The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats.

abstract：:[This corrects the article DOI: 10.3389/fphar.2018.00361.]. ...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Huang D,Xie S,Wang X,Pan Y,Yuan Z

更新日期：2018-11-29 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evid...

journal_title：Frontiers in pharmacology

authors： Tian G,Sun Y,Liu S,Li C,Chen S,Qiu R,Zhang X,Li Y,Li M,Shang H

更新日期：2018-09-05 00:00:00

abstract：:Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in ...

journal_title：Frontiers in pharmacology

authors： Zhao YF,Huang ZD,Gu HY,Guo GL,Yuan RX,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no ...

journal_title：Frontiers in pharmacology

authors： Benarba B,Pandiella A

更新日期：2020-08-07 00:00:00

abstract：Background and Aim:Platycodon grandiflorum (PG) has been widely used for treating chronic bronchitis (CB). However, the material basis and underlying mechanism of action of PG against CB have not yet been elucidated. Methods:To analyze the ingredients in PG, ultraperformance liquid chromatography-quadrupole-time-of-fl...

journal_title：Frontiers in pharmacology

authors： Deng Y,Ren H,Ye X,Xia L,Liu M,Liu Y,Yang M,Yang S,Ye X,Zhang J

更新日期：2020-09-08 00:00:00

abstract：:[This corrects the article on p. 216 in vol. 5, PMID: 25295006.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Production Office.

更新日期：2014-11-19 00:00:00

abstract：Introduction:Infliximab (IFX) was the first anti-tumor necrosis factor (TNFα) antibody to be used in the treatment of severe chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. A number of serious adverse drug reactions are known to be associated with IFX use; they include infections, malig...

journal_title：Frontiers in pharmacology

authors： Thillard EM,Gautier S,Babykina E,Carton L,Amad A,Bouzillé G,Beuscart JB,Ficheur G,Chazard E

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) formally known as aldo-keto reductase 1C3 (AKR1C3) play a major role in the formation and metabolism of androgens. The enzyme is highly expressed in the prostate gland and previous studies indicate that genetic variation in the AKR1C3 gene may influenc...

journal_title：Frontiers in pharmacology

authors： Schulze JJ,Karypidis H,Ekström L

更新日期：2012-08-06 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：Introduction:Acoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (e.g., a chemotherapeutic) and local ultrasound (US) insonation of the targeted pathological tissue (e.g., the tumor). PS101 is confined t...

journal_title：Frontiers in pharmacology

authors： Bush N,Healey A,Shah A,Box G,Kirkin V,Eccles S,Sontum PC,Kotopoulis S,Kvåle S,van Wamel A,Davies CL,Bamber J

更新日期：2020-02-20 00:00:00

abstract：:Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with 0.1 M trimethylammonium bromide (TMA) with full...

journal_title：Frontiers in pharmacology

authors： Onder S,David E,Tacal O,Schopfer LM,Lockridge O

更新日期：2017-10-10 00:00:00

abstract：:Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, ...

journal_title：Frontiers in pharmacology

authors： Mallet N,Leblois A,Maurice N,Beurrier C

更新日期：2019-12-13 00:00:00

abstract：:Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to ge...

journal_title：Frontiers in pharmacology

authors： Ali MS,Ichihara MY,Lopes LC,Barbosa GCG,Pita R,Carreiro RP,Dos Santos DB,Ramos D,Bispo N,Raynal F,Canuto V,de Araujo Almeida B,Fiaccone RL,Barreto ME,Smeeth L,Barreto ML

更新日期：2019-09-23 00:00:00

abstract：:Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

journal_title：Frontiers in pharmacology

authors： Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

更新日期：2019-09-20 00:00:00

abstract：:Acute lung injury (ALI) which is featured by a strong pulmonary inflammation, is a major cause of morbidity and mortality in critically ill patients. Magnoflorine, a quaternary alkaloid isolated from Chinese herb Magnolia or Aristolochia, has been reported to have potent anti-inflammatory properties. However, the effe...

journal_title：Frontiers in pharmacology

authors： Guo S,Jiang K,Wu H,Yang C,Yang Y,Yang J,Zhao G,Deng G

更新日期：2018-08-30 00:00:00

abstract：:The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over acti...

journal_title：Frontiers in pharmacology

authors： Arshad L,Jantan I,Bukhari SN,Haque MA

更新日期：2017-01-30 00:00:00

abstract：Background:Huangci Granule is a traditional Chinese medicine for treating metastatic colorectal cancer (mCRC). Objective:To evaluate the efficacy and safety of Huangci Granule combination with chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC. Methods:We performed a randomized, controlled, and do...

journal_title：Frontiers in pharmacology

authors： Liu N,Wu C,Jia R,Cai G,Wang Y,Zhou L,Ji Q,Sui H,Zeng P,Xiao H,Liu H,Huo J,Feng Y,Deng W,Li Q

更新日期：2020-04-21 00:00:00

abstract：:Calcium-calmodulin/dependent protein kinase II (CaMKII) plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has b...

journal_title：Frontiers in pharmacology

authors： Juárez-Muñoz Y,Ramos-Languren LE,Escobar ML

更新日期：2017-11-14 00:00:00

abstract：:Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals and consists of total obstruction of one kidney ureter. The UUO decreas...

journal_title：Frontiers in pharmacology

authors： Figueroa SM,Lozano M,Lobos C,Hennrikus MT,Gonzalez AA,Amador CA

更新日期：2019-11-14 00:00:00

abstract：:A dominant area of antibody research is the extension of the use of this mighty experimental and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and activity blocking. Despite the ability to raise antibodies against different proteins, numerous applications of antibodies in bas...

journal_title：Frontiers in pharmacology

authors： Slastnikova TA,Ulasov AV,Rosenkranz AA,Sobolev AS

更新日期：2018-10-24 00:00:00

abstract：:P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5'-RACE. A 1.9-kb fra...

journal_title：Frontiers in pharmacology

authors： Guo T,Huang J,Huan C,He F,Zhang Y,Bhutto ZA,Wang L

更新日期：2018-05-04 00:00:00

abstract：:Literature is scarce on acute ischemia after intra-arterial injection of crushed tablets and no effective medical treatment against the progression of lesions is reported. The only factor able to modify the outcome is the delay between injection and management by a specialized vascular team. Moreover the risk of necro...

journal_title：Frontiers in pharmacology

authors： Détriché G,Goudot G,Khider L,Galloula A,Guillet M,Lillo-Le Louët A,Messas E,Mirault T

更新日期：2020-12-03 00:00:00

abstract：:Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significan...

journal_title：Frontiers in pharmacology

authors： Agrawal S,Adholeya A,Deshmukh SK

更新日期：2016-10-25 00:00:00

abstract：:Breast cancer (BC) is one of the most prevalent types of cancer worldwide with high morbidity and mortality rates. Treatment modalities include systemic therapy, in which chemotherapy is a major component in many cases. Several chemotherapeutic agents are used in combinations or as single agents with many adverse even...

journal_title：Frontiers in pharmacology

authors： Al-Mahayri ZN,Patrinos GP,Ali BR

更新日期：2020-04-15 00:00:00

abstract：:[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

journal_title：Frontiers in pharmacology

authors： Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

更新日期：2016-12-05 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：:There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modulatory properties. ...

journal_title：Frontiers in pharmacology

authors： Prats-Ejarque G,Lu L,Salazar VA,Moussaoui M,Boix E

更新日期：2019-10-09 00:00:00

abstract：:Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

journal_title：Frontiers in pharmacology

authors： Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

更新日期：2017-05-30 00:00:00

abstract：:Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

journal_title：Frontiers in pharmacology

authors： Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

更新日期：2018-11-06 00:00:00

abstract：:Cissus quadrangularis (C. quadrangularis) is a plant of the Vitaceae family known for its anticonvulsant effects in traditional medicine. The objective of this study was to elucidate the anxiolytic and antiepileptic effects of aqueous extract of C. quadrangularis. The mice were divided into different groups and treate...

journal_title：Frontiers in pharmacology

authors： Moto FCO,Arsa'a A,Ngoupaye GT,Taiwe GS,Njapdounke JSK,Kandeda AK,Nkantchoua GCN,Omam Omam JP,Pale S,Kouemou NE,Ayissi Mbomo ER,Pahaye DB,Ojong L,Mairara V,Ngo Bum E

更新日期：2018-07-17 00:00:00