Abstract:
:The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cancer, is limited. Phosphorylation is a versatile tool to regulate protein functions. Thereby, phosphorylation can positively or negatively affect different aspects of transcription factor function including protein stability, protein-protein interaction, cellular localization, or DNA binding. The present review aims to summarize the current knowledge about the regulation of USFs by direct phosphorylation and the consequences for USF functions in tissue protection and cancer.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Horbach T,Götz C,Kietzmann T,Dimova EYdoi
10.3389/fphar.2015.00003subject
Has Abstractpub_date
2015-02-18 00:00:00pages
3issn
1663-9812journal_volume
6pub_type
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abstract::[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...
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pub_type: 杂志文章,已发布勘误
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journal_title:Frontiers in pharmacology
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