BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice.

abstract：:Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues in...

journal_title：Frontiers in pharmacology

authors： Aminuddin A,Ng PY

更新日期：2016-08-12 00:00:00

abstract：:Neuronal activity, astrocytic responses to this activity, and energy homeostasis are linked together during baseline, conscious conditions, and short-term rapid activation (as occurs with sensory or motor function). Nervous system energy homeostasis also varies during long-term physiological conditions (i.e., developm...

journal_title：Frontiers in pharmacology

authors： Shetty PK,Galeffi F,Turner DA

更新日期：2012-03-20 00:00:00

abstract：:The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform...

journal_title：Frontiers in pharmacology

authors： Chen G,Zhao H,Ma S,Chen L,Wu G,Zhu Y,Zhu J,Ma C,Zhao H

更新日期：2020-09-18 00:00:00

abstract：:In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRP...

journal_title：Frontiers in pharmacology

authors： Walcher L,Budde C,Böhm A,Reinach PS,Dhandapani P,Ljubojevic N,Schweiger MW,von der Waydbrink H,Reimers I,Köhrle J,Mergler S

更新日期：2018-11-13 00:00:00

abstract：:Background: New treatment platforms that can prevent acute respiratory distress syndrome (ARDS) or reduce its mortality rate in high-risk coronavirus disease 2019 (COVID-19) patients, such as those with an underlying cancer, are urgently needed. Rejuveinix (RJX) is an intravenous formulation of anti-oxidants and anti-...

journal_title：Frontiers in pharmacology

authors： Uckun FM,Carlson J,Orhan C,Powell J,Pizzimenti NM,van Wyk H,Ozercan IH,Volk M,Sahin K

更新日期：2020-11-10 00:00:00

abstract：:The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and IFNAR2, have differe...

journal_title：Frontiers in pharmacology

authors： Lee S,Son WS,Yang HB,Rajasekaran N,Kim SS,Hong S,Choi JS,Choi JY,Song K,Shin YK

更新日期：2019-01-24 00:00:00

abstract：:Styryllactones, a class of compounds obtained from the genus Goniothalamus (Annonaceae), have demonstrated in vitro antitumor activity. However, the aqueous solubility of these compounds is poor. In this study, we identified the absolute configurations of the previously isolated compounds, which were first isolated in...

journal_title：Frontiers in pharmacology

authors： Ma R,Chen JT,Ji XY,Xu XL,Mu Q

更新日期：2020-04-22 00:00:00

abstract：:Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significan...

journal_title：Frontiers in pharmacology

authors： Agrawal S,Adholeya A,Deshmukh SK

更新日期：2016-10-25 00:00:00

abstract：:Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F...

journal_title：Frontiers in pharmacology

authors： Kaplum V,Ramos AC,Consolaro MEL,Fernandez MA,Ueda-Nakamura T,Dias-Filho BP,Silva SO,de Mello JCP,Nakamura CV

更新日期：2018-07-03 00:00:00

abstract：:Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e., α1A and α1B) in antiarrhyth...

journal_title：Frontiers in pharmacology

authors： Pytka K,Lustyk K,Żmudzka E,Kotańska M,Siwek A,Zygmunt M,Dziedziczak A,Śniecikowska J,Olczyk A,Gałuszka A,Śmieja J,Waszkielewicz AM,Marona H,Filipek B,Sapa J,Mogilski S

更新日期：2016-08-03 00:00:00

abstract：:Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System medicine showed pr...

journal_title：Frontiers in pharmacology

authors： Lyu M,Zhou Z,Wang X,Lv H,Wang M,Pan G,Wang Y,Fan G,Gao X,Feng Y,Zhu Y

更新日期：2018-12-13 00:00:00

abstract：:Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and neurological defects, oral diseases, and cancers such as breast tumors...

journal_title：Frontiers in pharmacology

authors： Merzoug-Larabi M,Youssef I,Bui AT,Legay C,Loiodice S,Lognon S,Babajko S,Ricort JM

更新日期：2020-01-31 00:00:00

abstract：:γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined administration can bring forth an additive therapeutic effect. We tested this...

journal_title：Frontiers in pharmacology

authors： Liu W,Son DO,Lau HK,Zhou Y,Prud'homme GJ,Jin T,Wang Q

更新日期：2017-06-20 00:00:00

abstract：:Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with intravenous drug self-administration procedure to verify whether depr...

journal_title：Frontiers in pharmacology

authors： Amchova P,Kucerova J,Giugliano V,Babinska Z,Zanda MT,Scherma M,Dusek L,Fadda P,Micale V,Sulcova A,Fratta W,Fattore L

更新日期：2014-03-20 00:00:00

abstract：:Low-density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional matricellular receptor composed of a large ligand-binding subunit (515-kDa α-chain) associated with a short trans-membrane subunit (85-kDa β-chain). LRP-1, which exhibits both endocytosis and cell signaling properties, plays a key role in ...

journal_title：Frontiers in pharmacology

authors： Dekky B,Wahart A,Sartelet H,Féré M,Angiboust JF,Dedieu S,Piot O,Devy J,Emonard H

更新日期：2016-02-12 00:00:00

abstract：:15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), a non-invasive technique for sampling of airway secretions, in patients with cystic fibrosis (CF). Azithromycin has antioxidant properties in experimental models of CF, but its effects on oxidative...

journal_title：Frontiers in pharmacology

authors： Montuschi P,Lucidi V,Paris D,Montemitro E,Shohreh R,Mores N,Melck D,Santini G,Majo F,Motta A

更新日期：2018-06-18 00:00:00

abstract：:Literature is scarce on acute ischemia after intra-arterial injection of crushed tablets and no effective medical treatment against the progression of lesions is reported. The only factor able to modify the outcome is the delay between injection and management by a specialized vascular team. Moreover the risk of necro...

journal_title：Frontiers in pharmacology

authors： Détriché G,Goudot G,Khider L,Galloula A,Guillet M,Lillo-Le Louët A,Messas E,Mirault T

更新日期：2020-12-03 00:00:00

abstract：:Background: HIV pre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine is effective when taken daily. Previously, we developed a urine assay capable of detecting the prodrug tenofovir (TFV) in patients taking tenofovir disoproxil fumarate (TDF)-based PrEP. However, tenofovir alafenamide (TAF) has replaced TDF du...

journal_title：Frontiers in pharmacology

authors： Lalley-Chareczko L,Hiserodt E,Moorthy G,Zuppa A,Mounzer K,Koenig H

更新日期：2020-03-19 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Zhao L,Hu C,Wang T,Lu J,Wu C,Chen L,Jin M,Hu H,Ji G,Cao Q,Jiang Y

更新日期：2020-02-28 00:00:00

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2018.00361.]. ...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Huang D,Xie S,Wang X,Pan Y,Yuan Z

更新日期：2018-11-29 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：Background:Immunosuppressant non-adherence is a widespread problem among solid organ recipients. With the newly published clinical trials, the randomized controlled trials (RCTs) based systematic review of adherence-enhancing interventions on immunosuppressant adherence in solid organ recipients has not been completed....

journal_title：Frontiers in pharmacology

authors： Shi YX,Liu CX,Liu F,Zhang HM,Yu MM,Jin YH,Shang SM,Fu YX

更新日期：2020-10-20 00:00:00

abstract：:Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects. Methods: The pharmacokinetic profiles of ticagrelor and it...

journal_title：Frontiers in pharmacology

authors： Zhu Q,Zhong W,Wang X,Mai L,He G,Chen J,Tang L,Liu S,Lai W,Zhong S

更新日期：2019-03-18 00:00:00

abstract：:Gamithromycin is approved for the treatment and prevention of bovine respiratory disease (BRD), which is caused mainly by Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma species. In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in ...

journal_title：Frontiers in pharmacology

authors： Yang Q,Liu X,Zhang C,Yong K,Clifton AC,Ding H,Liu Y

更新日期：2019-09-24 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with 0.1 M trimethylammonium bromide (TMA) with full...

journal_title：Frontiers in pharmacology

authors： Onder S,David E,Tacal O,Schopfer LM,Lockridge O

更新日期：2017-10-10 00:00:00

abstract：:The clinical practice of selective serotonin reuptake inhibitor (SSRI) augmentation relies heavily on trial-and-error. Unfortunately, the drug combinations prescribed today fail to provide relief for many depressed patients. In order to identify potentially more effective treatments, we developed a computational model...

journal_title：Frontiers in pharmacology

authors： Camacho MB,Vijitbenjaronk WD,Anastasio TJ

更新日期：2019-10-25 00:00:00

abstract：:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) and INSTIs are the latest class of potent anti-HIV drugs. Compared to the first generation INSTIs, raltegravir, and elvitegravir, DTG shows a limited cross-resistance profile. More interestingly, clinical resistance mutations to DTG ...

journal_title：Frontiers in pharmacology

authors： Wainberg MA,Han YS

更新日期：2015-04-29 00:00:00

abstract：Objective:Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Method...

journal_title：Frontiers in pharmacology

authors： Li MY,Luo HJ,Wu X,Liu YH,Gan YX,Xu N,Zhang YM,Zhang SH,Zhou CL,Su ZR,Huang XQ,Zheng XB

更新日期：2020-01-20 00:00:00