Immunomodulatory properties of cacao extracts - potential consequences for medical applications.

abstract：:Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

journal_title：Frontiers in pharmacology

authors： Davino G,D'Alvano T,Esposito S

更新日期：2020-11-18 00:00:00

abstract：:Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for medical purposes. The term 'medical cannabis' refers to physician-recommended use o...

journal_title：Frontiers in pharmacology

authors： Vučković S,Srebro D,Vujović KS,Vučetić Č,Prostran M

更新日期：2018-11-13 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：:The development of new medicines today, requires a multi-professional workforce, both in industry and the clinical research arena. Pharmaceutical physicians (PPs) and medicines development scientists (MDS) need a certain level of competence, achieved through on-the-job experience, with a postgraduate education foundat...

journal_title：Frontiers in pharmacology

authors： Imamura K,Criscuolo D,Jurczynska A,Kesselring G,Stonier P,Tsuda T,Silva H

更新日期：2019-03-05 00:00:00

abstract：:Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in ASD; however, these studies are still ongoing, and data on the effects of its use is very limited. In this study ...

journal_title：Frontiers in pharmacology

authors： Barchel D,Stolar O,De-Haan T,Ziv-Baran T,Saban N,Fuchs DO,Koren G,Berkovitch M

更新日期：2019-01-09 00:00:00

abstract：:Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

journal_title：Frontiers in pharmacology

authors： Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

更新日期：2013-01-28 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

journal_title：Frontiers in pharmacology

authors： Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

更新日期：2020-01-24 00:00:00

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：:Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. "Resistance to chemotherapy," however, is a ...

journal_title：Frontiers in pharmacology

authors： El-Awady R,Saleh E,Hashim A,Soliman N,Dallah A,Elrasheed A,Elakraa G

更新日期：2017-01-10 00:00:00

abstract：:Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic plaque in ApoE-defi...

journal_title：Frontiers in pharmacology

authors： Chen Z,Gao X,Jiao Y,Qiu Y,Wang A,Yu M,Che F,Li S,Liu J,Li J,Zhang H,Yu C,Li G,Gao Y,Pan L,Sun W,Guo J,Cao B,Zhu Y,Xu H

更新日期：2019-07-26 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:Aims: The present study aims to detect the effect of acanthoic acid (AA) on alcohol exposure-induced liver lipid deposition and inflammation, and to explore the mechanisms. Methods: C57BL/6 mice were pretreated with single dose of AA (20 and 40 mg/kg) by oral gavage or equal volume of saline, and then exposed to three...

journal_title：Frontiers in pharmacology

authors： Yao YL,Han X,Li ZM,Lian LH,Nan JX,Wu YL

更新日期：2017-03-16 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

journal_title：Frontiers in pharmacology

authors： Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

更新日期：2019-03-19 00:00:00

abstract：:The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3-300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw e...

journal_title：Frontiers in pharmacology

authors： Bednarczyk-Cwynar B,Wachowiak N,Szulc M,Kamińska E,Bogacz A,Bartkowiak-Wieczorek J,Zaprutko L,Mikolajczak PL

更新日期：2016-07-12 00:00:00

abstract：:Extracellular vesicles (EVs) are currently being considered as promising drug delivery vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to serve as drug delivery vehicles. In addition, EVs have inherent properties for treatment of cancers and other diseases. For research and c...

journal_title：Frontiers in pharmacology

authors： Gangadaran P,Hong CM,Ahn BC

更新日期：2018-02-28 00:00:00

abstract：:Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanop...

journal_title：Frontiers in pharmacology

authors： Rezvantalab S,Drude NI,Moraveji MK,Güvener N,Koons EK,Shi Y,Lammers T,Kiessling F

更新日期：2018-11-02 00:00:00

abstract：:The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and IFNAR2, have differe...

journal_title：Frontiers in pharmacology

authors： Lee S,Son WS,Yang HB,Rajasekaran N,Kim SS,Hong S,Choi JS,Choi JY,Song K,Shin YK

更新日期：2019-01-24 00:00:00

abstract：:The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although...

journal_title：Frontiers in pharmacology

authors： Kunzelmann K,Ousingsawat J,Cabrita I,Doušová T,Bähr A,Janda M,Schreiber R,Benedetto R

更新日期：2019-01-29 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：:In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation. Ang II acts on Ang II type 1 receptors promoting sodium retention and vaso...

journal_title：Frontiers in pharmacology

authors： Gonzalez AA,Gallardo M,Cespedes C,Vio CP

更新日期：2019-10-15 00:00:00

abstract：:MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still large...

journal_title：Frontiers in pharmacology

authors： Huang T,Ning Z,Hu D,Zhang M,Zhao L,Lin C,Zhong LLD,Yang Z,Xu H,Bian Z

更新日期：2018-03-26 00:00:00

abstract：:Aims and Hypothesis: NEDD9 is highly expressed in gastric cancer and has a significant involvement in its pathogenesis. However, the mechanism behind hypoxia-promoted cancer cell migration and its regulation because of NEDD9 is still unknown. The aim of this study is to investigate the involvement of NEDD9 in gastric ...

journal_title：Frontiers in pharmacology

authors： Zhao S,Min P,Liu L,Zhang L,Zhang Y,Wang Y,Zhao X,Ma Y,Xie H,Zhu C,Jiang H,Du J,Gu L

更新日期：2019-04-04 00:00:00

abstract：:Bangpungtongsung-san (BTS) is a traditional Korean medicine consisting of 18 herbs, some which have antidepressant effects. Here, we used an animal model of reserpine-induced depression and lipopolysaccharide (LPS)-stimulated BV2 microglia to assess the antidepressant and anti-neuroinflammatory effects of BTS. Aside f...

journal_title：Frontiers in pharmacology

authors： Park BK,Kim NS,Kim YR,Yang C,Jung IC,Jang IS,Seo CS,Choi JJ,Lee MY

更新日期：2020-07-10 00:00:00

abstract：:The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using ...

journal_title：Frontiers in pharmacology

authors： Seshadri DR,Ramamurthi A

更新日期：2018-07-16 00:00:00

abstract：:We aimed to ascertain the mechanism underlying the effects of acteoside (ACT) from Ligustrum robustum (Roxb.) Blume (Oleaceae) on lipid metabolism and synthesis. ACT, a water-soluble phenylpropanoid glycoside, is the most abundant and major active component of L. robustum; the leaves of L. robustum, known as kudingcha...

journal_title：Frontiers in pharmacology

authors： Sun L,Yu F,Yi F,Xu L,Jiang B,Le L,Xiao P

更新日期：2019-05-24 00:00:00

abstract：Objective:Patient satisfaction is an indicator for quality of healthcare service and is sometimes linked to patients' willingness to pay. Willingness to pay is an economic method for estimating patient's inclination for a service in monetary terms. This study assessed satisfaction of patients from pharmacist counseling...

journal_title：Frontiers in pharmacology

authors： AlShayban DM,Naqvi AA,Islam MA,Almaskeen M,Almulla A,Alali M,AlQaroos A,Raafat M,Iqbal MS,Haseeb A

更新日期：2020-03-02 00:00:00

abstract：Background:Immunosuppressant non-adherence is a widespread problem among solid organ recipients. With the newly published clinical trials, the randomized controlled trials (RCTs) based systematic review of adherence-enhancing interventions on immunosuppressant adherence in solid organ recipients has not been completed....

journal_title：Frontiers in pharmacology

authors： Shi YX,Liu CX,Liu F,Zhang HM,Yu MM,Jin YH,Shang SM,Fu YX

更新日期：2020-10-20 00:00:00

abstract：:Background: Inhibiting proliferation and inducing apoptosis of myofibroblasts is becoming one of the promising and effective ways to treat hypertrophic scar. ABT-263, as an orally bioavailable BCL-2 family inhibitor, has showed great antitumor characteristics by targeting tumor cell apoptosis. The objective of this st...

journal_title：Frontiers in pharmacology

authors： Yang X,Xiao Y,Zhong C,Shu F,Xiao S,Zheng Y,Xia Z

更新日期：2021-01-14 00:00:00

abstract：:Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals and consists of total obstruction of one kidney ureter. The UUO decreas...

journal_title：Frontiers in pharmacology

authors： Figueroa SM,Lozano M,Lobos C,Hennrikus MT,Gonzalez AA,Amador CA

更新日期：2019-11-14 00:00:00