ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect.


:ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggressive growth. Furthermore, lung cancer patients with higher KDM1A levels have worse survival outcomes than patients with lower KDM1A levels. Interestingly, ORY-1001significantly inhibited the cell proliferation, colony formation, cell cycle, and induced apoptosis, by regulating the Warburg effect through controlling Hexokinases 2 (HK2) expression. In summary, these results indicate that ORY-1001 could inhibit the growth of lung cancer cells via regulating the Warburg effect by controlling HK2.


Front Pharmacol


Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C




Has Abstract


2018-12-04 00:00:00








  • Corrigendum: Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.

    abstract::[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,已发布勘误


    authors: Uttl L,Petrasek T,Sengul H,Svojanovska M,Lobellova V,Vales K,Radostova D,Tsenov G,Kubova H,Mikulecka A,Svoboda J,Stuchlik A

    更新日期:2018-06-20 00:00:00

  • Corrigendum: Safety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis.

    abstract::[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误


    authors: Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

    更新日期:2017-02-15 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lee JY,Kim GJ,Choi JK,Choi YA,Jeong NH,Park PH,Choi H,Kim SH

    更新日期:2018-07-20 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wuo-Silva R,Fukushiro-Lopes DF,Fialho BP,Hollais AW,Santos-Baldaia R,Marinho EAV,Mári-Kawamoto E,Yokoyama TS,Lopes-Silva LB,Berro LF,Frussa-Filho R,Longo BM

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lai SW,Lin CL,Liao KF

    更新日期:2017-09-11 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Valiunas V

    更新日期:2013-06-06 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Zhang T,Ikejima T,Li L,Wu R,Yuan X,Zhao J,Wang Y,Peng S

    更新日期:2017-10-26 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

    更新日期:2019-08-06 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: He J,Li X,Wang Z,Bennett S,Chen K,Xiao Z,Zhan J,Chen S,Hou Y,Chen J,Wang S,Xu J,Lin D

    更新日期:2019-11-25 00:00:00

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    authors: Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

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    pub_type: 杂志文章


    authors: Amchova P,Kucerova J,Giugliano V,Babinska Z,Zanda MT,Scherma M,Dusek L,Fadda P,Micale V,Sulcova A,Fratta W,Fattore L

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    journal_title:Frontiers in pharmacology

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    authors: Bröer A,Fairweather S,Bröer S

    更新日期:2018-07-19 00:00:00

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    authors: Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

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    journal_title:Frontiers in pharmacology

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    authors: Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Liu L,Zhao Z,Yin Q,Zhang X

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  • Network Pharmacology-Based Approach Uncovers the Mechanism of GuanXinNing Tablet for Treating Thrombus by MAPKs Signal Pathway.

    abstract:Background:GuanXinNing tablet (GXNT), a traditional Chinese patent medicine, has been found to have remarkable antithrombotic effects and can effectively inhibit pro-thrombotic factors in previous studies. However, the mechanism of its antithrombotic effects remains little known. Methods:In this study, we first determ...

    journal_title:Frontiers in pharmacology

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    authors: Wang ML,Yang QQ,Ying XH,Li YY,Wu YS,Shou QY,Ma QX,Zhu ZW,Chen ML

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    authors: Arora A,Bhuria V,Hazari PP,Pathak U,Mathur S,Roy BG,Sandhir R,Soni R,Dwarakanath BS,Bhatt AN

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    journal_title:Frontiers in pharmacology

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    authors: Luo X,Gu S,Zhang Y,Zhang J

    更新日期:2018-03-20 00:00:00

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    authors: Micheli L,Di Cesare Mannelli L,Lucarini E,Parisio C,Toti A,Fiorentino B,Rigamonti MA,Calosi L,Ghelardini C

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tocci N,Perenzoni D,Iamonico D,Fava F,Weil T,Mattivi F

    更新日期:2018-04-20 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


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    journal_title:Frontiers in pharmacology



    authors: Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

    更新日期:2019-08-14 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


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    更新日期:2015-12-01 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Panes JD,Godoy PA,Silva-Grecchi T,Celis MT,Ramirez-Molina O,Gavilan J,Muñoz-Montecino C,Castro PA,Moraga-Cid G,Yévenes GE,Guzmán L,Salisbury JL,Trushina E,Fuentealba J

    更新日期:2020-05-21 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zhou S,Skaar DJ,Jacobson PA,Huang RS

    更新日期:2018-12-04 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


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    更新日期:2020-01-20 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bao S,Chen Y,Yang F,Sun C,Yang M,Li W,Huang X,Li J,Wu H,Yin Y

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    journal_title:Frontiers in pharmacology



    authors: Gregnani MF,Hungaro TG,Martins-Silva L,Bader M,Araujo RC

    更新日期:2020-08-04 00:00:00

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    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Kohajda Z,Tóth N,Szlovák J,Loewe A,Bitay G,Gazdag P,Prorok J,Jost N,Levijoki J,Pollesello P,Papp JG,Varró A,Nagy N

    更新日期:2020-01-29 00:00:00