Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering.


:Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiological bone healing procedures, the sustained release of bioactive molecules plays a vital role in creating an optimal osteogenic microenvironment and achieving promising bone repair outcomes. The utilization of biomaterial scaffolds can positively affect the osteogenesis process by integrating cells with bioactive factors in a proper way. A high water content, tunable physio-mechanical properties, and diverse synthetic strategies make hydrogels ideal cell carriers and controlled drug release reservoirs. Herein, we reviewed the current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE).


Front Pharmacol


Zhang Y,Yu T,Peng L,Sun Q,Wei Y,Han B




Has Abstract


2020-05-06 00:00:00








  • Nuciferine Ameliorates Inflammatory Responses by Inhibiting the TLR4-Mediated Pathway in Lipopolysaccharide-Induced Acute Lung Injury.

    abstract::Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu H,Yang Y,Guo S,Yang J,Jiang K,Zhao G,Qiu C,Deng G

    更新日期:2017-12-21 00:00:00

  • Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing-Using Rifampicin as an Example.

    abstract::Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitude of IOV in rifamp...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Keutzer L,Simonsson USH

    更新日期:2020-05-27 00:00:00

  • A Simple Clinical Pre-procedure Risk Model for Predicting Thrombocytopenia Associated With Periprocedural Use of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention.

    abstract::Background: No risk model for predicting thrombocytopenia associated with periprocedural tirofiban exposure is available. The purpose of this study was to develop a simple clinical pre-procedure risk model based on pre-procedural characteristics for early prediction of thrombocytopenia before patients were exposed to ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yi YH,Yin WJ,Gu ZC,Fang WJ,Li DY,Hu C,Liu K,Ma RR,Zhou LY

    更新日期:2018-12-10 00:00:00

  • Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma.

    abstract::Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

    更新日期:2019-10-22 00:00:00

  • Propoxyphene Mediates Oxyhemoglobin-Induced Injury in Rat Cortical Neurons Through Up-Regulation of Active-β-Catenin.

    abstract::Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

    更新日期:2020-01-30 00:00:00

  • Short-Term Efficacy and Tolerability of Paroxetine Versus Placebo for Panic Disorder: A Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods:Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the...

    journal_title:Frontiers in pharmacology



    authors: Zhang B,Wang C,Cui L,Gao J,Wang C,Tan X,Fang S

    更新日期:2020-03-31 00:00:00

  • ATC-NLSP: Prediction of the Classes of Anatomical Therapeutic Chemicals Using a Network-Based Label Space Partition Method.

    abstract::Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

    更新日期:2019-09-05 00:00:00

  • Nanotherapeutics to Modulate the Compromised Micro-Environment for Lung Cancers and Chronic Obstructive Pulmonary Disease.

    abstract::The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Seshadri DR,Ramamurthi A

    更新日期:2018-07-16 00:00:00

  • Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease.

    abstract::Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System medicine showed pr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lyu M,Zhou Z,Wang X,Lv H,Wang M,Pan G,Wang Y,Fan G,Gao X,Feng Y,Zhu Y

    更新日期:2018-12-13 00:00:00

  • Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick.

    abstract::Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5-HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and inhibition at higher doses. The non-selective 5-HT receptor antagonist me...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Gibbs ME,Hertz L

    更新日期:2014-04-01 00:00:00

  • Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.

    abstract::Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

    更新日期:2017-06-08 00:00:00

  • Gyejibongnyeong-Hwan (Gui Zhi Fu Ling Wan) Ameliorates Human Uterine Myomas via Apoptosis.

    abstract::Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated. In Korea and China, Gyejibongnyeong-hwan (GBH) is widely used to treat gynecological diseases. Thus, we investigated the effects of GBH in human uteri...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lee SM,Choi ES,Ha E,Ji KY,Shin SJ,Jung J

    更新日期:2019-09-25 00:00:00

  • Anxiolytic and Antiepileptic Properties of the Aqueous Extract of Cissus quadrangularis (Vitaceae) in Mice Pilocarpine Model of Epilepsy.

    abstract::Cissus quadrangularis (C. quadrangularis) is a plant of the Vitaceae family known for its anticonvulsant effects in traditional medicine. The objective of this study was to elucidate the anxiolytic and antiepileptic effects of aqueous extract of C. quadrangularis. The mice were divided into different groups and treate...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Moto FCO,Arsa'a A,Ngoupaye GT,Taiwe GS,Njapdounke JSK,Kandeda AK,Nkantchoua GCN,Omam Omam JP,Pale S,Kouemou NE,Ayissi Mbomo ER,Pahaye DB,Ojong L,Mairara V,Ngo Bum E

    更新日期:2018-07-17 00:00:00

  • Metabonomic Analysis of the Therapeutic Effects of Chinese Medicine Sanqi Oral Solution on Rats With Exhaustive Exercise.

    abstract::Exhaustive exercise has emerged as an important health issue nowadays. This study was designed to assess the metabolite abnormalities of rats after exhaustive exercise and the holistic efficacy of Chinese medicine Sanqi oral solution (SQ). Through exhaustive swimming, the exhaustive exercise model in rats was establis...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xu P,Li S,Tian R,Han L,Mao W,Li L,Li C,Wang Y,Luo G,Yang N

    更新日期:2019-07-04 00:00:00

  • Risk Factors of Hypersensitivity to Carboplatin in Patients with Gynecologic Malignancies.

    abstract::We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combina...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Tai YH,Tai YJ,Hsu HC,Lee SP,Chen YY,Chiang YC,Chen YL,Chen CA,Cheng WF

    更新日期:2017-11-06 00:00:00

  • MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway.

    abstract::This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wang C,Liu E,Li W,Cui J,Li T

    更新日期:2018-12-11 00:00:00

  • Harnessing the Power of Optical Microscopic and Macroscopic Imaging for Natural Products as Cancer Therapeutics.

    abstract::Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

    更新日期:2019-11-28 00:00:00

  • TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

    abstract::The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Kunzelmann K,Ousingsawat J,Cabrita I,Doušová T,Bähr A,Janda M,Schreiber R,Benedetto R

    更新日期:2019-01-29 00:00:00

  • The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age.

    abstract::Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Gu ZC,Shi FH,Zhu J,Wan F,Shen L,Li H

    更新日期:2019-01-15 00:00:00

  • Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone.

    abstract::Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Rapoport RM,Merkus D

    更新日期:2017-10-24 00:00:00

  • Extracted Triterpenes from Antrodia cinnamomea Reduce the Inflammation to Promote the Wound Healing via the STZ Inducing Hyperglycemia-Diabetes Mice Model.

    abstract::This research evaluated the effects of triterpenes on the regulation of STZ-induced hyperglycaemic diabetes through an anti-inflammatory response. Diabetic mice were orally administered various concentrations of triterpenes on a daily basis. Weight gain, volume of drinking water, and liver and spleen weight were recor...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Wu YS,Chen SN

    更新日期:2016-06-13 00:00:00

  • A Preliminary, Multicenter, Prospective and Real World Study on the Hemostasis, Coagulation, and Safety of Hemocoagulase Bothrops Atrox in Patients Undergoing Transurethral Bipolar Plasmakinetic Prostatectomy.

    abstract::Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP). Methods: This study adopted a multicenter, prospective, and real world design. BPH patients undergoing TUPKP ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Li BH,Yu ZJ,Wang CY,Zi H,Li XD,Wang XH,Ren XY,Liu TZ,Zheng H

    更新日期:2019-11-27 00:00:00

  • Managing the complexity of communication: regulation of gap junctions by post-translational modification.

    abstract::Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

    更新日期:2013-10-22 00:00:00

  • The Effect of Pungent and Tingling Compounds from Piper nigrum L. on Background K+ Currents.

    abstract::Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

    更新日期:2017-06-26 00:00:00

  • Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets.

    abstract::The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinical in vivo models. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Bröer A,Fairweather S,Bröer S

    更新日期:2018-07-19 00:00:00

  • Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease.

    abstract::Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Mallet N,Leblois A,Maurice N,Beurrier C

    更新日期:2019-12-13 00:00:00

  • Corrigendum: Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer.

    abstract::[This corrects the article on p. 3 in vol. 6, PMID: 25741280.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误


    authors: Horbach T,Götz C,Kietzmann T,Dimova EY

    更新日期:2016-04-05 00:00:00

  • Conditioned Serum Enhances the Chondrogenic and Immunomodulatory Behavior of Mesenchymal Stem Cells.

    abstract::Osteoarthritis is one of the most common chronic health conditions associated with pain and disability. Advanced therapies based on mesenchymal stem cells have become valuable options for the treatment of these pathologies. Conditioned serum (CS, "Orthokine") has been used intra-articularly for osteoarthritic patients...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Blázquez R,Sánchez-Margallo FM,Reinecke J,Álvarez V,López E,Marinaro F,Casado JG

    更新日期:2019-06-28 00:00:00

  • Emerging microRNA Therapeutic Approaches for Cystic Fibrosis.

    abstract::Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance of ion concentrations across the cell membrane and results in more a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Bardin P,Sonneville F,Corvol H,Tabary O

    更新日期:2018-10-08 00:00:00

  • Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae.

    abstract::The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

    更新日期:2017-03-30 00:00:00