Abstract：
:The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no effective vaccines or specific treatments have been developed. Since the COVID-19 outbreak, different traditional herbal medicines with promising results have been used alone or in combination with conventional drugs to treat infected patients. Here, we review the recent findings regarding the use of natural products to prevent or treat COVID-19 infection. Furthermore, the mechanisms responsible for this preventive or therapeutic effect are discussed. We conducted literature research using PubMed, Google Scholar, Scopus, and WHO website. Dissertations and theses were not considered. Only the situation reports edited by the WHO were included. The different herbal products (extracts) and purified molecules may exert their anti-SARS-CoV-2 actions by direct inhibition of the virus replication or entry. Interestingly, some products may block the ACE-2 receptor or the serine protease TMPRRS2 required by SARS-CoV-2 to infect human cells. In addition, natural products were shown to inhibit the SARS-CoV-2 life-cycle related proteins such as papain-like or chymotrypsin-like proteases. In conclusion, we suggest that natural products could be used alone or in combination as alternative medicines to treat/prevent COVID-19 infection. Moreover, their structures may offer clues for the development of anti-SARS-CoV-2 drugs.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Benarba B,Pandiella Adoi
10.3389/fphar.2020.01189subject
Has Abstractpub_date
2020-08-07 00:00:00pages
1189issn
1663-9812journal_volume
11pub_type
杂志文章,评审abstract：:Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological methods. Here, we first explored the mechanism of action of DSD with the as...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.592903
更新日期：2021-01-11 00:00:00
abstract：:The objective of this study was to test the hypothesis that serotonin O-sulphate (5-HT-SO4) could be quantified in human plasma using modern liquid chromatography-mass spectrometry (LC-MS) method as well as develop and validate that method. First, a suitable LC-MS method for detection of 5-HT-SO4 in human plasma sampl...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2014.00062
更新日期：2014-04-08 00:00:00
abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.01091
更新日期：2018-10-05 00:00:00
abstract：:In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00196
更新日期：2017-05-08 00:00:00
abstract：:The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistan...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00692
更新日期：2019-06-21 00:00:00
abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00971
更新日期：2019-09-05 00:00:00
abstract：:[This retracts the article on p. 15 in vol. 2, PMID: 21687510.]. ...
journal_title：Frontiers in pharmacology
pub_type： 撤回出版物
doi：10.3389/fphar.2014.00283
更新日期：2014-12-17 00:00:00
abstract：:Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (CB1) and cannabinoid receptor two (CB2). However, end...
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pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.596572
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00108
更新日期：2019-02-12 00:00:00
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pub_type： 杂志文章
doi：10.3389/fphar.2019.00552
更新日期：2019-05-24 00:00:00
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pub_type： 杂志文章
doi：10.3389/fphar.2011.00044
更新日期：2011-07-29 00:00:00
abstract：:There is growing evidence that the metabolic network is an integral regulator of cellular physiology. Dynamic changes in metabolite concentrations, metabolic flux, or network topology act as reporters of biological or environmental signals, and are required for the cell to trigger an appropriate biological reaction. C...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2012.00032
更新日期：2012-03-08 00:00:00
abstract：:The development of new medicines today, requires a multi-professional workforce, both in industry and the clinical research arena. Pharmaceutical physicians (PPs) and medicines development scientists (MDS) need a certain level of competence, achieved through on-the-job experience, with a postgraduate education foundat...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00188
更新日期：2019-03-05 00:00:00
abstract：Objective:Patient satisfaction is an indicator for quality of healthcare service and is sometimes linked to patients' willingness to pay. Willingness to pay is an economic method for estimating patient's inclination for a service in monetary terms. This study assessed satisfaction of patients from pharmacist counseling...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00138
更新日期：2020-03-02 00:00:00
abstract：:[This retracts the article DOI: 10.3389/fphar.2018.00987.]. ...
journal_title：Frontiers in pharmacology
pub_type： 撤回出版物
doi：10.3389/fphar.2019.00135
更新日期：2019-02-07 00:00:00
abstract：:Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells. If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatment of malignant tu...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00379
更新日期：2020-03-27 00:00:00
abstract：:Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2016.00343
更新日期：2016-09-28 00:00:00
abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.527495
更新日期：2020-12-03 00:00:00
abstract：:The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2016.00218
更新日期：2016-07-21 00:00:00
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pub_type： 杂志文章
doi：10.3389/fphar.2017.00143
更新日期：2017-03-21 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.3389/fphar.2020.00095
更新日期：2020-02-27 00:00:00
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journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
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journal_title：Frontiers in pharmacology
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doi：10.3389/fphar.2018.01568
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.3389/fphar.2018.01522
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