Major Bioactive Compounds in Essential Oils Extracted From the Rhizomes of Zingiber zerumbet (L) Smith: A Mini-Review on the Anti-allergic and Immunomodulatory Properties.

abstract：:A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

journal_title：Frontiers in pharmacology

authors： Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

更新日期：2019-03-19 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to ge...

journal_title：Frontiers in pharmacology

authors： Ali MS,Ichihara MY,Lopes LC,Barbosa GCG,Pita R,Carreiro RP,Dos Santos DB,Ramos D,Bispo N,Raynal F,Canuto V,de Araujo Almeida B,Fiaccone RL,Barreto ME,Smeeth L,Barreto ML

更新日期：2019-09-23 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

journal_title：Frontiers in pharmacology

authors： Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

更新日期：2020-02-21 00:00:00

abstract：:Icariin is a main component of the Chinese medicinal plant Epimedium brevicornu Maxim, exhibits potent activity against inflammatory diseases. Our previous data demonstrated the valid bioactivity of icariin on mitigating rodent asthma. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NF-κB) pathway were involv...

journal_title：Frontiers in pharmacology

authors： Liu J,Liu L,Sun J,Luo Q,Yan C,Zhang H,Liu F,Wei Y,Dong J

更新日期：2020-01-31 00:00:00

abstract：:Mint [Mentha longifolia (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic. Recently, its antiproliferative role h...

journal_title：Frontiers in pharmacology

authors： Patti F,Palmioli A,Vitalini S,Bertazza L,Redaelli M,Zorzan M,Rubin B,Mian C,Bertolini C,Iacobone M,Armanini D,Barollo S,Airoldi C,Iriti M,Pezzani R

更新日期：2020-02-10 00:00:00

abstract：:Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, prolifer...

journal_title：Frontiers in pharmacology

authors： Lin X,Patil S,Gao YG,Qian A

更新日期：2020-05-26 00:00:00

abstract：:Radiotherapy and chemotherapy are widespread clinical modalities for cancer treatment. Among other biological influences, hypoxia is a main factor limiting the efficacy of radiotherapy, primarily because oxygen is involved in the stabilization of the DNA damage caused by ionizing radiations. Radiobiological hypoxia is...

journal_title：Frontiers in pharmacology

authors： Jordan BF,Sonveaux P

更新日期：2012-05-21 00:00:00

abstract：:Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

journal_title：Frontiers in pharmacology

authors： Gracia-Hernandez M,Sotomayor EM,Villagra A

更新日期：2020-10-29 00:00:00

abstract：:Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been well studied and reveal overall processes that are largely ubiquitous. However, it is important to note that althoug...

journal_title：Frontiers in pharmacology

authors： Mancini ML,Sonis ST

更新日期：2014-03-27 00:00:00

abstract：AIMS:Myocardial ischemia can result in marked mitochondrial damage leading to cardiac dysfunction, as such identifying novel mechanisms to limit mitochondrial injury is important. This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epoxyeicosatrienoic acids...

journal_title：Frontiers in pharmacology

authors： Akhnokh MK,Yang FH,Samokhvalov V,Jamieson KL,Cho WJ,Wagg C,Takawale A,Wang X,Lopaschuk GD,Hammock BD,Kassiri Z,Seubert JM

更新日期：2016-06-07 00:00:00

abstract：INTRODUCTION:European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. OBJECTIVE:To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future gui...

journal_title：Frontiers in pharmacology

authors： Godman B,Shrank W,Andersen M,Berg C,Bishop I,Burkhardt T,Garuoliene K,Herholz H,Joppi R,Kalaba M,Laius O,Lonsdale J,Malmström RE,Martikainen JE,Samaluk V,Sermet C,Schwabe U,Teixeira I,Tilson L,Tulunay FC,Vlahović-

更新日期：2011-01-07 00:00:00

abstract：:Complex disease is a cascade process which is associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing evidences show that Chinese herb formula usually treats complex diseases ...

journal_title：Frontiers in pharmacology

authors： Gao Y,Wang KX,Wang P,Li X,Chen JJ,Zhou BY,Tian JS,Guan DG,Qin XM,Lu AP

更新日期：2020-10-02 00:00:00

abstract：:Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to ...

journal_title：Frontiers in pharmacology

authors： Cenini G,Voos W

更新日期：2019-08-23 00:00:00

abstract：:Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

journal_title：Frontiers in pharmacology

authors： Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

更新日期：2020-11-27 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：:Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

journal_title：Frontiers in pharmacology

authors： Chen M,Bao L,Zhao M,Cao J,Zheng H

更新日期：2020-02-25 00:00:00

abstract：:Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with electrophysiological re...

journal_title：Frontiers in pharmacology

authors： Latapiat V,Rodríguez FE,Godoy F,Montenegro FA,Barrera NP,Huidobro-Toro JP

更新日期：2017-12-15 00:00:00

abstract：:Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produc...

journal_title：Frontiers in pharmacology

authors： Recchiuti A,Mattoscio D,Isopi E

更新日期：2019-04-02 00:00:00

abstract：:Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare the in vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles of conventional (LUV VAN), fusogenic (LUVfuso VAN), and cationic (LUVcat VAN) liposomes e...

journal_title：Frontiers in pharmacology

authors： Scriboni AB,Couto VM,Ribeiro LNM,Freires IA,Groppo FC,de Paula E,Franz-Montan M,Cogo-Müller K

更新日期：2019-11-29 00:00:00

abstract：:The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

journal_title：Frontiers in pharmacology

authors： Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

更新日期：2019-04-05 00:00:00

abstract：:The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and ubiquitous volume-...

journal_title：Frontiers in pharmacology

authors： Behe P,Foote JR,Levine AP,Platt CD,Chou J,Benavides F,Geha RS,Segal AW

更新日期：2017-05-12 00:00:00

abstract：:Cissus quadrangularis (C. quadrangularis) is a plant of the Vitaceae family known for its anticonvulsant effects in traditional medicine. The objective of this study was to elucidate the anxiolytic and antiepileptic effects of aqueous extract of C. quadrangularis. The mice were divided into different groups and treate...

journal_title：Frontiers in pharmacology

authors： Moto FCO,Arsa'a A,Ngoupaye GT,Taiwe GS,Njapdounke JSK,Kandeda AK,Nkantchoua GCN,Omam Omam JP,Pale S,Kouemou NE,Ayissi Mbomo ER,Pahaye DB,Ojong L,Mairara V,Ngo Bum E

更新日期：2018-07-17 00:00:00

abstract：:Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcu...

journal_title：Frontiers in pharmacology

authors： Li J,Niu C,Jiang Z,Zhang Z,Pan Y,Xing Q,Guo Q,An S,Hu Y,Wang L

更新日期：2020-12-04 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

journal_title：Frontiers in pharmacology

authors： Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

更新日期：2020-01-24 00:00:00

abstract：:Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. In addition, it is now known that astrocytic Kir4.1 channels are closely involved in the pathogenesis of epilepsy. Here, to explore the role ...

journal_title：Frontiers in pharmacology

authors： Mukai T,Kinboshi M,Nagao Y,Shimizu S,Ono A,Sakagami Y,Okuda A,Fujimoto M,Ito H,Ikeda A,Ohno Y

更新日期：2018-08-06 00:00:00

abstract：INTRODUCTION:Nicotinic acetylcholine receptors are present in the cerebral white matter (WM). We hypothesized that WM response to nicotine can be detected by diffusion tensor imaging (DTI); and that such responses may be associated with nicotine-led cognitive enhancement in sustained attention. METHODS:A randomized, n...

journal_title：Frontiers in pharmacology

authors： Kochunov P,Du X,Moran LV,Sampath H,Wijtenburg SA,Yang Y,Rowland LM,Stein EA,Hong LE

更新日期：2013-09-18 00:00:00

abstract：:We aimed to ascertain the mechanism underlying the effects of acteoside (ACT) from Ligustrum robustum (Roxb.) Blume (Oleaceae) on lipid metabolism and synthesis. ACT, a water-soluble phenylpropanoid glycoside, is the most abundant and major active component of L. robustum; the leaves of L. robustum, known as kudingcha...

journal_title：Frontiers in pharmacology

authors： Sun L,Yu F,Yi F,Xu L,Jiang B,Le L,Xiao P

更新日期：2019-05-24 00:00:00

abstract：:Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

journal_title：Frontiers in pharmacology

authors： Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

更新日期：2018-02-13 00:00:00

abstract：:Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects ...

journal_title：Frontiers in pharmacology

authors： Arora A,Bhuria V,Hazari PP,Pathak U,Mathur S,Roy BG,Sandhir R,Soni R,Dwarakanath BS,Bhatt AN

更新日期：2018-04-24 00:00:00