Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone.

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：:Recently, the use of plant-derived medicines is increasing interest in the prevention and treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is one of the major risk factors for cardiovascular diseases (CVDs) and incidence of mortality worldwide. Scientific evidence suggests that And...

journal_title：Frontiers in pharmacology

authors： Islam MT

更新日期：2017-08-23 00:00:00

abstract：:[This corrects the article on p. 648 in vol. 8, PMID: 28959205.]. ...

journal_title：Frontiers in pharmacology

authors： Zhong ZF,Yu HB,Wang CM,Qiang WA,Wang SP,Zhang JM,Yu H,Cui L,Wu T,Li DQ,Wang YT

更新日期：2017-12-18 00:00:00

abstract：:Background and Aims: Targeting inflammation is nowadays considered as a challenging pharmacological strategy to prevent or delay the development of vascular diseases. Angiotensin-(1-7) is a member of the renin-angiotensin system (RAS) that binds Mas receptors and has gained growing attention in the last years as a reg...

journal_title：Frontiers in pharmacology

authors： Villalobos LA,San Hipólito-Luengo Á,Ramos-González M,Cercas E,Vallejo S,Romero A,Romacho T,Carraro R,Sánchez-Ferrer CF,Peiró C

更新日期：2016-12-15 00:00:00

abstract：:Several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for retinaldehyde is...

journal_title：Frontiers in pharmacology

authors： Ruiz FX,Porté S,Parés X,Farrés J

更新日期：2012-04-17 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment that increasingly afflicts the elderly population. Soluble oligomers (AβOs) has been implicated in AD pathogenesis: however, the molecular events underlying a role for Aβ are not well understood. We studied the effects of Aβ...

journal_title：Frontiers in pharmacology

authors： Panes JD,Godoy PA,Silva-Grecchi T,Celis MT,Ramirez-Molina O,Gavilan J,Muñoz-Montecino C,Castro PA,Moraga-Cid G,Yévenes GE,Guzmán L,Salisbury JL,Trushina E,Fuentealba J

更新日期：2020-05-21 00:00:00

abstract：:Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-O-methyl RNA (2'-OMe-RNA) and phosphoryl guanidine ol...

journal_title：Frontiers in pharmacology

authors： Novopashina D,Vorobyeva M,Nazarov A,Davydova A,Danilin N,Koroleva L,Matveev A,Bardasheva A,Tikunova N,Kupryushkin M,Pyshnyi D,Altman S,Venyaminova A

更新日期：2019-07-19 00:00:00

abstract：:Aim: Little is known regarding the relationship between use of oral corticosteroids and hip fracture in the elderly in Taiwan. The aim of the study was to examine this issue. Methods: A retrospective population-based case-control study using the database of the Taiwan National Health Insurance Program (2000-2013) was ...

journal_title：Frontiers in pharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2017-09-11 00:00:00

abstract：:Deregulated activity of the Src tyrosine kinases leads to malignant transformation. Since the FDA approval of the tyrosine kinase inhibitor, imatinib, in 2001 for the treatment of chronic myeloid leukemia (CML), the number of these inhibitors together with Src tyrosine kinase inhibitors (STKIs) has increased notably d...

journal_title：Frontiers in pharmacology

authors： Rivera-Torres J,San José E

更新日期：2019-09-18 00:00:00

abstract：:ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggre...

journal_title：Frontiers in pharmacology

authors： Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C

更新日期：2018-12-04 00:00:00

abstract：:Introduction: Over the past decades, early awareness and alert (EAA) activities and systems have gained importance and become a key early health technology assessment (HTA) tool. While a pioneer in HTA, Sweden had no national level EAA activities until 2010. We describe the evolution and current status of the Swedish ...

journal_title：Frontiers in pharmacology

authors： Eriksson I,Wettermark B,Persson M,Edström M,Godman B,Lindhé A,Malmström RE,Ramström H,von Euler M,Bergkvist Christensen A

更新日期：2017-10-05 00:00:00

abstract：:Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

journal_title：Frontiers in pharmacology

authors： Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

更新日期：2018-01-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00512.]. ...

journal_title：Frontiers in pharmacology

authors： Jiang YH,Jiang LY,Wang YC,Ma DF,Li X

更新日期：2020-05-29 00:00:00

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

journal_title：Frontiers in pharmacology

authors： Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

更新日期：2020-01-31 00:00:00

abstract：:It is currently thought that the dementia of Alzheimer's disease is due to the neurotoxicity of the deposits or aggregates of amyloid-β (Aβ) in the extracellular space of the cerebral cortex. This model has been widely criticized because there is a poor correlation between deposits and dementia. Others have questioned...

journal_title：Frontiers in pharmacology

authors： Holtzman JL

更新日期：2013-05-13 00:00:00

abstract：:Fasudil, a Rho-kinase inhibitor, has shown outstanding therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH) in humans. Studies show various biological effects of fasudil in the cardiovascular system. We conducted a preclinical systematic review to determine the efficacy and possible mecha...

journal_title：Frontiers in pharmacology

authors： Huang YY,Wu JM,Su T,Zhang SY,Lin XJ

更新日期：2018-10-01 00:00:00

abstract：Background:Salvianolate, a compound mainly composed of salvia magnesium acetate, is extracted from the Chinese herb Salvia miltiorrhiza. Because of its biological activity, easy quality control and certain efficacy, salvianolate is widely used in treating ischemic cardiocerebral vascular disease, liver damage, renal in...

journal_title：Frontiers in pharmacology

authors： Shen Y,Wang S,Liu Y,Ge L,Xia L,Zhang X,Miao Y,Shen J,Zhou Q

更新日期：2020-06-12 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited cell proliferation...

journal_title：Frontiers in pharmacology

authors： Hsu JL,Leu WJ,Hsu LC,Liu SP,Zhong NS,Guh JH

更新日期：2018-11-13 00:00:00

abstract：:Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and scientific interest about therapeutic properties of these compounds for the treatment of several neurologic diseases, not just epilepsy. The discovered role of the endocannabinoid system in epile...

journal_title：Frontiers in pharmacology

authors： Raucci U,Pietrafusa N,Paolino MC,Di Nardo G,Villa MP,Pavone P,Terrin G,Specchio N,Striano P,Parisi P

更新日期：2020-09-29 00:00:00

abstract：:Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

journal_title：Frontiers in pharmacology

authors： McVicker BL,Bennett RG

更新日期：2017-05-31 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

journal_title：Frontiers in pharmacology

authors： Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

更新日期：2017-04-04 00:00:00

abstract：Background:Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration ...

journal_title：Frontiers in pharmacology

authors： Ortner M,Stange M,Schneider H,Schroeder C,Buerger K,Müller C,Dorn B,Goldhardt O,Diehl-Schmid J,Förstl H,Steimer W,Grimmer T

更新日期：2020-05-21 00:00:00

abstract：:Localized neuropathic pain can be relieved following the topical application of high-concentration capsaicin. This clinical effect is thought to be related to the temporary desensitization of capsaicin- and heat-sensitive epidermal nociceptors. The objective of the present study was to examine whether the changes in t...

journal_title：Frontiers in pharmacology

authors： van Neerven SGA,Mouraux A

更新日期：2020-05-19 00:00:00

abstract：:Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...

journal_title：Frontiers in pharmacology

authors： Liu G,An L,Zhang H,Du P,Sheng Y

更新日期：2019-03-28 00:00:00

abstract：:Purpose: This study aimed to identify the active components of Fuzheng Huayu (FZHY) formula and the mechanism by which they inhibit the viability of hepatic stellate cells (HSCs) by a combination of network pharmacology and transcriptomics. Methods: The active components of FZHY formula were screened out by text minin...

journal_title：Frontiers in pharmacology

authors： Xing X,Chen S,Li L,Cao Y,Chen L,Wang X,Zhu Z

更新日期：2018-05-24 00:00:00

abstract：:P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5'-RACE. A 1.9-kb fra...

journal_title：Frontiers in pharmacology

authors： Guo T,Huang J,Huan C,He F,Zhang Y,Bhutto ZA,Wang L

更新日期：2018-05-04 00:00:00

abstract：:Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. "Resistance to chemotherapy," however, is a ...

journal_title：Frontiers in pharmacology

authors： El-Awady R,Saleh E,Hashim A,Soliman N,Dallah A,Elrasheed A,Elakraa G

更新日期：2017-01-10 00:00:00