Identification of Hub Genes in Protective Effect of Astragaloside IV on Aconitine-Induced Cardiac Damage in Zebrafish Based on Bioinformatics Analysis.

abstract：:We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mu...

journal_title：Frontiers in pharmacology

authors： Wang K,Yang X,Wu Z,Wang H,Li Q,Mei H,You R,Zhang Y

更新日期：2020-03-12 00:00:00

abstract：:Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or add...

journal_title：Frontiers in pharmacology

authors： He X,Fang J,Chen X,Zhao Z,Li Y,Meng Y,Huang L

更新日期：2019-10-30 00:00:00

abstract：:The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform...

journal_title：Frontiers in pharmacology

authors： Chen G,Zhao H,Ma S,Chen L,Wu G,Zhu Y,Zhu J,Ma C,Zhao H

更新日期：2020-09-18 00:00:00

abstract：:Background: No risk model for predicting thrombocytopenia associated with periprocedural tirofiban exposure is available. The purpose of this study was to develop a simple clinical pre-procedure risk model based on pre-procedural characteristics for early prediction of thrombocytopenia before patients were exposed to ...

journal_title：Frontiers in pharmacology

authors： Yi YH,Yin WJ,Gu ZC,Fang WJ,Li DY,Hu C,Liu K,Ma RR,Zhou LY

更新日期：2018-12-10 00:00:00

abstract：:The market authorization procedure for medicinal products for human use is relying on their demonstrated efficacy, safety, and pharmaceutical quality. This applies to all medicinal products whether of chemical or biological origin. Since October 2009, the first advanced therapy medicinal product (ATMP) has been author...

journal_title：Frontiers in pharmacology

authors： Van Wilder P

更新日期：2012-02-14 00:00:00

abstract：:Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-function mutations in the CLCNKB and BSND genes coding respectively for the ClC-Kb chloride channels and accessory subunit barttin. ClC-K channels are expressed in the Henle's loop, distal convoluted tubule, and cortical collecting ...

journal_title：Frontiers in pharmacology

authors： Sahbani D,Strumbo B,Tedeschi S,Conte E,Camerino GM,Benetti E,Montini G,Aceto G,Procino G,Imbrici P,Liantonio A

更新日期：2020-03-17 00:00:00

abstract：:Introduction and objectives: Metastatic penile squamous cell carcinoma (PSCC) is associated with dismal outcomes with median overall survival (OS) of 6-12 months in the first-line and <6 months in the salvage setting. Given the rarity of this disease, randomized trials are difficult. Prognostic risk models may assist ...

journal_title：Frontiers in pharmacology

authors： Buonerba C,Di Lorenzo G,Pond G,Cartenì G,Scagliarini S,Rozzi A,Quevedo FJ,Dorff T,Nappi L,Lanzetta G,Pagliaro L,Eigl BJ,Naik G,Ferro M,Galdiero M,De Placido S,Sonpavde G

更新日期：2016-12-20 00:00:00

abstract：:Adamantyl groups are key structural subunit commonly used in many marketed drugs targeting diseases ranging from viral infections to neurological disorders. The metabolic disposition of adamantyl compounds has been mostly studied using LC-MS based approaches. However, metabolite quantities isolated from biological pre...

journal_title：Frontiers in pharmacology

authors： Honrao C,Ma X,Kulkarni S,Joshi V,Malamas M,Zvonok A,Wood J,Strand D,Guo JJ,Makriyannis A

更新日期：2020-09-30 00:00:00

abstract：:Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal medicine, has been traditionally prescribed in China and other countries to treat affective disorders. The medicinal parts of ginseng, the roots and flower buds, have become increasingly popular as dietary supplements due to the current holisti...

journal_title：Frontiers in pharmacology

authors： Wang G,Lei C,Tian Y,Wang Y,Zhang L,Zhang R

更新日期：2019-09-13 00:00:00

abstract：:Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

journal_title：Frontiers in pharmacology

authors： Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

更新日期：2016-10-13 00:00:00

abstract：:The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

journal_title：Frontiers in pharmacology

authors： Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

更新日期：2017-03-30 00:00:00

abstract：:How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In thi...

journal_title：Frontiers in pharmacology

authors： Swanson LR

更新日期：2018-03-02 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

journal_title：Frontiers in pharmacology

authors： Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

更新日期：2016-12-05 00:00:00

abstract：:Cognitive impairment is a central feature of schizophrenia and has shown to play a crucial role in the psychosocial function of the disorder. Over the past few years, several cognitive remediation (CR) interventions have been developed for schizophrenia, whose effectiveness has also been widely demonstrated by systema...

journal_title：Frontiers in pharmacology

authors： Barlati S,Deste G,Galluzzo A,Perin AP,Valsecchi P,Turrina C,Vita A

更新日期：2019-01-10 00:00:00

abstract：Background:Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction, an early marker for atherosclerosis. In addition, intercellular...

journal_title：Frontiers in pharmacology

authors： Ramadan R,Vromans E,Anang DC,Goetschalckx I,Hoorelbeke D,Decrock E,Baatout S,Leybaert L,Aerts A

更新日期：2020-03-05 00:00:00

abstract：:Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e., α1A and α1B) in antiarrhyth...

journal_title：Frontiers in pharmacology

authors： Pytka K,Lustyk K,Żmudzka E,Kotańska M,Siwek A,Zygmunt M,Dziedziczak A,Śniecikowska J,Olczyk A,Gałuszka A,Śmieja J,Waszkielewicz AM,Marona H,Filipek B,Sapa J,Mogilski S

更新日期：2016-08-03 00:00:00

abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

journal_title：Frontiers in pharmacology

authors： Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

更新日期：2019-09-05 00:00:00

abstract：:Phytoestrogen has been proposed as an alternative to hormone replacement therapy, which has been demonstrated to promote a high risk of breast cancer. However, the effect of phytoestrogen on breast cancer development has not been fully understood. Bakuchiol is an active ingredient of a traditional Chinese herbal medic...

journal_title：Frontiers in pharmacology

authors： Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

更新日期：2016-05-24 00:00:00

abstract：:Zingiber zerumbet (L) Smith is part of the Zingiberaceae family, one of the largest families of the plant kingdom. Z. zerumbet is a perennial, aromatic and tuberose plant that grows in humid locations where its center of distribution is located in the South-East Asia region. This plant has been traditionally used in f...

journal_title：Frontiers in pharmacology

authors： Tan JW,Israf DA,Tham CL

更新日期：2018-06-20 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00

abstract：:Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

journal_title：Frontiers in pharmacology

authors： Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

更新日期：2018-11-06 00:00:00

abstract：Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

journal_title：Frontiers in pharmacology

authors： Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

更新日期：2020-01-31 00:00:00

abstract：:Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA's anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic plaque in ApoE-defi...

journal_title：Frontiers in pharmacology

authors： Chen Z,Gao X,Jiao Y,Qiu Y,Wang A,Yu M,Che F,Li S,Liu J,Li J,Zhang H,Yu C,Li G,Gao Y,Pan L,Sun W,Guo J,Cao B,Zhu Y,Xu H

更新日期：2019-07-26 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

journal_title：Frontiers in pharmacology

authors： Yu T,Li Y,Gu X,Li Q

更新日期：2020-08-28 00:00:00

abstract：:Background: Rhein is considered to have beneficial influence on diabetic nephropathy. Animal experiments suggested that the mechanisms of rhein against diabetic nephropathy may involve many processes, but the credibility of the evidence is unclear. Therefore, we conducted systematic review and meta-analysis of pre-cli...

journal_title：Frontiers in pharmacology

authors： Hu HC,Zheng LT,Yin HY,Tao Y,Luo XQ,Wei KS,Yin LP

更新日期：2019-12-13 00:00:00

abstract：:Neuropathic pain is still an extremely important problem in today's medicine because opioids, which are commonly used to reduce pain, have limited efficacy in this type of pathology. Therefore, complementary therapy is needed. Our experiments were performed in rats to evaluate the contribution of the purinergic system...

journal_title：Frontiers in pharmacology

authors： Jurga AM,Piotrowska A,Makuch W,Przewlocka B,Mika J

更新日期：2017-02-16 00:00:00

abstract：:Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-ind...

journal_title：Frontiers in pharmacology

authors： Franks LN,Ford BM,Prather PL

更新日期：2016-12-22 00:00:00

abstract：Introduction:Diabetes is a metabolic disease with a high incidence and serious harm to human health. Islet β-cell function defects can occur in the late stage of type 1 diabetes and type 2 diabetes. Studies have shown that stem cell is a promising new approach in bioengineering regenerative medicine. In the study of st...

journal_title：Frontiers in pharmacology

authors： Xu B,Fan D,Zhao Y,Li J,Wang Z,Wang J,Wang X,Guan Z,Niu B

更新日期：2020-01-24 00:00:00