CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection.

abstract：:Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial encroachment. In addition to their antimicrobial activities, defensins in general, and human β-defensin 2 (hBD2) in particular, also exhibit immunomodulatory ca...

journal_title：Frontiers in immunology

authors： Koeninger L,Armbruster NS,Brinch KS,Kjaerulf S,Andersen B,Langnau C,Autenrieth SE,Schneidawind D,Stange EF,Malek NP,Nordkild P,Jensen BAH,Wehkamp J

更新日期：2020-01-31 00:00:00

abstract：:In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a coronary artery. A similar phenomenon is observed in heart transplantation (HTx) when, after cold storage, the donor heart is connected to ...

journal_title：Frontiers in immunology

authors： Silvis MJM,Kaffka Genaamd Dengler SE,Odille CA,Mishra M,van der Kaaij NP,Doevendans PA,Sluijter JPG,de Kleijn DPV,de Jager SCA,Bosch L,van Hout GPJ

更新日期：2020-12-08 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:Anti-tumor immunity is limited by a number of factors including the lack of fully activated T-cells, insufficient antigenic stimulation and the immune-suppressive tumor microenvironment. We addressed these hurdles by developing a novel class of immunoconjugates, Antibody-Targeted Pathogen-derived Peptides (ATPPs), whi...

journal_title：Frontiers in immunology

authors： Sefrin JP,Hillringhaus L,Mundigl O,Mann K,Ziegler-Landesberger D,Seul H,Tabares G,Knoblauch D,Leinenbach A,Friligou I,Dziadek S,Offringa R,Lifke V,Lifke A

更新日期：2019-08-21 00:00:00

abstract：:MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their re...

journal_title：Frontiers in immunology

authors： Berzins SP,Wallace ME,Kannourakis G,Kelly J

更新日期：2020-05-20 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transp...

journal_title：Frontiers in immunology

authors： Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

更新日期：2017-03-23 00:00:00

abstract：:Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and neuropathic pain) are prevalent in cancer patients and survivors. These mental and neurological health issues reduce quality-of-life, which is a significant societal concern given the increasing rates of long-term survival after variou...

journal_title：Frontiers in immunology

authors： Santos JC,Pyter LM

更新日期：2018-06-07 00:00:00

abstract：:Antigen capturing at the periphery is one of the earliest, crucial functions of antigen-presenting cells (APCs) to initiate immune responses. Langerhans cells (LCs), the epidermal APCs migrate to draining lymph nodes (DLNs) upon acquiring antigens. An arsenal of endocytic molecules is available to this end, including ...

journal_title：Frontiers in immunology

authors： Becerril-García MA,Yam-Puc JC,Maqueda-Alfaro R,Beristain-Covarrubias N,Heras-Chavarría M,Gallegos-Hernández IA,Calderón-Amador J,Munguía-Fuentes R,Donis-Maturano L,Flores-Langarica A,Flores-Romo L

更新日期：2020-04-27 00:00:00

abstract：:Proteinuria is an adverse prognostic feature in renal diseases. In proteinuric nephropathies, filtered proteins exert an injurious effect on the renal tubulointerstitium, resulting in inflammation and fibrosis. In the present study, we assessed to what extent complement activation via the lectin pathway may contribute...

journal_title：Frontiers in immunology

authors： Alghadban S,Kenawy HI,Dudler T,Schwaeble WJ,Brunskill NJ

更新日期：2019-09-23 00:00:00

abstract：:The dynamics of skin-draining cells following infection or vaccination provide important insight into the initiation of immune responses. In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. A transient but remarkab...

journal_title：Frontiers in immunology

authors： Lund H,Boysen P,Åkesson CP,Lewandowska-Sabat AM,Storset AK

更新日期：2016-08-29 00:00:00

abstract：:Age-related deficits in the immune system have been associated with an increased incidence of infections, autoimmune diseases, and cancer. Human B cell populations change quantitatively and qualitatively in the elderly. However, the function of human B-1 cells, which play critical anti-microbial and housekeeping roles...

journal_title：Frontiers in immunology

authors： Rodriguez-Zhurbenko N,Quach TD,Hopkins TJ,Rothstein TL,Hernandez AM

更新日期：2019-03-19 00:00:00

abstract：:Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

journal_title：Frontiers in immunology

authors： Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

更新日期：2018-06-18 00:00:00

abstract：:Resident memory T cells (TRM) are broadly defined as a population of T cells, which persist in non-lymphoid sites long-term, do not re-enter the circulation, and are distinct from central memory T cells (TCM) and circulating effector memory T cells (TEM). Recent studies have described populations of TRM cells in the s...

journal_title：Frontiers in immunology

authors： Shane HL,Klonowski KD

更新日期：2014-07-08 00:00:00

abstract：:Chimeric antigen receptor (CAR) therapy has been proved effective in a stream of clinical trials, especially in hematologic malignancies. However, current CAR therapy is highly personalized as cells used are derived from patients themselves, which can be costly, time-consuming, and sometimes fails to achieve optimal t...

journal_title：Frontiers in immunology

authors： Zhang Y,Li P,Fang H,Wang G,Zeng X

更新日期：2020-12-10 00:00:00

abstract：:Immunotherapies based on natural killer (NK) cells are among the most promising therapies under development for the treatment of so far incurable forms of leukemia and other types of cancer. The importance of NK cells for the control of viral infections and cancer is supported among others by the findings that viruses...

journal_title：Frontiers in immunology

authors： Hofer E,Koehl U

更新日期：2017-07-12 00:00:00

abstract：:THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF ind...

journal_title：Frontiers in immunology

authors： Faustman DL,Davis M

更新日期：2013-12-23 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.01529.]. ...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-11-18 00:00:00

abstract：:Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-vs.-ho...

journal_title：Frontiers in immunology

authors： Baumeister SHC,Rambaldi B,Shapiro RM,Romee R

更新日期：2020-02-14 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:Atherosclerosis is an inflammatory disease caused by endothelial injury, lipid deposition, and oxidative stress. This progressive disease can be converted into an acute clinical event by plaque rupture and thrombosis. In the context of atherosclerosis, the underlying cause of myocardial infarction and stroke, macropha...

journal_title：Frontiers in immunology

authors： de Gaetano M,Crean D,Barry M,Belton O

更新日期：2016-07-19 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopon...

journal_title：Frontiers in immunology

authors： Scutera S,Salvi V,Lorenzi L,Piersigilli G,Lonardi S,Alotto D,Casarin S,Castagnoli C,Dander E,D'Amico G,Sozzani S,Musso T

更新日期：2018-06-01 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00

abstract：BACKGROUND:Subjects are considered infected with Trypanosoma cruzi when tested positive by at least two out of three serological tests, whereas a positive result in only one of up to three tests is termed "serodiscordant" (SD). Assessment of parasite-specific T-cell responses may help discriminate the uninfected from i...

journal_title：Frontiers in immunology

authors： Castro Eiro MD,Alvarez MG,Cooley G,Viotti RJ,Bertocchi GL,Lococo B,Albareda MC,De Rissio AM,Natale MA,Parodi C,Tarleton RL,Laucella SA

更新日期：2017-09-15 00:00:00

abstract：:CNS autoantigens conjugated to oxidized mannan (OM) induce antigen-specific T cell tolerance and protect mice against autoimmune encephalomyelitis (EAE). To investigate whether OM-peptides treat EAE initiated by human MHC class II molecules, we administered OM-conjugated murine myelin oligodendrocyte glycoprotein pept...

journal_title：Frontiers in immunology

authors： Dagkonaki A,Avloniti M,Evangelidou M,Papazian I,Kanistras I,Tseveleki V,Lampros F,Tselios T,Jensen LT,Möbius W,Ruhwedel T,Androutsou ME,Matsoukas J,Anagnostouli M,Lassmann H,Probert L

更新日期：2020-11-19 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC3) have been detected in human decidua, where they play a role in the...

journal_title：Frontiers in immunology

authors： Pelosi A,Alicata C,Tumino N,Ingegnere T,Loiacono F,Mingari MC,Moretta L,Vacca P

更新日期：2020-02-06 00:00:00

abstract：:B cell activation and differentiation yields plasma cells with high affinity antibodies to a given antigen in a time-frame that allows for host protection. Although the end product is most commonly humoral immunity, the rapid proliferation and somatic mutation of the B cell receptor also results in oncogenic mutations...

journal_title：Frontiers in immunology

authors： Barwick BG,Gupta VA,Vertino PM,Boise LH

更新日期：2019-05-21 00:00:00

abstract：:Betaine is a critical nutrient for mammal health, and has been found to alleviate inflammation by lowering interleukin (IL)-1β secretion; however, the underlying mechanisms by which betaine inhibits IL-1β secretion remain to be uncovered. In this review, we summarize the current understanding about the mechanisms of b...

journal_title：Frontiers in immunology

authors： Xia Y,Chen S,Zhu G,Huang R,Yin Y,Ren W

更新日期：2018-11-20 00:00:00

abstract：:Malaria is caused by infection with Plasmodium parasites. Various studies with knockout mice have indicated that IFN-γ plays essential roles in protective immunity against blood-stage Plasmodium infection. However, after Plasmodium infection, increased IFN-γ production by various types of cells is involved not only in...

journal_title：Frontiers in immunology

authors： Inoue S,Niikura M,Mineo S,Kobayashi F

更新日期：2013-08-29 00:00:00

abstract：:Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections, yet interactions of the anti-viral and anti-bacterial responses remain elusive. Here, we hav...

journal_title：Frontiers in immunology

authors： Boucontet L,Passoni G,Thiry V,Maggi L,Herbomel P,Levraud JP,Colucci-Guyon E

更新日期：2018-05-24 00:00:00