Abstract:
:Background: No risk model for predicting thrombocytopenia associated with periprocedural tirofiban exposure is available. The purpose of this study was to develop a simple clinical pre-procedure risk model based on pre-procedural characteristics for early prediction of thrombocytopenia before patients were exposed to tirofiban. Methods: The series included 1862 patients who underwent percutaneous coronary intervention with tirofiban exposure. Baseline demographic and clinical characteristics were collected from the hospital information system on admission. The earliest pro-procedural platelets within 72 h were used to evaluate the thrombocytopenia incidence. Risk factors associated with thrombocytopenia in patients with tirofiban exposure were investigated by univariable and multivariable analyses. Locally weighted scatterplot smoothing procedure was used to identify the cut points for the numeric variables. The discriminatory power of the scoring system was assessed with the receiver operating characteristic (ROC) curve analysis. Results: The occurrence of thrombocytopenia was 4.02% (75 of 1862), 4.01% (56 of 1396), and 4.08% (19 of 466) in the overall, developmental, and validation data sets, respectively. The risk score was developed based on five independent predictors: age ≥65y, white blood cell ≥12 × 109/L, diabetes mellitus, congestive heart failure, and chronic kidney disease. This tool was well calibrated (Hosmer Lemeshow χ2 = 6.914; P = 0.546) and good discrimination was well obtained in validation data set (C-statistic, 0.82). Conclusion: The clinical pre-procedure risk model is a simple and accurate tool for early identification of high-risk patients of thrombocytopenia before tirofiban exposure, allowing for timely and appropriate intervention.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Yi YH,Yin WJ,Gu ZC,Fang WJ,Li DY,Hu C,Liu K,Ma RR,Zhou LYdoi
10.3389/fphar.2018.01456subject
Has Abstractpub_date
2018-12-10 00:00:00pages
1456issn
1663-9812journal_volume
9pub_type
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journal_title:Frontiers in pharmacology
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章,评审
doi:10.3389/fphar.2018.00102
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journal_title:Frontiers in pharmacology
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doi:10.3389/fphar.2018.00377
更新日期:2018-04-19 00:00:00
abstract::Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...
journal_title:Frontiers in pharmacology
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更新日期:2020-05-08 00:00:00
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2017.00688
更新日期:2017-09-26 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3389/fphar.2016.00327
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doi:10.3389/fphar.2019.01397
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-12-04 00:00:00
abstract::Ethanol-induced gastric mucosal injury is a common gastrointestinal disorder. Polysaccharides separated from herbs have been shown to be effective for ethanol-induced gastric mucosal injury, but whether the polysaccharides from Dendrobium officinale Kimura & Migo leaves (LDOP-1) protected mucosa from ethanol-induced i...
journal_title:Frontiers in pharmacology
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更新日期:2020-11-11 00:00:00
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章
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doi:10.3389/fphar.2017.00812
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pub_type: 杂志文章,评审
doi:10.3389/fphar.2018.01260
更新日期:2018-11-02 00:00:00
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