The Top-100 Highly Cited Original Articles on Drug Therapy for Ventilator-Associated Pneumonia.


:Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bibliometric approaches. Methods: The Institute for Scientific Information (ISI) Web of Science core collection database was searched for the VAP-related articles. The time period for retrieval was from the beginning of the database to September 30, 2018. The top 100 most cited articles were selected to obtain their information on the authors, title, publication, number of citations, author's affiliations, country, etc. These general information and bibliometric data were collected for analysis. VOSviewer software was used to generate a term co-occurrence graph that visualized a reference pattern for different terms in the 100 articles. Results: The number of citations for the 100 selected articles ranged from 142 to 3,218. These articles were published in 31 different journals. The top three journals in terms of the number of our selected articles they published were "Critical Care Medicine" (17 articles), "American Journal of Respiratory and Critical Care Medicine" (11 articles) and "Clinical Infectious Diseases" (10 articles). The most frequently nominated author was Marin H. Kollef from the University of Washington, and of the top 100 articles, 16 listed his name. These top 100 articles were published after the year of 2000. The most common type of article in the top 100 was an original article (53%). The United States and France were the countries that contributed the most articles to the top 100. Gram-negative bacilli, pseudomonas aeruginosa, antibiotics, risk factors and other terms appeared more frequently, suggesting that attentions on this issue currently focused on the rational application and management of antibiotics. Conclusion: This study analyzed the 100 most cited articles on drug-treated VAP, and provided insights into the historical developments and characteristics of the most cited articles in the field of VAP.


Front Pharmacol


Wang CY,Li BH,Ma LL,Zhao MJ,Deng T,Jin YH,Ren XQ




Has Abstract


2019-02-12 00:00:00








  • Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling.

    abstract::Genistein and icariin are flavonoid compounds that exhibit estrogen-like properties in inducing bone formation and reducing bone loss associated with estrogen deficiency in both preclinical and clinical studies. However, the mechanisms that are involved in mediating their estrogenic actions in bone cells are far from ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Ho MX,Poon CC,Wong KC,Qiu ZC,Wong MS

    更新日期:2018-05-11 00:00:00

  • Periplaneta americana Extracts Accelerate Liver Regeneration via a Complex Network of Pathways.

    abstract::Successful recovery from hepatectomy is partially contingent upon the rate of residual liver regeneration. The traditional Chinese medicines known as Periplaneta americana extracts (PAEs) positively influence wound healing by promoting tissue repair. However, the effect of PAEs on liver regeneration is unknown. We use...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zou Y,Zhang M,Zeng D,Ruan Y,Shen L,Mu Z,Zou J,Xie C,Yang Z,Qian Z,Xu R,Li S,Kang Q,Zou H,Zhao S,Liu L,Wang K,Wang X,Zhang X

    更新日期:2020-07-31 00:00:00

  • How the Toxin got its Toxicity.

    abstract::Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subset of their constituent molecules-"toxins"-share this ecological function and are therefore molecules that mediate interactions between organisms. Such molecules have been referred to as "ex...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jackson TNW,Koludarov I

    更新日期:2020-12-14 00:00:00

  • miR-133: A Suppressor of Cardiac Remodeling?

    abstract::Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Li N,Zhou H,Tang Q

    更新日期:2018-08-17 00:00:00

  • MiR-409-3p Inhibits Cell Proliferation and Invasion of Osteosarcoma by Targeting Zinc-Finger E-Box-Binding Homeobox-1.

    abstract::Osteosarcoma (OS) is the most common bone cancer worldwide. There is evidence that microRNA-409 (miR-409-3p) is involved in tumorigenesis and cancer progression, however, its possible role in OS requires clarification. In the present study, we evaluated the expression level, clinical significance, and mode of action o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu L,Zhang Y,Huang Z,Gu H,Zhou K,Yin X,Xu J

    更新日期:2019-02-21 00:00:00

  • Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats.

    abstract::In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation. Ang II acts on Ang II type 1 receptors promoting sodium retention and vaso...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Gonzalez AA,Gallardo M,Cespedes C,Vio CP

    更新日期:2019-10-15 00:00:00

  • Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.

    abstract::Advances in molecular pathology have changed the landscape of oncology. The ability to interrogate tissue samples for oncogene amplification, driver mutations, and other molecular alterations provides clinicians with an enormous level of detail about their patient's cancer. In some cases, this information informs trea...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kersh AE,Sasaki M,Cooper LA,Kissick HT,Pollack BP

    更新日期:2016-09-26 00:00:00

  • Poly(Ethylene Glycol)-Polylactide Micelles for Cancer Therapy.

    abstract::For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising n...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Wang J,Li S,Han Y,Guan J,Chung S,Wang C,Li D

    更新日期:2018-03-08 00:00:00

  • The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism.

    abstract::The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Li S,Xu Y,Guo W,Chen F,Zhang C,Tan HY,Wang N,Feng Y

    更新日期:2020-03-24 00:00:00

  • Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials.

    abstract::Background: Currently, although non-steroidal anti-inflammatory drugs (NSAIDs) were recommended for acute renal colic in the 2018 European Association of Urology guidelines, there are no specific NSAIDs and no specific routes of administration in this guideline. The clinical practice of advocating intravenous opioids ...

    journal_title:Frontiers in pharmacology



    authors: Gu HY,Luo J,Wu JY,Yao QS,Niu YM,Zhang C

    更新日期:2019-02-22 00:00:00

  • Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents.

    abstract::Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited cell proliferation...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hsu JL,Leu WJ,Hsu LC,Liu SP,Zhong NS,Guh JH

    更新日期:2018-11-13 00:00:00

  • New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA.

    abstract::Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

    更新日期:2020-08-21 00:00:00

  • Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.

    abstract::The trace amine-associated receptor 1 (TAAR1) is expressed by dopaminergic neurons, but the precise influence of trace amines upon their functional activity remains to be fully characterized. Here, we examined the regulation of tyrosine hydroxylase (TH) by tyramine and beta-phenylethylamine (β-PEA) compared to 3-iodot...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang X,Mantas I,Alvarsson A,Yoshitake T,Shariatgorji M,Pereira M,Nilsson A,Kehr J,Andrén PE,Millan MJ,Chergui K,Svenningsson P

    更新日期:2018-03-01 00:00:00

  • The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB.

    abstract::Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Kubota K,Fukue H,Sato H,Hashimoto K,Fujikane A,Moriyama H,Watanabe T,Katsurabayashi S,Kainuma M,Iwasaki K

    更新日期:2017-11-21 00:00:00

  • Pharmacotherapy of patients with mild persistent asthma: strategies and unresolved issues.

    abstract::In studies comparing regular versus on-demand treatment for patients with mild persistent asthma, on-demand treatment seems to have a similar efficacy on clinical and functional outcomes, but it does not suppress chronic airway inflammation or airway hyper-responsiveness (AHR) associated with asthma. Data on the effic...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Montuschi P

    更新日期:2011-07-14 00:00:00

  • Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect.

    abstract::The study under investigation focuses on in vitro antiproliferative efficacy of the flavonoid morin and the mechanisms by which it inhibits the growth of colon cancer using SW480 colon cancer cells with emphasis on Warburg effect. It was found that the cell proliferation was significantly inhibited by morin in a dose ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sithara T,Arun KB,Syama HP,Reshmitha TR,Nisha P

    更新日期:2017-09-12 00:00:00

  • Immune Checkpoint Inhibitor Toxicity in Head and Neck Cancer: From Identification to Management.

    abstract::Benefiting from the continuously clarifying underlying biology of immune checkpoints and ligand-receptor interactions, the emergence of new anticancer treatment strategy, immunotherapy has shown substantial benefits on several liquid and solid tumors. Immune checkpoint inhibitors (ICIs) can block the negative regulato...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Wang H,Mustafa A,Liu S,Liu J,Lv D,Yang H,Zou J

    更新日期:2019-10-23 00:00:00

  • Shexiang Baoxin Pill, a Formulated Chinese Herbal Mixture, Induces Neuronal Differentiation of PC12 Cells: A Signaling Triggered by Activation of Protein Kinase A.

    abstract::Background: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), which is commonly used today in treating cardiovascular diseases. SBP consists of seven materials thereof, including Moschus, extract of Ginseng Radix et Rhizoma, Bovis Calculus Artifactus, Cinnamomi Cortex,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xu ML,Zheng ZY,Xia YJ,Liu EY,Chan SK,Hu WH,Duan R,Dong TT,Zhan CS,Shang XH,Tsim KW

    更新日期:2019-10-09 00:00:00

  • Vitamin d and susceptibility of chronic lung diseases: role of epigenetics.

    abstract::Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environment...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sundar IK,Rahman I

    更新日期:2011-08-30 00:00:00

  • The High "Cost" of Experimental Drugs Obtained Through Health Litigation in Brazil.

    abstract:Background:Brazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines from clinical studies, expanded access and compassionate use progr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: da Silva RE,Lima EDC,Novaes MRCG,Osorio-de-Castro CGS

    更新日期:2020-05-19 00:00:00

  • Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.

    abstract::Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the pres...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

    更新日期:2019-09-13 00:00:00

  • Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model.

    abstract::Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy. The aim of the study was to assess the antiplasmodial efficacy and safety of cu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Oyeyemi O,Morenkeji O,Afolayan F,Dauda K,Busari Z,Meena J,Panda A

    更新日期:2018-05-30 00:00:00

  • Metabolomics of Clinical Poisoning by Aconitum Alkaloids Using Derivatization LC-MS.

    abstract::The root of Aconitum kusnezoffii (Caowu in Chinese, CW) is not only commonly used as a traditional Chinese medicine (TCM), but also served as a tonic in China. Due to its high toxicity, clinical poisoning cases induced by CW have frequently been reported. However, the mechanism is still unclear. In this study, Aconitu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang Y,Bian X,Yang J,Wu H,Wu JL,Li N

    更新日期:2019-03-22 00:00:00

  • Antimutagenic and Chemopreventive Properties of 6-(Methylsulfinyl) Hexyl Isothiocyanate on TK6 Human Cells by Flow Cytometry.

    abstract::6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Cocchi V,Hrelia P,Lenzi M

    更新日期:2020-08-18 00:00:00

  • Immunomodulatory properties of cacao extracts - potential consequences for medical applications.

    abstract::Anti-inflammatory properties of cacao, fruits of Theobroma cacao L. (Sterculiaceae), are well documented, and therapeutic applications are described for gastrointestinal, nervous, and cardiovascular abnormalities. Most, if not all of these disease conditions involve inflammation or immune activation processes. The pro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Becker K,Geisler S,Ueberall F,Fuchs D,Gostner JM

    更新日期:2013-12-12 00:00:00

  • TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

    abstract::The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kunzelmann K,Ousingsawat J,Cabrita I,Doušová T,Bähr A,Janda M,Schreiber R,Benedetto R

    更新日期:2019-01-29 00:00:00

  • The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term Potentiation via the Regulation of M-Currents in a Pilocarpine-Induced Epilepsy Model.

    abstract::Recent studies have documented that reduced M-current promotes epileptogenesis and attenuates synaptic remodeling. Neurite growth is closely related to the level of 5-HT6 receptor (5-HT6R) in the central nervous system. However, little research is available regarding the relation between 5-HT6R and M-current and the r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhu C,Lin R,Liu C,Huang M,Lin F,Zhang G,Zhang Y,Miao J,Lin W,Huang H

    更新日期:2020-04-28 00:00:00

  • Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

    abstract::Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. S...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

    更新日期:2018-10-23 00:00:00

  • Natural Product Ginsenoside 20(S)-25-Methoxyl-Dammarane-3β, 12β, 20-Triol in Cancer Treatment: A Review of the Pharmacological Mechanisms and Pharmacokinetics.

    abstract::Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

    更新日期:2020-04-22 00:00:00

  • The Ultrasmall Biocompatible CuS@BSA Nanoparticle and Its Photothermal Effects.

    abstract::Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

    更新日期:2019-02-26 00:00:00