Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain.

abstract：:[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

journal_title：Frontiers in pharmacology

authors： Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

更新日期：2020-02-21 00:00:00

abstract：:Resolution Pharmacology identifies drugs developed on the biology of the resolution phase of inflammation, the complex molecular and cellular network of events that ensure the tight temporal and spatial control on the inflammatory response. As such, new anti-inflammatory and pro-resolving drugs could derive from pro-r...

journal_title：Frontiers in pharmacology

authors： Patruno S,Garrido-Mesa J,Romano M,Perretti M,Montero-Melendez T

更新日期：2018-08-14 00:00:00

abstract：:Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

journal_title：Frontiers in pharmacology

authors： Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

更新日期：2017-06-26 00:00:00

abstract：:Diabetes is affecting the social and economic developments in developing countries like Sri Lanka. Siddha Medicine (Tamil Medicine) is mostly practiced in the Eastern and Northern Provinces of Sri Lanka. Our recent review of Sri Lankan Siddha historical documents identified 171 plant species used to prepare anti-diabe...

journal_title：Frontiers in pharmacology

authors： Sathasivampillai SV,Rajamanoharan PRS,Heinrich M

更新日期：2018-10-10 00:00:00

abstract：:Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self...

journal_title：Frontiers in pharmacology

authors： Singh L,Joshi T,Tewari D,Echeverría J,Mocan A,Sah AN,Parvanov E,Tzvetkov NT,Ma ZF,Lee YY,Poznański P,Huminiecki L,Sacharczuk M,Jóźwik A,Horbańczuk JO,Feder-Kubis J,Atanasov AG

更新日期：2020-02-14 00:00:00

abstract：Background:GuanXinNing tablet (GXNT), a traditional Chinese patent medicine, has been found to have remarkable antithrombotic effects and can effectively inhibit pro-thrombotic factors in previous studies. However, the mechanism of its antithrombotic effects remains little known. Methods:In this study, we first determ...

journal_title：Frontiers in pharmacology

authors： Wang ML,Yang QQ,Ying XH,Li YY,Wu YS,Shou QY,Ma QX,Zhu ZW,Chen ML

更新日期：2020-05-13 00:00:00

abstract：Objective:To explore the role of pharmacists and innovation of pharmacy interventions for COVID-19 patients in China. Methods:We comprehensively searched PubMed and Chinese databases Sinomed, China National Knowledge Infrastructure to identify articles reporting pharmacist interventions and pharmacy services for COVID...

journal_title：Frontiers in pharmacology

authors： Yi ZM,Hu Y,Wang GR,Zhao RS

更新日期：2020-10-02 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:This study was aimed to investigate the effects of baicalin (BA), a major flavonoid constituent found in the herb Baikal skullcap, on dendritic cells (DCs). DCs were generated by culturing murine bone marrow (BM) cells for 6 days with granulocyte-macrophage colony-stimulating factor and interleukin (IL)-4, and lipopol...

journal_title：Frontiers in pharmacology

authors： Zhang H,Jiao Q,Gong Q,Zhang Y,Zhang W,Hu Z

更新日期：2011-03-29 00:00:00

abstract：:MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still large...

journal_title：Frontiers in pharmacology

authors： Huang T,Ning Z,Hu D,Zhang M,Zhao L,Lin C,Zhong LLD,Yang Z,Xu H,Bian Z

更新日期：2018-03-26 00:00:00

abstract：:Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

journal_title：Frontiers in pharmacology

authors： Turner RM,Chen YW,Fernandes AW

更新日期：2017-11-30 00:00:00

abstract：:Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO(®), a...

journal_title：Frontiers in pharmacology

authors： Tan T,Watts SW,Davis RP

更新日期：2011-07-29 00:00:00

abstract：:Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute lung injury. The p38 mitogen-activated protein kinase (MAPK) is involved in breakdown of the endothelial barrier during LIRI, but the mechanism is still unclear. Therefore, we investi...

journal_title：Frontiers in pharmacology

authors： Wang T,Liu C,Pan LH,Liu Z,Li CL,Lin JY,He Y,Xiao JY,Wu S,Qin Y,Li Z,Lin F

更新日期：2020-12-11 00:00:00

abstract：:Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in ASD; however, these studies are still ongoing, and data on the effects of its use is very limited. In this study ...

journal_title：Frontiers in pharmacology

authors： Barchel D,Stolar O,De-Haan T,Ziv-Baran T,Saban N,Fuchs DO,Koren G,Berkovitch M

更新日期：2019-01-09 00:00:00

abstract：:Zingiber zerumbet (L) Smith is part of the Zingiberaceae family, one of the largest families of the plant kingdom. Z. zerumbet is a perennial, aromatic and tuberose plant that grows in humid locations where its center of distribution is located in the South-East Asia region. This plant has been traditionally used in f...

journal_title：Frontiers in pharmacology

authors： Tan JW,Israf DA,Tham CL

更新日期：2018-06-20 00:00:00

abstract：:Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotectio...

journal_title：Frontiers in pharmacology

authors： Inserra A

更新日期：2018-04-05 00:00:00

abstract：:Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

journal_title：Frontiers in pharmacology

authors： Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

更新日期：2018-11-06 00:00:00

abstract：:Anti-inflammatory properties of cacao, fruits of Theobroma cacao L. (Sterculiaceae), are well documented, and therapeutic applications are described for gastrointestinal, nervous, and cardiovascular abnormalities. Most, if not all of these disease conditions involve inflammation or immune activation processes. The pro...

journal_title：Frontiers in pharmacology

authors： Becker K,Geisler S,Ueberall F,Fuchs D,Gostner JM

更新日期：2013-12-12 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controversy, we investigated ...

journal_title：Frontiers in pharmacology

authors： Beneventano M,Spampinato SF,Merlo S,Chisari M,Platania P,Ragusa M,Purrello M,Nicoletti F,Sortino MA

更新日期：2017-11-09 00:00:00

abstract：:The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant A549/DDP cells wer...

journal_title：Frontiers in pharmacology

authors： Hong W,Cai P,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2018-01-31 00:00:00

abstract：:Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), has been extensively used as a synthetic antibacterial agent. To evaluate the reproductive toxicity of MEQ, different concentrations of MEQ were administered to Wistar rats by feeding diets containing 0, 25, 55, 110, and 275 mg/kg, respectively. Each group...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Awais I,Shabbir MAB,Ahmed S,Fatima Z,Wang X,Pan Y,Xie S,Yuan Z

更新日期：2018-08-17 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study w...

journal_title：Frontiers in pharmacology

authors： Gimeno-Hernández R,Cantó A,Fernández-Carbonell A,Olivar T,Hernández-Rabaza V,Almansa I,Miranda M

更新日期：2020-12-23 00:00:00

abstract：:Fingolimod is used for the treatment of multiple sclerosis (MS) and targets receptors for the bioactive sphingolipid sphingosine-1-phosphate (S1P). Whether fingolimod or other MS therapies conversely affect plasma concentrations of sphingolipids has, however, not yet been analyzed. Herein, we quantified 15 representat...

journal_title：Frontiers in pharmacology

authors： Ottenlinger FM,Mayer CA,Ferreirós N,Schreiber Y,Schwiebs A,Schmidt KG,Ackermann H,Pfeilschifter JM,Radeke HH

更新日期：2016-11-03 00:00:00

abstract：:The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situa...

journal_title：Frontiers in pharmacology

authors： Saha P,Talukdar AD,Nath R,Sarker SD,Nahar L,Sahu J,Choudhury MD

更新日期：2019-05-24 00:00:00

abstract：:Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid receptors. CB1 receptors are highly expressed in projection neurons and s...

journal_title：Frontiers in pharmacology

authors： Van Waes V,Beverley JA,Siman H,Tseng KY,Steiner H

更新日期：2012-03-12 00:00:00

abstract：:Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...

journal_title：Frontiers in pharmacology

authors： Belo RF,Martins MLF,Shvachiy L,Costa-Coelho T,de Almeida-Borlido C,Fonseca-Gomes J,Neves V,Vicente Miranda H,Outeiro TF,Coelho JE,Xapelli S,Valente CA,Heras M,Bardaji E,Castanho MARB,Diógenes MJ,Sebastião AM

更新日期：2020-07-09 00:00:00

abstract：:Dermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. ...

journal_title：Frontiers in pharmacology

authors： Bartels EJH,Dekker D,Amiche M

更新日期：2019-11-26 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in preclinical models of multiple kidney diseases, including acute kidney in...

journal_title：Frontiers in pharmacology

authors： Yu C,Zhuang S

更新日期：2019-12-06 00:00:00

abstract：:The Glp-1 analog, liraglutide (Lir), has been shown to reduce infarct size and improve cardiac function after myocardial ischemia in rodents with or without diabetes. However, the effect of Lir on angiotensin II (AngII) and pressure overload induced cardiac hypertrophy in nondiabetic mice and the underlying mechanisms...

journal_title：Frontiers in pharmacology

authors： Li R,Shan Y,Gao L,Wang X,Wang X,Wang F

更新日期：2019-06-05 00:00:00