Acute Liver Failure in a Patient Treated With Metamizole.

abstract：:Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues in...

journal_title：Frontiers in pharmacology

authors： Aminuddin A,Ng PY

更新日期：2016-08-12 00:00:00

abstract：Background:Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration ...

journal_title：Frontiers in pharmacology

authors： Ortner M,Stange M,Schneider H,Schroeder C,Buerger K,Müller C,Dorn B,Goldhardt O,Diehl-Schmid J,Förstl H,Steimer W,Grimmer T

更新日期：2020-05-21 00:00:00

abstract：:The dermis of human skin contains large numbers of fibroblasts that are responsible for the production of the extracellular matrix (ECM) that supporting skin integrity, elasticity and wound healing. Previously, an in vivo study demonstrated that dermal fibroblasts siting in the lower dermis are capable to convert into...

journal_title：Frontiers in pharmacology

authors： Fang CL,Wang Y,Tsai KH,Chang HI

更新日期：2018-03-06 00:00:00

abstract：:Βeta-cyclodextrin (β-CD) with a hydrophobic cavity enables the formation of inclusion complexes with organic molecules. The formation of host-guest complexes makes the application of β-CD popular in many fields, but their interaction with organisms is poorly understood. In the present study, the effect of β-CD on gut ...

journal_title：Frontiers in pharmacology

authors： Lv S,Zhang X,Feng Y,Jiang Q,Niu C,Yang Y,Wang X

更新日期：2021-01-14 00:00:00

abstract：:[This retracts the article DOI: 10.3389/fphar.2018.00987.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Editorial Office.

更新日期：2019-02-07 00:00:00

abstract：:Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

journal_title：Frontiers in pharmacology

authors： Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

更新日期：2020-02-28 00:00:00

abstract：:Background: D-dimer is a small protein fragment and high levels of D-dimer have been associated with increased mortality in patients presenting to emergency departments with infection. Previous studies have reported increased levels of D-dimer in COVID-19; however, it is unclear whether an increased D-dimer level prov...

journal_title：Frontiers in pharmacology

authors： Li J,Liu Z,Wu G,Yi M,Chen Y,Li K,Xu X,Xiao L,Wu Q,Chen J,Wu X

更新日期：2020-12-21 00:00:00

abstract：:Drug scheduling within the international system of drug control and national legislation has been recently criticized as having insufficient footing in scientific evidence. The legal harms related to non-medical uses of certain drugs (e.g., cannabis) have arguably exceeded their physiological and social harmfulness co...

journal_title：Frontiers in pharmacology

authors： Dubljević V

更新日期：2018-08-20 00:00:00

abstract：:The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situa...

journal_title：Frontiers in pharmacology

authors： Saha P,Talukdar AD,Nath R,Sarker SD,Nahar L,Sahu J,Choudhury MD

更新日期：2019-05-24 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pan...

journal_title：Frontiers in pharmacology

authors： Kamatham S,Shahjehan F,Kasi PM

更新日期：2020-02-10 00:00:00

abstract：:The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinical in vivo models. ...

journal_title：Frontiers in pharmacology

authors： Bröer A,Fairweather S,Bröer S

更新日期：2018-07-19 00:00:00

abstract：Objective:To explore the role of pharmacists and innovation of pharmacy interventions for COVID-19 patients in China. Methods:We comprehensively searched PubMed and Chinese databases Sinomed, China National Knowledge Infrastructure to identify articles reporting pharmacist interventions and pharmacy services for COVID...

journal_title：Frontiers in pharmacology

authors： Yi ZM,Hu Y,Wang GR,Zhao RS

更新日期：2020-10-02 00:00:00

abstract：:Benefiting from the continuously clarifying underlying biology of immune checkpoints and ligand-receptor interactions, the emergence of new anticancer treatment strategy, immunotherapy has shown substantial benefits on several liquid and solid tumors. Immune checkpoint inhibitors (ICIs) can block the negative regulato...

journal_title：Frontiers in pharmacology

authors： Wang H,Mustafa A,Liu S,Liu J,Lv D,Yang H,Zou J

更新日期：2019-10-23 00:00:00

abstract：:Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

journal_title：Frontiers in pharmacology

authors： Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

更新日期：2019-09-24 00:00:00

abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

journal_title：Frontiers in pharmacology

authors： Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

更新日期：2019-10-22 00:00:00

abstract：:The synthesis, antimicrobial activity evaluations, biomolecule-binding properties (DNA), and absorption and emission properties of a new series of (Z)-1,1,1-trichloro-4-alkyl(aryl)amino-4-arylbut-3-en-2-ones (4, 5) and 2,2-difluoro-3-alkyl(aryl)amino-4-aryl-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides (6, 7...

journal_title：Frontiers in pharmacology

authors： Rosa WC,Rocha IO,Rodrigues MB,Coelho HS,Denardi LB,Ledur PC,Zanatta N,Acunha TV,Iglesias BA,Bonacorso HG

更新日期：2020-09-02 00:00:00

abstract：:Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5'-UTR and coding regi...

journal_title：Frontiers in pharmacology

authors： Jhun EH,Sadhu N,Hu X,Yao Y,He Y,Wilkie DJ,Molokie RE,Wang ZJ

更新日期：2019-02-07 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

journal_title：Frontiers in pharmacology

authors： Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

更新日期：2020-10-02 00:00:00

abstract：:[This corrects the article on p. 727 in vol. 8, PMID: 29114222.]. ...

journal_title：Frontiers in pharmacology

authors： Qiao L,Zhang X,Liu M,Liu X,Dong M,Cheng J,Zhang X,Zhai C,Song Y,Lu H,Chen W

更新日期：2018-01-09 00:00:00

abstract：:The Kinin B2 receptor (B2R) is classically involved in vasodilation and inflammatory responses. However, through the observation of hypoglycemic effects of Angiotensin-I-Converting Enzyme (ACE) inhibitors, this protein has been related to metabolic glucose modulation in physiological and pathophysiological contexts. A...

journal_title：Frontiers in pharmacology

authors： Gregnani MF,Hungaro TG,Martins-Silva L,Bader M,Araujo RC

更新日期：2020-08-04 00:00:00

abstract：:Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains unclear. In this s...

journal_title：Frontiers in pharmacology

authors： Yuan XL,Li XQ,Xu K,Hou XD,Zhang ZF,Xue L,Liu XM,Zhang P

更新日期：2020-10-15 00:00:00

abstract：:The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

journal_title：Frontiers in pharmacology

authors： Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

更新日期：2017-03-30 00:00:00

abstract：:Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...

journal_title：Frontiers in pharmacology

authors： Wu H,Yang Y,Guo S,Yang J,Jiang K,Zhao G,Qiu C,Deng G

更新日期：2017-12-21 00:00:00

abstract：UNLABELLED:Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management of chronic...

journal_title：Frontiers in pharmacology

authors： Graziani M,Nisticò R

更新日期：2015-06-09 00:00:00

abstract：:Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critical for hypertensive...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang F,Yang P,Wang X,Xu R,Chen J,Yuan Y,Lu Z,Duan J

更新日期：2018-03-09 00:00:00

abstract：:Lapatinib and capecitabine have been widely used in the therapy of breast cancer. However, long-term use of lapatinib and capecitabine often causes the most common side effect diarrhea, which limit the medicine use. Fructus mume (F. mume) has been proved to be effective to treat chronic diarrhea with few side effects....

journal_title：Frontiers in pharmacology

authors： Xing H,Zhang L,Ma J,Liu Z,Song C,Liu Y

更新日期：2018-05-23 00:00:00

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for a...

journal_title：Frontiers in pharmacology

authors： Ma DSL,Tan LT,Chan KG,Yap WH,Pusparajah P,Chuah LH,Ming LC,Khan TM,Lee LH,Goh BH

更新日期：2018-02-19 00:00:00

abstract：:Salmonella typhimurium is a highly transmissible pathogen in rabbits that causes significant losses. Danofloxacin shows excellent efficacy against S. typhimurium infections. However, there are few reports of the pharmacokinetic/pharmacodynamic (PK/PD) modeling of danofloxacin against this pathogen. The aim of this stu...

journal_title：Frontiers in pharmacology

authors： Xiao X,Pei L,Jiang LJ,Lan WX,Xiao JY,Jiang YJ,Wang ZQ

更新日期：2018-04-17 00:00:00

abstract：:The scaffold protein syntenin abounds during fetal life where it is important for developmental movements. In human adulthood, syntenin gain-of-function is increasingly associated with various cancers and poor prognosis. Depending on the cancer model analyzed, syntenin affects various signaling pathways. We previously...

journal_title：Frontiers in pharmacology

authors： Kashyap R,Roucourt B,Lembo F,Fares J,Carcavilla AM,Restouin A,Zimmermann P,Ghossoub R

更新日期：2015-10-21 00:00:00