ORY-1001 Suppresses Cell Growth and Induces Apoptosis in Lung Cancer Through Triggering HK2 Mediated Warburg Effect.

abstract：:The objective of this study was to test the hypothesis that serotonin O-sulphate (5-HT-SO4) could be quantified in human plasma using modern liquid chromatography-mass spectrometry (LC-MS) method as well as develop and validate that method. First, a suitable LC-MS method for detection of 5-HT-SO4 in human plasma sampl...

journal_title：Frontiers in pharmacology

authors： Lozda R,Purviņš I

更新日期：2014-04-08 00:00:00

abstract：:Objective: Clinical trials are the source of evidence. ClinicalTrials.gov is valuable for analyzing current conditions. Until now, the state of drug interventions for heart infections is unknown. The purpose of this study was to comprehensively assess the characteristics of trials on cardiac-related infections and the...

journal_title：Frontiers in pharmacology

authors： Ma LL,Qiu Y,Song MN,Chen Y,Qu JX,Li BH,Zhao MJ,Liu XC

更新日期：2019-07-05 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:Background: No risk model for predicting thrombocytopenia associated with periprocedural tirofiban exposure is available. The purpose of this study was to develop a simple clinical pre-procedure risk model based on pre-procedural characteristics for early prediction of thrombocytopenia before patients were exposed to ...

journal_title：Frontiers in pharmacology

authors： Yi YH,Yin WJ,Gu ZC,Fang WJ,Li DY,Hu C,Liu K,Ma RR,Zhou LY

更新日期：2018-12-10 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver...

journal_title：Frontiers in pharmacology

authors： Li F,Gao C,Yan P,Zhang M,Wang Y,Hu Y,Wu X,Wang X,Sheng J

更新日期：2018-11-22 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

journal_title：Frontiers in pharmacology

authors： Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

更新日期：2017-08-15 00:00:00

abstract：:High levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to determine whether these memory systems may be similarly affected in an animal model of post-traumatic ...

journal_title：Frontiers in pharmacology

authors： Goodman J,McIntyre CK

更新日期：2017-09-22 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. It takes some time from chronic gastritis to develop in GC. Early detection of GC will help patients obtain timely treatment. Understanding disease evolution is crucial for the prevention and treatment of GC. Here, we present a convolu...

journal_title：Frontiers in pharmacology

authors： Ma B,Guo Y,Hu W,Yuan F,Zhu Z,Yu Y,Zou H

更新日期：2020-10-02 00:00:00

abstract：:Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

journal_title：Frontiers in pharmacology

authors： Ménard C,Quirion R

更新日期：2012-10-12 00:00:00

abstract：:Icariin is a main component of the Chinese medicinal plant Epimedium brevicornu Maxim, exhibits potent activity against inflammatory diseases. Our previous data demonstrated the valid bioactivity of icariin on mitigating rodent asthma. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NF-κB) pathway were involv...

journal_title：Frontiers in pharmacology

authors： Liu J,Liu L,Sun J,Luo Q,Yan C,Zhang H,Liu F,Wei Y,Dong J

更新日期：2020-01-31 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...

journal_title：Frontiers in pharmacology

authors： Tao T,He T,Mao H,Wu X,Liu X

更新日期：2020-05-08 00:00:00

abstract：:[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

journal_title：Frontiers in pharmacology

authors： Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

更新日期：2017-02-15 00:00:00

abstract：:[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

journal_title：Frontiers in pharmacology

authors： Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

更新日期：2016-12-05 00:00:00

abstract：:Background: D-dimer is a small protein fragment and high levels of D-dimer have been associated with increased mortality in patients presenting to emergency departments with infection. Previous studies have reported increased levels of D-dimer in COVID-19; however, it is unclear whether an increased D-dimer level prov...

journal_title：Frontiers in pharmacology

authors： Li J,Liu Z,Wu G,Yi M,Chen Y,Li K,Xu X,Xiao L,Wu Q,Chen J,Wu X

更新日期：2020-12-21 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are a standard of care for the pharmacotherapy of patients suffering from Major Depressive Disorder (MDD). However, only one-half to two-thirds of MDD patients respond to SSRI therapy. Recently, a "multiple omics" research strategy was applied to identify genetic differe...

journal_title：Frontiers in pharmacology

authors： Nguyen TTL,Liu D,Ho MF,Athreya AP,Weinshilboum R

更新日期：2021-01-11 00:00:00

abstract：:The mTOR signaling pathway is abnormally activated in pancreatic cancer and is related to tumor glucose metabolism. However, its specific regulation mechanism is still unclear. Therefore, this study aims to investigate whether Sestrin2 affects the glucose metabolism of pancreatic cancer by modulating mTOR signal and t...

journal_title：Frontiers in pharmacology

authors： Guo Y,Zhu H,Weng M,Zhang H,Wang C,Sun L

更新日期：2020-11-11 00:00:00

abstract：:Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

journal_title：Frontiers in pharmacology

authors： Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

更新日期：2020-02-28 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

journal_title：Frontiers in pharmacology

authors： Yu T,Li Y,Gu X,Li Q

更新日期：2020-08-28 00:00:00

abstract：:The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

journal_title：Frontiers in pharmacology

authors： Schurman LD,Lichtman AH

更新日期：2017-02-17 00:00:00

abstract：:Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signali...

journal_title：Frontiers in pharmacology

authors： Sun X,Chen WD,Wang YD

更新日期：2017-08-23 00:00:00

abstract：:Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to ...

journal_title：Frontiers in pharmacology

authors： Cenini G,Voos W

更新日期：2019-08-23 00:00:00

abstract：Background:Huangci Granule is a traditional Chinese medicine for treating metastatic colorectal cancer (mCRC). Objective:To evaluate the efficacy and safety of Huangci Granule combination with chemotherapy and cetuximab (CET) or bevacizumab (BV) for treating mCRC. Methods:We performed a randomized, controlled, and do...

journal_title：Frontiers in pharmacology

authors： Liu N,Wu C,Jia R,Cai G,Wang Y,Zhou L,Ji Q,Sui H,Zeng P,Xiao H,Liu H,Huo J,Feng Y,Deng W,Li Q

更新日期：2020-04-21 00:00:00

abstract：:Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

journal_title：Frontiers in pharmacology

authors： da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

更新日期：2019-04-12 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is a debilitating disease with complex pathophysiology. Amyloid beta (Aβ) (1-42) is a reliable model of AD that recapitulates many aspects of human AD. OBJECTIVE:The intent of the present study was to investigate the neuroprotective potential of Coenzyme Q10 (CoQ10) and its modulatio...

journal_title：Frontiers in pharmacology

authors： Singh A,Kumar A

更新日期：2015-11-09 00:00:00

abstract：:Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment. In this study, we investigated the effect of ginsenoside Rb1 (Rb1), a saponin derived from Panax ginse...

journal_title：Frontiers in pharmacology

authors： Lim S,Park J,Um JY

更新日期：2019-10-15 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by extensive areas of hypox...

journal_title：Frontiers in pharmacology

authors： Maugeri G,D'Amico AG,Reitano R,Magro G,Cavallaro S,Salomone S,D'Agata V

更新日期：2016-05-31 00:00:00

abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

journal_title：Frontiers in pharmacology

authors： Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

更新日期：2019-11-29 00:00:00