MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7.


:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tumor tissues compared with those in the paired paratumor tissues. Further, expression of miR-532-3p was detected in four TSCC cell lines, TSCCA, TCA8113, CAL-27, and SCC-25. The miR-532-3p mimics and inhibitor were transfected into the CAL-27 and TCA8113 cell lines which were the relatively lowest and highest miR-532-3p expressions, respectively. It was found that the overexpression of miR-532-3p suppressed TSCC cell proliferation, migration, invasion, and promoted apoptosis in vitro, whilst the knockdown of miR-532-3p reversed these behaviors. The bioinformatics predicted that CCR7 was a downstream gene of miR-532-3p, which was confirmed via luciferase assay. Following, the decline of CCR7 in the miR-532-3p mimics group and the rise of CCR7 in the miR-532-3p inhibitor group were also verified. In addition, enhanced cell proliferation, migration and invasion induced by CCR7 were partly restrained by miR-532-3p in TSCC cell. Meanwhile, miR-532-3p attenuated tumourigenesis in vivo due to the reduction of tumor volume and Ki-67 positive rate and the increase of apoptotic cells. Taken together, these findings reveal a pivotal role for the miR-532-3p/CCR7 axis in regulating TSCC, and this novel axis could be suitable for therapeutic intervention in TSCC disease.


Front Pharmacol


Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z




Has Abstract


2019-08-29 00:00:00








  • Novel Anti-fibrotic Therapies.

    abstract::Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: McVicker BL,Bennett RG

    更新日期:2017-05-31 00:00:00

  • Toxic Effects of Trichloroethylene on Rat Neuroprogenitor Cells.

    abstract::Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

    更新日期:2018-07-10 00:00:00

  • The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome.

    abstract::The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we invest...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Steiner MA,Sciarretta C,Pasquali A,Jenck F

    更新日期:2013-12-30 00:00:00

  • Total Flavonoids of Rhizoma Drynariae Enhances Angiogenic-Osteogenic Coupling During Distraction Osteogenesis by Promoting Type H Vessel Formation Through PDGF-BB/PDGFR-β Instead of HIF-1α/ VEGF Axis.

    abstract::Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

    更新日期:2020-11-27 00:00:00

  • PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity.

    abstract::Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

    更新日期:2018-09-26 00:00:00

  • A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats.

    abstract::The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metab...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xiao HH,Sham TT,Chan CO,Li MH,Chen X,Wu QC,Mok DK,Yao XS,Wong MS

    更新日期:2018-08-21 00:00:00

  • Elevated Pressure Changes the Purinergic System of Microglial Cells.

    abstract::Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

    更新日期:2018-01-24 00:00:00

  • Clinical and Economic Evaluation of Salvianolate Injection for Coronary Heart Disease: A Retrospective Study Based on National Health Insurance Data in China.

    abstract:Objective:The study aimed to conduct clinical and economic evaluation of salvianolate injection for patients with coronary heart disease (CHD) in comparison to Danhong injection and alprostadil injection. Method:This was a retrospective study using National Health Insurance Data about inpatients diagnosed with CHD in ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang L,Chen X,Oi Lam Ung C,Zhu H,Hu H,Han S

    更新日期:2020-06-18 00:00:00

  • Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.

    abstract::Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A1 and M2 receptors coupled to inwardly rectifying GIRK/KIR3.1/3.4 channels, respectively. Unlike M2 receptors, bradycardia produced by A1 receptors activation predominates over negative inotropy. Such diffe...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bragança B,Oliveira-Monteiro N,Ferreirinha F,Lima PA,Faria M,Fontes-Sousa AP,Correia-de-Sá P

    更新日期:2016-03-07 00:00:00

  • Corrigendum: Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.

    abstract::[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,已发布勘误


    authors: Uttl L,Petrasek T,Sengul H,Svojanovska M,Lobellova V,Vales K,Radostova D,Tsenov G,Kubova H,Mikulecka A,Svoboda J,Stuchlik A

    更新日期:2018-06-20 00:00:00

  • Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing-Using Rifampicin as an Example.

    abstract::Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitude of IOV in rifamp...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Keutzer L,Simonsson USH

    更新日期:2020-05-27 00:00:00

  • Advances and Challenges of Liposome Assisted Drug Delivery.

    abstract::The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Sercombe L,Veerati T,Moheimani F,Wu SY,Sood AK,Hua S

    更新日期:2015-12-01 00:00:00

  • Liraglutide Ameliorates Erectile Dysfunction via Regulating Oxidative Stress, the RhoA/ROCK Pathway and Autophagy in Diabetes Mellitus.

    abstract:Background:Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the prote...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yuan P,Ma D,Gao X,Wang J,Li R,Liu Z,Wang T,Wang S,Liu J,Liu X

    更新日期:2020-08-12 00:00:00

  • Growth Pattern in Chinese Children With 5α-Reductase Type 2 Deficiency: A Retrospective Multicenter Study.

    abstract:Background:5α-reductase type 2 deficiency (5αRD) is an autosomal recessive hereditary disease of the group of 46, XY disorders of sex development (DSD). Objective:To study the growth pattern in Chinese pediatric patients with 5αRD. Subjects:Data were obtained from 141 patients with 5αRD (age: 0-16 years old) who visi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhao X,Song Y,Chen S,Wang X,Luo F,Yang Y,Chen L,Chen R,Chen H,Su Z,Wu D,Gong C

    更新日期:2019-03-15 00:00:00

  • Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

    abstract::The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Thomas M,Winter S,Klumpp B,Turpeinen M,Klein K,Schwab M,Zanger UM

    更新日期:2015-11-04 00:00:00

  • Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks.

    abstract::Background: Details of the extraction and purification procedure can have a profound impact on the composition of plant-derived extracts, and thus on their efficacy and safety. So far, studies with head-to-head comparison of the pharmacology of Ginkgo extracts rendered by different procedures have been rare. Objective...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bader BM,Jügelt K,Schultz L,Schroeder OH

    更新日期:2018-08-03 00:00:00

  • Glucocorticoid-Induced Leucine Zipper: A Novel Anti-inflammatory Molecule.

    abstract::Glucocorticoids (GCs) are the most commonly used drugs for treatment of autoimmune and inflammatory diseases. Their efficacy is due to their ability to bind cytoplasmic receptors (glucocorticoid receptors, GR) and other cytoplasmic proteins, thus regulating gene expression. Although GCs are potent life-saving drugs, t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Bereshchenko O,Migliorati G,Bruscoli S,Riccardi C

    更新日期:2019-03-27 00:00:00

  • Psychiatric Adverse Events Associated With Infliximab: A Cohort Study From the French Nationwide Discharge Abstract Database.

    abstract:Introduction:Infliximab (IFX) was the first anti-tumor necrosis factor (TNFα) antibody to be used in the treatment of severe chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. A number of serious adverse drug reactions are known to be associated with IFX use; they include infections, malig...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Thillard EM,Gautier S,Babykina E,Carton L,Amad A,Bouzillé G,Beuscart JB,Ficheur G,Chazard E

    更新日期:2020-04-22 00:00:00

  • Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P.

    abstract::Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-O-methyl RNA (2'-OMe-RNA) and phosphoryl guanidine ol...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Novopashina D,Vorobyeva M,Nazarov A,Davydova A,Danilin N,Koroleva L,Matveev A,Bardasheva A,Tikunova N,Kupryushkin M,Pyshnyi D,Altman S,Venyaminova A

    更新日期:2019-07-19 00:00:00

  • Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway.

    abstract::Oncogenic activation of the KRAS gene via point mutations occurs in 20-30% of patients with non-small cell lung cancer (NSCLC). The RAS-RAF-ERK and RAS-PI3K-AKT pathways are the major hyper-activated downstream pathways in RAS mutation, which promotes the unlimited lifecycle of cancer cells and their metastasis in hum...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lai H,Wang Y,Duan F,Li Y,Jiang Z,Luo L,Liu L,Leung ELH,Yao X

    更新日期:2018-08-22 00:00:00

  • Non-linear Entropy Analysis in EEG to Predict Treatment Response to Repetitive Transcranial Magnetic Stimulation in Depression.

    abstract::Background: Biomarkers that predict clinical outcomes in depression are essential for increasing the precision of treatments and clinical outcomes. The electroencephalogram (EEG) is a non-invasive neurophysiological test that has promise as a biomarker sensitive to treatment effects. The aim of our study was to invest...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Shalbaf R,Brenner C,Pang C,Blumberger DM,Downar J,Daskalakis ZJ,Tham J,Lam RW,Farzan F,Vila-Rodriguez F

    更新日期:2018-10-30 00:00:00

  • Gyejibongnyeong-Hwan (Gui Zhi Fu Ling Wan) Ameliorates Human Uterine Myomas via Apoptosis.

    abstract::Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated. In Korea and China, Gyejibongnyeong-hwan (GBH) is widely used to treat gynecological diseases. Thus, we investigated the effects of GBH in human uteri...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lee SM,Choi ES,Ha E,Ji KY,Shin SJ,Jung J

    更新日期:2019-09-25 00:00:00

  • Fructus mume Extracts Alleviate Diarrhea in Breast Cancer Patients Receiving the Combination Therapy of Lapatinib and Capecitabine.

    abstract::Lapatinib and capecitabine have been widely used in the therapy of breast cancer. However, long-term use of lapatinib and capecitabine often causes the most common side effect diarrhea, which limit the medicine use. Fructus mume (F. mume) has been proved to be effective to treat chronic diarrhea with few side effects....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xing H,Zhang L,Ma J,Liu Z,Song C,Liu Y

    更新日期:2018-05-23 00:00:00

  • Economic Evaluation of Oral Alendronate Therapy for Osteoporosis in Chinese Postmenopausal Women: The Impact of Medication Compliance and Persistence.

    abstract::Objective: Prevalence of osteoporosis in Chinese postmenopausal women has significantly increased over the past decade and oral bisphosphonates are the most potent antiresorptive drugs. The purpose of the present research was to evaluate the cost-effectiveness of oral alendronate for individuals with osteoporosis. We ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: You R,Liu Z

    更新日期:2020-11-16 00:00:00

  • Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT.

    abstract::Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

    更新日期:2020-08-12 00:00:00

  • Cornel Iridoid Glycoside Inhibits Tau Hyperphosphorylation via Regulating Cross-Talk Between GSK-3β and PP2A Signaling.

    abstract::Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer's disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside (CIG) is a main com...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang C,Li X,Gao W,Wang Q,Zhang L,Li Y,Li L,Zhang L

    更新日期:2018-06-26 00:00:00

  • Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries.

    abstract::Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pha...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lyu M,Cui Y,Zhao T,Ning Z,Ren J,Jin X,Fan G,Zhu Y

    更新日期:2018-04-06 00:00:00

  • Semen cassiae Extract Inhibits Contraction of Airway Smooth Muscle.

    abstract::β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), however, they induce severe side effects. Therefore, developing new bronchodilators is essential. Herbal plants were extracted and the extracts' effect on ai...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: She YS,Ma LQ,Liu BB,Zhang WJ,Qiu JY,Chen YY,Li MY,Xue L,Luo X,Wang Q,Xu H,Zang DA,Zhao XX,Cao L,Shen J,Peng YB,Zhao P,Yu MF,Chen W,Nie X,Shen C,Chen S,Chen S,Qin G,Dai J,Chen J,Liu QH

    更新日期:2018-12-04 00:00:00

  • Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain.

    abstract::Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Ménard C,Quirion R

    更新日期:2012-10-12 00:00:00

  • Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis.

    abstract::Reports in the last decade have suggested that the role of platelets in atherosclerosis and its thrombotic complications may be mediated, in part, by local secretion of platelet-derived microvesicles (pMVs), small cell blebs released during the platelet activation process. MVs are the most abundant cell-derived microv...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Badimon L,Suades R,Fuentes E,Palomo I,Padró T

    更新日期:2016-08-31 00:00:00