Retraction: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria.


:[This retracts the article DOI: 10.3389/fphar.2018.00987.].


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2019-02-07 00:00:00








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    abstract::Li-Ru-Kang (LRK), a formula of eight traditional Chinese medicines (TCM), has been used to treat hyperplasia of mammary gland (HMG) in TCM clinics. However, how LRK works in HMG patients is unclear. To explore the possible mechanisms of LRK against HMG, the network pharmacology was used to screen the potential targets...

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    authors: Wang Y,Wei S,Gao T,Yang Y,Lu X,Zhou X,Li H,Wang T,Qian L,Zhao Y,Zou W

    更新日期:2018-11-20 00:00:00

  • Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro.

    abstract::A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Ther...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lewenhofer V,Schweighofer L,Ledermüller T,Eichsteininger J,Kählig H,Zehl M,Nguyen CH,Krupitza G,Özmen A,Krenn L

    更新日期:2018-04-03 00:00:00

  • In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber.

    abstract::Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

    更新日期:2019-11-08 00:00:00

  • β-Sheet Breaker Peptide-HPYD for the Treatment of Alzheimer's Disease: Primary Studies on Behavioral Test and Transcriptional Profiling.

    abstract::Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

    更新日期:2018-01-08 00:00:00

  • To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

    abstract::The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and pathophysiological processes. Transgenic animals have been influenti...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Stokes L,Bidula S,Bibič L,Allum E

    更新日期:2020-05-12 00:00:00

  • The Bone Extracellular Matrix in Bone Formation and Regeneration.

    abstract::Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, prolifer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Lin X,Patil S,Gao YG,Qian A

    更新日期:2020-05-26 00:00:00

  • In silico Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens.

    abstract::The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two protein families: the AT...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: César-Razquin A,Girardi E,Yang M,Brehme M,Saez-Rodriguez J,Superti-Furga G

    更新日期:2018-09-07 00:00:00

  • First-Line Immune-Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Current Landscape and Future Progress.

    abstract::Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhib...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Huang Z,Su W,Lu T,Wang Y,Dong Y,Qin Y,Liu D,Sun L,Jiao W

    更新日期:2020-10-07 00:00:00

  • Dipeptidyl Peptidase-4 Inhibitors Use and Relative Risk of Ischemic Cerebrovascular Disease in Type 2 Diabetic Patients in a Case-Control Study.

    abstract::Background and Objectives: Limited research focuses on the risk of ischemic cerebrovascular disease associated with use of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) in patients with type 2 diabetes mellitus in Taiwan. This study aimed to investigate the association between DPP-4 inhibitors use and the first...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lai SW,Liao KF,Lin CL,Lin HF

    更新日期:2017-11-22 00:00:00

  • Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells.

    abstract::With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia sinensis) has been widely used as a traditional beverage beneficial to human health, including anti-NSCLC activity. Theabrownin (TB) is one majo...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu F,Zhou L,Jin W,Yang W,Wang Y,Yan B,Du W,Zhang Q,Zhang L,Guo Y,Zhang J,Shan L,Efferth T

    更新日期:2016-12-02 00:00:00

  • IRAP Inhibitors: M1-Aminopeptidase Family Inspiration.

    abstract::The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Barlow N,Thompson PE

    更新日期:2020-09-25 00:00:00

  • Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters.

    abstract::This review describes artificial modular nanotransporters (MNTs) delivering their cargos into target cells and then into the nuclei - the most vulnerable cell compartment for most anticancer agents and especially for radionuclides emitting short-range particles. The MNT strategy uses natural subcellular transport proc...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Sobolev AS

    更新日期:2018-08-27 00:00:00

  • l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson's Disease.

    abstract::l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Goshima Y,Masukawa D,Kasahara Y,Hashimoto T,Aladeokin AC

    更新日期:2019-10-03 00:00:00

  • Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity.

    abstract::As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2 channel activation and the IQ-like motif in th...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Luo Y,Yu X,Ma C,Luo J,Yang W

    更新日期:2018-06-04 00:00:00

  • Non-Exosomal and Exosomal Circulatory MicroRNAs: Which Are More Valid as Biomarkers?

    abstract::MicroRNAs (miRNAs) are a group of small non-coding RNAs with approximately 19-25 nucleotides that are involved in regulating a range of developmental and physiological processes. Non-exosomal circulating and exosomal miRNAs have also been proposed to be useful in diagnostics as biomarkers for diseases and different ty...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Nik Mohamed Kamal NNSB,Shahidan WNS

    更新日期:2020-01-20 00:00:00

  • Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.

    abstract::Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

    更新日期:2017-06-08 00:00:00

  • Patient Satisfaction and Their Willingness to Pay for a Pharmacist Counseling Session in Hospital and Community Pharmacies in Saudi Healthcare Settings.

    abstract:Objective:Patient satisfaction is an indicator for quality of healthcare service and is sometimes linked to patients' willingness to pay. Willingness to pay is an economic method for estimating patient's inclination for a service in monetary terms. This study assessed satisfaction of patients from pharmacist counseling...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: AlShayban DM,Naqvi AA,Islam MA,Almaskeen M,Almulla A,Alali M,AlQaroos A,Raafat M,Iqbal MS,Haseeb A

    更新日期:2020-03-02 00:00:00

  • Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2.

    abstract::Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an ex vivo model of global myocardial I/R was investigated. After treatment with different concentrati...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li D,Lu N,Han J,Chen X,Hao W,Xu W,Liu X,Ye L,Zheng Q

    更新日期:2018-01-30 00:00:00

  • Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

    abstract::Many current chemotherapies function by damaging genomic DNA in rapidly dividing cells ultimately leading to cell death. This therapeutic approach differentially targets cancer cells that generally display rapid cell division compared to normal tissue cells. However, although these treatments are initially effective i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Davidson D,Amrein L,Panasci L,Aloyz R

    更新日期:2013-01-31 00:00:00

  • Integrating Strategies of Herbal Metabolomics, Network Pharmacology, and Experiment Validation to Investigate Frankincense Processing Effects.

    abstract::In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

    更新日期:2018-12-18 00:00:00

  • Pharmacogenomics: what is next?

    abstract::Pharmacogenomics is moving from a candidate gene strategy to large scale approaches. This is in line with the new paradigm of linking a trait to (a) pathway(s) rather than to single genes. In addition, breakthroughs in genomics offer a non-a priori assessment of implicated genes, expanding the possibilities in pharmac...

    journal_title:Frontiers in pharmacology

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    authors: di Iulio J,Rotger M

    更新日期:2012-01-13 00:00:00

  • Salvianolic Acid B Inhibits Activation of Human Primary Hepatic Stellate Cells Through Downregulation of the Myocyte Enhancer Factor 2 Signaling Pathway.

    abstract::Various isoforms of myocyte enhancer factor 2 (MEF2) have been shown to play a role in the activation of rat hepatic stellate cells (HSCs) in culture. The signals that regulate MEF2 in HSCs are unknown. In addition, whether MEF2s regulate the activation of human HSCs (H-HSCs) is unclear. Here, we studied the expressio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang W,Ping J,Zhou Y,Chen G,Xu L

    更新日期:2019-04-11 00:00:00

  • Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells.

    abstract::Rape bee pollen possesses many nutritional and therapeutic properties because of its abundant nutrimental and bioactive components. In this study, free (FPE) and bound (BPE) phenolic extracts of rape bee pollen were obtained, phenolic and flavonoid contents were determined, and composition of phenolic acids was analyz...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sun L,Guo Y,Zhang Y,Zhuang Y

    更新日期:2017-03-09 00:00:00

  • Altered Expression of Endoplasmic Reticulum Stress Associated Genes in Hippocampus of Learned Helpless Rats: Relevance to Depression Pathophysiology.

    abstract::The unfolded protein response (UPR) is an evolutionarily conserved defensive mechanism that is used by cells to correct misfolded proteins that accumulate in the endoplasmic reticulum. These proteins are misfolded as a result of physical stress on a cell and initiate a host of downstream effects that govern processes ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Timberlake MA 2nd,Dwivedi Y

    更新日期:2016-01-12 00:00:00

  • A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.

    abstract::Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological methods. Here, we first explored the mechanism of action of DSD with the as...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Pan B,Wang Y,Wu C,Jia J,Huang C,Fang S,Liu L

    更新日期:2021-01-11 00:00:00

  • Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.

    abstract::Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A1 and M2 receptors coupled to inwardly rectifying GIRK/KIR3.1/3.4 channels, respectively. Unlike M2 receptors, bradycardia produced by A1 receptors activation predominates over negative inotropy. Such diffe...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bragança B,Oliveira-Monteiro N,Ferreirinha F,Lima PA,Faria M,Fontes-Sousa AP,Correia-de-Sá P

    更新日期:2016-03-07 00:00:00

  • Hydrogen Sulfide and Endoplasmic Reticulum Stress: A Potential Therapeutic Target for Central Nervous System Degeneration Diseases.

    abstract::There are three members of the endogenous gas transmitter family. The first two are nitric oxide and carbon monoxide, and the third newly added member is hydrogen sulfide (H2S). They all have similar functions: relaxing blood vessels, smoothing muscles, and getting involved in the regulation of neuronal excitation, le...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zhong H,Yu H,Chen J,Sun J,Guo L,Huang P,Zhong Y

    更新日期:2020-05-14 00:00:00

  • ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect.

    abstract::ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggre...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C

    更新日期:2018-12-04 00:00:00

  • Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy.

    abstract::With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

    更新日期:2016-09-29 00:00:00

  • Hemolytic Anemia and Reactive Thrombocytosis Associated With Cefoperazone/Sulbactam.

    abstract::Background: Cefoperazone/sulbactam is a broad-spectrum antibacterial agent. Drug-induced immune hemolytic anemia is a rare but serious condition, and reactive thrombocytosis is caused by processes extrinsic to the megakaryocyte. Limited data are available for cefoperazone/sulbactam-associated hemolytic anemia and reac...

    journal_title:Frontiers in pharmacology



    authors: Zhou L,Bao J,Ma J

    更新日期:2019-11-08 00:00:00