Polysaccharides of Dendrobium officinale Kimura & Migo Leaves Protect Against Ethanol-Induced Gastric Mucosal Injury via the AMPK/mTOR Signaling Pathway in Vitro and vivo.

abstract：:Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

journal_title：Frontiers in pharmacology

authors： Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

更新日期：2019-12-06 00:00:00

abstract：:Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hosp...

journal_title：Frontiers in pharmacology

authors： Mazzotta E,Villalobos-Hernandez EC,Fiorda-Diaz J,Harzman A,Christofi FL

更新日期：2020-11-24 00:00:00

abstract：:One of the most difficult challenges in clinical hepatology is the diagnosis of a drug-induced liver injury (DILI). The timing of the events, exclusion of alternative causes, and taking into account the clinical context should be systematically assessed and scored in a transparent manner. RUCAM (Roussel Uclaf Causalit...

journal_title：Frontiers in pharmacology

authors： Teschke R

更新日期：2019-07-23 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

journal_title：Frontiers in pharmacology

authors： Rapoport RM,Merkus D

更新日期：2017-10-24 00:00:00

abstract：:There is an urgent unmet need to develop new therapeutics for lung squamous cell carcinoma (LSCC) as the current gold standard treatment regimens are dominated by chemotherapy. In this study, we observed the treatment effects of the natural compound tambulin on LSCC and explored its mechanism of action. LSCC cell line...

journal_title：Frontiers in pharmacology

authors： Wang W,Liu Y,Zhao L

更新日期：2020-08-12 00:00:00

abstract：:Fasudil, a Rho-kinase inhibitor, has shown outstanding therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH) in humans. Studies show various biological effects of fasudil in the cardiovascular system. We conducted a preclinical systematic review to determine the efficacy and possible mecha...

journal_title：Frontiers in pharmacology

authors： Huang YY,Wu JM,Su T,Zhang SY,Lin XJ

更新日期：2018-10-01 00:00:00

abstract：:Diabetes is affecting the social and economic developments in developing countries like Sri Lanka. Siddha Medicine (Tamil Medicine) is mostly practiced in the Eastern and Northern Provinces of Sri Lanka. Our recent review of Sri Lankan Siddha historical documents identified 171 plant species used to prepare anti-diabe...

journal_title：Frontiers in pharmacology

authors： Sathasivampillai SV,Rajamanoharan PRS,Heinrich M

更新日期：2018-10-10 00:00:00

abstract：:Extracellular vesicles (EVs) are currently being considered as promising drug delivery vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to serve as drug delivery vehicles. In addition, EVs have inherent properties for treatment of cancers and other diseases. For research and c...

journal_title：Frontiers in pharmacology

authors： Gangadaran P,Hong CM,Ahn BC

更新日期：2018-02-28 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Previous studies compared the molecular similarity of marketed drugs and endogenous human metabolites (endogenites), using a series of fingerprint-type encodings, variously ranked and clustered using the Tanimoto (Jaccard) similarity coefficient (TS). Because this gives equal weight to all parts of the encod...

journal_title：Frontiers in pharmacology

authors： O'Hagan S,Kell DB

更新日期：2016-08-22 00:00:00

abstract：:Background: Details of the extraction and purification procedure can have a profound impact on the composition of plant-derived extracts, and thus on their efficacy and safety. So far, studies with head-to-head comparison of the pharmacology of Ginkgo extracts rendered by different procedures have been rare. Objective...

journal_title：Frontiers in pharmacology

authors： Bader BM,Jügelt K,Schultz L,Schroeder OH

更新日期：2018-08-03 00:00:00

abstract：:Lead is a multi-organ toxicant implicated in various cancers, diseases of the hepatic, renal, and reproductive systems etc. In search of cheap and readily available antidote this study has investigated the role of activated charcoal in chronic lead exposure in albino rats. Eighteen mature male albino rats were used, d...

journal_title：Frontiers in pharmacology

authors： Offor SJ,Mbagwu HO,Orisakwe OE

更新日期：2017-03-14 00:00:00

abstract：:Cancer stem cells are involved in cancer establishment, progression, and resistance to current treatments. We demonstrated the in vitro and in vivo anti-breast cancer effect of bakuchiol in a previous study. However, the ability of bakuchiol to target breast cancer stem cells (BCSCs) and inhibit breast cancer metastas...

journal_title：Frontiers in pharmacology

authors： Li L,Liu CC,Chen X,Xu S,Hernandez Cortes-Manno S,Cheng SH

更新日期：2017-10-18 00:00:00

abstract：:Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholester...

journal_title：Frontiers in pharmacology

authors： Režen T,Ogris I,Sever M,Merzel F,Golic Grdadolnik S,Rozman D

更新日期：2017-06-30 00:00:00

abstract：:Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...

journal_title：Frontiers in pharmacology

authors： Kubota K,Fukue H,Sato H,Hashimoto K,Fujikane A,Moriyama H,Watanabe T,Katsurabayashi S,Kainuma M,Iwasaki K

更新日期：2017-11-21 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rhizoma Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects of TFRD on type H vessels, angiogenic-osteogenic coupling ...

journal_title：Frontiers in pharmacology

authors： Shen Z,Chen Z,Li Z,Zhang Y,Jiang T,Lin H,Huang M,Chen H,Feng J,Jiang Z

更新日期：2020-11-27 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

journal_title：Frontiers in pharmacology

authors： Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

更新日期：2019-02-04 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is characterized by inflammation and fibrosis, in addition to steatosis, of the liver, but no therapeutic agents have yet been established. The mast cell protease chymase can generate angiotensin II, matrix metalloproteinase-9 and transforming growth factor-β, all of which are asso...

journal_title：Frontiers in pharmacology

authors： Takai S,Jin D

更新日期：2018-02-21 00:00:00

abstract：:The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although...

journal_title：Frontiers in pharmacology

authors： Kunzelmann K,Ousingsawat J,Cabrita I,Doušová T,Bähr A,Janda M,Schreiber R,Benedetto R

更新日期：2019-01-29 00:00:00

abstract：:P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5'-RACE. A 1.9-kb fra...

journal_title：Frontiers in pharmacology

authors： Guo T,Huang J,Huan C,He F,Zhang Y,Bhutto ZA,Wang L

更新日期：2018-05-04 00:00:00

abstract：:Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, ...

journal_title：Frontiers in pharmacology

authors： Mallet N,Leblois A,Maurice N,Beurrier C

更新日期：2019-12-13 00:00:00

abstract：INTRODUCTION:European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. OBJECTIVE:To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future gui...

journal_title：Frontiers in pharmacology

authors： Godman B,Shrank W,Andersen M,Berg C,Bishop I,Burkhardt T,Garuoliene K,Herholz H,Joppi R,Kalaba M,Laius O,Lonsdale J,Malmström RE,Martikainen JE,Samaluk V,Sermet C,Schwabe U,Teixeira I,Tilson L,Tulunay FC,Vlahović-

更新日期：2011-01-07 00:00:00

abstract：:There is growing evidence that the metabolic network is an integral regulator of cellular physiology. Dynamic changes in metabolite concentrations, metabolic flux, or network topology act as reporters of biological or environmental signals, and are required for the cell to trigger an appropriate biological reaction. C...

journal_title：Frontiers in pharmacology

authors： Ralser M,Michel S,Breitenbach M

更新日期：2012-03-08 00:00:00

abstract：AIMS:Myocardial ischemia can result in marked mitochondrial damage leading to cardiac dysfunction, as such identifying novel mechanisms to limit mitochondrial injury is important. This study investigated the hypothesis that inhibiting soluble epoxide hydrolase (sEH), responsible for converting epoxyeicosatrienoic acids...

journal_title：Frontiers in pharmacology

authors： Akhnokh MK,Yang FH,Samokhvalov V,Jamieson KL,Cho WJ,Wagg C,Takawale A,Wang X,Lopaschuk GD,Hammock BD,Kassiri Z,Seubert JM

更新日期：2016-06-07 00:00:00

abstract：:Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Ca...

journal_title：Frontiers in pharmacology

authors： Lashmanova E,Zemskaya N,Proshkina E,Kudryavtseva A,Volosnikova M,Marusich E,Leonov S,Zhavoronkov A,Moskalev A

更新日期：2017-12-07 00:00:00

abstract：:The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before...

journal_title：Frontiers in pharmacology

authors： Puiu AA,Radke S,Votinov M,Habel U,Herpertz-Dahlmann B,Turetsky B,Konrad K

更新日期：2019-11-21 00:00:00

abstract：:Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described - OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), and OAT2 transcript variant 3 (OAT2-tv3). Early studies helping to define the liga...

journal_title：Frontiers in pharmacology

authors： Hotchkiss AG,Berrigan L,Pelis RM

更新日期：2015-10-06 00:00:00

abstract：Background:Immunosuppressant non-adherence is a widespread problem among solid organ recipients. With the newly published clinical trials, the randomized controlled trials (RCTs) based systematic review of adherence-enhancing interventions on immunosuppressant adherence in solid organ recipients has not been completed....

journal_title：Frontiers in pharmacology

authors： Shi YX,Liu CX,Liu F,Zhang HM,Yu MM,Jin YH,Shang SM,Fu YX

更新日期：2020-10-20 00:00:00