l-DOPA and Its Receptor GPR143: Implications for Pathogenesis and Therapy in Parkinson's Disease.

Abstract:

:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a neurotransmitter. Recently, GPR143 (OA1), the gene product of ocular albinism 1 was identified as a receptor candidate for l-DOPA. GPR143 is widely expressed in the central and peripheral nervous system. GPR143 immunoreactivity was colocalized with phosphorylated α-synuclein in Lewy bodies in PD brains. GPR143 may contribute to the therapeutic effectiveness of l-DOPA and might be related to pathogenesis of PD.

journal_name

Front Pharmacol

authors

Goshima Y,Masukawa D,Kasahara Y,Hashimoto T,Aladeokin AC

doi

10.3389/fphar.2019.01119

subject

Has Abstract

pub_date

2019-10-03 00:00:00

pages

1119

issn

1663-9812

journal_volume

10

pub_type

杂志文章,评审
  • Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.

    abstract::The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction. Emerging data has generated scientific interest and excitement around targeting the P2X7 ion channel as a potential drug target for CNS disorders. Ov...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.00030

    authors: Bhattacharya A

    更新日期:2018-02-01 00:00:00

  • A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment.

    abstract::There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac myocytes for this p...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2015.00059

    authors: Mistry HB,Davies MR,Di Veroli GY

    更新日期:2015-03-24 00:00:00

  • TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway.

    abstract::Neonatal hypoxic/ischemic encephalopathy (NHIE) is a severe condition that leads to death or neurological disability in newborns. The underlying pathological mechanisms are unclear, and developing the target neuroprotective strategies are urgent. 2,7,2'-trihydroxy-4,4'7'-trimethoxy-1,1'-biphenanthrene (TTB) is a natur...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00792

    authors: Liu L,Zhao Z,Yin Q,Zhang X

    更新日期:2019-07-16 00:00:00

  • Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?

    abstract::The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnatal insult such as cerebral ischemia, stroke, brain trauma, or infection. These insults share common pathophysiological pathways involving innate immune activation including neuroinflammation...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00002

    authors: Semple BD,Dill LK,O'Brien TJ

    更新日期:2020-02-04 00:00:00

  • Paracrine Fibroblast Growth Factor 1 Functions as Potent Therapeutic Agent for Intrahepatic Cholestasis by Downregulating Synthesis of Bile Acid.

    abstract::Endocrine fibroblast growth factor (FGF) 19 has been shown to be capable of maintaining bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for cholestasis liver disease. However, whether paracrine FGFs possess this BA regulatory activity remains to be determined. In our study, we iden...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01515

    authors: Lin H,Zhou C,Hou Y,Li Q,Qiao G,Wang Y,Huang Z,Niu J

    更新日期:2019-12-20 00:00:00

  • Administration of Δ9-Tetrahydrocannabinol (THC) Post-Staphylococcal Enterotoxin B Exposure Protects Mice From Acute Respiratory Distress Syndrome and Toxicity.

    abstract::Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydro...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00893

    authors: Mohammed A,Alghetaa H,Sultan M,Singh NP,Nagarkatti P,Nagarkatti M

    更新日期:2020-06-16 00:00:00

  • Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics.

    abstract::Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis (AS), an...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00460

    authors: Li P,Zheng Y,Chen X

    更新日期:2017-07-12 00:00:00

  • Corrigendum: Improvement of Sepsis Prognosis by Ulinastatin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract::[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 已发布勘误

    doi:10.3389/fphar.2019.01697

    authors: Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

    更新日期:2020-02-21 00:00:00

  • The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome.

    abstract::The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we invest...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2013.00165

    authors: Steiner MA,Sciarretta C,Pasquali A,Jenck F

    更新日期:2013-12-30 00:00:00

  • The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

    abstract::Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00985

    authors: Belo RF,Martins MLF,Shvachiy L,Costa-Coelho T,de Almeida-Borlido C,Fonseca-Gomes J,Neves V,Vicente Miranda H,Outeiro TF,Coelho JE,Xapelli S,Valente CA,Heras M,Bardaji E,Castanho MARB,Diógenes MJ,Sebastião AM

    更新日期:2020-07-09 00:00:00

  • The Droplet Digital PCR: A New Valid Molecular Approach for the Assessment of B-RAF V600E Mutation in Hairy Cell Leukemia.

    abstract::Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2016.00363

    authors: Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

    更新日期:2016-10-13 00:00:00

  • Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease.

    abstract::Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other pro-inflammatory cytokines gives rise to the development of new ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01074

    authors: Galozzi P,Baggio C,Bindoli S,Oliviero F,Sfriso P

    更新日期:2018-09-21 00:00:00

  • Calcium Handling Defects and Cardiac Arrhythmia Syndromes.

    abstract::Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00072

    authors: Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

    更新日期:2020-02-25 00:00:00

  • Doxycycline for Alzheimer's Disease: Fighting β-Amyloid Oligomers and Neuroinflammation.

    abstract::Alzheimer's disease (AD) is the most widespread form of dementia, affecting about 45 million people worldwide. Although the β-amyloid peptide (Aβ) remains the most acknowledged culprit of AD, the multiple failures of Aβ-centric therapies call for alternative therapeutic approaches. Conceivably, the complexity of the A...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.00738

    authors: Balducci C,Forloni G

    更新日期:2019-07-03 00:00:00

  • Cellular Links between Neuronal Activity and Energy Homeostasis.

    abstract::Neuronal activity, astrocytic responses to this activity, and energy homeostasis are linked together during baseline, conscious conditions, and short-term rapid activation (as occurs with sensory or motor function). Nervous system energy homeostasis also varies during long-term physiological conditions (i.e., developm...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2012.00043

    authors: Shetty PK,Galeffi F,Turner DA

    更新日期:2012-03-20 00:00:00

  • Model-Informed Precision Dosing of Vancomycin in Hospitalized Children: Implementation and Adoption at an Academic Children's Hospital.

    abstract:Background:Model-informed precision dosing (MIPD) can serve as a powerful tool during therapeutic drug monitoring (TDM) to help individualize dosing in populations with large pharmacokinetic variation. Yet, adoption of MIPD in the clinical setting has been limited. Overcoming technologic hurdles that allow access to MI...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00551

    authors: Frymoyer A,Schwenk HT,Zorn Y,Bio L,Moss JD,Chasmawala B,Faulkenberry J,Goswami S,Keizer RJ,Ghaskari S

    更新日期:2020-04-29 00:00:00

  • Harnessing the Power of Optical Microscopic and Macroscopic Imaging for Natural Products as Cancer Therapeutics.

    abstract::Natural products (NPs) are an important source for new drug discovery over the past decades, which have been demonstrated to be effectively used in cancer prevention, treatment, and adjuvant therapy. Many methods, such as the genomic and metabolomic approaches, immunochemistry, mass spectrometry, and chromatography, h...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.01438

    authors: Yan T,Zeng Q,Wang L,Wang N,Cao H,Xu X,Chen X

    更新日期:2019-11-28 00:00:00

  • Fish Oil, Cannabidiol and the Gut Microbiota: An Investigation in a Murine Model of Colitis.

    abstract::Inflammatory bowel disorders can be associated with alterations in gut microbiota (dysbiosis) and behavioral disturbances. In experimental colitis, administration of fish oil (FO) or cannabinoids, such as cannabidiol (CBD), reduce inflammation. We investigated the effect of combined FO/CBD administration on inflammati...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.585096

    authors: Silvestri C,Pagano E,Lacroix S,Venneri T,Cristiano C,Calignano A,Parisi OA,Izzo AA,Di Marzo V,Borrelli F

    更新日期:2020-10-08 00:00:00

  • New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA.

    abstract::Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.01314

    authors: Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

    更新日期:2020-08-21 00:00:00

  • Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide.

    abstract::Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with 0.1 M trimethylammonium bromide (TMA) with full...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00713

    authors: Onder S,David E,Tacal O,Schopfer LM,Lockridge O

    更新日期:2017-10-10 00:00:00

  • Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway.

    abstract::Glucocorticoid (GC) therapy is the leading cause of secondary osteoporosis and the therapeutic and preventative drugs for GC-induced osteoporosis are limited. In this study, we investigated the protective effects of geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00411

    authors: Xie B,Wu J,Li Y,Wu X,Zeng Z,Zhou C,Xu D,Wu L

    更新日期:2019-04-18 00:00:00

  • Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro.

    abstract::Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, leading to inter-individual variability in drug metabolism. Quinine is ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00591

    authors: Zhou XY,Hu XX,Wang CC,Lu XR,Chen Z,Liu Q,Hu GX,Cai JP

    更新日期:2019-05-31 00:00:00

  • Digoxin and Amiodarone on the Risk of Ischemic Stroke in Atrial Fibrillation: An Observational Study.

    abstract::Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00448

    authors: Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

    更新日期:2018-05-07 00:00:00

  • Salvinorin A Inhibits Airway Hyperreactivity Induced by Ovalbumin Sensitization.

    abstract::Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2016.00525

    authors: Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

    更新日期:2017-01-13 00:00:00

  • Striatal Cholinergic Interneurons: How to Elucidate Their Function in Health and Disease.

    abstract::Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01488

    authors: Mallet N,Leblois A,Maurice N,Beurrier C

    更新日期:2019-12-13 00:00:00

  • Progress in Research on the Role of FGF in the Formation and Treatment of Corneal Neovascularization.

    abstract::Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00111

    authors: Chen M,Bao L,Zhao M,Cao J,Zheng H

    更新日期:2020-02-25 00:00:00

  • Phenotypic Screening Identifies Synergistically Acting Natural Product Enhancing the Performance of Biomaterial Based Wound Healing.

    abstract::The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00433

    authors: Sivasubramanian S,Chandrasekar G,Svensson Akusjärvi S,Thangam R,Sathuvan M,Kumar RBS,Hussein H,Vincent S,Madhan B,Gunasekaran P,Kitambi SS

    更新日期:2017-07-18 00:00:00

  • Three-Dimensional Culture Promotes the Differentiation of Human Dental Pulp Mesenchymal Stem Cells Into Insulin-Producing Cells for Improving the Diabetes Therapy.

    abstract:Introduction:Diabetes is a metabolic disease with a high incidence and serious harm to human health. Islet β-cell function defects can occur in the late stage of type 1 diabetes and type 2 diabetes. Studies have shown that stem cell is a promising new approach in bioengineering regenerative medicine. In the study of st...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01576

    authors: Xu B,Fan D,Zhao Y,Li J,Wang Z,Wang J,Wang X,Guan Z,Niu B

    更新日期:2020-01-24 00:00:00

  • Traditional Japanese herbal medicines for treatment of odontopathy.

    abstract::This article highlights several refractory oral diseases, such as stomatitis, burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP), oral cancer, dry mouth, and Sjögren's syndrome (SJS), in which use of Japanese herbal medicines, Kampo medicines (KM), on the basis of Kampo theory could exert the maximum...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2015.00176

    authors: Yamaguchi K

    更新日期:2015-08-28 00:00:00

  • Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019.

    abstract::Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.577571

    authors: Gracia-Hernandez M,Sotomayor EM,Villagra A

    更新日期:2020-10-29 00:00:00