Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease.

abstract：:Aims: The present study aims to detect the effect of acanthoic acid (AA) on alcohol exposure-induced liver lipid deposition and inflammation, and to explore the mechanisms. Methods: C57BL/6 mice were pretreated with single dose of AA (20 and 40 mg/kg) by oral gavage or equal volume of saline, and then exposed to three...

journal_title：Frontiers in pharmacology

authors： Yao YL,Han X,Li ZM,Lian LH,Nan JX,Wu YL

更新日期：2017-03-16 00:00:00

abstract：:Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment exits for them; likely as result of the absence of neural markers associated to memory. Neurotransmitter systems and signaling pathways have been implicated in memory and dysfunctional memory; however, their role is poorly under...

journal_title：Frontiers in pharmacology

authors： Meneses A

更新日期：2015-07-21 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We studied the effects of Aβ...

journal_title：Frontiers in pharmacology

authors： Panes JD,Godoy PA,Silva-Grecchi T,Celis MT,Ramirez-Molina O,Gavilan J,Muñoz-Montecino C,Castro PA,Moraga-Cid G,Yévenes GE,Guzmán L,Salisbury JL,Trushina E,Fuentealba J

更新日期：2020-05-21 00:00:00

abstract：:Localized neuropathic pain can be relieved following the topical application of high-concentration capsaicin. This clinical effect is thought to be related to the temporary desensitization of capsaicin- and heat-sensitive epidermal nociceptors. The objective of the present study was to examine whether the changes in t...

journal_title：Frontiers in pharmacology

authors： van Neerven SGA,Mouraux A

更新日期：2020-05-19 00:00:00

abstract：:The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant A549/DDP cells wer...

journal_title：Frontiers in pharmacology

authors： Hong W,Cai P,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2018-01-31 00:00:00

abstract：Background:Salvianolate, a compound mainly composed of salvia magnesium acetate, is extracted from the Chinese herb Salvia miltiorrhiza. Because of its biological activity, easy quality control and certain efficacy, salvianolate is widely used in treating ischemic cardiocerebral vascular disease, liver damage, renal in...

journal_title：Frontiers in pharmacology

authors： Shen Y,Wang S,Liu Y,Ge L,Xia L,Zhang X,Miao Y,Shen J,Zhou Q

更新日期：2020-06-12 00:00:00

abstract：:Three new dimeric naphthoquinones, 5,4'-dihydroxy-1'-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,5',8'-tetraone (1), 5',8'-dihydroxy-5-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2) and 8,5',8'-trihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (3), were isolated from the roots of Diospyros lotus....

journal_title：Frontiers in pharmacology

authors： Rauf A,Uddin G,Siddiqui BS,Molnár J,Csonka Á,Ahmad B,Szabó D,Farooq U,Khan A

更新日期：2015-12-16 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician know...

journal_title：Frontiers in pharmacology

authors： Weller CD,Team V,Sussman G

更新日期：2020-02-28 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

journal_title：Frontiers in pharmacology

authors： Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

更新日期：2019-11-29 00:00:00

abstract：:[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

journal_title：Frontiers in pharmacology

authors： Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

更新日期：2017-02-15 00:00:00

abstract：:Nonmuscle myosin ⅡA, a kind of ATP-dependent molecular motor, binds actin to form the molecular motors of the cell. We found that interfering with nonmuscle myosin heavy chain (NMMHC) ⅡA could affect the exosome release from microglial cells stimulated by LPS. LPS could enhance exosome release from microglial cells by...

journal_title：Frontiers in pharmacology

authors： Lv Y,Chen J,Hu J,Qian Y,Kong Y,Fu L

更新日期：2020-12-08 00:00:00

abstract：:β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), however, they induce severe side effects. Therefore, developing new bronchodilators is essential. Herbal plants were extracted and the extracts' effect on ai...

journal_title：Frontiers in pharmacology

authors： She YS,Ma LQ,Liu BB,Zhang WJ,Qiu JY,Chen YY,Li MY,Xue L,Luo X,Wang Q,Xu H,Zang DA,Zhao XX,Cao L,Shen J,Peng YB,Zhao P,Yu MF,Chen W,Nie X,Shen C,Chen S,Chen S,Qin G,Dai J,Chen J,Liu QH

更新日期：2018-12-04 00:00:00

abstract：:Medication with neuroleptics has been associated with adipose tissue dysfunctions and, in particular, with increased visceral fat amount. However, several studies suggested that antipsychotic treatment might not be the main responsible of fat mass accumulation, as this has been also described in not treated psychotic ...

journal_title：Frontiers in pharmacology

authors： Schiavone S,Camerino GM,Mhillaj E,Zotti M,Colaianna M,De Giorgi A,Trotta A,Cantatore FP,Conte E,Bove M,Tucci P,Morgese MG,Trabace L

更新日期：2017-11-08 00:00:00

abstract：:Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability ...

journal_title：Frontiers in pharmacology

authors： Filatova E,Kasian A,Kolomin T,Rybalkina E,Alieva A,Andreeva L,Limborska S,Myasoedov N,Pavlova G,Slominsky P,Shadrina M

更新日期：2017-02-28 00:00:00

abstract：:Aims and Hypothesis: NEDD9 is highly expressed in gastric cancer and has a significant involvement in its pathogenesis. However, the mechanism behind hypoxia-promoted cancer cell migration and its regulation because of NEDD9 is still unknown. The aim of this study is to investigate the involvement of NEDD9 in gastric ...

journal_title：Frontiers in pharmacology

authors： Zhao S,Min P,Liu L,Zhang L,Zhang Y,Wang Y,Zhao X,Ma Y,Xie H,Zhu C,Jiang H,Du J,Gu L

更新日期：2019-04-04 00:00:00

abstract：:Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

journal_title：Frontiers in pharmacology

authors： Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

更新日期：2020-11-27 00:00:00

abstract：:Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regardin...

journal_title：Frontiers in pharmacology

authors： van Schaik RHN,Müller DJ,Serretti A,Ingelman-Sundberg M

更新日期：2020-09-11 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till date, reports show...

journal_title：Frontiers in pharmacology

authors： Kouam AF,Yuan F,Njayou FN,He H,Tsayem RF,Oladejo BO,Song F,Moundipa PF,Gao GF

更新日期：2017-09-19 00:00:00

abstract：:Recent studies have documented that reduced M-current promotes epileptogenesis and attenuates synaptic remodeling. Neurite growth is closely related to the level of 5-HT6 receptor (5-HT6R) in the central nervous system. However, little research is available regarding the relation between 5-HT6R and M-current and the r...

journal_title：Frontiers in pharmacology

authors： Zhu C,Lin R,Liu C,Huang M,Lin F,Zhang G,Zhang Y,Miao J,Lin W,Huang H

更新日期：2020-04-28 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00

abstract：:In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide ...

journal_title：Frontiers in pharmacology

authors： Nguyen TM,Muhammad SA,Ibrahim S,Ma L,Guo J,Bai B,Zeng B

更新日期：2018-06-05 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:The pathological superoxidative condition that retinal pigment epithelium (RPE) cells experience contributed to the advancement of age-related macular degeneration (AMD), which was accompanied by significant neovascularization. Therefore, the discovery of novel pharmacological candidates to ameliorate oxidative damage...

journal_title：Frontiers in pharmacology

authors： Luo X,Gu S,Zhang Y,Zhang J

更新日期：2018-03-20 00:00:00

abstract：:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was ...

journal_title：Frontiers in pharmacology

authors： Bukhsh A,Khan TM,Lee SWH,Lee LH,Chan KG,Goh BH

更新日期：2018-04-10 00:00:00

abstract：:Blockchain systems are a fast emerging and a currently widely discussed novel strategy for a decentralized cryptographically enhanced digital ledger recording transactions among stakeholders. This perspective paper looks at its potential uses in the context of high value and mostly low volume botanical material traded...

journal_title：Frontiers in pharmacology

authors： Heinrich M,Scotti F,Booker A,Fitzgerald M,Kum KY,Löbel K

更新日期：2019-04-24 00:00:00

abstract：:The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives maladaptive learning chronically during disease development suggests a...

journal_title：Frontiers in pharmacology

authors： Kätzel D,Wolff AR,Bygrave AM,Bannerman DM

更新日期：2020-10-16 00:00:00

abstract：:Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

journal_title：Frontiers in pharmacology

authors： Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

更新日期：2018-02-13 00:00:00

abstract：:Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

journal_title：Frontiers in pharmacology

authors： Turner RM,Chen YW,Fernandes AW

更新日期：2017-11-30 00:00:00