Nanotherapeutics to Modulate the Compromised Micro-Environment for Lung Cancers and Chronic Obstructive Pulmonary Disease.

abstract：:Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

journal_title：Frontiers in pharmacology

authors： Boccia M,Vecchione F,Piccardi L,Guariglia C

更新日期：2017-07-25 00:00:00

abstract：:Saponins are natural compounds and possess the most promising anti-cancer function. Here, a saponin gleditsia saponin C (GSC), extracted from gleditsiae fructus abnormalis, could induce apoptosis of lung tumor cell line A549 via caspase dependent cascade and this effect could be prevented by the caspase inhibitors. In...

journal_title：Frontiers in pharmacology

authors： Cheng Y,He W,He Y

更新日期：2018-01-15 00:00:00

abstract：:The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine r...

journal_title：Frontiers in pharmacology

authors： Kim M,Lee SH,Kim Y,Kwon Y,Park Y,Lee HK,Jung HS,Jeoung D

更新日期：2018-11-06 00:00:00

abstract：:One approach to experimental science involves creating hypotheses, then testing them by varying one or more independent variables, and assessing the effects of this variation on the processes of interest. We use this strategy to compare the intellectual status and available evidence for two models or views of mechanis...

journal_title：Frontiers in pharmacology

authors： Kell DB,Oliver SG

更新日期：2014-10-31 00:00:00

abstract：:The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and IFNAR2, have differe...

journal_title：Frontiers in pharmacology

authors： Lee S,Son WS,Yang HB,Rajasekaran N,Kim SS,Hong S,Choi JS,Choi JY,Song K,Shin YK

更新日期：2019-01-24 00:00:00

abstract：:Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and explored the underlyi...

journal_title：Frontiers in pharmacology

authors： Chen T,Wang Y,Zhang T,Zhang B,Chen L,Zhao L,Chen L

更新日期：2018-04-12 00:00:00

abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...

journal_title：Frontiers in pharmacology

authors： Mahmoud AB,Danton O,Kaiser M,Khalid S,Hamburger M,Mäser P

更新日期：2020-08-14 00:00:00

abstract：:Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...

journal_title：Frontiers in pharmacology

authors： Bojanić L,Marković-Peković V,Škrbić R,Stojaković N,Ðermanović M,Bojanić J,Fürst J,Kurdi AB,Godman B

更新日期：2018-05-29 00:00:00

abstract：:Persistent activation of STAT3 plays an important role in the development of triple-negative breast cancer (TNBC), and suppression of STAT3 is considered as a novel approach for cancer therapy. In this project, we aimed to examine the anticancer activity and molecular mechanism of eupalinolide J (EJ) in TNBC cells. Th...

journal_title：Frontiers in pharmacology

authors： Lou C,Chen Y,Zhang J,Yang B,Zhao H

更新日期：2019-09-19 00:00:00

abstract：:Diabetes is affecting the social and economic developments in developing countries like Sri Lanka. Siddha Medicine (Tamil Medicine) is mostly practiced in the Eastern and Northern Provinces of Sri Lanka. Our recent review of Sri Lankan Siddha historical documents identified 171 plant species used to prepare anti-diabe...

journal_title：Frontiers in pharmacology

authors： Sathasivampillai SV,Rajamanoharan PRS,Heinrich M

更新日期：2018-10-10 00:00:00

abstract：:During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum inc...

journal_title：Frontiers in pharmacology

authors： Tocci N,Perenzoni D,Iamonico D,Fava F,Weil T,Mattivi F

更新日期：2018-04-20 00:00:00

abstract：:Local people in the Sudhnoti district of Pakistan share a rich practice of traditional medicine for the treatment of a variety of ailments. We selected nine plants from the Sudhnoti ethnopharmacological tradition used for the treatment of infectious and inflammatory disease. Our aim was to evaluate the in vitro anti-i...

journal_title：Frontiers in pharmacology

authors： Khan MF,Tang H,Lyles JT,Pineau R,Mashwani ZU,Quave CL

更新日期：2018-08-02 00:00:00

abstract：:Limited data are available on the adherence to opioid therapy and the influence of different patient groups on adherence. This study examined the patterns of adherence in opioid naïve and opioid existing patients with varying age and gender. This retrospective cohort study was conducted using the prescription database...

journal_title：Frontiers in pharmacology

authors： Zin CS,Taufek NH,Ahmad MM

更新日期：2019-10-29 00:00:00

abstract：:Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

journal_title：Frontiers in pharmacology

authors： Chen M,Bao L,Zhao M,Cao J,Zheng H

更新日期：2020-02-25 00:00:00

abstract：:Red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM) induce endothelial dysfunction and impair cardiac function following ischemia via increase in RBC arginase and oxidative stress. Here, we aimed to elucidate whether the effect of RBC-mediated cardiac impairment following ischemia and endothelial...

journal_title：Frontiers in pharmacology

authors： Mahdi A,Jiao T,Yang J,Kövamees O,Alvarsson M,von Heijne M,Zhou Z,Pernow J

更新日期：2019-08-02 00:00:00

abstract：:Background: Cefoperazone/sulbactam is a broad-spectrum antibacterial agent. Drug-induced immune hemolytic anemia is a rare but serious condition, and reactive thrombocytosis is caused by processes extrinsic to the megakaryocyte. Limited data are available for cefoperazone/sulbactam-associated hemolytic anemia and reac...

journal_title：Frontiers in pharmacology

authors： Zhou L,Bao J,Ma J

更新日期：2019-11-08 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

journal_title：Frontiers in pharmacology

authors： Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

更新日期：2020-07-14 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

journal_title：Frontiers in pharmacology

authors： Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

更新日期：2019-02-04 00:00:00

abstract：:Saikosaponin d (SSd) is a major hepatoprotective component of saikosaponins derived from Radix Bupleuri, which was also linked to hepatotoxicity. Previous studies have demonstrated that caspases play a key role in SSd-induced liver cell death. Our in vitro and in vivo studies also showed that treatment with caspase in...

journal_title：Frontiers in pharmacology

authors： Zhang QQ,Huang WQ,Gao YQ,Han ZD,Zhang W,Zhang ZJ,Xu FG

更新日期：2018-07-06 00:00:00

abstract：:Crataegus oxyacantha is an important herbal supplement and famous for its antioxidant potential. The antioxidant in combination with anticholinesterase activity can be considered as an important target in the management of Alzheimer's disease. The compounds isolated from C. oxyacantha were evaluated for cholinesterase...

journal_title：Frontiers in pharmacology

authors： Ali M,Muhammad S,Shah MR,Khan A,Rashid U,Farooq U,Ullah F,Sadiq A,Ayaz M,Ali M,Ahmad M,Latif A

更新日期：2017-06-07 00:00:00

abstract：:Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have significant adverse effects. One approach is targeting either neurotrophic...

journal_title：Frontiers in pharmacology

authors： Sidorova YA,Bespalov MM,Wong AW,Kambur O,Jokinen V,Lilius TO,Suleymanova I,Karelson G,Rauhala PV,Karelson M,Osborne PB,Keast JR,Kalso EA,Saarma M

更新日期：2017-06-21 00:00:00

abstract：:Reports in the last decade have suggested that the role of platelets in atherosclerosis and its thrombotic complications may be mediated, in part, by local secretion of platelet-derived microvesicles (pMVs), small cell blebs released during the platelet activation process. MVs are the most abundant cell-derived microv...

journal_title：Frontiers in pharmacology

authors： Badimon L,Suades R,Fuentes E,Palomo I,Padró T

更新日期：2016-08-31 00:00:00

abstract：:The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

journal_title：Frontiers in pharmacology

authors： Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

更新日期：2019-04-05 00:00:00

abstract：:In recent years, the heme catabolic pathway is considered to play an important regulatory role in cell protection, apoptosis, inflammation, and other physiological and pathological processes. An appropriate amount of heme forms the basic elements of various life activities, while when released in large quantities, it ...

journal_title：Frontiers in pharmacology

authors： Wu B,Wu Y,Tang W

更新日期：2019-07-24 00:00:00

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-ind...

journal_title：Frontiers in pharmacology

authors： Franks LN,Ford BM,Prather PL

更新日期：2016-12-22 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, prolifer...

journal_title：Frontiers in pharmacology

authors： Lin X,Patil S,Gao YG,Qian A

更新日期：2020-05-26 00:00:00

abstract：:Neurofibrillary pathology contributes to neuronal dysfunction and correlates with the clinical progression of Alzheimer's disease (AD). Tau phosphorylation is mainly regulated by a balance of glycogen synthase kinase-3β (GSK-3β) and protein phosphatase 2A (PP2A) activities. Cornel iridoid glycoside (CIG) is a main com...

journal_title：Frontiers in pharmacology

authors： Yang C,Li X,Gao W,Wang Q,Zhang L,Li Y,Li L,Zhang L

更新日期：2018-06-26 00:00:00