Mechanistic Study of Bakuchiol-Induced Anti-breast Cancer Stem Cell and in Vivo Anti-metastasis Effects.

abstract：:The present paper continues a more complex research related to the increased synergism in terms of both anti-inflammatory and analgesic effect obtained by the addition of chlorpheniramine (CLF) to the common acetylsalicylic acid (ASA), acetaminophen (PAR), and caffeine (CAF) combination. This synergistic effect was pr...

journal_title：Frontiers in pharmacology

authors： Voicu VA,Mircioiu C,Plesa C,Jinga M,Balaban V,Sandulovici R,Costache AM,Anuta V,Mircioiu I

更新日期：2019-06-20 00:00:00

abstract：:Objective: Advanced age is associated with impaired angiogenesis in part because of mitochondrial dysfunction. We have recently reported that leonurine exerts protective effects in neuron via regulation of mitochondrial function. The aim of this study was to explore whether leonurine is able to attenuate mitochondrial...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang JJ,Duan JL,Lu ZY,Yuan YG

更新日期：2017-06-06 00:00:00

abstract：:Background: D-dimer is a small protein fragment and high levels of D-dimer have been associated with increased mortality in patients presenting to emergency departments with infection. Previous studies have reported increased levels of D-dimer in COVID-19; however, it is unclear whether an increased D-dimer level prov...

journal_title：Frontiers in pharmacology

authors： Li J,Liu Z,Wu G,Yi M,Chen Y,Li K,Xu X,Xiao L,Wu Q,Chen J,Wu X

更新日期：2020-12-21 00:00:00

abstract：:Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects. Methods: The pharmacokinetic profiles of ticagrelor and it...

journal_title：Frontiers in pharmacology

authors： Zhu Q,Zhong W,Wang X,Mai L,He G,Chen J,Tang L,Liu S,Lai W,Zhong S

更新日期：2019-03-18 00:00:00

abstract：:Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2) (+)-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser(16) by PKA or Thr(17) by Ca(2) (+)-calmodulin-dependent protei...

journal_title：Frontiers in pharmacology

authors： Mattiazzi A,Kranias EG

更新日期：2014-01-27 00:00:00

abstract：:Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...

journal_title：Frontiers in pharmacology

authors： Jiang X,Li Y,Wang W,Han X,Han J,Chen M,Zhang J,Wang C,Li S,Luo J,Wang X,Xu Y,Xu Y,Cheng J,Si S

更新日期：2020-11-16 00:00:00

abstract：:In Mexico, the Adenophyllum aurantium (L.) Strother plant is consumed as an infusion to treat intestinal diseases such as amoebiasis, which is an endemic health problem in Mexico and other countries. However, the effect of A. aurantium on Entamoeba histolytica, the causative agent of amoebiasis, is unknown. An aerial ...

journal_title：Frontiers in pharmacology

authors： Herrera-Martínez M,Hernández-Ramírez VI,Hernández-Carlos B,Chávez-Munguía B,Calderón-Oropeza MA,Talamás-Rohana P

更新日期：2016-06-27 00:00:00

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：:The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over acti...

journal_title：Frontiers in pharmacology

authors： Arshad L,Jantan I,Bukhari SN,Haque MA

更新日期：2017-01-30 00:00:00

abstract：:Local people in the Sudhnoti district of Pakistan share a rich practice of traditional medicine for the treatment of a variety of ailments. We selected nine plants from the Sudhnoti ethnopharmacological tradition used for the treatment of infectious and inflammatory disease. Our aim was to evaluate the in vitro anti-i...

journal_title：Frontiers in pharmacology

authors： Khan MF,Tang H,Lyles JT,Pineau R,Mashwani ZU,Quave CL

更新日期：2018-08-02 00:00:00

abstract：Background:Emerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction, an early marker for atherosclerosis. In addition, intercellular...

journal_title：Frontiers in pharmacology

authors： Ramadan R,Vromans E,Anang DC,Goetschalckx I,Hoorelbeke D,Decrock E,Baatout S,Leybaert L,Aerts A

更新日期：2020-03-05 00:00:00

abstract：:Product mislabeling and/or species fraud in Traditional Chinese Medicine (TCM) not only decrease TCM quality, but also pose a potential health issue to the end user. Up to now, methods to control TCM quality have been developed to detect specific metabolites or identify the original species. However, species quantific...

journal_title：Frontiers in pharmacology

authors： Zhao B,Xiong C,Li J,Zhang D,Shi Y,Sun W,Duan X

更新日期：2020-11-26 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:Salmonella typhimurium is a highly transmissible pathogen in rabbits that causes significant losses. Danofloxacin shows excellent efficacy against S. typhimurium infections. However, there are few reports of the pharmacokinetic/pharmacodynamic (PK/PD) modeling of danofloxacin against this pathogen. The aim of this stu...

journal_title：Frontiers in pharmacology

authors： Xiao X,Pei L,Jiang LJ,Lan WX,Xiao JY,Jiang YJ,Wang ZQ

更新日期：2018-04-17 00:00:00

abstract：Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

journal_title：Frontiers in pharmacology

authors： Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

更新日期：2020-01-31 00:00:00

abstract：:Despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (ALS) no novel disease-modifying therapies have been successfully implemented in clinical routine. Riluzole still remains the only clinically approved substance in human ALS treatment with limited effic...

journal_title：Frontiers in pharmacology

authors： Günther R,Balck A,Koch JC,Nientiedt T,Sereda M,Bähr M,Lingor P,Tönges L

更新日期：2017-01-31 00:00:00

abstract：:The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated...

journal_title：Frontiers in pharmacology

authors： Thomas M,Winter S,Klumpp B,Turpeinen M,Klein K,Schwab M,Zanger UM

更新日期：2015-11-04 00:00:00

abstract：:Purpose: This study aimed to identify the active components of Fuzheng Huayu (FZHY) formula and the mechanism by which they inhibit the viability of hepatic stellate cells (HSCs) by a combination of network pharmacology and transcriptomics. Methods: The active components of FZHY formula were screened out by text minin...

journal_title：Frontiers in pharmacology

authors： Xing X,Chen S,Li L,Cao Y,Chen L,Wang X,Zhu Z

更新日期：2018-05-24 00:00:00

abstract：:Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...

journal_title：Frontiers in pharmacology

authors： Wu H,Yang Y,Guo S,Yang J,Jiang K,Zhao G,Qiu C,Deng G

更新日期：2017-12-21 00:00:00

abstract：:In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and prepara...

journal_title：Frontiers in pharmacology

authors： Ning Z,Wang C,Liu Y,Song Z,Ma X,Liang D,Liu Z,Lu A

更新日期：2018-12-18 00:00:00

abstract：:Accumulation of methylglyoxal (MG) contributes to oxidative stress, apoptosis, and mitochondrial dysfunction, leading to the development of type 2 diabetes and cardiovascular diseases. Inhibition of mitochondrial abnormalities induced by MG in the heart may improve and delay the progression of heart failure. Although ...

journal_title：Frontiers in pharmacology

authors： Nuamnaichati N,Mangmool S,Chattipakorn N,Parichatikanond W

更新日期：2020-05-29 00:00:00

abstract：:Cerebral energy deficiency is a key pathophysiologic cascade that results in neuronal injury and necrosis after ischemic stroke. Shengui Sansheng San (SSS) has been used to treat stroke for more than 300 years. In present study, we investigated the therapeutic efficacy and mechanism of SSS extraction on cerebral energ...

journal_title：Frontiers in pharmacology

authors： Luo C,Bian X,Zhang Q,Xia Z,Liu B,Chen Q,Ke C,Wu JL,Zhao Y

更新日期：2019-04-23 00:00:00

abstract：:A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's disease, Huntington disease, amyotrophic lateral sclerosis, Friedrich's ataxia and Parkinson'...

journal_title：Frontiers in pharmacology

authors： Urrutia PJ,Mena NP,Núñez MT

更新日期：2014-03-10 00:00:00

abstract：:The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of...

journal_title：Frontiers in pharmacology

authors： Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

更新日期：2020-12-10 00:00:00

abstract：:[This corrects the article on p. 727 in vol. 8, PMID: 29114222.]. ...

journal_title：Frontiers in pharmacology

authors： Qiao L,Zhang X,Liu M,Liu X,Dong M,Cheng J,Zhang X,Zhai C,Song Y,Lu H,Chen W

更新日期：2018-01-09 00:00:00

abstract：:Exhaustive exercise has emerged as an important health issue nowadays. This study was designed to assess the metabolite abnormalities of rats after exhaustive exercise and the holistic efficacy of Chinese medicine Sanqi oral solution (SQ). Through exhaustive swimming, the exhaustive exercise model in rats was establis...

journal_title：Frontiers in pharmacology

authors： Xu P,Li S,Tian R,Han L,Mao W,Li L,Li C,Wang Y,Luo G,Yang N

更新日期：2019-07-04 00:00:00

abstract：:Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

journal_title：Frontiers in pharmacology

authors： Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

更新日期：2018-06-15 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

journal_title：Frontiers in pharmacology

authors： Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

更新日期：2020-08-12 00:00:00

abstract：:[This corrects the article on p. 216 in vol. 5, PMID: 25295006.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Production Office.

更新日期：2014-11-19 00:00:00