Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer.

Abstract:

:The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cancer, is limited. Phosphorylation is a versatile tool to regulate protein functions. Thereby, phosphorylation can positively or negatively affect different aspects of transcription factor function including protein stability, protein-protein interaction, cellular localization, or DNA binding. The present review aims to summarize the current knowledge about the regulation of USFs by direct phosphorylation and the consequences for USF functions in tissue protection and cancer.

journal_name

Front Pharmacol

authors

Horbach T,Götz C,Kietzmann T,Dimova EY

doi

10.3389/fphar.2015.00003

subject

Has Abstract

pub_date

2015-02-18 00:00:00

pages

3

issn

1663-9812

journal_volume

6

pub_type

杂志文章
  • Ion Channel Regulation by Sex Steroid Hormones and Vitamin D in Cancer: A Potential Opportunity for Cancer Diagnosis and Therapy.

    abstract::Many ion channels are involved in tumor development, promoting cancer cell proliferation, migration, invasion, and survival. Accordingly, some of them have been suggested as tumor markers and novel targets for cancer therapy. Some sex steroid hormones (SSH), including estrogens and androgens, favor cancer progression....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00152

    authors: Restrepo-Angulo I,Bañuelos C,Camacho J

    更新日期:2020-02-28 00:00:00

  • Leaf and Root Extracts from Campomanesia adamantium (Myrtaceae) Promote Apoptotic Death of Leukemic Cells via Activation of Intracellular Calcium and Caspase-3.

    abstract::Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00466

    authors: Campos JF,Espindola PPT,Torquato HFV,Vital WD,Justo GZ,Silva DB,Carollo CA,de Picoli Souza K,Paredes-Gamero EJ,Dos Santos EL

    更新日期:2017-08-14 00:00:00

  • Clonal evolution and therapeutic resistance in solid tumors.

    abstract::Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2013.00002

    authors: Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

    更新日期:2013-01-28 00:00:00

  • 1H NMR-Based Metabolomics Study of the Toxicological Effects in Rats Induced by "Renqing Mangjue" Pill, a Traditional Tibetan Medicine.

    abstract::"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unint...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00602

    authors: Xu C,Rezeng C,Li J,Zhang L,Yan Y,Gao J,Wang Y,Li Z,Chen J

    更新日期:2017-09-04 00:00:00

  • Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.

    abstract::Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. S...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01178

    authors: Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

    更新日期:2018-10-23 00:00:00

  • The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties.

    abstract::Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.552428

    authors: Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

    更新日期:2020-09-11 00:00:00

  • Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling.

    abstract::Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00841

    authors: Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

    更新日期:2020-06-05 00:00:00

  • Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice.

    abstract:Introduction:Acoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (e.g., a chemotherapeutic) and local ultrasound (US) insonation of the targeted pathological tissue (e.g., the tumor). PS101 is confined t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00075

    authors: Bush N,Healey A,Shah A,Box G,Kirkin V,Eccles S,Sontum PC,Kotopoulis S,Kvåle S,van Wamel A,Davies CL,Bamber J

    更新日期:2020-02-20 00:00:00

  • Anticancer Effects of Wild Mountain Mentha longifolia Extract in Adrenocortical Tumor Cell Models.

    abstract::Mint [Mentha longifolia (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic. Recently, its antiproliferative role h...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01647

    authors: Patti F,Palmioli A,Vitalini S,Bertazza L,Redaelli M,Zorzan M,Rubin B,Mian C,Bertolini C,Iacobone M,Armanini D,Barollo S,Airoldi C,Iriti M,Pezzani R

    更新日期:2020-02-10 00:00:00

  • Increased Levels of miRNA-146a in Serum and Histologic Samples of Patients with Uveal Melanoma.

    abstract::Purpose: To analyze MiRs expression in serum of UM patients, respect to healthy donors, and to compare this data with MiRs expressed in formalin-fixed, paraffin-embedded UM samples. Methods: Expression profile of 754 miRNAs was performed in serum of patients with uveal melanoma who underwent primary enucleation. The l...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2016.00424

    authors: Russo A,Caltabiano R,Longo A,Avitabile T,Franco LM,Bonfiglio V,Puzzo L,Reibaldi M

    更新日期:2016-11-15 00:00:00

  • 4-(Hydroxymethyl)catechol Extracted From Fungi in Marine Sponges Attenuates Rheumatoid Arthritis by Inhibiting PI3K/Akt/NF-κB Signaling.

    abstract::Rheumatoid arthritis (RA) is a progressive autoimmune disease specific to synovial joints; it causes joint damage and other systemic abnormalities, thereby leading to physical disability and early mortality. Marine sponge-derived fungi, Pestalotiopsis sp., secrete immunosuppressive compounds in the culture broth. In t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00726

    authors: Lee JY,Kim GJ,Choi JK,Choi YA,Jeong NH,Park PH,Choi H,Kim SH

    更新日期:2018-07-20 00:00:00

  • Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes.

    abstract::The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situa...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.00509

    authors: Saha P,Talukdar AD,Nath R,Sarker SD,Nahar L,Sahu J,Choudhury MD

    更新日期:2019-05-24 00:00:00

  • Montelukast Improves Symptoms and Lung Function in Asthmatic Women Compared With Men.

    abstract::Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01094

    authors: Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

    更新日期:2019-09-24 00:00:00

  • Warfarin and the Risk of Death, Stroke, and Major Bleeding in Patients With Atrial Fibrillation Receiving Hemodialysis: A Systematic Review and Meta-Analysis.

    abstract::Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01218

    authors: Lei H,Yu LT,Wang WN,Zhang SG

    更新日期:2018-11-06 00:00:00

  • Corrigendum: Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.

    abstract::[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fphar.2018.00693

    authors: Uttl L,Petrasek T,Sengul H,Svojanovska M,Lobellova V,Vales K,Radostova D,Tsenov G,Kubova H,Mikulecka A,Svoboda J,Stuchlik A

    更新日期:2018-06-20 00:00:00

  • Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2.

    abstract:Background:The importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although natural food contains much more potassium than sodium. The benef...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00920

    authors: Vio CP,Gallardo P,Cespedes C,Salas D,Diaz-Elizondo J,Mendez N

    更新日期:2020-06-18 00:00:00

  • Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate.

    abstract::Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of this study was to inve...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2016.00242

    authors: Kong LL,Shen GL,Wang ZY,Zhuang XM,Xiao WB,Yuan M,Gong ZH,Li H

    更新日期:2016-08-09 00:00:00

  • Polymedication Electronic Monitoring System (POEMS) - a new technology for measuring adherence.

    abstract:INTRODUCTION:Reliable and precise measurement of patient adherence to medications is feasible by incorporating a microcircuitry into pharmaceutical packages of various designs, such that the maneuvers needed to remove a dose of drug are detected, time-stamped, and stored. The principle is called "electronic medication ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2013.00026

    authors: Arnet I,Walter PN,Hersberger KE

    更新日期:2013-03-13 00:00:00

  • Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia.

    abstract::Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00549

    authors: Yadav E,Singh D,Yadav P,Verma A

    更新日期:2018-05-23 00:00:00

  • Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?

    abstract::The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnatal insult such as cerebral ischemia, stroke, brain trauma, or infection. These insults share common pathophysiological pathways involving innate immune activation including neuroinflammation...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00002

    authors: Semple BD,Dill LK,O'Brien TJ

    更新日期:2020-02-04 00:00:00

  • Impact of Biologic Treatment of Crohn's Disease on the Rate of Surgeries and Other Healthcare Resources: An Analysis of a Nationwide Database From Poland.

    abstract::Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn's disease (CD). We aimed to assess real-world consequences of biologic treatment of CD. Methods: All adult patients with CD treated with infliximab and adalimumab in the years 2012-2014 wer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00621

    authors: Holko P,Kawalec P,Pilc A

    更新日期:2018-06-11 00:00:00

  • Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines.

    abstract::Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described - OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), and OAT2 transcript variant 3 (OAT2-tv3). Early studies helping to define the liga...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2015.00216

    authors: Hotchkiss AG,Berrigan L,Pelis RM

    更新日期:2015-10-06 00:00:00

  • The Effects of Salvianolate Combined With Western Medicine on Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

    abstract:Background:Salvianolate, a compound mainly composed of salvia magnesium acetate, is extracted from the Chinese herb Salvia miltiorrhiza. Because of its biological activity, easy quality control and certain efficacy, salvianolate is widely used in treating ischemic cardiocerebral vascular disease, liver damage, renal in...

    journal_title:Frontiers in pharmacology

    pub_type:

    doi:10.3389/fphar.2020.00851

    authors: Shen Y,Wang S,Liu Y,Ge L,Xia L,Zhang X,Miao Y,Shen J,Zhou Q

    更新日期:2020-06-12 00:00:00

  • JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells.

    abstract::Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.01087

    authors: Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

    更新日期:2020-07-17 00:00:00

  • Recent Initiatives in the Republic of Srpska to Enhance Appropriate Use of Antibiotics in Ambulatory Care; Their Influence and Implications.

    abstract::Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00442

    authors: Bojanić L,Marković-Peković V,Škrbić R,Stojaković N,Ðermanović M,Bojanić J,Fürst J,Kurdi AB,Godman B

    更新日期:2018-05-29 00:00:00

  • The Mechanisms of Traditional Chinese Medicine Underlying the Prevention and Treatment of Parkinson's Disease.

    abstract::Parkinson's disease (PD), characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neurodegenerative disorder. Along with the largely aging population in the world, the incidence is increasing year by year, which imposes the negative impacts on patients, their fam...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00634

    authors: Li X,Zhang Y,Wang Y,Xu J,Xin P,Meng Y,Wang Q,Kuang H

    更新日期:2017-09-19 00:00:00

  • MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway.

    abstract::This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01362

    authors: Wang C,Liu E,Li W,Cui J,Li T

    更新日期:2018-12-11 00:00:00

  • Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo.

    abstract::Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00307

    authors: Liu G,An L,Zhang H,Du P,Sheng Y

    更新日期:2019-03-28 00:00:00

  • Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile.

    abstract::The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00154

    authors: Coricovac DE,Moacă EA,Pinzaru I,Cîtu C,Soica C,Mihali CV,Păcurariu C,Tutelyan VA,Tsatsakis A,Dehelean CA

    更新日期:2017-03-28 00:00:00

  • Identification of Pharmacokinetic Markers for Guanxin Danshen Drop Pills in Rats by Combination of Pharmacokinetics, Systems Pharmacology, and Pharmacodynamic Assays.

    abstract::This paper reported a feasibility study strategy of identifying pharmacokinetic (PK) markers for a cardiovascular herbal medicine, Guanxin Danshen drop pill (GDDP). First, quantification analysis revealed the constituent composition in the preparation by high-performance liquid chromatography (HPLC). Subsequently, phy...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01493

    authors: Yao H,Huang X,Xie Y,Huang X,Ruan Y,Lin X,Huang L,Shi P

    更新日期:2018-12-21 00:00:00