Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications.

Abstract:

:Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transplantation but as we gain a better understanding of the characteristics of each immune cell that UCB contains, we will also be able to develop new cell therapies for cancer. In this review, we present what is currently known of the phenotype and functions of UCB NK cells and how these cells could be used in the future for cancer immunotherapy.

journal_name

Front Immunol

journal_title

Frontiers in immunology

authors

Sarvaria A,Jawdat D,Madrigal JA,Saudemont A

doi

10.3389/fimmu.2017.00329

subject

Has Abstract

pub_date

2017-03-23 00:00:00

pages

329

issn

1664-3224

journal_volume

8

pub_type

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