Natural-Killer-Derived Extracellular Vesicles: Immune Sensors and Interactors.

abstract：:Systemic Lupus Erythematosus (SLE) is a common and devastating autoimmune disease, characterized by a dysregulated adaptive immune response against intracellular antigens, which involves both autoreactive T and B cells. In SLE, mainly intracellular autoantigens generate autoantibodies and these assemble into immune co...

journal_title：Frontiers in immunology

authors： Ugarte-Berzal E,Boon L,Martens E,Rybakin V,Blockmans D,Vandooren J,Proost P,Opdenakker G

更新日期：2019-03-22 00:00:00

abstract：:Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and vaccine-elicited antibodies prevent or treat infectious diseases, cancers and autoimmune disorders by binding FcγRs, thus there is a need to fully...

journal_title：Frontiers in immunology

authors： Patel KR,Roberts JT,Barb AW

更新日期：2019-02-14 00:00:00

abstract：:B cells in fish were recently proven to have potent innate immune activities like macrophages. This inspired us to further explore the innate nature of B cells in fish. Moreover, antimicrobial peptides (AMPs) are representative molecules of innate immunity, and they can modulate the functions of macrophages. These mak...

journal_title：Frontiers in immunology

authors： Zhang XJ,Wang P,Zhang N,Chen DD,Nie P,Li JL,Zhang YA

更新日期：2017-04-04 00:00:00

abstract：:Advances in microsurgical techniques and immunomodulatory protocols have contributed to the expansion of vascularized composite allotransplantation (VCA) with very encouraging immunological, functional, and cosmetic results. Rejection remains however a major hurdle that portends serious threats to recipients. Rejectio...

journal_title：Frontiers in immunology

authors： Sarhane KA,Tuffaha SH,Broyles JM,Ibrahim AE,Khalifian S,Baltodano P,Santiago GF,Alrakan M,Ibrahim Z

更新日期：2013-11-25 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Soil-transmitted helminths represent a major global health burden with infections and infection-related comorbidities causing significant reductions in the quality of life for individuals living in endemic areas. Repeated infections and chronic colonization by these large extracellular worms in mammals led to the evol...

journal_title：Frontiers in immunology

authors： Miller MM,Reinhardt RL

更新日期：2020-07-23 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues ass...

journal_title：Frontiers in immunology

authors： Mancheño-Corvo P,Lopez-Santalla M,Menta R,DelaRosa O,Mulero F,Del Rio B,Ramirez C,Büscher D,Bueren JA,Lopez-Belmonte J,Dalemans W,Garin MI,Lombardo E

更新日期：2017-04-21 00:00:00

abstract：:The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for...

journal_title：Frontiers in immunology

authors： Domnich M,Riedesel J,Pylaeva E,Kürten CHL,Buer J,Lang S,Jablonska J

更新日期：2020-10-09 00:00:00

abstract：:Proteinuria has been identified as prognosticator of renal outcome in patients with ANCA-associated glomerulonephritis, but whether proteinuria is related to podocyte abnormalities in these patients is largely unknown. We here investigate podocyte foot process width and number of podocytes positive for the podocyte ma...

journal_title：Frontiers in immunology

authors： van Daalen EE,Neeskens P,Zandbergen M,Harper L,Karras A,Vaglio A,de Zoysa J,Bruijn JA,Bajema IM

更新日期：2019-06-26 00:00:00

abstract：:The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma (RRMM) was a critical advance for immunotherapies for multiple myeloma (MM). Importantly, the outcome of patients continues to improve with the inc...

journal_title：Frontiers in immunology

authors： Cho SF,Anderson KC,Tai YT

更新日期：2018-08-10 00:00:00

abstract：:West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

journal_title：Frontiers in immunology

authors： Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

更新日期：2020-01-23 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：:Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone...

journal_title：Frontiers in immunology

authors： Clark HL,Abbondante S,Minns MS,Greenberg EN,Sun Y,Pearlman E

更新日期：2018-05-29 00:00:00

abstract：:Major trauma-induced tissue injury causes a dysregulation of the immune system. Severe systemic inflammation occurs early after the insult. Later on, an enhanced risk for life-threatening opportunistic infections develops that culminates at the end of the first week after trauma. CD56bright Natural killer (NK) cells p...

journal_title：Frontiers in immunology

authors： Bösken B,Hepner-Schefczyk M,Vonderhagen S,Dudda M,Flohé SB

更新日期：2020-06-25 00:00:00

abstract：:Background: Optimal timing of gestational tetanus-diphtheria-acellular pertussis (Tdap) vaccination is not well-defined. No well-established specific anti-pertussis antibody level correlates with protection, suggesting the importance of antibody quality such as avidity. We aimed to determine the effect of timing of va...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Giles ML,Kollmann TR,Sadarangani M

更新日期：2019-10-11 00:00:00

abstract：:Obesity induces local/systemic inflammation accompanied by increases in macrophage infiltration into adipose tissue and production of inflammatory cytokines, chemokines, and hormones. Previous studies have shown that probiotics could improve the intestinal dysbiosis induced by metabolic diseases such as obesity, diabe...

journal_title：Frontiers in immunology

authors： Fabersani E,Abeijon-Mukdsi MC,Ross R,Medina R,González S,Gauffin-Cano P

更新日期：2017-03-13 00:00:00

abstract：:The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to ...

journal_title：Frontiers in immunology

authors： Yuan X,Cao H,Wang J,Tang K,Li B,Zhao Y,Cheng M,Qin H,Liu X,Zhang X

更新日期：2017-09-29 00:00:00

abstract：:Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical signs of infections in children, second, the early appearance of...

journal_title：Frontiers in immunology

authors： Fierz W,Walz B

更新日期：2020-06-05 00:00:00

abstract：:Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, and sometimes appeared to be inconsistent across different studies. In this review, we collectively discussed many lines...

journal_title：Frontiers in immunology

authors： Wu L,Zhang XH

更新日期：2020-12-02 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:In adaptation to rising stimulant strength, innate monocytes can be dynamically programed to preferentially express either pro- or anti-inflammatory mediators. Such dynamic innate adaptation or programing may bear profound relevance in host health and disease. However, molecular mechanisms that govern innate adaptatio...

journal_title：Frontiers in immunology

authors： Yuan R,Geng S,Li L

更新日期：2016-11-10 00:00:00

abstract：:Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, wh...

journal_title：Frontiers in immunology

authors： Thompson KK,Nissen JC,Pretory A,Tsirka SE

更新日期：2018-11-28 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide. Efforts to develop a next-generation vaccine have largely focused on envelope glycoproteins to target virus-neutralizing antibody responses. However, these approach...

journal_title：Frontiers in immunology

authors： Mokhtar H,Pedrera M,Frossard JP,Biffar L,Hammer SE,Kvisgaard LK,Larsen LE,Stewart GR,Somavarapu S,Steinbach F,Graham SP

更新日期：2016-02-16 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：Background:Allergic rhinitis is a common disorder that affects 10% to 40% of the population worldwide. Allergen immunotherapy (AIT) represents the only therapy that has the potential to resolve clinical symptoms of allergic rhinitis. However, up to 30% of patients do not respond to AIT. Biomarkers predicting the clinic...

journal_title：Frontiers in immunology

authors： Ma TT,Cao MD,Yu RL,Shi HY,Yan WJ,Liu JG,Pan C,Sun J,Wei QY,Wang DY,Wei JF,Wang XY,Yin JS

更新日期：2020-11-24 00:00:00

abstract：:The small GTPase Rab5 is one of the master regulators of vesicular trafficking that participates in early stages of the endocytic pathway, such as endocytosis and endosome maturation. Three Rab5 isoforms (a, b, and c) share high sequence identity, and exhibit complex functions. However, the role of Rab5c in virus infe...

journal_title：Frontiers in immunology

authors： Wang L,Li C,Zhang X,Yang M,Wei S,Huang Y,Qin Q,Wang S

更新日期：2020-09-02 00:00:00

abstract：:Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the majority of the humora...

journal_title：Frontiers in immunology

authors： Yermanos AD,Dounas AK,Stadler T,Oxenius A,Reddy ST

更新日期：2018-10-02 00:00:00

abstract：:The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth fa...

journal_title：Frontiers in immunology

authors： Foster SL,Seehus CR,Woolf CJ,Talbot S

更新日期：2017-11-03 00:00:00

abstract：:Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...

journal_title：Frontiers in immunology

authors： Hussain K,Letley DP,Greenaway AB,Kenefeck R,Winter JA,Tomlinson W,Rhead J,Staples E,Kaneko K,Atherton JC,Robinson K

更新日期：2016-03-07 00:00:00

abstract：:Channel catfish farming dominates the aquaculture industry in the United States. However, epidemic outbreaks of motile Aeromonas septicemia (MAS), caused by virulent Aeromonas hydrophila (vAh), have become a prominent problem in the catfish industry. Although vaccination is an effective preventive method, there is no ...

journal_title：Frontiers in immunology

authors： Abdelhamed H,Banes M,Karsi A,Lawrence ML

更新日期：2019-07-16 00:00:00