Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma.

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 w...

journal_title：Frontiers in pharmacology

authors： Wang J,Lian DW,Yang XF,Xu YF,Chen FJ,Lin WJ,Wang R,Tang LY,Ren WK,Fu LJ,Huang P,Cao HY

更新日期：2019-05-24 00:00:00

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：:Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bib...

journal_title：Frontiers in pharmacology

authors： Wang CY,Li BH,Ma LL,Zhao MJ,Deng T,Jin YH,Ren XQ

更新日期：2019-02-12 00:00:00

abstract：:Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A1 and M2 receptors coupled to inwardly rectifying GIRK/KIR3.1/3.4 channels, respectively. Unlike M2 receptors, bradycardia produced by A1 receptors activation predominates over negative inotropy. Such diffe...

journal_title：Frontiers in pharmacology

authors： Bragança B,Oliveira-Monteiro N,Ferreirinha F,Lima PA,Faria M,Fontes-Sousa AP,Correia-de-Sá P

更新日期：2016-03-07 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is a debilitating disease with complex pathophysiology. Amyloid beta (Aβ) (1-42) is a reliable model of AD that recapitulates many aspects of human AD. OBJECTIVE:The intent of the present study was to investigate the neuroprotective potential of Coenzyme Q10 (CoQ10) and its modulatio...

journal_title：Frontiers in pharmacology

authors： Singh A,Kumar A

更新日期：2015-11-09 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：:Despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (ALS) no novel disease-modifying therapies have been successfully implemented in clinical routine. Riluzole still remains the only clinically approved substance in human ALS treatment with limited effic...

journal_title：Frontiers in pharmacology

authors： Günther R,Balck A,Koch JC,Nientiedt T,Sereda M,Bähr M,Lingor P,Tönges L

更新日期：2017-01-31 00:00:00

abstract：:Product mislabeling and/or species fraud in Traditional Chinese Medicine (TCM) not only decrease TCM quality, but also pose a potential health issue to the end user. Up to now, methods to control TCM quality have been developed to detect specific metabolites or identify the original species. However, species quantific...

journal_title：Frontiers in pharmacology

authors： Zhao B,Xiong C,Li J,Zhang D,Shi Y,Sun W,Duan X

更新日期：2020-11-26 00:00:00

abstract：:The Glp-1 analog, liraglutide (Lir), has been shown to reduce infarct size and improve cardiac function after myocardial ischemia in rodents with or without diabetes. However, the effect of Lir on angiotensin II (AngII) and pressure overload induced cardiac hypertrophy in nondiabetic mice and the underlying mechanisms...

journal_title：Frontiers in pharmacology

authors： Li R,Shan Y,Gao L,Wang X,Wang X,Wang F

更新日期：2019-06-05 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated from biological pre...

journal_title：Frontiers in pharmacology

authors： Honrao C,Ma X,Kulkarni S,Joshi V,Malamas M,Zvonok A,Wood J,Strand D,Guo JJ,Makriyannis A

更新日期：2020-09-30 00:00:00

abstract：:Flavonoids are some of the most important natural products with a variety of physiological activities. 8-Formylophiopogonanone B (8-FOB) is a naturally existing homoisoflavonoid in Ophiopogon japonicus. Paraquat (PQ) has been widely used as a potent herbicide and has high toxicity in humans. The goal of the present st...

journal_title：Frontiers in pharmacology

authors： Qian JY,Deng P,Liang YD,Pang L,Wu LC,Yang LL,Zhou Z,Yu ZP

更新日期：2019-10-24 00:00:00

abstract：Background:The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream of the CYP2D6 gene ...

journal_title：Frontiers in pharmacology

authors： Boone EC,Wang WY,Gaedigk R,Cherner M,Bérard A,Leeder JS,Miller NA,Gaedigk A

更新日期：2020-05-08 00:00:00

abstract：:It is currently thought that the dementia of Alzheimer's disease is due to the neurotoxicity of the deposits or aggregates of amyloid-β (Aβ) in the extracellular space of the cerebral cortex. This model has been widely criticized because there is a poor correlation between deposits and dementia. Others have questioned...

journal_title：Frontiers in pharmacology

authors： Holtzman JL

更新日期：2013-05-13 00:00:00

abstract：:Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral ...

journal_title：Frontiers in pharmacology

authors： Zhao Z,Li D,Wu Z,Wang Q,Ma Z,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coro...

journal_title：Frontiers in pharmacology

authors： Gu ZC,Shi FH,Zhu J,Wan F,Shen L,Li H

更新日期：2019-01-15 00:00:00

abstract：:In Mexico, the Adenophyllum aurantium (L.) Strother plant is consumed as an infusion to treat intestinal diseases such as amoebiasis, which is an endemic health problem in Mexico and other countries. However, the effect of A. aurantium on Entamoeba histolytica, the causative agent of amoebiasis, is unknown. An aerial ...

journal_title：Frontiers in pharmacology

authors： Herrera-Martínez M,Hernández-Ramírez VI,Hernández-Carlos B,Chávez-Munguía B,Calderón-Oropeza MA,Talamás-Rohana P

更新日期：2016-06-27 00:00:00

abstract：Objective:To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods:Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the...

journal_title：Frontiers in pharmacology

authors： Zhang B,Wang C,Cui L,Gao J,Wang C,Tan X,Fang S

更新日期：2020-03-31 00:00:00

abstract：:Understanding the mechanistic basis for temozolomide (TMZ)-induced glioma resistance is an important obstacle in developing an effective form of chemotherapy for this type of tumor. Glycogenolysis is known to play an essential role in cellular proliferation and potassium homeostasis and involves the glycogen phosphory...

journal_title：Frontiers in pharmacology

authors： Xu J,Zhang Y,Guo X,Sun T

更新日期：2018-08-07 00:00:00

abstract：:Purpose: To analyze MiRs expression in serum of UM patients, respect to healthy donors, and to compare this data with MiRs expressed in formalin-fixed, paraffin-embedded UM samples. Methods: Expression profile of 754 miRNAs was performed in serum of patients with uveal melanoma who underwent primary enucleation. The l...

journal_title：Frontiers in pharmacology

authors： Russo A,Caltabiano R,Longo A,Avitabile T,Franco LM,Bonfiglio V,Puzzo L,Reibaldi M

更新日期：2016-11-15 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new ...

journal_title：Frontiers in pharmacology

authors： Galozzi P,Baggio C,Bindoli S,Oliviero F,Sfriso P

更新日期：2018-09-21 00:00:00

abstract：:MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 has been reported to be associated with carcinogenesis. However, the role of MYCT1 in the development and progress of acute myeloid leukemia (...

journal_title：Frontiers in pharmacology

authors： Fu S,Fu Y,Chen F,Hu Y,Quan B,Zhang J

更新日期：2018-09-18 00:00:00

abstract：:Background: HIV pre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine is effective when taken daily. Previously, we developed a urine assay capable of detecting the prodrug tenofovir (TFV) in patients taking tenofovir disoproxil fumarate (TDF)-based PrEP. However, tenofovir alafenamide (TAF) has replaced TDF du...

journal_title：Frontiers in pharmacology

authors： Lalley-Chareczko L,Hiserodt E,Moorthy G,Zuppa A,Mounzer K,Koenig H

更新日期：2020-03-19 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the ...

journal_title：Frontiers in pharmacology

authors： Rohleder C,Müller JK,Lange B,Leweke FM

更新日期：2016-11-08 00:00:00

abstract：:Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

journal_title：Frontiers in pharmacology

authors： Gracia-Hernandez M,Sotomayor EM,Villagra A

更新日期：2020-10-29 00:00:00

abstract：:Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a referen...

journal_title：Frontiers in pharmacology

authors： Wu G,Chen J,Hu X,Zhou H,Liu J,Lv D,Wu L,Shentu J

更新日期：2017-04-20 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which PLP affects ANIT-indu...

journal_title：Frontiers in pharmacology

authors： Ma X,Chi YH,Niu M,Zhu Y,Zhao YL,Chen Z,Wang JB,Zhang CE,Li JY,Wang LF,Gong M,Wei SZ,Chen C,Zhang L,Wu MQ,Xiao XH

更新日期：2016-02-04 00:00:00