PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling.

abstract：:The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, a...

journal_title：Frontiers in immunology

authors： Natoli R,Mason E,Jiao H,Chuah A,Patel H,Fernando N,Valter K,Wells CA,Provis J,Rutar M

更新日期：2018-07-18 00:00:00

abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

journal_title：Frontiers in immunology

authors： Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

更新日期：2020-07-23 00:00:00

abstract：:Liver fibrosis can result from various causes and could progress to cirrhosis and cancer; however, there are no effective treatments due to that its molecular mechanism is unclear. liver fibrosis model made by Schistosoma japonicum (S. japonicum) infection or Carbon tetrachloride (CCl4) intraperitoneal injection is a ...

journal_title：Frontiers in immunology

authors： Song LJ,Yin XR,Mu SS,Li JH,Gao H,Zhang Y,Dong PP,Mei CJ,Hua ZC

更新日期：2020-10-07 00:00:00

abstract：:Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of transcription (STAT)-3 as dominant signaling mode. IL-10, formerly known as c...

journal_title：Frontiers in immunology

authors： Mühl H

更新日期：2013-02-04 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

journal_title：Frontiers in immunology

authors： Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

更新日期：2020-06-17 00:00:00

abstract：:According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25⁺Foxp3⁻ developmental intermediate. These precursors subsequently require cy...

journal_title：Frontiers in immunology

authors： Hinterberger M,Wirnsberger G,Klein L

更新日期：2011-07-25 00:00:00

abstract：:CD4+ T cells comprise multiple functionally distinct cell populations that play a key role in immunity. Despite blood monitoring of CD4+ T-cell subsets is of potential clinical utility, no standardized and validated approaches have been proposed so far. The aim of this study was to design and validate a single 14-colo...

journal_title：Frontiers in immunology

authors： Botafogo V,Pérez-Andres M,Jara-Acevedo M,Bárcena P,Grigore G,Hernández-Delgado A,Damasceno D,Comans S,Blanco E,Romero A,Arriba-Méndez S,Gastaca-Abasolo I,Pedreira CE,van Gaans-van den Brink JAM,Corbiere V,Mascart F,van El

更新日期：2020-02-27 00:00:00

abstract：:Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the major cause of peptic ulcer disease and gastric cancer, disease occurs in a minority of thos...

journal_title：Frontiers in immunology

authors： Hussain K,Letley DP,Greenaway AB,Kenefeck R,Winter JA,Tomlinson W,Rhead J,Staples E,Kaneko K,Atherton JC,Robinson K

更新日期：2016-03-07 00:00:00

abstract：:Mutants of a catalytically inactive variant of Proteinase 3 (PR3)-iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103-offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in granulomatosis with polyangiitis (GPA) and whether such interactions can...

journal_title：Frontiers in immunology

authors： Pang YP,Casal Moura M,Thompson GE,Nelson DR,Hummel AM,Jenne DE,Emerling D,Volkmuth W,Robinson WH,Specks U

更新日期：2019-10-25 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B vi...

journal_title：Frontiers in immunology

authors： Yong YK,Saeidi A,Tan HY,Rosmawati M,Enström PF,Batran RA,Vasuki V,Chattopadhyay I,Murugesan A,Vignesh R,Kamarulzaman A,Rajarajeswaran J,Ansari AW,Vadivelu J,Ussher JE,Velu V,Larsson M,Shankar EM

更新日期：2018-03-19 00:00:00

abstract：:Significant advances have been made to identify effective therapies that either restore or generate de novo a patient's immune response to cancer, so-called immunotherapy or immuno-oncology (IO) therapies. Some tumors overcome immune surveillance by promoting mechanisms to evade or suppress the immune system. This con...

journal_title：Frontiers in immunology

authors： Wilkinson RW,Leishman AJ

更新日期：2018-06-01 00:00:00

abstract：:Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the strength of interaction between the T-cell receptor (TCR) and peptide...

journal_title：Frontiers in immunology

authors： Jones N,Cronin JG,Dolton G,Panetti S,Schauenburg AJ,Galloway SAE,Sewell AK,Cole DK,Thornton CA,Francis NJ

更新日期：2017-11-09 00:00:00

abstract：:Inflammation is a complex process which is highly conserved among species. Inflammation occurs in response to injury, infection, and cancer, as an allostatic mechanism to return the tissue and to return the organism back to health and homeostasis. Excessive, or chronic inflammation is associated with numerous diseases...

journal_title：Frontiers in immunology

authors： Desgeorges T,Caratti G,Mounier R,Tuckermann J,Chazaud B

更新日期：2019-07-09 00:00:00

abstract：:Macrophages, as professional phagocytes of the immune system, possess the ability to detect and clear invading pathogens and apoptotic cells through phagocytosis. Phagocytosis involves membrane reorganization and remodeling events on the cell surface, which play an essential role in innate immunity and tissue homeosta...

journal_title：Frontiers in immunology

authors： Rubio JM,Astudillo AM,Casas J,Balboa MA,Balsinde J

更新日期：2018-07-24 00:00:00

abstract：:Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding RNAs (lncRNAs), some of which may play critical roles in the cell. We have previously shown that a large number of lncRNAs show differential expression in response to interferon (IFN)α stimulation in primary human cells. Here...

journal_title：Frontiers in immunology

authors： Kambara H,Gunawardane L,Zebrowski E,Kostadinova L,Jobava R,Krokowski D,Hatzoglou M,Anthony DD,Valadkhan S

更新日期：2015-01-30 00:00:00

abstract：:CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in human...

journal_title：Frontiers in immunology

authors： Wu YC,Kipling D,Dunn-Walters DK

更新日期：2011-12-26 00:00:00

abstract：:Immunotherapies are rapidly being integrated into standard of care (SOC) therapy in conjunction with surgery, chemotherapy, and radiotherapy for many cancers and a large number of clinical studies continue to explore immunotherapy alone and as part of combination therapies in patients with cancer. It is evident that c...

journal_title：Frontiers in immunology

authors： Holl EK,Frazier VN,Landa K,Beasley GM,Hwang ES,Nair SK

更新日期：2019-07-31 00:00:00

abstract：:Influenza virus NS2 is well known for its role in viral ribonucleoprotein nuclear export; however, its function has not been fully understood. A recent study showed that NS2 might interact with HIST1H1C (H1C, H1.2). Histones have been found to affect influenza virus replication, such as the H2A, H2B, H3, and H4, but H...

journal_title：Frontiers in immunology

authors： Liu X,Yang C,Hu Y,Lei E,Lin X,Zhao L,Zou Z,Zhang A,Zhou H,Chen H,Qian P,Jin M

更新日期：2017-03-24 00:00:00

abstract：OBJECTIVE:Multiple solid cancers contain tertiary lymphoid organs (TLO). However, it is unclear whether they promote tumor rejection, facilitate tumor evasion, or simply whether they are a byproduct of chronic inflammation. We hypothesize that although chronic inflammation induces TLO formation, the tumor milieu can mo...

journal_title：Frontiers in immunology

authors： García-Hernández ML,Uribe-Uribe NO,Espinosa-González R,Kast WM,Khader SA,Rangel-Moreno J

更新日期：2017-05-17 00:00:00

abstract：:The mechanistic requirements of antigen recognition by T cells expressing a γδ TCR has revealed important differences with those of αβ TCR cells and, despite impressive new data generated in the very recent years, they remain poorly understood. Based on the structure of the TCR chains and the tissue distribution, γδ c...

journal_title：Frontiers in immunology

authors： De Libero G,Lau SY,Mori L

更新日期：2015-01-15 00:00:00

abstract：:Cell signaling is an essential requirement for mammalian cell invasion by Trypanosoma cruzi. Depending on the parasite strain and the parasite developmental form, distinct signaling pathways may be induced. In this short review, we focus on the data coming from studies with metacyclic trypomastigotes (MT) generated in...

journal_title：Frontiers in immunology

authors： Maeda FY,Cortez C,Yoshida N

更新日期：2012-11-28 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00

abstract：:The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial...

journal_title：Frontiers in immunology

authors： Xu HY,Dong F,Zhai X,Meng KF,Han GK,Cheng GF,Wu ZB,Li N,Xu Z

更新日期：2020-09-23 00:00:00

abstract：:Leprosy is a chronic bacterial disease caused by Mycobacterium leprae. Cytokines are known to play vital role as a peacekeeper during inflammatory and other immunocompromised conditions such as leprosy. This study has tried to bridge the gap of information on cytokine gene polymorphisms and its potential role in the p...

journal_title：Frontiers in immunology

authors： Tarique M,Naz H,Saini C,Suhail M,Shankar H,Khanna N,Sharma A

更新日期：2020-08-06 00:00:00

abstract：:The large family of chemoattractant cytokines (chemokines) embraces multiple, in part unrelated functions that go well beyond chemotaxis. Undoubtedly, the control of immune cell migration (chemotaxis) is the single, unifying response mediated by all chemokines, which involves the sequential engagement of chemokine rec...

journal_title：Frontiers in immunology

authors： Wolf M,Moser B

更新日期：2012-07-23 00:00:00

abstract：:Abnormal gene expression patterns underlie many diseases that represent major public health concerns and robust therapeutic challenges. Posttranscriptional gene regulation by RNA-binding proteins (RBPs) is well-recognized, and the biological functions of RBPs have been implicated in many diseases, such as autoimmune d...

journal_title：Frontiers in immunology

authors： Nyati KK,Agarwal RG,Sharma P,Kishimoto T

更新日期：2019-12-05 00:00:00

abstract：:Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). However, the specific biological function of extracellular AMP has not been identified. We evaluated the effect of extracellular AM...

journal_title：Frontiers in immunology

authors： Hua Y,Liu D,Zhang D,Wang X,Wei Q,Qin W

更新日期：2020-07-07 00:00:00

abstract：:T lymphocytes first carried foreign genes safely into humans over two decades ago. Since these pioneering studies, scientific techniques to better understand the genomic landscape of cells has directly led to a more sophisticated appreciation of the diversity, functional complexity, and therapeutic potential of T cell...

journal_title：Frontiers in immunology

authors： Kerkar SP

更新日期：2013-09-27 00:00:00

abstract：Purpose:Patients with juvenile idiopathic arthritis (JIA) are prone to developing chronic anterior uveitis (JIA-U+). Although several risk factors for JIA-U+ have been identified, the underlying etiology is poorly understood. Histopathological studies demonstrate B cell infiltrates in eye tissues of patients with JIA-U...

journal_title：Frontiers in immunology

authors： Wennink RAW,Pandit A,Haasnoot AJW,Hiddingh S,Kalinina Ayuso V,Wulffraat NM,Vastert BJ,Radstake TRDJ,de Boer JH,Kuiper JJW

更新日期：2020-09-17 00:00:00