00:00

abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...

journal_title：Frontiers in pharmacology

authors： Tomko A,O'Leary L,Trask H,Achenbach JC,Hall SR,Goralski KB,Ellis LD,Dupré DJ

更新日期：2019-09-27 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonists, the S1R-selecti...

journal_title：Frontiers in pharmacology

authors： Cirino TJ,Eans SO,Medina JM,Wilson LL,Mottinelli M,Intagliata S,McCurdy CR,McLaughlin JP

更新日期：2019-06-14 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：:MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 has been reported to be associated with carcinogenesis. However, the role of MYCT1 in the development and progress of acute myeloid leukemia (...

journal_title：Frontiers in pharmacology

authors： Fu S,Fu Y,Chen F,Hu Y,Quan B,Zhang J

更新日期：2018-09-18 00:00:00

abstract：:Diabetic kidney disease (DKD) is a major health problem and one of the leading causes of end-stage renal disease worldwide. Despite recent advances, there exists an urgent need for the development of new treatments for DKD. DKD is characterized by the excessive synthesis and deposition of extracellular matrix proteins...

journal_title：Frontiers in pharmacology

authors： Sakuma H,Hagiwara S,Kantharidis P,Gohda T,Suzuki Y

更新日期：2020-11-13 00:00:00

abstract：:2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT2A), 2B (5-HT2B), and (5-HT2C) rec...

journal_title：Frontiers in pharmacology

authors： Papaseit E,Olesti E,Pérez-Mañá C,Torrens M,Grifell M,Ventura M,Pozo OJ,de Sousa Fernandes Perna EB,Ramaekers JG,de la Torre R,Farré M

更新日期：2020-03-18 00:00:00

abstract：:Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats. Many genetically determined intestinal diseases occur in specific tissue microenvironments that are not adequately...

journal_title：Frontiers in pharmacology

authors： Liu F,Huang J,Ning B,Liu Z,Chen S,Zhao W

更新日期：2016-09-22 00:00:00

abstract：:Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy. Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs and activated sign...

journal_title：Frontiers in pharmacology

authors： Li M,Cui L,Feng X,Wang C,Zhang Y,Wang L,Ding Y,Zhao T

更新日期：2019-06-07 00:00:00

abstract：:Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic plaque in ApoE-defi...

journal_title：Frontiers in pharmacology

authors： Chen Z,Gao X,Jiao Y,Qiu Y,Wang A,Yu M,Che F,Li S,Liu J,Li J,Zhang H,Yu C,Li G,Gao Y,Pan L,Sun W,Guo J,Cao B,Zhu Y,Xu H

更新日期：2019-07-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice...

journal_title：Frontiers in pharmacology

authors： Wang T,Jia Q,Chen T,Yin H,Tian X,Lin X,Liu Y,Zhao Y,Wang Y,Shi Q,Huang C,Xu H,Liang Q

更新日期：2020-02-14 00:00:00

abstract：:Chronic pain is a common detrimental condition that affects around 20% of the world population. The current drugs to treat chronic pain states, especially neuropathic pain, have a limited clinical efficiency and present significant adverse effects that complicates their regular use. Recent studies have proposed new th...

journal_title：Frontiers in pharmacology

authors： Lara CO,Burgos CF,Moraga-Cid G,Carrasco MA,Yévenes GE

更新日期：2020-03-03 00:00:00

abstract：:Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adult...

journal_title：Frontiers in pharmacology

authors： Ragavendran C,Srinivasan R,Kim M,Natarajan D

更新日期：2018-11-26 00:00:00

abstract：:In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by ...

journal_title：Frontiers in pharmacology

authors： Herradón E,González C,Uranga JA,Abalo R,Martín MI,López-Miranda V

更新日期：2017-05-08 00:00:00

abstract：:Glucocorticoids (GCs) are the most commonly used drugs for treatment of autoimmune and inflammatory diseases. Their efficacy is due to their ability to bind cytoplasmic receptors (glucocorticoid receptors, GR) and other cytoplasmic proteins, thus regulating gene expression. Although GCs are potent life-saving drugs, t...

journal_title：Frontiers in pharmacology

authors： Bereshchenko O,Migliorati G,Bruscoli S,Riccardi C

更新日期：2019-03-27 00:00:00

abstract：:Lipopolysaccharide (LPS) can induce bone loss by stimulating bone resorption. Natural compounds have great potential for the treatment of osteolytic bone diseases. Magnesium lithospermate B (MLB) plays an important role in protecting against oxidative damage and also has potential anti-inflammatory pharmacological pro...

journal_title：Frontiers in pharmacology

authors： Wang J,Wu X,Duan Y

更新日期：2018-02-06 00:00:00

abstract：:The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two protein families: the AT...

journal_title：Frontiers in pharmacology

authors： César-Razquin A,Girardi E,Yang M,Brehme M,Saez-Rodriguez J,Superti-Furga G

更新日期：2018-09-07 00:00:00

abstract：:Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanop...

journal_title：Frontiers in pharmacology

authors： Rezvantalab S,Drude NI,Moraveji MK,Güvener N,Koons EK,Shi Y,Lammers T,Kiessling F

更新日期：2018-11-02 00:00:00

abstract：:Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly influenced by the surrounding microenvironment of the tumor. Therefore, the ability to change these surroundings represents an important property through which tumor cells are able to acquire specific functions necessary for tumor ...

journal_title：Frontiers in pharmacology

authors： Noël A,Gutiérrez-Fernández A,Sounni NE,Behrendt N,Maquoi E,Lund IK,Cal S,Hoyer-Hansen G,López-Otín C

更新日期：2012-07-17 00:00:00

abstract：:The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before...

journal_title：Frontiers in pharmacology

authors： Puiu AA,Radke S,Votinov M,Habel U,Herpertz-Dahlmann B,Turetsky B,Konrad K

更新日期：2019-11-21 00:00:00

abstract：:Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

journal_title：Frontiers in pharmacology

authors： Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

更新日期：2013-10-22 00:00:00

abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

journal_title：Frontiers in pharmacology

authors： Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

更新日期：2020-12-03 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Saponins are natural compounds and possess the most promising anti-cancer function. Here, a saponin gleditsia saponin C (GSC), extracted from gleditsiae fructus abnormalis, could induce apoptosis of lung tumor cell line A549 via caspase dependent cascade and this effect could be prevented by the caspase inhibitors. In...

journal_title：Frontiers in pharmacology

authors： Cheng Y,He W,He Y

更新日期：2018-01-15 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

journal_title：Frontiers in pharmacology

authors： Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

更新日期：2019-09-05 00:00:00