Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways.

Abstract:

:Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates oxidative stress response, but also represses inflammation by regulating cytokines production and cross-talking with NF-κB signaling pathways. Nrf2 plays an essential role in liver injury induced by oxidative stress and inflammation. Triptriolide (T11) is a minor component of Tripterygium wilfordii Hook F. (TwHF), which can be obtained by hydrolysis reaction of triptolide (T9). The major purpose of this study is to clarify the regulating effects of T11 on oxidative stress and inflammation in vivo and in vitro. LPS-stimulated RAW 264.7 cells were used to verify the regulating effects of T11 on oxidative stress (ROS and Nrf2 signaling pathway) and inflammatory cytokines production (TNF-α, IL-6 and IL-1β). The antioxidant responsive element (ARE) luciferase assay was employed to evaluate Nrf2 activation effect of T11 in HEK-293T cells. Lipopolysaccharides (LPS) induced acute liver injury (ALI) in BALB/c mice were used to study the protective effects (ALT, AST, MDA, SOD, histopathology and neutrophils/macrophages filtration) and the underlying protection mechanisms of ALI amelioration (Nrf2 and NF-κB signaling pathway) of T11. Firstly, the results showed that T11 can not only effectively decrease the productions of inflammatory cytokines (TNF-α, IL-6 and IL-1β), ROS and NO in LPS-stimulated RAW 264.7 cells, but also further significantly increase the activity of Nrf2 in HEK-293T cells. Secondly, the results suggested that T11 could dramatically decrease the oxidative stress responses (SOD and MDA) and inflammation (histopathology, neutrophils/macrophages filtration, TNF-α, IL-6 and IL-1β production) in LPS-induced ALI in BALB/c mice. Finally, the results implied that T11 could dramatically increase Nrf2 protein expression and decrease p-TAK1, p-IκBα and NF-κB protein expression both in vivo and in vitro. In conclusion, our findings indicated that T11 could alleviate LPS induced oxidative stress and inflammation by regulating Nrf2 and NF-κB signaling pathways in vitro and in vivo, which offers a novel insights for the application of TwHF in clinical.

journal_name

Front Pharmacol

authors

Yang YQ,Yan XT,Wang K,Tian RM,Lu ZY,Wu LL,Xu HT,Wu YS,Liu XS,Mao W,Xu P,Liu B

doi

10.3389/fphar.2018.00999

subject

Has Abstract

pub_date

2018-08-29 00:00:00

pages

999

issn

1663-9812

journal_volume

9

pub_type

杂志文章
  • Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells.

    abstract::Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00906

    authors: de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

    更新日期:2017-12-12 00:00:00

  • Impact of Biologic Treatment of Crohn's Disease on the Rate of Surgeries and Other Healthcare Resources: An Analysis of a Nationwide Database From Poland.

    abstract::Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn's disease (CD). We aimed to assess real-world consequences of biologic treatment of CD. Methods: All adult patients with CD treated with infliximab and adalimumab in the years 2012-2014 wer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00621

    authors: Holko P,Kawalec P,Pilc A

    更新日期:2018-06-11 00:00:00

  • Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System.

    abstract::The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant A549/DDP cells wer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00043

    authors: Hong W,Cai P,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

    更新日期:2018-01-31 00:00:00

  • Serum Metabolic Profiling Reveals the Antidepressive Effects of the Total Iridoids of Valeriana jatamansi Jones on Chronic Unpredictable Mild Stress Mice.

    abstract:Background:Depression is a long-term complex psychiatric disorder, and its etiology remains largely unknown. Valeriana jatamansi Jones ex Roxb (V. jatamansi) is used in the clinic for the treatment of depression, but there are insufficient reports of its antidepressive mechanisms and a poor understanding of its endogen...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00338

    authors: Li Y,Wu L,Chen C,Wang L,Guo C,Zhao X,Zhao T,Wang X,Liu A,Yan Z

    更新日期:2020-03-20 00:00:00

  • Managed Entry Agreements for Oncology Drugs: Lessons from the European Experience to Inform the Future.

    abstract::Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00171

    authors: Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

    更新日期:2017-04-04 00:00:00

  • Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics.

    abstract::Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis (AS), an...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00460

    authors: Li P,Zheng Y,Chen X

    更新日期:2017-07-12 00:00:00

  • Functional Study of Novel Bartter's Syndrome Mutations in ClC-Kb and Rescue by the Accessory Subunit Barttin Toward Personalized Medicine.

    abstract::Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-function mutations in the CLCNKB and BSND genes coding respectively for the ClC-Kb chloride channels and accessory subunit barttin. ClC-K channels are expressed in the Henle's loop, distal convoluted tubule, and cortical collecting ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00327

    authors: Sahbani D,Strumbo B,Tedeschi S,Conte E,Camerino GM,Benetti E,Montini G,Aceto G,Procino G,Imbrici P,Liantonio A

    更新日期:2020-03-17 00:00:00

  • Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.

    abstract::Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00358

    authors: Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

    更新日期:2017-06-08 00:00:00

  • Metabolic Profiling of a CB2 Agonist, AM9338, Using LC-MS and Microcoil-NMR: Identification of a Novel Dihydroxy Adamantyl Metabolite.

    abstract::Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated from biological pre...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.575691

    authors: Honrao C,Ma X,Kulkarni S,Joshi V,Malamas M,Zvonok A,Wood J,Strand D,Guo JJ,Makriyannis A

    更新日期:2020-09-30 00:00:00

  • Novel Anti-fibrotic Therapies.

    abstract::Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00318

    authors: McVicker BL,Bennett RG

    更新日期:2017-05-31 00:00:00

  • Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.

    abstract::Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01094

    authors: Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

    更新日期:2019-09-24 00:00:00

  • Obesity: A New Adverse Effect of Antibiotics?

    abstract::Since the introduction of antibiotics, they have been used freely, with their prescription occurring almost always when they were not necessary. The other major form of contact between humans and antibiotics, now unintentionally, is with the large amount of these drugs in the environment and in our food. The relations...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.01408

    authors: Del Fiol FS,Balcão VM,Barberato-Fillho S,Lopes LC,Bergamaschi CC

    更新日期:2018-12-03 00:00:00

  • The High "Cost" of Experimental Drugs Obtained Through Health Litigation in Brazil.

    abstract:Background:Brazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines from clinical studies, expanded access and compassionate use progr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00752

    authors: da Silva RE,Lima EDC,Novaes MRCG,Osorio-de-Castro CGS

    更新日期:2020-05-19 00:00:00

  • Epidemiological associations between iron and cardiovascular disease and diabetes.

    abstract::Disruptions in iron homeostasis are linked to a broad spectrum of chronic conditions including cardiovascular, malignant, metabolic, and neurodegenerative disease. Evidence supporting this contention derives from a variety of analytical approaches, ranging from molecular to population-based studies. This review focuse...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2014.00117

    authors: Basuli D,Stevens RG,Torti FM,Torti SV

    更新日期:2014-05-20 00:00:00

  • Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

    abstract:Background:Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction, an early marker for atherosclerosis. In addition, intercellular...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00212

    authors: Ramadan R,Vromans E,Anang DC,Goetschalckx I,Hoorelbeke D,Decrock E,Baatout S,Leybaert L,Aerts A

    更新日期:2020-03-05 00:00:00

  • The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway.

    abstract::Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor of salt-inducible k...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.624429

    authors: Liu Y,Tang W,Ji C,Gu J,Chen Y,Huang J,Zhao X,Sun Y,Wang C,Guan W,Liu J,Jiang B

    更新日期:2021-01-14 00:00:00

  • Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.

    abstract::Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00092

    authors: Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

    更新日期:2018-02-13 00:00:00

  • Parecoxib Shortens the Duration of Acute Postoperative Pain After Laparoscopic-Assisted Vaginal Hysterectomy.

    abstract::The effect of parecoxib sodium on the duration and severity of acute postoperative pain after laparoscopic-assisted vaginal hysterectomy has been inadequately studied. This randomized, controlled trial compared the effects of parecoxib, methylprednisolone, and placebo on the duration of acute postoperative pain after ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00689

    authors: Yang S,Xiao W,Wang S,Meng L,Zhou L,Wan A,Liu Y,Feng S,Wang T

    更新日期:2019-06-18 00:00:00

  • PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.

    abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by extensive areas of hypox...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2016.00139

    authors: Maugeri G,D'Amico AG,Reitano R,Magro G,Cavallaro S,Salomone S,D'Agata V

    更新日期:2016-05-31 00:00:00

  • Cyclic nucleotide permeability through unopposed connexin hemichannels.

    abstract::Cyclic adenosine monophosphate (cAMP) is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine-like or paracrine-like delivery. Here experiments have been designed to demonstrate whether gap junction hemichannels, composed of c...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2013.00075

    authors: Valiunas V

    更新日期:2013-06-06 00:00:00

  • ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway.

    abstract::Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01596

    authors: Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

    更新日期:2020-01-24 00:00:00

  • Corrigendum: Pazopanib in Metastatic Renal Cancer: A "Real-World" Experience at National Cancer Institute "Fondazione G. Pascale".

    abstract::[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误

    doi:10.3389/fphar.2016.00468

    authors: Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

    更新日期:2016-12-05 00:00:00

  • Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model.

    abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00045

    authors: Wang T,Jia Q,Chen T,Yin H,Tian X,Lin X,Liu Y,Zhao Y,Wang Y,Shi Q,Huang C,Xu H,Liang Q

    更新日期:2020-02-14 00:00:00

  • An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology.

    abstract::Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00857

    authors: Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

    更新日期:2019-08-06 00:00:00

  • A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors.

    abstract::Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00891

    authors: Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

    更新日期:2020-06-12 00:00:00

  • Transcriptome Profiling and Cytological Assessments for Identifying Regulatory Pathways Associated With Diorcinol N-Induced Autophagy in A3 Cells.

    abstract::Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains unclear. In this s...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.570450

    authors: Yuan XL,Li XQ,Xu K,Hou XD,Zhang ZF,Xue L,Liu XM,Zhang P

    更新日期:2020-10-15 00:00:00

  • The Effects of Salvianolate Combined With Western Medicine on Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

    abstract:Background:Salvianolate, a compound mainly composed of salvia magnesium acetate, is extracted from the Chinese herb Salvia miltiorrhiza. Because of its biological activity, easy quality control and certain efficacy, salvianolate is widely used in treating ischemic cardiocerebral vascular disease, liver damage, renal in...

    journal_title:Frontiers in pharmacology

    pub_type:

    doi:10.3389/fphar.2020.00851

    authors: Shen Y,Wang S,Liu Y,Ge L,Xia L,Zhang X,Miao Y,Shen J,Zhou Q

    更新日期:2020-06-12 00:00:00

  • Exploring the Role of P2X Receptors in Alzheimer's Disease.

    abstract::Several studies have pointed to soluble oligomers of beta amyloid peptide (SOAβ) as the principal neurotoxic agents responsible for the generation of synaptotoxic events that can explain the main symptoms of Alzheimer's disease (AD). Among the toxic features associated with SOAβ, one of the most notorious is the forma...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.01330

    authors: Godoy PA,Ramírez-Molina O,Fuentealba J

    更新日期:2019-11-07 00:00:00

  • Integrating Strategies of Herbal Metabolomics, Network Pharmacology, and Experiment Validation to Investigate Frankincense Processing Effects.

    abstract::In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01482

    authors: Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

    更新日期:2018-12-18 00:00:00

  • Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9.

    abstract::Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 w...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00552

    authors: Wang J,Lian DW,Yang XF,Xu YF,Chen FJ,Lin WJ,Wang R,Tang LY,Ren WK,Fu LJ,Huang P,Cao HY

    更新日期:2019-05-24 00:00:00