Environmental Stressors on Skin Aging. Mechanistic Insights.

Abstract:

:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). More specifically, we have evaluated ambient air pollution, household air pollutants from non-combustion sources, and exposure to light (ultraviolet radiation and blue and red light). We approach the molecular pathways involved in skin aging and pathology as a result of exposure to these external environmental stressors. Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases.

journal_name

Front Pharmacol

authors

Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

doi

10.3389/fphar.2019.00759

subject

Has Abstract

pub_date

2019-07-09 00:00:00

pages

759

issn

1663-9812

journal_volume

10

pub_type

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