Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome.

abstract：:Previous studies have shown targeting different tissues via the transcutaneous (TC) and intramuscular injection (IM) with or without electroporation (EP) has the potential to trigger immune responses to DNA vaccination. The CUTHIVTHER 001 Phase I/II randomized controlled clinical trial was designed to determine whethe...

journal_title：Frontiers in immunology

authors： Haidari G,Day S,Wood M,Ridgers H,Cope AV,Fleck S,Yan C,Reijonen K,Hannaman D,Spentzou A,Hayes P,Vogt A,Combadiere B,Cook A,McCormack S,Shattock RJ

更新日期：2019-12-13 00:00:00

abstract：:Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV during infection and this virus triggers robust TNF production in the host macrophages, which might be a key mediator of virus induced inflam...

journal_title：Frontiers in immunology

authors： Nayak TK,Mamidi P,Sahoo SS,Kumar PS,Mahish C,Chatterjee S,Subudhi BB,Chattopadhyay S,Chattopadhyay S

更新日期：2019-04-12 00:00:00

abstract：:Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first performed exploratory...

journal_title：Frontiers in immunology

authors： Quintela-Carvalho G,Luz NF,Celes FS,Zanette DL,Andrade D,Menezes D,Tavares NM,Brodskyn CI,Prates DB,Gonçalves MS,de Oliveira CI,Almeida RP,Bozza MT,Andrade BB,Borges VM

更新日期：2017-11-23 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:Cow's milk protein allergy (CMPA) is the most common allergy in the first year of life. Non-IgE mediated CMPA is characterized by digestive symptoms and tolerance development before the age of three. Gut microbiota composition in early life has been associated with food allergy. The ingestion of different foods/nutrie...

journal_title：Frontiers in immunology

authors： Guadamuro L,Diaz M,Jiménez S,Molinos-Norniella C,Pérez-Solis D,Rodríguez JM,Bousoño C,Gueimonde M,Margolles A,Delgado S,Díaz JJ

更新日期：2019-08-02 00:00:00

abstract：:Minimal residual disease remaining after resection of primary tumors can lead to tumor recurrence and metastasis, increasing mortality and morbidity rates among cancer patients. Thus, there is a need for new technologies for recognition and elimination of single cancer cells remaining in a patient's body after radiati...

journal_title：Frontiers in immunology

authors： Kuznetsova M,Lopatnikova J,Shevchenko J,Silkov A,Maksyutov A,Sennikov S

更新日期：2019-05-09 00:00:00

abstract：:Immunotherapy with anti-CD20-specific antibodies (rituximab), has become the standard of care for B cell lymphoproliferative disorders and many autoimmune diseases. In rheumatological patients the effect of rituximab on bone mass yielded conflicting results, while in lymphoma patients it has not yet been described. He...

journal_title：Frontiers in immunology

authors： Kolomansky A,Kaye I,Ben-Califa N,Gorodov A,Awida Z,Sadovnic O,Ibrahim M,Liron T,Hiram-Bab S,Oster HS,Sarid N,Perry C,Gabet Y,Mittelman M,Neumann D

更新日期：2020-10-19 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hBtk) display spontaneous ...

journal_title：Frontiers in immunology

authors： Rip J,de Bruijn MJW,Appelman MK,Pal Singh S,Hendriks RW,Corneth OBJ

更新日期：2019-01-30 00:00:00

abstract：:We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diver...

journal_title：Frontiers in immunology

authors： Gordon S,Plüddemann A

更新日期：2019-08-09 00:00:00

abstract：:Neuronal apoptosis inhibitory protein (NAIP)/NOD-like receptor (NLR) containing a caspase activating and recruitment domain (CARD) 4 (NLRC4) inflammasome complexes are activated in response to proteins from virulent bacteria that reach the cell cytosol. Specific NAIP proteins bind to the agonists and then physically a...

journal_title：Frontiers in immunology

authors： Lage SL,Longo C,Branco LM,da Costa TB,Buzzo Cde L,Bortoluci KR

更新日期：2014-07-02 00:00:00

abstract：:Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for citrullination. PAD2 ...

journal_title：Frontiers in immunology

authors： Zhou Y,Chen B,Mittereder N,Chaerkady R,Strain M,An LL,Rahman S,Ma W,Low CP,Chan D,Neal F,Bingham CO 3rd,Sampson K,Darrah E,Siegel RM,Hasni S,Andrade F,Vousden KA,Mustelin T,Sims GP

更新日期：2017-09-25 00:00:00

abstract：:Microtubules play critical roles in regulating the activation of NLRP3 inflammasome and microtubule-destabilizing agents such as colchicine have been shown to suppress the activation of this inflammasome. However, it remains largely unknown whether paclitaxel, a microtubule-stabilizing agent being used in cancer thera...

journal_title：Frontiers in immunology

authors： Zeng QZ,Yang F,Li CG,Xu LH,He XH,Mai FY,Zeng CY,Zhang CC,Zha QB,Ouyang DY

更新日期：2019-01-29 00:00:00

abstract：Objective:Antiphospholipid syndrome (APS) is characterized by the presence of anti-phospholipid (aPL) antibodies. However, the relationship between the immunoglobulin (Ig) A isotype of aPL positivity and its clinical utility in APS diagnosis is controversial. Presently, we determine the clinical utility of IgA-aPL from...

journal_title：Frontiers in immunology

authors： Hu C,Li X,Zhao J,Wang Q,Li M,Tian X,Zeng X

更新日期：2020-10-05 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...

journal_title：Frontiers in immunology

authors： Weber TS

更新日期：2018-06-12 00:00:00

abstract：:Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its re...

journal_title：Frontiers in immunology

authors： Haskó G,Cronstein B

更新日期：2013-04-08 00:00:00

abstract：:Two decades of clinical cancer research with dendritic cell (DC)-based vaccination have proved that this type of personalized medicine is safe and has the capacity to improve survival, but monotherapy is unlikely to cure the cancer. Designed to empower the patient's antitumor immunity, huge research efforts are set to...

journal_title：Frontiers in immunology

authors： Versteven M,Van den Bergh JMJ,Marcq E,Smits ELJ,Van Tendeloo VFI,Hobo W,Lion E

更新日期：2018-03-01 00:00:00

abstract：:Background: Although immunotherapy has emerged as the "next generation" of cancer treatments, it has not yet been shown to be successful in the treatment of patients with prostate cancer, for whom therapeutic options remain limited to radiotherapy and androgen (hormone) deprivation therapy. Previous studies have shown...

journal_title：Frontiers in immunology

authors： Hood SP,Foulds GA,Imrie H,Reeder S,McArdle SEB,Khan M,Pockley AG

更新日期：2019-01-25 00:00:00

abstract：:Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors for the vaccine design. The number and location of glycan moieties in t...

journal_title：Frontiers in immunology

authors： Macioła AK,Pietrzak MA,Kosson P,Czarnocki-Cieciura M,Śmietanka K,Minta Z,Kopera E

更新日期：2017-04-20 00:00:00

abstract：:Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) have been extensively studied. Their pleotropic roles were observed in multiple steps of tumor progression and metastasis, and sometimes appeared to be inconsistent across different studies. In this review, we collectively discussed many lines...

journal_title：Frontiers in immunology

authors： Wu L,Zhang XH

更新日期：2020-12-02 00:00:00

abstract：:Inflammation has been recognized as an important driver in the development and growth of malignancies. Inflammatory signaling in cancer emerges from the combinatorial interaction of several deregulated pathways. Pathway deregulation is often driven by changes in the underlying gene regulatory networks. Confronted with...

journal_title：Frontiers in immunology

authors： Velazquez-Caldelas TE,Alcalá-Corona SA,Espinal-Enríquez J,Hernandez-Lemus E

更新日期：2019-01-29 00:00:00

abstract：:Current pain therapeutics offer inadequate relief to patients with chronic pain. A growing literature supports that pro-inflammatory cytokine signaling between immune, glial, and neural cells is integral to the development of pathological pain. Modulation of these communications may hold the key to improved pain manag...

journal_title：Frontiers in immunology

authors： Vanderwall AG,Milligan ED

更新日期：2019-12-23 00:00:00

abstract：:Blood-feeding enriched gut-microbiota boosts mosquitoes' anti-Plasmodium immunity. Here, we ask how Plasmodium vivax alters gut-microbiota, anti-Plasmodial immunity, and impacts tripartite Plasmodium-mosquito-microbiota interactions in the gut lumen. We used a metagenomics and RNAseq strategy to address these question...

journal_title：Frontiers in immunology

authors： Sharma P,Rani J,Chauhan C,Kumari S,Tevatiya S,Das De T,Savargaonkar D,Pandey KC,Dixit R

更新日期：2020-05-14 00:00:00

abstract：:Iron is an essential micronutrient for most living species. In mammals, hemoglobin (Hb) stores more than two thirds of the body's iron content. In the bloodstream, haptoglobin (Hp) and hemopexin (Hpx) sequester free Hb or heme. Pathogenic microorganisms usually acquire iron from their hosts and have evolved complex sy...

journal_title：Frontiers in immunology

authors： Mozzi A,Forni D,Clerici M,Cagliani R,Sironi M

更新日期：2018-09-11 00:00:00

abstract：:Sepsis is one of the well-established diseases with specific patterns of neutrophil dysfunctions. Previous studies demonstrated sepsis-related neutrophil dysfunctions in comparison with subjects without infection. Since sepsis and infection are recently recognized as distinctive processes, whether these neutrophil dys...

journal_title：Frontiers in immunology

authors： Seree-Aphinan C,Vichitkunakorn P,Navakanitworakul R,Khwannimit B

更新日期：2020-12-23 00:00:00

abstract：:Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the establishment of protein antigen-specific B cell memory and long-lived pla...

journal_title：Frontiers in immunology

authors： Lang ML

更新日期：2018-02-22 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and skin during development. However, the roles of IL34 and CSF1 at homeost...

journal_title：Frontiers in immunology

authors： Lin W,Xu D,Austin CD,Caplazi P,Senger K,Sun Y,Jeet S,Young J,Delarosa D,Suto E,Huang Z,Zhang J,Yan D,Corzo C,Barck K,Rajan S,Looney C,Gandham V,Lesch J,Liang WC,Mai E,Ngu H,Ratti N,Chen Y,Misner D,Lin T

更新日期：2019-09-04 00:00:00

abstract：:Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent ...

journal_title：Frontiers in immunology

authors： Blomberg J,Gottfries CG,Elfaitouri A,Rizwan M,Rosén A

更新日期：2018-02-15 00:00:00

abstract：:S100A12 is a calcium-binding protein of the S100 subfamily of myeloid-related proteins that acts as an alarmin to induce a pro-inflammatory innate immune response. It has been linked to several chronic inflammatory diseases, however its role in the common oral immunopathology periodontitis is largely unknown. Previous...

journal_title：Frontiers in immunology

authors： Lira-Junior R,Holmström SB,Clark R,Zwicker S,Majster M,Johannsen G,Axtelius B,Åkerman S,Svensson M,Klinge B,Boström EA

更新日期：2020-01-31 00:00:00

abstract：:Enterovirus and Coxsackievirus are the major viruses that cause hand, foot, and mouth disease (HFMD) outbreaks worldwide. Several studies have shown the potential of viral envelope protein 1 (VP1) on providing protective effects from viral strains of different genotypes. However, whether VP1 has the cross-protection i...

journal_title：Frontiers in immunology

authors： Chen FH,Liu X,Fang HL,Nan N,Li Z,Ning NZ,Luo DY,Li T,Wang H

更新日期：2019-11-08 00:00:00