Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.

abstract：:The Health Improvement Network UK primary care database was used to identify a cohort of 38 077 individuals aged 50-84 years with a first prescription of low-dose acetylsalicylic acid (ASA; 75-300 mg/day) for secondary prevention of cardiovascular or cerebrovascular events during 2000-2007. From this cohort, 169 incid...

journal_title：Frontiers in pharmacology

authors： Cea Soriano L,Rodríguez LA

更新日期：2010-10-14 00:00:00

abstract：:Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combin...

journal_title：Frontiers in pharmacology

authors： Ma H,Zhang G,Mou C,Fu X,Chen Y

更新日期：2018-03-20 00:00:00

abstract：:Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for medical purposes. The term 'medical cannabis' refers to physician-recommended use o...

journal_title：Frontiers in pharmacology

authors： Vučković S,Srebro D,Vujović KS,Vučetić Č,Prostran M

更新日期：2018-11-13 00:00:00

abstract：:Hypertension is a prevalent, complex, and polygenic cardiovascular disease, which is associated with increased mortality and morbidity. Across the world, traditional Chinese medicine (TCM) constituted by herbal medicine and non-pharmacological therapies is used to assist blood pressure management. Though widely accept...

journal_title：Frontiers in pharmacology

authors： Yang M,Lao L

更新日期：2019-03-08 00:00:00

abstract：:Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality of life and survivability. As such, a defense against chemotherapy-induced skeletal muscle d...

journal_title：Frontiers in pharmacology

authors： Sorensen JC,Petersen AC,Timpani CA,Campelj DG,Cook J,Trewin AJ,Stojanovska V,Stewart M,Hayes A,Rybalka E

更新日期：2017-04-10 00:00:00

abstract：:Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-orientated, single target, and conventional antidepressants are insufficient and far from ideal. Traditional Chinese Medicine (TCM) has historically been used to treat depression up till today, particularly in Asia. Its holistic, ...

journal_title：Frontiers in pharmacology

authors： Li C,Huang J,Cheng YC,Zhang YW

更新日期：2020-05-07 00:00:00

abstract：:Aim: Little is known regarding the relationship between use of oral corticosteroids and hip fracture in the elderly in Taiwan. The aim of the study was to examine this issue. Methods: A retrospective population-based case-control study using the database of the Taiwan National Health Insurance Program (2000-2013) was ...

journal_title：Frontiers in pharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2017-09-11 00:00:00

abstract：:The immunotherapy agent pembrolizumab has been approved for gastric cancer (GC) patients with recurrent or advanced disease who are PD-L1 positive. Mutations in the primary lesion may drive the expression of immune targets thereby priming the tumor to therapeutic sensitivity. In this study, we aimed to uncover mutatio...

journal_title：Frontiers in pharmacology

authors： Menyhárt O,Pongor LS,Győrffy B

更新日期：2019-01-08 00:00:00

abstract：:Background/Aims: Previous studies have suggested that myricetin (Myr) could promote the expression and nuclear translocation of nuclear factor (erythroid-derived 2)-like (Nrf2). This study aimed to investigate whether Myr could attenuate diabetes-associated kidney injuries and dysfunction in wild-type (WT) and Nrf2 kn...

journal_title：Frontiers in pharmacology

authors： Yang ZJ,Wang HR,Wang YI,Zhai ZH,Wang LW,Li L,Zhang C,Tang L

更新日期：2019-06-11 00:00:00

abstract：:Complex disease is a cascade process which is associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing evidences show that Chinese herb formula usually treats complex diseases ...

journal_title：Frontiers in pharmacology

authors： Gao Y,Wang KX,Wang P,Li X,Chen JJ,Zhou BY,Tian JS,Guan DG,Qin XM,Lu AP

更新日期：2020-10-02 00:00:00

abstract：:Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...

journal_title：Frontiers in pharmacology

authors： Liu G,An L,Zhang H,Du P,Sheng Y

更新日期：2019-03-28 00:00:00

abstract：:Background: Comparative efficacy of different pharmacist based interventions on glycemic control of type 2 diabetes patients is unclear. This review aimed to evaluate and compare the efficacy of different pharmacist based interventions on clinical outcomes of type 2 diabetes patients. Methods: A systematic search was ...

journal_title：Frontiers in pharmacology

authors： Bukhsh A,Khan TM,Lee SWH,Lee LH,Chan KG,Goh BH

更新日期：2018-04-10 00:00:00

abstract：:The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles a...

journal_title：Frontiers in pharmacology

authors： Coricovac DE,Moacă EA,Pinzaru I,Cîtu C,Soica C,Mihali CV,Păcurariu C,Tutelyan VA,Tsatsakis A,Dehelean CA

更新日期：2017-03-28 00:00:00

abstract：:Background and Purpose:Drynaria fortunei J. Sm (D. fortunei), known as Gu-Sui-Bu, is used in traditional Chinese medicine to treat common injuries, including bone fractures and bruising. The specific functional mechanisms of the angiogenic and endothelial cell migration properties of D. fortunei are currently unclear....

journal_title：Frontiers in pharmacology

authors： Huang ST,Chang CC,Pang JS,Huang HS,Chou SC,Kao MC,You HL

更新日期：2018-09-21 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

journal_title：Frontiers in pharmacology

authors： Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

更新日期：2020-01-24 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00512.]. ...

journal_title：Frontiers in pharmacology

authors： Jiang YH,Jiang LY,Wang YC,Ma DF,Li X

更新日期：2020-05-29 00:00:00

abstract：:The clinical benefit of therapies using Mesenchymal Stem Cells (MSCs) is attributable to their pleiotropic effect over cells and tissues, mainly through their secretome. This paracrine effect is mediated by secreted growth factors and extracellular vesicles (EV) including small EV (sEV). sEV are extra-cellular, membra...

journal_title：Frontiers in pharmacology

authors： Zavala G,Ramos MP,Figueroa-Valdés AI,Cisternas P,Wyneken U,Hernández M,Toa P,Salmons B,Dangerfield J,Gunzburg WH,Khoury M

更新日期：2020-05-21 00:00:00

abstract：:Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

journal_title：Frontiers in pharmacology

authors： Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

更新日期：2020-07-17 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resu...

journal_title：Frontiers in pharmacology

authors： Lim SH,Legere EA,Snider J,Stagljar I

更新日期：2018-01-17 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia sinensis) has been widely used as a traditional beverage beneficial to human health, including anti-NSCLC activity. Theabrownin (TB) is one majo...

journal_title：Frontiers in pharmacology

authors： Wu F,Zhou L,Jin W,Yang W,Wang Y,Yan B,Du W,Zhang Q,Zhang L,Guo Y,Zhang J,Shan L,Efferth T

更新日期：2016-12-02 00:00:00

abstract：:In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRP...

journal_title：Frontiers in pharmacology

authors： Walcher L,Budde C,Böhm A,Reinach PS,Dhandapani P,Ljubojevic N,Schweiger MW,von der Waydbrink H,Reimers I,Köhrle J,Mergler S

更新日期：2018-11-13 00:00:00

abstract：:Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

journal_title：Frontiers in pharmacology

authors： Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

更新日期：2018-06-15 00:00:00

abstract：:The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cance...

journal_title：Frontiers in pharmacology

authors： Horbach T,Götz C,Kietzmann T,Dimova EY

更新日期：2015-02-18 00:00:00

abstract：:Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in ASD; however, these studies are still ongoing, and data on the effects of its use is very limited. In this study ...

journal_title：Frontiers in pharmacology

authors： Barchel D,Stolar O,De-Haan T,Ziv-Baran T,Saban N,Fuchs DO,Koren G,Berkovitch M

更新日期：2019-01-09 00:00:00

abstract：:Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and neurological defects, oral diseases, and cancers such as breast tumors...

journal_title：Frontiers in pharmacology

authors： Merzoug-Larabi M,Youssef I,Bui AT,Legay C,Loiodice S,Lognon S,Babajko S,Ricort JM

更新日期：2020-01-31 00:00:00

abstract：:Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains unclear. In this s...

journal_title：Frontiers in pharmacology

authors： Yuan XL,Li XQ,Xu K,Hou XD,Zhang ZF,Xue L,Liu XM,Zhang P

更新日期：2020-10-15 00:00:00

abstract：:The serotonin [5-hydroxytryptamine (5-HT)] system has been implicated in the pathogenesis of major depressive disorder (MDD). Among the 5-HT receptor subtypes, 5-HT2 is one of the major pharmacological therapeutic targets for MDD. There have been inconsistent findings in previous pharmacogenetic studies investigating ...

journal_title：Frontiers in pharmacology

authors： Kao CF,Kuo PH,Yu YW,Yang AC,Lin E,Liu YL,Tsai SJ

更新日期：2020-12-03 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver...

journal_title：Frontiers in pharmacology

authors： Li F,Gao C,Yan P,Zhang M,Wang Y,Hu Y,Wu X,Wang X,Sheng J

更新日期：2018-11-22 00:00:00