Corrigendum: Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases.

abstract：:Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56++CD16...

journal_title：Frontiers in immunology

authors： Huenecke S,Cappel C,Esser R,Pfirrmann V,Salzmann-Manrique E,Betz S,Keitl E,Banisharif-Dehkordi J,Bakhtiar S,Königs C,Jarisch A,Soerensen J,Ullrich E,Klingebiel T,Bader P,Bremm M

更新日期：2017-02-10 00:00:00

abstract：:The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial...

journal_title：Frontiers in immunology

authors： Xu HY,Dong F,Zhai X,Meng KF,Han GK,Cheng GF,Wu ZB,Li N,Xu Z

更新日期：2020-09-23 00:00:00

abstract：Background:Interleukin-9 (IL9) plays a critical role in immunity and the pathogenesis of endometrial cancer (EC), especially endometrioid EC (EEC). This study aimed to identify the IL9+ immune cell subsets and their pleiotropic functions and establish an optimized prognostic nomogram towards the promotion of personaliz...

journal_title：Frontiers in immunology

authors： Tong H,Feng H,Hu X,Wang MF,Song YF,Wen XL,Li YR,Wan XP

更新日期：2020-11-19 00:00:00

abstract：:The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+ cell population to ...

journal_title：Frontiers in immunology

authors： Wang X,Laan M,Bichele R,Kisand K,Scott HS,Peterson P

更新日期：2012-03-01 00:00:00

abstract：:The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined...

journal_title：Frontiers in immunology

authors： Yang L,Fu J,Zhou Y

更新日期：2020-08-27 00:00:00

abstract：:Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since uncleared apoptotic c...

journal_title：Frontiers in immunology

authors： Lloyd KA,Wigerblad G,Sahlström P,Garimella MG,Chemin K,Steen J,Titcombe PJ,Marklein B,Zhou D,Stålesen R,Ossipova E,Lundqvist C,Ekwall O,Rönnelid J,Mueller DL,Karlsson MCI,Kaplan MJ,Skriner K,Klareskog L,Wermeling F

更新日期：2019-01-04 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...

journal_title：Frontiers in immunology

authors： Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

更新日期：2020-08-18 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:Chronic periodontitis is an inflammatory disease caused by the formation of oral microbial biofilms. Periodontitis is associated with general health and not only oral diseases. Porphyromonas gingivalis is a well-known keystone pathogen for periodontitis and is associated with several systemic diseases, such as diabete...

journal_title：Frontiers in immunology

authors： Hirai K,Yamaguchi-Tomikawa T,Eguchi T,Maeda H,Takashiba S

更新日期：2020-06-05 00:00:00

abstract：:Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied. Here we report an essential role of protein arginine methyltransferase 5 (PRMT5) in T cell homeostasis and activation-induced expansion. Usi...

journal_title：Frontiers in immunology

authors： Tanaka Y,Nagai Y,Okumura M,Greene MI,Kambayashi T

更新日期：2020-04-09 00:00:00

abstract：:TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also bacteria. We previously identified a TLR8-IFN regulatory factor 5 (IRF5) signaling pathway that mediates IFNβ and interleukin-12 (IL-12) induction by Staphyloco...

journal_title：Frontiers in immunology

authors： Ehrnström B,Beckwith KS,Yurchenko M,Moen SH,Kojen JF,Lentini G,Teti G,Damås JK,Espevik T,Stenvik J

更新日期：2017-10-03 00:00:00

abstract：:The intestinal microbiota, composed of a large population of microorganisms, is often considered a "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis of the intestinal microbiota is closely related to colorectal cancer (CRC). The roles for intestinal microorganisms that initia...

journal_title：Frontiers in immunology

authors： Cheng Y,Ling Z,Li L

更新日期：2020-11-30 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer. The influence of age on levels and functional characteristics of circulating MAIT cells have not been fully addressed. Here w...

journal_title：Frontiers in immunology

authors： Chen P,Deng W,Li D,Zeng T,Huang L,Wang Q,Wang J,Zhang W,Yu X,Duan D,Wang J,Xia H,Chen H,Huang W,Li J,Zhang D,Zhong XP,Gao J

更新日期：2019-02-19 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, ser...

journal_title：Frontiers in immunology

authors： Wang D,Jiang X,Teng S,Zhang Y,Liu Y,Li X,Li Y

更新日期：2019-05-08 00:00:00

abstract：:Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI (peptide-major histocompatibility complex class I) molecules. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI...

journal_title：Frontiers in immunology

authors： Wooldridge L

更新日期：2013-07-23 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:The effects of calcium (Ca) or strontium (Sr) on host osteogenesis and immune responses have been investigated separately. In clinical practice, these two elements may both be present around an orthopedic device, but their potential synergistic effects on osteogenesis and the immune response have not been explored to ...

journal_title：Frontiers in immunology

authors： Yuan X,Cao H,Wang J,Tang K,Li B,Zhao Y,Cheng M,Qin H,Liu X,Zhang X

更新日期：2017-09-29 00:00:00

abstract：:In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible TCRs encoded in the genome (the potential repertoire) and the nu...

journal_title：Frontiers in immunology

authors： Zarnitsyna VI,Evavold BD,Schoettle LN,Blattman JN,Antia R

更新日期：2013-12-26 00:00:00

abstract：:Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a...

journal_title：Frontiers in immunology

authors： Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X

更新日期：2019-03-19 00:00:00

abstract：:Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adjuvant principle. How...

journal_title：Frontiers in immunology

authors： Schubert N,Lisenko K,Auerbach C,Weitzmann A,Ghouse SM,Muhandes L,Haase C,Häring T,Schulze L,Voehringer D,Gunzer F,Müller W,Feyerabend TB,Rodewald HR,Dudeck A,Roers A

更新日期：2018-08-28 00:00:00

abstract：:Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

journal_title：Frontiers in immunology

authors： Zwaini Z,Alammari D,Byrne S,Stover C

更新日期：2016-03-30 00:00:00

abstract：:Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucidated. We tested the hypothesis that the mechanisms also involve ...

journal_title：Frontiers in immunology

authors： Kwun J,Park J,Yi JS,Farris AB,Kirk AD,Knechtle SJ

更新日期：2018-10-15 00:00:00

abstract：:Despite significant breakthroughs in understanding of immunological and physiological features of autoimmune diseases, there is currently no specific therapeutic option with prolonged remission. Cell-based therapy using engineered-T cells has attracted tremendous attention as a practical treatment for autoimmune disea...

journal_title：Frontiers in immunology

authors： Sadeqi Nezhad M,Seifalian A,Bagheri N,Yaghoubi S,Karimi MH,Adbollahpour-Alitappeh M

更新日期：2020-11-26 00:00:00

abstract：:Recent studies have demonstrated that combination of modulatory immune strategies may potentiate tumor cell elimination. Most strategies rely on the use of monoclonal antibodies that can block cell surface receptors to overcome tumor-induced immunosuppression or acting as costimulatory ligands to boost activation of T...

journal_title：Frontiers in immunology

authors： Manrique-Rincón AJ,Beraldo CM,Toscaro JM,Bajgelman MC

更新日期：2017-09-19 00:00:00

abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...

journal_title：Frontiers in immunology

authors： Serrano-Coll H,Ospina JP,Salazar-Peláez L,Cardona-Castro N

更新日期：2020-03-19 00:00:00

abstract：:Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the reso...

journal_title：Frontiers in immunology

authors： Barnig C,Bezema T,Calder PC,Charloux A,Frossard N,Garssen J,Haworth O,Dilevskaya K,Levi-Schaffer F,Lonsdorfer E,Wauben M,Kraneveld AD,Te Velde AA

更新日期：2019-07-23 00:00:00

abstract：:Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-β1), are involved in tumor immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represent opportunities for the...

journal_title：Frontiers in immunology

authors： Klöss S,Chambron N,Gardlowski T,Weil S,Koch J,Esser R,Pogge von Strandmann E,Morgan MA,Arseniev L,Seitz O,Köhl U

更新日期：2015-11-02 00:00:00