T-cell immunity to infection with dengue virus in humans.

abstract：:Background: Alemtuzumab is a highly effective drug for the treatment of multiple sclerosis (MS), characterized by specific patterns of depletion and repopulation. As an induction-like treatment concept, two mandatory infusion courses can inhibit long-term disease activity in the majority of patients, and additional co...

journal_title：Frontiers in immunology

authors： Akgün K,Blankenburg J,Marggraf M,Haase R,Ziemssen T

更新日期：2020-01-31 00:00:00

abstract：:The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies. So far only two alleles, the HLA-B*2706 in Asia and the HLA-B*2709 in Sardinia, have not been f...

journal_title：Frontiers in immunology

authors： Paladini F,Fiorillo MT,Tedeschi V,Cauli A,Mathieu A,Sorrentino R

更新日期：2019-01-25 00:00:00

abstract：:Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacter...

journal_title：Frontiers in immunology

authors： Chandrasekaran P,Saravanan N,Bethunaickan R,Tripathy S

更新日期：2017-10-18 00:00:00

abstract：:Background: CXCL13 is preferentially secreted by Follicular Helper T cells (TFH) to attract B cells to germinal centers. Plasma levels of CXCL13 have been reported to be elevated during chronic HIV-infection, however there is limited data on such elevation during early phases of infection and on the effect of ART. Mor...

journal_title：Frontiers in immunology

authors： Mehraj V,Ramendra R,Isnard S,Dupuy FP,Lebouché B,Costiniuk C,Thomas R,Szabo J,Baril JG,Trottier B,Coté P,LeBlanc R,Durand M,Chartrand-Lefebvre C,Kema I,Zhang Y,Finkelman M,Tremblay C,Routy JP

更新日期：2019-02-21 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive polyarthritis. Beyond joint pathology, RA is associated with neuropsychiatric comorbidity including depression, anxiety, and an increased risk to develop neurodegenerative diseases in later life. Studies investigating the central nerv...

journal_title：Frontiers in immunology

authors： Süß P,Rothe T,Hoffmann A,Schlachetzki JCM,Winkler J

更新日期：2020-12-10 00:00:00

abstract：:Cell signaling is an essential requirement for mammalian cell invasion by Trypanosoma cruzi. Depending on the parasite strain and the parasite developmental form, distinct signaling pathways may be induced. In this short review, we focus on the data coming from studies with metacyclic trypomastigotes (MT) generated in...

journal_title：Frontiers in immunology

authors： Maeda FY,Cortez C,Yoshida N

更新日期：2012-11-28 00:00:00

abstract：:Newborns are prone to fungal infections, largely due to Candida species. The immunological basis for this vulnerability is not yet fully understood. However, useful insights can be gained from the knowledge of the maturation of immune pathways during ontogeny, particularly when placed in context with how rare genetic ...

journal_title：Frontiers in immunology

authors： Michalski C,Kan B,Lavoie PM

更新日期：2017-03-15 00:00:00

abstract：:Migraine is a common, little understood, and debilitating disease. It is much more prominent in women than in men (~2/3 are women) but the reasons for female preponderance are not clear. Migraineurs frequently experience severe comorbidities, such as allergies, depression, irritable bowel syndrome, and others; many of...

journal_title：Frontiers in immunology

authors： Loewendorf AI,Matynia A,Saribekyan H,Gross N,Csete M,Harrington M

更新日期：2016-04-19 00:00:00

abstract：:Allergic asthma is a chronic Th2 inflammatory disease of the lower airways affecting a growing number of people worldwide. The impact of infections and microbiota composition on allergic asthma has been investigated frequently. Until now, however, there have been few attempts to investigate the impact of asthma on the...

journal_title：Frontiers in immunology

authors： Machelart A,Potemberg G,Van Maele L,Demars A,Lagneaux M,De Trez C,Sabatel C,Bureau F,De Prins S,Percier P,Denis O,Jurion F,Romano M,Vanderwinden JM,Letesson JJ,Muraille E

更新日期：2018-08-10 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2020.00367.]. ...

journal_title：Frontiers in immunology

authors： Iizasa H,Kim H,Kartika AV,Kanehiro Y,Yoshiyama H

更新日期：2020-04-03 00:00:00

abstract：:Background: The systemic inflammatory cascade triggered in donors after brain death enhances the ischemia-reperfusion injury after organ transplantation. Intravenous steroids are routinely used in the intensive care units for the donor preconditioning. Immunosuppressive medications could be potentially used for this p...

journal_title：Frontiers in immunology

authors： Abbasi Dezfouli S,Nikdad M,Ghamarnejad O,Khajeh E,Arefidoust A,Mohammadi S,Majlesara A,Sabagh M,Gharabaghi N,Kentar M,Younsi A,Eckert C,Poth T,Golriz M,Mehrabi A,Nickkholgh A

更新日期：2020-06-18 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and mal...

journal_title：Frontiers in immunology

authors： Patel SY,Carbone J,Jolles S

更新日期：2019-02-08 00:00:00

abstract：:Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and initiate the actin polymerization that drives internalization. Tissue-r...

journal_title：Frontiers in immunology

authors： Kwon W,Freeman SA

更新日期：2020-11-13 00:00:00

abstract：:An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a ...

journal_title：Frontiers in immunology

authors： Fazilleau N,Aloulou M

更新日期：2018-08-13 00:00:00

abstract：:A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit highest activity on di...

journal_title：Frontiers in immunology

authors： Schäfer D,Henze J,Pfeifer R,Schleicher A,Brauner J,Mockel-Tenbrinck N,Barth C,Gudert D,Al Rawashdeh W,Johnston ICD,Hardt O

更新日期：2020-08-07 00:00:00

abstract：:Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL). The proper o...

journal_title：Frontiers in immunology

authors： Bannas P,Hambach J,Koch-Nolte F

更新日期：2017-11-22 00:00:00

abstract：:Background: The relationship between SARS-CoV-2-carrying time and specific antibody production has not yet been reported in re-admitted COVID-19 patients. We reported a case of mild COVID-19 with long virus-carrying time, weak production of virus-specific IgG and IgM antibodies, and recurrence of positive SARS-CoV-2 R...

journal_title：Frontiers in immunology

authors： Guo X,Zeng L,Huang Z,He Y,Zhang Z,Zhong Z

更新日期：2020-08-07 00:00:00

abstract：:The immunization of allogeneic hematopoietic cell transplantation (HCT) recipients against vaccine-preventable diseases is a part of posttransplantation guidelines. We conducted a prospective study to assess clinical and immunological parameters that would determine the response and long-term maintenance of protective...

journal_title：Frontiers in immunology

authors： Piekarska A,Wisniewski P,Lewandowski K,Gil L,Trzonkowski P,Bieniaszewska M,Zaucha JM

更新日期：2020-11-24 00:00:00

abstract：:Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different...

journal_title：Frontiers in immunology

authors： Bouvier I,Jusforgues-Saklani H,Lim A,Lemaître F,Lemercier B,Auriau C,Nicola MA,Leroy S,Law HK,Bandeira A,Moon JJ,Bousso P,Albert ML

更新日期：2011-12-08 00:00:00

abstract：:Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize antigens presented on M...

journal_title：Frontiers in immunology

authors： Accolla RS,Ramia E,Tedeschi A,Forlani G

更新日期：2019-07-30 00:00:00

abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

journal_title：Frontiers in immunology

authors： Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

更新日期：2020-07-23 00:00:00

abstract：:Crystallopathies are a heterogeneous group of diseases caused by intrinsic or environmental microparticles or crystals, promoting tissue inflammation and scarring. Certain proteins interfere with crystal formation and growth, e.g., with intrarenal calcium oxalate (CaOx) crystal formation, a common cause of kidney ston...

journal_title：Frontiers in immunology

authors： Steiger S,Grill JF,Ma Q,Bäuerle T,Jordan J,Smolle M,Böhland C,Lech M,Anders HJ

更新日期：2018-03-29 00:00:00

abstract：:West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. F...

journal_title：Frontiers in immunology

authors： Koblischke M,Spitzer FS,Florian DM,Aberle SW,Malafa S,Fae I,Cassaniti I,Jungbauer C,Knapp B,Laferl H,Fischer G,Baldanti F,Stiasny K,Heinz FX,Aberle JH

更新日期：2020-01-23 00:00:00

abstract：:Dendritic cells (DC), master antigen-presenting cells that orchestrate interactions between the adaptive and innate immune arms, are increasingly utilized in cancer immunotherapy. Despite remarkable progress in our understanding of DC immunobiology, as well as several encouraging clinical applications - such as DC-bas...

journal_title：Frontiers in immunology

authors： Datta J,Berk E,Cintolo JA,Xu S,Roses RE,Czerniecki BJ

更新日期：2015-06-02 00:00:00

abstract：:Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature upregulated in stressed cells and therefore abundantly present as potential targets for such regulation...

journal_title：Frontiers in immunology

authors： van Eden W,Jansen MAA,de Wolf ACM,Ludwig IS,Leufkens P,Broere F

更新日期：2017-11-30 00:00:00

abstract：:PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs, and a well-known antagonist of terminal erythroid cell differentiation, it is also expressed in the earliest stages of T-cell development of each...

journal_title：Frontiers in immunology

authors： Rothenberg EV,Hosokawa H,Ungerbäck J

更新日期：2019-02-20 00:00:00

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:Malaria infections remain a serious global health problem in the world, particularly among children and pregnant women in Sub-Saharan Africa. Moreover, malaria control and elimination is hampered by rapid development of resistance by the parasite and the vector to commonly used antimalarial drugs and insecticides, res...

journal_title：Frontiers in immunology

authors： Kengne-Ouafo JA,Sutherland CJ,Binka FN,Awandare GA,Urban BC,Dinko B

更新日期：2019-02-11 00:00:00