Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:Many ion channels are involved in tumor development, promoting cancer cell proliferation, migration, invasion, and survival. Accordingly, some of them have been suggested as tumor markers and novel targets for cancer therapy. Some sex steroid hormones (SSH), including estrogens and androgens, favor cancer progression....

journal_title：Frontiers in pharmacology

authors： Restrepo-Angulo I,Bañuelos C,Camacho J

更新日期：2020-02-28 00:00:00

abstract：:Background: Little is known about the humanistic burden of small cell lung cancer (SCLC), specifically the impact on health-related quality of life (HRQoL). The aim of this systematic literature review was to explore the impact of SCLC on HRQoL and the patient reported outcomes (PROs) used to capture this impact. Meth...

journal_title：Frontiers in pharmacology

authors： Bennett BM,Wells JR,Panter C,Yuan Y,Penrod JR

更新日期：2017-06-15 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

journal_title：Frontiers in pharmacology

authors： Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

更新日期：2017-08-15 00:00:00

abstract：:Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-D...

journal_title：Frontiers in pharmacology

authors： Dai Y,Yeo SCM,Barnes PJ,Donnelly LE,Loo LC,Lin HS

更新日期：2018-07-11 00:00:00

abstract：:Several studies have pointed to soluble oligomers of beta amyloid peptide (SOAβ) as the principal neurotoxic agents responsible for the generation of synaptotoxic events that can explain the main symptoms of Alzheimer's disease (AD). Among the toxic features associated with SOAβ, one of the most notorious is the forma...

journal_title：Frontiers in pharmacology

authors： Godoy PA,Ramírez-Molina O,Fuentealba J

更新日期：2019-11-07 00:00:00

abstract：:Background: Several initiatives have assessed if mining electronic health records (EHRs) may accelerate the process of drug safety signal detection. In Europe, Exploring and Understanding Adverse Drug Reactions (EU-ADR) Project Focused on utilizing clinical data from EHRs of over 30 million patients from several Europ...

journal_title：Frontiers in pharmacology

authors： Patadia VK,Schuemie MJ,Coloma PM,Herings R,van der Lei J,Sturkenboom M,Trifirò G

更新日期：2018-06-06 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

journal_title：Frontiers in pharmacology

authors： Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

更新日期：2020-01-24 00:00:00

abstract：:Excessive cerebral inflammation plays a key role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Berberine, an isoquinoline alkaloid isolated from Chinese herb Coptis chinensis, possesses anti-inflammatory, and neuroprotective effects. Here we evaluated the beneficial effects of berberine against SAH-...

journal_title：Frontiers in pharmacology

authors： Zhang XH,Peng L,Zhang J,Dong YP,Wang CJ,Liu C,Xia DY,Zhang XS

更新日期：2020-07-10 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these do...

journal_title：Frontiers in pharmacology

authors： Hartman SJF,Swaving JGE,van Beek SW,van Groen BD,de Hoop M,van der Zanden TM,Ter Heine R,de Wildt SN

更新日期：2020-12-16 00:00:00

abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

journal_title：Frontiers in pharmacology

authors： Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

更新日期：2019-09-05 00:00:00

abstract：:Lead is a multi-organ toxicant implicated in various cancers, diseases of the hepatic, renal, and reproductive systems etc. In search of cheap and readily available antidote this study has investigated the role of activated charcoal in chronic lead exposure in albino rats. Eighteen mature male albino rats were used, d...

journal_title：Frontiers in pharmacology

authors： Offor SJ,Mbagwu HO,Orisakwe OE

更新日期：2017-03-14 00:00:00

abstract：:Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcu...

journal_title：Frontiers in pharmacology

authors： Li J,Niu C,Jiang Z,Zhang Z,Pan Y,Xing Q,Guo Q,An S,Hu Y,Wang L

更新日期：2020-12-04 00:00:00

abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...

journal_title：Frontiers in pharmacology

authors： Issa ME,Wijeratne EMK,Gunatilaka AAL,Cuendet M

更新日期：2017-09-08 00:00:00

abstract：:The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an ...

journal_title：Frontiers in pharmacology

authors： Sivasubramanian S,Chandrasekar G,Svensson Akusjärvi S,Thangam R,Sathuvan M,Kumar RBS,Hussein H,Vincent S,Madhan B,Gunasekaran P,Kitambi SS

更新日期：2017-07-18 00:00:00

abstract：:Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic t...

journal_title：Frontiers in pharmacology

authors： Bordon KCF,Cologna CT,Fornari-Baldo EC,Pinheiro-Júnior EL,Cerni FA,Amorim FG,Anjolette FAP,Cordeiro FA,Wiezel GA,Cardoso IA,Ferreira IG,de Oliveira IS,Boldrini-França J,Pucca MB,Baldo MA,Arantes EC

更新日期：2020-07-24 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with electrophysiological re...

journal_title：Frontiers in pharmacology

authors： Latapiat V,Rodríguez FE,Godoy F,Montenegro FA,Barrera NP,Huidobro-Toro JP

更新日期：2017-12-15 00:00:00

abstract：:Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression. Over the years, we and others have uncovered key pathways that regulate macrophage number/function and identified how metabolic d...

journal_title：Frontiers in pharmacology

authors： Flynn MC,Pernes G,Lee MKS,Nagareddy PR,Murphy AJ

更新日期：2019-06-13 00:00:00

abstract：:A dominant area of antibody research is the extension of the use of this mighty experimental and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and activity blocking. Despite the ability to raise antibodies against different proteins, numerous applications of antibodies in bas...

journal_title：Frontiers in pharmacology

authors： Slastnikova TA,Ulasov AV,Rosenkranz AA,Sobolev AS

更新日期：2018-10-24 00:00:00

abstract：:Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

journal_title：Frontiers in pharmacology

authors： Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

更新日期：2018-09-26 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a ...

journal_title：Frontiers in pharmacology

authors： Goshima Y,Masukawa D,Kasahara Y,Hashimoto T,Aladeokin AC

更新日期：2019-10-03 00:00:00

abstract：:The serotonin [5-hydroxytryptamine (5-HT)] system has been implicated in the pathogenesis of major depressive disorder (MDD). Among the 5-HT receptor subtypes, 5-HT2 is one of the major pharmacological therapeutic targets for MDD. There have been inconsistent findings in previous pharmacogenetic studies investigating ...

journal_title：Frontiers in pharmacology

authors： Kao CF,Kuo PH,Yu YW,Yang AC,Lin E,Liu YL,Tsai SJ

更新日期：2020-12-03 00:00:00

abstract：:Phytoestrogen has been proposed as an alternative to hormone replacement therapy, which has been demonstrated to promote a high risk of breast cancer. However, the effect of phytoestrogen on breast cancer development has not been fully understood. Bakuchiol is an active ingredient of a traditional Chinese herbal medic...

journal_title：Frontiers in pharmacology

authors： Li L,Chen X,Liu CC,Lee LS,Man C,Cheng SH

更新日期：2016-05-24 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have lon...

journal_title：Frontiers in pharmacology

authors： Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI

更新日期：2012-01-19 00:00:00

abstract：:The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a...

journal_title：Frontiers in pharmacology

authors： Brilli M,Trabocchi A,Weil T,Cavalieri D,Stefanini I

更新日期：2017-03-30 00:00:00

abstract：:Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5'-UTR and coding regi...

journal_title：Frontiers in pharmacology

authors： Jhun EH,Sadhu N,Hu X,Yao Y,He Y,Wilkie DJ,Molokie RE,Wang ZJ

更新日期：2019-02-07 00:00:00