Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer.

abstract：:[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

journal_title：Frontiers in pharmacology

authors： Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

更新日期：2017-02-15 00:00:00

abstract：:Icariin is a main component of the Chinese medicinal plant Epimedium brevicornu Maxim, exhibits potent activity against inflammatory diseases. Our previous data demonstrated the valid bioactivity of icariin on mitigating rodent asthma. Endoplasmic reticulum (ER) stress and nuclear factor-κB (NF-κB) pathway were involv...

journal_title：Frontiers in pharmacology

authors： Liu J,Liu L,Sun J,Luo Q,Yan C,Zhang H,Liu F,Wei Y,Dong J

更新日期：2020-01-31 00:00:00

abstract：:In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRP...

journal_title：Frontiers in pharmacology

authors： Walcher L,Budde C,Böhm A,Reinach PS,Dhandapani P,Ljubojevic N,Schweiger MW,von der Waydbrink H,Reimers I,Köhrle J,Mergler S

更新日期：2018-11-13 00:00:00

abstract：:Asthma is a chronic inflammatory disease characterized by airflow limitation and variable respiratory symptoms. It is characterized by variable symptoms such as cough, wheeze, chest tightness, and shortness of breath which vary in intensity and time. In order to reach a comprehensive approach of disease management, th...

journal_title：Frontiers in pharmacology

authors： Zampogna E,Zappa M,Spanevello A,Visca D

更新日期：2020-05-06 00:00:00

abstract：:Aflatoxin B1 (AFB1) is one of the most hazardous mycotoxins contamination in food and feed products, which leads to hepatocellular carcinoma in humans and animals. In the present study, we isolated and characterized an AFB1 degrading bacteria CG1061 from chicken cecum, exhibited an 93.7% AFB1 degradation rate by HPLC....

journal_title：Frontiers in pharmacology

authors： Wang L,Wu J,Liu Z,Shi Y,Liu J,Xu X,Hao S,Mu P,Deng F,Deng Y

更新日期：2019-01-17 00:00:00

abstract：:Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric car...

journal_title：Frontiers in pharmacology

authors： Hua S,Wu SY

更新日期：2013-11-21 00:00:00

abstract：:Agrocybe aegerita has long been utilized for promoting diuresis in traditional Chinese medicine (TCM) with a close correlation to hypouricemia. Ethanol (AAE) and water (AAW) extracts of the compound led to a remarkable decrease in serum uric acid levels (SUA) in hyperuricemia mice, approaching that of the normal contr...

journal_title：Frontiers in pharmacology

authors： Yong T,Chen S,Xie Y,Shuai O,Li X,Chen D,Su J,Jiao C,Liang Y

更新日期：2018-05-15 00:00:00

abstract：:The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (R...

journal_title：Frontiers in pharmacology

authors： Han J,Wang D,Ye L,Li P,Hao W,Chen X,Ma J,Wang B,Shang J,Li D,Zheng Q

更新日期：2017-07-11 00:00:00

abstract：:Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L. Previous study has reported that orientin protected myocardial from ischemia reperfusion injury. However, whether orientin could protect against cardiac remodeling after myocardial injury remains unclear. The aim of our study is to...

journal_title：Frontiers in pharmacology

authors： Li F,Zong J,Zhang H,Zhang P,Xu L,Liang K,Yang L,Yong H,Qian W

更新日期：2017-12-21 00:00:00

abstract：:Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

journal_title：Frontiers in pharmacology

authors： Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

更新日期：2019-09-24 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Background: New treatment platforms that can prevent acute respiratory distress syndrome (ARDS) or reduce its mortality rate in high-risk coronavirus disease 2019 (COVID-19) patients, such as those with an underlying cancer, are urgently needed. Rejuveinix (RJX) is an intravenous formulation of anti-oxidants and anti-...

journal_title：Frontiers in pharmacology

authors： Uckun FM,Carlson J,Orhan C,Powell J,Pizzimenti NM,van Wyk H,Ozercan IH,Volk M,Sahin K

更新日期：2020-11-10 00:00:00

abstract：:Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiologica...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Yu T,Peng L,Sun Q,Wei Y,Han B

更新日期：2020-05-06 00:00:00

abstract：:Paeoniflorin (PF) is the main active component of Paeonia lactiflora Pall., which is used in the treatment of severe cholestatic hepatitis. However, its biological mechanism in regulating bile acid metabolism and cholestatic liver injury has not been fully revealed. Our study aimed to reveal the mechanism of PF in the...

journal_title：Frontiers in pharmacology

authors： Wei S,Ma X,Niu M,Wang R,Yang T,Wang D,Wen J,Li H,Zhao Y

更新日期：2020-10-20 00:00:00

abstract：UNLABELLED:Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management of chronic...

journal_title：Frontiers in pharmacology

authors： Graziani M,Nisticò R

更新日期：2015-06-09 00:00:00

abstract：:Osteosarcoma (OS) is the most common bone cancer worldwide. There is evidence that microRNA-409 (miR-409-3p) is involved in tumorigenesis and cancer progression, however, its possible role in OS requires clarification. In the present study, we evaluated the expression level, clinical significance, and mode of action o...

journal_title：Frontiers in pharmacology

authors： Wu L,Zhang Y,Huang Z,Gu H,Zhou K,Yin X,Xu J

更新日期：2019-02-21 00:00:00

abstract：:Medication with neuroleptics has been associated with adipose tissue dysfunctions and, in particular, with increased visceral fat amount. However, several studies suggested that antipsychotic treatment might not be the main responsible of fat mass accumulation, as this has been also described in not treated psychotic ...

journal_title：Frontiers in pharmacology

authors： Schiavone S,Camerino GM,Mhillaj E,Zotti M,Colaianna M,De Giorgi A,Trotta A,Cantatore FP,Conte E,Bove M,Tucci P,Morgese MG,Trabace L

更新日期：2017-11-08 00:00:00

abstract：:Why antidepressants vary in terms of efficacy is currently unclear. Despite the leadership of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise neurobiological mechanisms involved in their therapeutic action are poorly understood. A better knowledge of molecular interactions b...

journal_title：Frontiers in pharmacology

authors： Gardier AM

更新日期：2013-08-08 00:00:00

abstract：:Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

journal_title：Frontiers in pharmacology

authors： Davino G,D'Alvano T,Esposito S

更新日期：2020-11-18 00:00:00

abstract：:Cytochrome P450 enzymes are often responsible for the toxic and carcinogenic effects of toxicants, such as aflatoxin B1 (AFB1). The human hepatic CYP2A6 enzyme mediates the oxidative metabolism of several procarcinogens. In this study, we characterized a partial sequence of CYP2A6 gene from Arbor Acres (AA) broiler an...

journal_title：Frontiers in pharmacology

authors： Muhammad I,Sun X,Wang H,Li W,Wang X,Cheng P,Li S,Zhang X,Hamid S

更新日期：2017-03-21 00:00:00

abstract：:The abscisic acid (ABA) is a phytohormone involved in plant growth, development and environmental stress response. Recent study showed ABA can also be detected in other organisms, including mammals. And it has been reported that ABA can improve learning and memory in rats. In this study, we attempted to investigate th...

journal_title：Frontiers in pharmacology

authors： Liu J,Gu X,Zou R,Nan W,Yang S,Wang HL,Chen XT

更新日期：2018-10-09 00:00:00

abstract：:Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), has been extensively used as a synthetic antibacterial agent. To evaluate the reproductive toxicity of MEQ, different concentrations of MEQ were administered to Wistar rats by feeding diets containing 0, 25, 55, 110, and 275 mg/kg, respectively. Each group...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Awais I,Shabbir MAB,Ahmed S,Fatima Z,Wang X,Pan Y,Xie S,Yuan Z

更新日期：2018-08-17 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. S...

journal_title：Frontiers in pharmacology

authors： Lin J,Lin R,Li S,Wu H,Ding J,Xiang G,Li S,Wang Y,Lin D,Gao W,Kong J,Xu H,Zhou K

更新日期：2018-10-23 00:00:00

abstract：:Background: Genetic variability in some of the genes that affect absorption, distribution, metabolism, and elimination ("pharmacogenes") can significantly influence an individual's response to the drug and consequently the effectiveness of treatment and possible adverse drug events. The rapid development of sequencing...

journal_title：Frontiers in pharmacology

authors： Hočevar K,Maver A,Peterlin B

更新日期：2019-03-14 00:00:00

abstract：:Aims: C1q/tumor necrosis factor (TNF)-related protein 5 (CTRP5) belongs to the C1q/TNF-α related protein family and regulates glucose, lipid metabolism, and inflammation production. However, the roles of CTRP5 in ischemia/reperfusion (I/R) associated with cardiac injuries and heart failure (HF) needs to be elaborated....

journal_title：Frontiers in pharmacology

authors： Peng M,Liu Y,Zhang XQ,Xu YW,Zhao YT,Yang HB

更新日期：2020-12-22 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00

abstract：:Inflammatory bowel disorders can be associated with alterations in gut microbiota (dysbiosis) and behavioral disturbances. In experimental colitis, administration of fish oil (FO) or cannabinoids, such as cannabidiol (CBD), reduce inflammation. We investigated the effect of combined FO/CBD administration on inflammati...

journal_title：Frontiers in pharmacology

authors： Silvestri C,Pagano E,Lacroix S,Venneri T,Cristiano C,Calignano A,Parisi OA,Izzo AA,Di Marzo V,Borrelli F

更新日期：2020-10-08 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5'-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most cases by giving la...

journal_title：Frontiers in pharmacology

authors： Chen PY,Tu HC,Schirch V,Safo MK,Fu TF

更新日期：2019-09-20 00:00:00