Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers.

abstract：:Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in the murine experimental autoimmune encephalomyelitis (EAE) model of MS, and that TLR2-stimulation of regulatory T cells (...

journal_title：Frontiers in immunology

authors： Hossain MJ,Morandi E,Tanasescu R,Frakich N,Caldano M,Onion D,Faraj TA,Erridge C,Gran B

更新日期：2018-03-14 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:The conceptualization of immunological self is amongst the most important theories of modern biology, representing a sort of theoretical guideline for experimental immunologists, in order to understand how host constituents are ignored by the immune system (IS). A consistent advancement in this field has been represen...

journal_title：Frontiers in immunology

authors： Grignolio A,Mishto M,Faria AM,Garagnani P,Franceschi C,Tieri P

更新日期：2014-04-09 00:00:00

abstract：:T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive...

journal_title：Frontiers in immunology

authors： Good-Jacobson KL,Groom JR

更新日期：2018-03-08 00:00:00

abstract：:The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Smolen KK,Willems F,Kollmann TR,Marchant A

更新日期：2016-08-31 00:00:00

abstract：:One of the most significant challenges of cell biology is to understand how each type of cell copes with its specific workload without suffering damage. Among the most intriguing questions concerns intestinal epithelial cells in mammals; these cells act as a barrier between the internally protected region and the exte...

journal_title：Frontiers in immunology

authors： Randall-Demllo S,Chieppa M,Eri R

更新日期：2013-09-30 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1-3, recognizing HLA-C allotypes through Ig-like domains of the D1-D2 type, KIR2DL5 shares a D0-D2 configuration with KIR2DL4, and its ligands have not...

journal_title：Frontiers in immunology

authors： Cisneros E,Estefanía E,Vilches C

更新日期：2017-01-17 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00

abstract：:We have recently designed a soluble synthetic peptide that functionally mimics the HIV-1 coreceptor CXCR4, which is a chemokine receptor that belongs to the family of seven-transmembrane GPCRs. This CXCR4 mimetic peptide, termed CX4-M1, presents the three extracellular loops (ECLs) of the receptor. In binding assays i...

journal_title：Frontiers in immunology

authors： Groß A,Möbius K,Haußner C,Donhauser N,Schmidt B,Eichler J

更新日期：2013-09-03 00:00:00

abstract：:Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inf...

journal_title：Frontiers in immunology

authors： Kostovcikova K,Coufal S,Galanova N,Fajstova A,Hudcovic T,Kostovcik M,Prochazkova P,Jiraskova Zakostelska Z,Cermakova M,Sediva B,Kuzma M,Tlaskalova-Hogenova H,Kverka M

更新日期：2019-04-26 00:00:00

abstract：:Visceral leishmaniasis is a severe form of the disease, caused by Leishmania infantum in the New World. Patients present an anergic immune response that favors parasite establishment and spreading through tissues like bone marrow and liver. On the other hand, Leishmania braziliensis causes localized cutaneous lesions,...

journal_title：Frontiers in immunology

authors： Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB

更新日期：2016-08-03 00:00:00

abstract：:Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell (HSC) transplantation, but when histocompatibility leukocyte antigen-matched donors are lacking, this can be a high-risk procedure. Correcting the patient's o...

journal_title：Frontiers in immunology

authors： Ott de Bruin LM,Volpi S,Musunuru K

更新日期：2015-05-21 00:00:00

abstract：:Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their relatively recent discovery, several studies have revealed that Tfr interact with other cells within this niche and shape ensuing res...

journal_title：Frontiers in immunology

authors： Miles B,Connick E

更新日期：2018-11-20 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:Induced expression of serum amyloid A (SAA) is a hallmark of many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 is the predominant isoform of inducible SAA proteins that also include SAA1 and SAA...

journal_title：Frontiers in immunology

authors： Zhang G,Liu J,Wu L,Fan Y,Sun L,Qian F,Chen D,Ye RD

更新日期：2018-06-29 00:00:00

abstract：:The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leu...

journal_title：Frontiers in immunology

authors： Sachamitr P,Leishman AJ,Davies TJ,Fairchild PJ

更新日期：2018-01-08 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumstances (i.e., strong...

journal_title：Frontiers in immunology

authors： Agazio A,Cimons J,Shotts KM,Guo K,Santiago ML,Pelanda R,Torres RM

更新日期：2020-07-22 00:00:00

abstract：:The mucin gene, MUC5AC, is highly expressed both in chronic respiratory inflammatory diseases and inflammatory bowel disease where mucin secretion is regulated by members of the interleukin IL-20 subfamily. This study was conducted to determine the roles and mechanisms of IL-19, a member of the IL-20 subfamily, in reg...

journal_title：Frontiers in immunology

authors： Lai X,Li X,Chang L,Chen X,Huang Z,Bao H,Huang J,Yang L,Wu X,Wang Z,Bellanti JA,Zheng SG,Zhang G

更新日期：2019-07-17 00:00:00

abstract：:Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear receptor (NR) family of transcription factors have been reported to aff...

journal_title：Frontiers in immunology

authors： Tel-Karthaus N,Kers-Rebel ED,Looman MW,Ichinose H,de Vries CJ,Ansems M

更新日期：2018-08-03 00:00:00

abstract：:Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and mal...

journal_title：Frontiers in immunology

authors： Patel SY,Carbone J,Jolles S

更新日期：2019-02-08 00:00:00

abstract：:The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-s...

journal_title：Frontiers in immunology

authors： Ashley CL,Abendroth A,McSharry BP,Slobedman B

更新日期：2019-12-11 00:00:00

abstract：:Hepatitis B virus (HBV) infection is regarded as the main etiological risk factor in the process of hepatocellular carcinoma (HCC), as it promotes an immunosuppressive microenvironment that is partially mediated by the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling pathway. The tumo...

journal_title：Frontiers in immunology

authors： Li B,Yan C,Zhu J,Chen X,Fu Q,Zhang H,Tong Z,Liu L,Zheng Y,Zhao P,Jiang W,Fang W

更新日期：2020-05-28 00:00:00

abstract：:Tumor necrosis factor-α inhibitors (TNFis) have revolutionized the management of rheumatoid arthritis (RA), however despite considerable progress, only a small proportion of patients maintain long-term clinical response. Selection of, and switching between, biologics is mainly empirical, experiential, and not evidence...

journal_title：Frontiers in immunology

authors： Mehta P,Manson JJ

更新日期：2020-04-07 00:00:00

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the Royal-Free-Hospital (RFH) London CVID cohort, including symptoms,...

journal_title：Frontiers in immunology

authors： van Schewick CM,Nöltner C,Abel S,Burns SO,Workman S,Symes A,Guzman D,Proietti M,Bulashevska A,Moreira F,Soetedjo V,Lowe DM,Grimbacher B

更新日期：2020-07-31 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2019.01137.]. ...

journal_title：Frontiers in immunology

authors： Luchini LSG,Pidde G,Squaiella-Baptistão CC,Tambourgi DV

更新日期：2019-07-03 00:00:00

abstract：:Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polym...

journal_title：Frontiers in immunology

authors： Xu-Yang Z,Pei-Yu B,Chuan-Tao Y,Wei Y,Hong-Wei M,Kang T,Chun-Mei Z,Ying-Feng L,Xin W,Ping-Zhong W,Chang-Xing H,Xue-Fan B,Ying Z,Zhan-Sheng J

更新日期：2017-01-03 00:00:00

abstract：:Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading to disability in young adults. The outcome of the disease is unpredictable, and over time, neurological disabilities accumulate. Interferon beta-1b was the first drug to be approved in the 1990s for relapsing-remitting MS to modula...

journal_title：Frontiers in immunology

authors： Rommer PS,Milo R,Han MH,Satyanarayan S,Sellner J,Hauer L,Illes Z,Warnke C,Laurent S,Weber MS,Zhang Y,Stuve O

更新日期：2019-07-11 00:00:00