T-cell immunity to infection with dengue virus in humans.


:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate and progress to dengue hemorrhagic fever and/or dengue shock syndrome, characterized by severe vascular leakage, thrombocytopenia, and hemorrhagic manifestations. A unique challenge in vaccine development against DENV is the high degree of sequence variation, characteristically associated with RNA viruses. This is of particular relevance in the case of DENV since infection with one DENV serotype (primary infection) presumably affords life-long serotype-specific immunity but only partial and temporary immunity to other serotypes in secondary infection settings. The role of T cells in DENV infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin theory, skewing of T-cell responses induced by primary infection with one serotype causes less effective response upon secondary infection with a different serotype, predisposing to severe disease. Our recent study has suggested an HLA-linked protective role for T cells. Herein, we will discuss the role of T cells in protection and pathogenesis from severe disease as well as the implications for vaccine design.


Front Immunol


Frontiers in immunology


Weiskopf D,Sette A




Has Abstract


2014-03-07 00:00:00








  • Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.

    abstract::A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irrad...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Liu J,Zhou J,Wu M,Hu C,Yang J,Li D,Wu P,Chen Y,Chen P,Lin S,Cui Y,Fu S,Wu J

    更新日期:2019-02-27 00:00:00

  • Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment.

    abstract::Infiltration of immune cells into the tumor microenvironment (TME) can regulate growth and survival of neoplastic cells, impacting tumorigenesis and tumor progression. Correlations between the number of effector immune cells present in a tumor and clinical outcomes in many human tumors, including breast, have been wid...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Pachynski RK,Wang P,Salazar N,Zheng Y,Nease L,Rosalez J,Leong WI,Virdi G,Rennier K,Shin WJ,Nguyen V,Butcher EC,Zabel BA

    更新日期:2019-05-08 00:00:00

  • Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms.

    abstract::The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved therapeutics do not ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Sharma V,Wright KL,Epling-Burnette PK,Reuther GW

    更新日期:2020-11-30 00:00:00

  • Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected with Leishmania infantum.

    abstract::Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

    更新日期:2017-11-23 00:00:00

  • Human NK Cell Subsets in Pregnancy and Disease: Toward a New Biological Complexity.

    abstract::In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anat...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Cristiani CM,Palella E,Sottile R,Tallerico R,Garofalo C,Carbone E

    更新日期:2016-12-27 00:00:00

  • Innate immune programing by endotoxin and its pathological consequences.

    abstract::Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent studies suggest that dynamic programing of macrophages and monocytes may give rise to distinct "memory" states. Lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate immune responses. Emerging...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Morris MC,Gilliam EA,Li L

    更新日期:2015-01-06 00:00:00

  • The Landscape and Prognosis Potential of the T-Cell Repertoire in Membranous Nephropathy.

    abstract::Membranous nephropathy (MN), a common pathological type of adult nephrotic syndrome, is an antibody-mediated kidney disease. It is widely accepted now that MN is an immune-related disease that involves the whole immune system. In this study, we analyzed the T-cell receptor beta chain (TCRβ) repertoire of the circulati...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhang Y,Jin Y,Guan Z,Li H,Su Z,Xie C,Chen X,Liu X,Pan Y,Ye P,Zhang L,Kong Y,Luo W

    更新日期:2020-03-10 00:00:00

  • Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis.

    abstract::Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and significant alterations of glycosylation are observed. These changes ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Läubli H,Borsig L

    更新日期:2019-09-06 00:00:00

  • Age-Based Dynamics of a Stable Circulating Cd8 T Cell Repertoire Component.

    abstract::T-cell memory to pathogens can be envisioned as a receptor-based imprint of the pathogenic environment on the naïve repertoire of clonotypes. Recurrent exposures to a pathogen inform and reinforce memory, leading to a mature state. The complexity and temporal stability of this system in man is only beginning to be ade...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Naumova EN,Yassai MB,Demos W,Reed E,Unruh M,Haribhai D,Williams CB,Naumov YN,Gorski J

    更新日期:2019-08-06 00:00:00

  • A Review of the Progress and Challenges of Developing a Vaccine for COVID-19.

    abstract::A novel coronavirus, which has been designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and causes the highly infectious disease referred to as COVID-19. COVID-19 has now spread worldwide to become a global pandemic affecting over 24 million pe...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Sharma O,Sultan AA,Ding H,Triggle CR

    更新日期:2020-10-14 00:00:00

  • Murine Intraepithelial Dendritic Cells Interact With Phagocytic Cells During Aspergillus fumigatus-Induced Inflammation.

    abstract::People are constantly exposed to airborne fungal spores, including Aspergillus fumigatus conidia that can cause life-threatening conditions in immunocompromised patients or acute exacerbations in allergics. However, immunocompetent hosts do not exhibit mycoses or systemic inflammation, due to the sufficient but not ex...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bogorodskiy AO,Bolkhovitina EL,Gensch T,Troyanova NI,Mishin AV,Okhrimenko IS,Braun A,Spies E,Gordeliy VI,Sapozhnikov AM,Borshchevskiy VI,Shevchenko MA

    更新日期:2020-02-25 00:00:00

  • Longer Duration of SARS-CoV-2 Infection in a Case of Mild COVID-19 With Weak Production of the Specific IgM and IgG Antibodies.

    abstract::Background: The relationship between SARS-CoV-2-carrying time and specific antibody production has not yet been reported in re-admitted COVID-19 patients. We reported a case of mild COVID-19 with long virus-carrying time, weak production of virus-specific IgG and IgM antibodies, and recurrence of positive SARS-CoV-2 R...

    journal_title:Frontiers in immunology



    authors: Guo X,Zeng L,Huang Z,He Y,Zhang Z,Zhong Z

    更新日期:2020-08-07 00:00:00

  • Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy.

    abstract::Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respir...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Vázquez A,Fernández-Sevilla LM,Jiménez E,Pérez-Cabrera D,Yañez R,Subiza JL,Varas A,Valencia J,Vicente A

    更新日期:2020-11-19 00:00:00

  • Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL1505.

    abstract::The oral administration of Lacticaseibacillus rhamnosus CRL1505 differentially modulates the respiratory innate antiviral immune response triggered by Toll-like receptor 3 (TLR3) activation in infant mice, improving the resistance to Respiratory Syncytial Virus (RSV) infection. In this work, by using macrophages deple...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Garcia-Castillo V,Tomokiyo M,Raya Tonetti F,Islam MA,Takahashi H,Kitazawa H,Villena J

    更新日期:2020-09-29 00:00:00

  • Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus.

    abstract::Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Nelson SA,Sant AJ

    更新日期:2019-05-07 00:00:00

  • Recent Developments in Recombinant Protein-Based Dengue Vaccines.

    abstract::Recombinant proteins are gaining enormous importance these days due to their wide application as biopharmaceutical products and proven safety record. Various recombinant proteins of therapeutic and prophylactic importance have been successfully produced in microbial and higher expression host systems. Since there is n...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Tripathi NK,Shrivastava A

    更新日期:2018-08-23 00:00:00

  • Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.

    abstract::Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a membrane (m)Hsp70-positive phenotype correlates with a high aggressiveness of th...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gunther S,Ostheimer C,Stangl S,Specht HM,Mozes P,Jesinghaus M,Vordermark D,Combs SE,Peltz F,Jung MP,Multhoff G

    更新日期:2015-11-02 00:00:00

  • Every breath you take: the impact of environment on resident memory CD8 T cells in the lung.

    abstract::Resident memory T cells (TRM) are broadly defined as a population of T cells, which persist in non-lymphoid sites long-term, do not re-enter the circulation, and are distinct from central memory T cells (TCM) and circulating effector memory T cells (TEM). Recent studies have described populations of TRM cells in the s...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Shane HL,Klonowski KD

    更新日期:2014-07-08 00:00:00

  • The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish.

    abstract::The inappropriate retention of neutrophils at inflammatory sites is a major driver of the excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, ARDS, and cystic fibrosis. The molecular programmes which orchestrate neutrophil recruitment to inflammatory sites through chemotactic gu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Isles HM,Herman KD,Robertson AL,Loynes CA,Prince LR,Elks PM,Renshaw SA

    更新日期:2019-07-31 00:00:00

  • Overcoming Target Driven Fratricide for T Cell Therapy.

    abstract::Chimeric Antigen Receptor (CAR) T cells expressing the fusion of the NKG2D protein with CD3ζ (NKG2D-CAR T Cells) acquire a specificity for stress-induced ligands expressed on hematological and solid cancers. However, these stress ligands are also transiently expressed by activated T cells implying that NKG2D-based T c...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Breman E,Demoulin B,Agaugué S,Mauën S,Michaux A,Springuel L,Houssa J,Huberty F,Jacques-Hespel C,Marchand C,Marijsse J,Nguyen T,Ramelot N,Violle B,Daro D,De Waele P,Gilham DE,Steenwinckel V

    更新日期:2018-12-12 00:00:00

  • Ionizing Radiation Induces Morphological Changes and Immunological Modulation of Jurkat Cells.

    abstract::Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

    更新日期:2018-04-30 00:00:00

  • Novel Association of High C-Reactive Protein Levels and A69S at Risk Alleles in Wet Age-Related Macular Degeneration Women.

    abstract:Purpose:To explore the relationship between plasma C-reactive protein (CRP) levels, the main ARMS2 gene single nucleotide polymorphism (SNP), and gender in patients with neovascular age-related macular degeneration (wet AMD). Methods:Our study included 131 patients with wetAMD [age-related eye disease study (AREDS) ca...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Fernandez-Robredo P,Recalde S,Hernandez M,Zarranz-Ventura J,Molins B,Casaroli-Marano RP,Adan A,Saenz-de-Viteri M,García-Layana A

    更新日期:2018-08-14 00:00:00

  • Circulating LPS and (1→3)-β-D-Glucan: A Folie à Deux Contributing to HIV-Associated Immune Activation.

    abstract::Immune activation is the driving force behind the occurrence of AIDS and non-AIDS events, and is only partially reduced by antiretroviral therapy (ART). Soon after HIV infection, intestinal CD4+ T cells are depleted leading to epithelial gut damage and subsequent translocation of microbes and/or their products into sy...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Ramendra R,Isnard S,Mehraj V,Chen J,Zhang Y,Finkelman M,Routy JP

    更新日期:2019-03-18 00:00:00

  • Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice.

    abstract::The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although the mechanism is still unknown, some studies have shown that cigarette exposure affects the intestinal barrier of the small bowel. Among the factors that may be involved in this process are Paneth ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Berkowitz L,Pardo-Roa C,Salazar GA,Salazar-Echegarai F,Miranda JP,Ramírez G,Chávez JL,Kalergis AM,Bueno SM,Álvarez-Lobos M

    更新日期:2019-09-25 00:00:00

  • Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1.

    abstract::Microglia are the brain-innate immune cells which actively surveil their environment and mediate multiple aspects of neuroinflammation, due to their ability to acquire diverse activation states and phenotypes. Simplified, M1-like microglia are defined as pro-inflammatory cells, while the alternative M2-like cells prom...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Collmann FM,Pijnenburg R,Hamzei-Taj S,Minassian A,Folz-Donahue K,Kukat C,Aswendt M,Hoehn M

    更新日期:2019-06-04 00:00:00

  • CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease.

    abstract::Mechanisms driving acute graft-versus-host disease (aGVHD) onset in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are still poorly understood. To provide a detailed characterization of tissue-infiltrating T lymphocytes (TL) and search for eventual site-specific specificities, we de...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Alhaj Hussen K,Michonneau D,Biajoux V,Keita S,Dubouchet L,Nelson E,Setterblad N,Le Buanec H,Bouaziz JD,Guimiot F,Socié G,Canque B

    更新日期:2020-11-24 00:00:00

  • Extracellular Chromatin Triggers Release of Soluble CEACAM8 Upon Activation of Neutrophils.

    abstract::Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In SLE and RA, extracellular chromatin may behave as a danger-associated molecular pattern (DAMP). Polymorphonuclear neutrophils...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ribon M,Mussard J,Semerano L,Singer BB,Decker P

    更新日期:2019-06-14 00:00:00

  • Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units.

    abstract::The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects chan...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Wehbi VL,Taskén K

    更新日期:2016-06-08 00:00:00

  • Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension.

    abstract::Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term outcome of BPD infa...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bui CB,Kolodziej M,Lamanna E,Elgass K,Sehgal A,Rudloff I,Schwenke DO,Tsuchimochi H,Kroon MAGM,Cho SX,Maksimenko A,Cholewa M,Berger PJ,Young MJ,Bourke JE,Pearson JT,Nold MF,Nold-Petry CA

    更新日期:2019-07-11 00:00:00

  • Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization.

    abstract::Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the liposome-based adjuvants CAF01 and CAF09 and the protein-based adjuva...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Bhide Y,Dong W,Gribonika I,Voshart D,Meijerhof T,de Vries-Idema J,Norley S,Guilfoyle K,Skeldon S,Engelhardt OG,Boon L,Christensen D,Lycke N,Huckriede A

    更新日期:2019-03-29 00:00:00