Species Quantification in Complex Herbal Formulas-Vector Control Quantitative Analysis as a New Method.

abstract：:Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...

journal_title：Frontiers in pharmacology

authors： Bojanić L,Marković-Peković V,Škrbić R,Stojaković N,Ðermanović M,Bojanić J,Fürst J,Kurdi AB,Godman B

更新日期：2018-05-29 00:00:00

abstract：:Aflatoxin B1 (AFB1) is one of the most hazardous mycotoxins contamination in food and feed products, which leads to hepatocellular carcinoma in humans and animals. In the present study, we isolated and characterized an AFB1 degrading bacteria CG1061 from chicken cecum, exhibited an 93.7% AFB1 degradation rate by HPLC....

journal_title：Frontiers in pharmacology

authors： Wang L,Wu J,Liu Z,Shi Y,Liu J,Xu X,Hao S,Mu P,Deng F,Deng Y

更新日期：2019-01-17 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine (Radix Ophiopogonis) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-...

journal_title：Frontiers in pharmacology

authors： Lu Z,Wang H,Zhu M,Song W,Wang J,Wu C,Kong Y,Guo J,Li N,Liu J,Li Y,Xu H

更新日期：2018-04-30 00:00:00

abstract：:There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac myocytes for this p...

journal_title：Frontiers in pharmacology

authors： Mistry HB,Davies MR,Di Veroli GY

更新日期：2015-03-24 00:00:00

abstract：:Zingiber zerumbet (L) Smith is part of the Zingiberaceae family, one of the largest families of the plant kingdom. Z. zerumbet is a perennial, aromatic and tuberose plant that grows in humid locations where its center of distribution is located in the South-East Asia region. This plant has been traditionally used in f...

journal_title：Frontiers in pharmacology

authors： Tan JW,Israf DA,Tham CL

更新日期：2018-06-20 00:00:00

abstract：:Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hosp...

journal_title：Frontiers in pharmacology

authors： Mazzotta E,Villalobos-Hernandez EC,Fiorda-Diaz J,Harzman A,Christofi FL

更新日期：2020-11-24 00:00:00

abstract：:ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggre...

journal_title：Frontiers in pharmacology

authors： Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C

更新日期：2018-12-04 00:00:00

abstract：Background:Brazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines from clinical studies, expanded access and compassionate use progr...

journal_title：Frontiers in pharmacology

authors： da Silva RE,Lima EDC,Novaes MRCG,Osorio-de-Castro CGS

更新日期：2020-05-19 00:00:00

abstract：:The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using ...

journal_title：Frontiers in pharmacology

authors： Seshadri DR,Ramamurthi A

更新日期：2018-07-16 00:00:00

abstract：:Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

journal_title：Frontiers in pharmacology

authors： Lei H,Yu LT,Wang WN,Zhang SG

更新日期：2018-11-06 00:00:00

abstract：:Oxidative insult, inflammation, apoptosis and autophagy play a pivotal role in the etiology of diabetic nephropathy, a global health concern. Ferulic acid, a phytochemical, is reported to protect against varied diseased conditions. However, the ameliorative role and mechanisms of ferulic acid in averting STZ-mediated ...

journal_title：Frontiers in pharmacology

authors： Chowdhury S,Ghosh S,Das AK,Sil PC

更新日期：2019-02-05 00:00:00

abstract：:Background: Clozapine, an antipsychotic used in treatment-resistant schizophrenia, has adverse gastrointestinal effects with significant associated morbidity and mortality. However, its effects on defined patterns of colonic contractile activity have not been assessed. Method: We used novel radial and longitudinal spa...

journal_title：Frontiers in pharmacology

authors： Every-Palmer S,Lentle RG,Reynolds G,Hulls C,Chambers P,Dunn H,Ellis PM

更新日期：2017-04-24 00:00:00

abstract：:Objective: Calcium dobesilate (CaD), an effective drug for the treatment of diabetic microvascular complications, especially diabetic retinopathy, is widely used in the clinic. Interestingly, several studies have indicated that CaD is therapeutic for diabetic kidney disease (DKD). Recently, evidence has indicated that...

journal_title：Frontiers in pharmacology

authors： Wang Y,Lu YH,Tang C,Xue M,Li XY,Chang YP,Cheng Y,Li T,Yu XC,Sun B,Li CJ,Chen LM

更新日期：2019-08-09 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Inflammation-related intestinal diseases are a set of various conditions presenting an overactive enteric immune system. A continuous overproduction of pro-inflammatory cytokines and a decreased production of anti-inflammatory modulators are generally observed, while morpho-functional alterations of the enteric nervou...

journal_title：Frontiers in pharmacology

authors： Dal Ben D,Antonioli L,Lambertucci C,Fornai M,Blandizzi C,Volpini R

更新日期：2018-03-14 00:00:00

abstract：:Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging from lower (virus, bacteria, and parasite) to the higher organisms (mammals). Proteases cleave proteins into smaller fragments by catalyzing peptide bonds hydrolysis. Proteases are classified according to their catalytic site, a...

journal_title：Frontiers in pharmacology

authors： Verma S,Dixit R,Pandey KC

更新日期：2016-04-25 00:00:00

abstract：:Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of phenotypic variance resu...

journal_title：Frontiers in pharmacology

authors： Lim SH,Legere EA,Snider J,Stagljar I

更新日期：2018-01-17 00:00:00

abstract：:Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

journal_title：Frontiers in pharmacology

authors： Turner RM,Chen YW,Fernandes AW

更新日期：2017-11-30 00:00:00

abstract：Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...

journal_title：Frontiers in pharmacology

authors： Zhang W,Liu C,Li J,Liu R,Zhuang J,Feng F,Yao Y,Sun C

更新日期：2020-08-07 00:00:00

abstract：:The response to pazopanib in patients with metastatic renal cell carcinoma (mRCC) has been found to differ in Western and Eastern populations. Here, we analyzed the efficacy and side effects of pazopanib as first-line therapy in 31 consecutive patients with mRCC who were treated at a single Chinese center. Thirty-one ...

journal_title：Frontiers in pharmacology

authors： Wang B,Song JW,Chen HQ

更新日期：2020-10-29 00:00:00

abstract：:Fungal secondary metabolites serve as a rich resource for exploring lead compounds with medicinal importance. Diorcinol N (DN), a fungal secondary metabolite isolated from an endophytic fungus, Arthrinium arundinis, exhibits robust anticancer activity. However, the anticancer mechanism of DN remains unclear. In this s...

journal_title：Frontiers in pharmacology

authors： Yuan XL,Li XQ,Xu K,Hou XD,Zhang ZF,Xue L,Liu XM,Zhang P

更新日期：2020-10-15 00:00:00

abstract：:Objective: Prevalence of osteoporosis in Chinese postmenopausal women has significantly increased over the past decade and oral bisphosphonates are the most potent antiresorptive drugs. The purpose of the present research was to evaluate the cost-effectiveness of oral alendronate for individuals with osteoporosis. We ...

journal_title：Frontiers in pharmacology

authors： You R,Liu Z

更新日期：2020-11-16 00:00:00

abstract：:MaZiRenWan (MZRW, also known as Hemp Seed Pill) is a Chinese Herbal Medicine which has been demonstrated to safely and effectively alleviate functional constipation (FC) in a randomized, placebo-controlled clinical study with 120 subjects. However, the underlying pharmacological actions of MZRW for FC, are still large...

journal_title：Frontiers in pharmacology

authors： Huang T,Ning Z,Hu D,Zhang M,Zhao L,Lin C,Zhong LLD,Yang Z,Xu H,Bian Z

更新日期：2018-03-26 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

journal_title：Frontiers in pharmacology

authors： Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

更新日期：2020-08-12 00:00:00

abstract：:Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are importan...

journal_title：Frontiers in pharmacology

authors： Fu L,Han B,Zhou Y,Ren J,Cao W,Patel G,Kai G,Zhang J

更新日期：2020-03-19 00:00:00

abstract：:Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

journal_title：Frontiers in pharmacology

authors： Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

更新日期：2013-01-28 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：:Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self...

journal_title：Frontiers in pharmacology

authors： Singh L,Joshi T,Tewari D,Echeverría J,Mocan A,Sah AN,Parvanov E,Tzvetkov NT,Ma ZF,Lee YY,Poznański P,Huminiecki L,Sacharczuk M,Jóźwik A,Horbańczuk JO,Feder-Kubis J,Atanasov AG

更新日期：2020-02-14 00:00:00

abstract：:The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives maladaptive learning chronically during disease development suggests a...

journal_title：Frontiers in pharmacology

authors： Kätzel D,Wolff AR,Bygrave AM,Bannerman DM

更新日期：2020-10-16 00:00:00

abstract：:Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and r...

journal_title：Frontiers in pharmacology

authors： Caudle RM,Caudle SL,Flenor ND,Rohrs EL,Neubert JK

更新日期：2020-12-03 00:00:00