Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering.

Abstract:

:Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiological bone healing procedures, the sustained release of bioactive molecules plays a vital role in creating an optimal osteogenic microenvironment and achieving promising bone repair outcomes. The utilization of biomaterial scaffolds can positively affect the osteogenesis process by integrating cells with bioactive factors in a proper way. A high water content, tunable physio-mechanical properties, and diverse synthetic strategies make hydrogels ideal cell carriers and controlled drug release reservoirs. Herein, we reviewed the current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE).

journal_name

Front Pharmacol

authors

Zhang Y,Yu T,Peng L,Sun Q,Wei Y,Han B

doi

10.3389/fphar.2020.00622

subject

Has Abstract

pub_date

2020-05-06 00:00:00

pages

622

issn

1663-9812

journal_volume

11

pub_type

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